Development of BNCT TPS
Development of BNCT TPS
Development of BNCT TPS
Mar.17, 2022
3.0x107 Epi-thermal
(0.5 eV < En < 10 keV)
0.0
10-9 10-8 10-7 10-6 10-5 10-4 10-3 10-2 10-1 100 101
Neutron Energy [MeV]
• ‘seraMC’ : Multi group Monte-Carlo code for neutron and gamma transport
• seraMC.sigma : cross section library based on ENDF/B V & VI
• seraMC.mat : Material library
• 18 elements (H, O, Al, Li, C, N, B, Na, S, Ca, Mg, Cl, K, P, Pb, F, Cd, Bi)
• 51 of mixtures w/ density (ICRU-64 for human organ)
• xxxx.source : Radiation source file w/,
• neutron : 94 Egroup - group1(> 9.12 keV), group2(0.414 eV ~ 9.12 keV), thermal (<0.4 eV)
• gamma : 86 Egroup
ROI setup
Material library
segmentation value seraMC+plus (seraMC.mat) +add
𝒕′ 𝑬′
𝑫𝒊 = න න 𝑲 𝑬 𝝓 𝑬, 𝒕 𝒅𝑬𝒅𝒕
𝒕 𝑬
source term
Dose map RT Dose (mybnct.source) * mod.
S2D
, DVH (DICOM)
10-5
E*dΦ/dE
• < 3% for B-10, N-14, gamma dose 10-7
8.0x10-8
Φ/bin
6.0x10-8
adjusted 4.0x10-8
(2)
2.0x10-8
Snyder phantom
0.0
10-3 10-2 10-1 100 101 102
Photon Energy [MeV]
dose calculation
dose calculation
D2S S2D
no significant diff.
increase N cores in dose for cores
• Enlarge Batch size (the number of neutron histories to run in each batch)
no significant diff.
increase ‘Batch size’ in dose for batch size
Source Uncertainty
198
Au(n, γ)198Au cross section 0.20%
Gamma(411 keV) emission rate 0.06%
Detector efficiency calibration 0.53%
Bare wire 0.48 ~ 0.79 %
Counting statistics
Cd covered wire 0.56 ~ 1.13 %
Bare wire 0.10%
Wire mass
Cd covered wire 0.10%
Combined (k=1) 1.04 ~ 1.7 %
Combined (k=2) 2.08 ~ 3.4 %
Epi-Fast neutron
Gamma dose
Source dose
Uncertainty
Uncertainty
Calibration 1.40% 1.40%
Measurement 2.37% 2.60%
Neutron sensitivity of T.E chamber 6.00% 1.00%
Neutron sensitivity of Graphite chamber 4.00% 3.00%
Thermal neutron response of T.E chamber 13.00% 1.00%
Thermal neutron response of Graphite chamber 3.00% 2.00%
jungyu.yi@dawonmedax.com Combind (k=1) 2022 TM BNCT | DM-BTPS
15.42% 4.87% 10
Combind (k=2) 30.84% 9.74%
(before integration seraMC w/ UI)
https://neuroimage.usc.edu/neuro/Digimouse
mice silhouette!