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    MLS313 WBCs Morphology in Health and Diseases

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    Mariam Khalil
    This document provides information on white blood cell morphology in health and disease. It discusses the normal white blood cell populations including neutrophils, lymphocytes, monocytes, eosinophils and basophils. It then describes abnormalities seen in various disease states, such as Dohle bodies, toxic granulation, and ring shaped nuclei in neutrophils in infections and leukemia. It also covers abnormalities seen in lymphocytes, such as atypical lymphocytes in reactive conditions and plasma cells in multiple myeloma. Various leukemia subtypes are discussed based on the type of blast cell present, such as myeloblasts in myeloid leukemias and lymphoblasts in lymphoblastic leukemias. Common references on clinical hematology are also provided.

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    MLS313 WBCs Morphology in Health and Diseases

    Uploaded by

    Mariam Khalil
    22 views60 pages
    This document provides information on white blood cell morphology in health and disease. It discusses the normal white blood cell populations including neutrophils, lymphocytes, monocytes, eosinophils and basophils. It then describes abnormalities seen in various disease states, such as Dohle bodies, toxic granulation, and ring shaped nuclei in neutrophils in infections and leukemia. It also covers abnormalities seen in lymphocytes, such as atypical lymphocytes in reactive conditions and plasma cells in multiple myeloma. Various leukemia subtypes are discussed based on the type of blast cell present, such as myeloblasts in myeloid leukemias and lymphoblasts in lymphoblastic leukemias. Common references on clinical hematology are also provided.

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    This document provides information on white blood cell morphology in health and disease. It discusses the normal white blood cell populations including neutrophils, lymphocytes, monocytes, eosinophils and basophils. It then describes abnormalities seen in various disease states, such as Dohle bodies, toxic granulation, and ring shaped nuclei in neutrophils in infections and leukemia. It also covers abnormalities seen in lymphocytes, such as atypical lymphocytes in reactive conditions and plasma cells in multiple myeloma. Various leukemia subtypes are discussed based on the type of blast cell present, such as myeloblasts in myeloid leukemias and lymphoblasts in lymphoblastic leukemias. Common references on clinical hematology are also provided.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    22 views60 pages

    MLS313 WBCs Morphology in Health and Diseases

    Uploaded by

    Mariam Khalil
    This document provides information on white blood cell morphology in health and disease. It discusses the normal white blood cell populations including neutrophils, lymphocytes, monocytes, eosinophils and basophils. It then describes abnormalities seen in various disease states, such as Dohle bodies, toxic granulation, and ring shaped nuclei in neutrophils in infections and leukemia. It also covers abnormalities seen in lymphocytes, such as atypical lymphocytes in reactive conditions and plasma cells in multiple myeloma. Various leukemia subtypes are discussed based on the type of blast cell present, such as myeloblasts in myeloid leukemias and lymphoblasts in lymphoblastic leukemias. Common references on clinical hematology are also provided.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 60

    MLS313

    White Blood cells


    1
    Morphology in health and
    diseases
    2 Normocellular BM
    3 Hypocellular BM
    4 Hypercellular BM
    5 Morphology of Leukocytes

    Normal WBC populations:


    Neutrophils (Granulocytes)
    Lymphocytes
    Monocytes
    Eosinophils
    Basophils
    6 Neutrophil
    7 ??
    8 Eosinophil
    9 Neutrophils Eosinophils
    10 Monocytes
    11 Monocytes
    12 Lymphocytes
    Small Large

    Intermediate
    13 Basophils
    14 Plasma cell
    15 ????
    16 Granulocyte Inclusions or Variants
    Terminology Description Condition
    Dohle bodies Pale blue areas in neutrophil Infections, pregnancy,
    cytoplasm cancer
    Toxic Granulation Large purple granules in Infection
    neutrophil cytoplasm

    Vacuoles Transparent areas in neutrophil Infection, Toxin


    cytoplasm
    Hypersegmented ≥ 6 nuclear lobes e.g. Megaloblastic anemia

    Auer rods Reddish long needle AML


    Drumstick nuclear appendage attached to Neutrophils of females
    the nucleus by a filament. Males with Klinefelter
    syndrome

    Ring shaped Nucleus ring or doughnut shaped AML, CML, MA, MDS
    nuclei
    17 Dohle Bodies
    18 Toxic Granulation
    19 Hypogranulation
    20 Hypersegmented Neutrophils
    21
    22 Ring shaped nuclei
    23 Toxic Granulation and Vacuole Formation
    24 Phagocytosed Parasites
    25 Phagocytosed bacteria
    26 Apoptotic neutrophil

    Found in:
    Occasionally in healthy subjects, In vitro artefact, AML
    27 satelitissm of platelet around
    neutrophil
    28 Chediak-Higashi anomaly
    29 Pelger-Huet Abnormality
    30 May-Higglen anomaly
    31 Auer Rod: AML
    32
    33 Abnormalities of Lymphocytes
    Variant Morphologic categories
    Atypical lymphocyte Abundant cytoplasm, RBC “skirting”,
    Basophilia may be confined to the cytoplasmic
    margins.

    Abnormal lymphs Nuclear abnormalities i.e. clefts, folds, notches

    Plasmacytoid lymphs Abundant cytoplasm


    Hairy cells Cytoplasmic projections
    Sezary cells Deeply folded nucleus
    Prolymphocyte Large lymph with prominent nucleolus

    Binucleated Lymphocytes Viral infection

    Rieder Cells CLL


    34 Atypical (Reactive) Lymphocytes
    35 Large Granular Lymphocyte
    36 Plasmacytoid Lymphocytes
    37 Sezary Cell
    38 Chronic Lymphocytic Leukemia (CLL)
    39 CLL: Smudge Cells
    40 CLL: basket cells
    41 Rieder Cells
    42 Plasmacytoid Lymphocytes
    Acute Lymphoblastic Leukemia: L1
    43
    Acute Lymphoblastic Leukemia: L2
    44
    Acute Lymphoblastic Leukemia: L3 (Burkitts)
    45
    46 ?
    47 Plasma Cell: MM
    48
    49
    50 Hairy Cell: Hairy Cell Leukemia
    51 CML
    52 M1: Myeloblasts without Differentiation
    M2: Myeloblasts with Some Differentiation
    53
    54 M3 Promyelocytic Leukemia
    M4: Myelomonocytic Leukemia
    55
    M5: Monocytic Leukemia
    56
    57 M6: Erythroleukemia
    58 M7: Megakaryocytic Leukemia
    59 identify
    References
    60

     Clinical Hematology :- Theory and Procedures, Fifth Edition, by Mary Louise Turgeon

     Essential Haematology: By: Hoffbrand, A. V. Malden, Mass.: Blackwell Pub., 2011.

     Dacie and Lewis practical haematology 10th ed., Indian ed. Author Lewis, S. M. (Shirley Mitchell).

     Wintrobe's Atlas of Clinical Hematology, 1st edition, by Douglas C. Tkachuk , Jan V. Hirschmann.

     Internet.

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