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Drug Study Norepinephrine

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DRUG STUDY

Name of Drug Classification Mechanism of Action Indication Contraindication Adverse Effects Nursing Precautions
Norepinephrine Alpha/Beta Norepinephrine is a Used for blood pressure Norepinephrine use Excessive 1. Blood pressure
Adrenergic sympathomimetic amine control in specific acute may be vasoconstriction, requires close
Agonists derived from tyrosine.  It is hypotensive states, as well as contraindicated to increased monitoring
structurally identical to being a potential adjunct in treat hypotension pulmonary whenever
epinephrine but differs in the treatment of cardiac that is likely vascular vasopressors such
that it lacks a methyl group arrest with profound secondary to resistance, as norepinephrine
on its nitrogen atom.  This hypotension. cardiogenic increased are in use; this is
difference makes it mechanisms.  systemic vascular possible via
primarily agonistic at Additionally, for resistance, and invasive or non-
alpha1 and beta1 receptors, hypotension decreased hepatic invasive
with little-to-no beta2 or primarily related to flow. measurement
alpha2 activity. The hypovolemia. techniques.  If
increased activation of the following non-
alpha1 receptors will result invasive
in vasoconstriction and measurements,
dose-dependent increases in then it is
systemic vascular recommended to
resistance. obtain values
every 2 to 3
minutes during
initial titration and
then at least every
5 minutes
following the
determination of
the appropriate
maintenance dose.
2. Assess patient
frequently for
headache, chest
pain, or other
signs of toxicity.

3. Defibrillator and
resuscitation cart
should be close by
during infusion.

4. Cardiac monitor
should be used on
patients receiving
norepinephrine IV
infusions.

5. For overdose case,


Phentolamine, an
alpha-1 antagonist
may be given.

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