Safety Data Sheet

ALLANTOIN USP

Safety Data Sheet dated 5/11/2015, version 1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1. Product identifier
Mixture identification:
Trade name: ALLANTOIN USP

CAS number: 97-59-6

EC number: 202-592-8
1.2. Relevant identified uses of the substance or mixture and uses advised against
Recommended use:
Cosmetics sector.
1.3. Details of the supplier of the safety data sheet
Company:
CISME Italy SRL
Via Giuseppe Marcora 7
20121 Milano
Tel 0030 02 29000402
Fax 0039 02 654946
CISME Italy SRL - Phone 0039 0229000402
Competent person responsible for the safety data sheet:
msds@cismeitaly.com
1.4. Emergency telephone number
CISME Italy SRL - Phone 0039 0229000402

SECTION 2: Hazards identification

2.1. Classification of the substance or mixture
EC regulation criteria 1272/2008 (CLP)
The product is not classified as dangerous according to Regulation EC 1272/2008 (CLP).
Adverse physicochemical, human health and environmental effects:
No other hazards
2.2. Label elements
Symbols:
None
Hazard statements:
None
Precautionary statements:
None
Special Provisions:
None
Special provisions according to Annex XVII of REACH and subsequent amendments:
None
2.3. Other hazards
vPvB Substances: None - PBT Substances: None
Other Hazards:
No other hazards

SECTION 3: Composition/information on ingredients

3.1. Substances
Identification of the substance: Urea, (2,5-dioxo-4-imidazolidinyl)-

CAS number: 97-59-6

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EC number: 202-592-8

3.2. Mixtures
N.A.

SECTION 4: First aid measures

4.1. Description of first aid measures
In case of skin contact:
Wash with plenty of water and soap.
In case of eyes contact:
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
In case of Ingestion:
Do not under any circumstances induce vomiting. OBTAIN A MEDICAL EXAMINATION
IMMEDIATELY.
In case of Inhalation:
Remove casualty to fresh air and keep warm and at rest.
4.2. Most important symptoms and effects, both acute and delayed
None
4.3. Indication of any immediate medical attention and special treatment needed
Treatment:
None

SECTION 5: Firefighting measures

5.1. Extinguishing media
Suitable extinguishing media:
Water.
Carbon dioxide (CO2).
Extinguishing media which must not be used for safety reasons:
None in particular.
5.2. Special hazards arising from the substance or mixture
Do not inhale explosion and combustion gases.
Burning produces heavy smoke.
5.3. Advice for firefighters
Use suitable breathing apparatus .
Collect contaminated fire extinguishing water separately. This must not be discharged into
drains.
Move undamaged containers from immediate hazard area if it can be done safely.

SECTION 6: Accidental release measures

6.1. Personal precautions, protective equipment and emergency procedures
Wear personal protection equipment.
Remove all sources of ignition.
Remove persons to safety.
See protective measures under point 7 and 8.
6.2. Environmental precautions
Do not allow to enter into soil/subsoil. Do not allow to enter into surface water or drains.
Retain contaminated washing water and dispose it.
In case of gas escape or of entry into waterways, soil or drains, inform the responsible
authorities.
Suitable material for taking up: absorbing material, organic, sand
6.3. Methods and material for containment and cleaning up
Wash with plenty of water.
6.4. Reference to other sections
See also section 8 and 13

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SECTION 7: Handling and storage
7.1. Precautions for safe handling
Avoid contact with skin and eyes, inhaltion of vapours and mists.
Don't use empty container before they have been cleaned.
Before making transfer operations, assure that there aren't any incompatible material
residuals in the containers.
Contamined clothing should be changed before entering eating areas.
Do not eat or drink while working.
See also section 8 for recommended protective equipment.
7.2. Conditions for safe storage, including any incompatibilities
Handle the product after consultation with all sections of this SDS.
Store in its original packaging, in a cool, well-ventilated area away from open flames and heat
sources.
Do not eat, drink or smoke in storage place.
Keep away from food, drink and feed.
Incompatible materials:
None in particular.
Instructions as regards storage premises:
Adequately ventilated premises.
7.3. Specific end use(s)
None in particular

SECTION 8: Exposure controls/personal protection

8.1. Control parameters
No occupational exposure limit available
DNEL Exposure Limit Values
N.A.
PNEC Exposure Limit Values
N.A.
8.2. Exposure controls
Eye protection:
You should wear safety goggles.
Protection for skin:
Chemical protection clothing.
Protection for hands:
Protect hands with suitable gloves, the duration of which will depend on the time of use and
use.
Suitable gloves type:
NR (natural rubber - natural latex).
NBR (nitrile rubber - butyl rubber).
PVC (polyvinyl chloride).
Respiratory protection:
The use of protective equipment, such as masks of the type indicated, is necessary in the
absence of technical measures limiting worker exposure.
Not required for normal use.
Thermal Hazards:
Data not available.
Environmental exposure controls:
As the use of adequate technical equipment must always take priority over personal
protective equipment, make sure that workplace is well aired through effective local
aspiration. When choosing protective equipment, ask your chemical substance supplier.
Personal protective equipment must be CE marked, showing that is complies with applicable
standard.
Appropriate engineering controls:
None

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SECTION 9: Physical and chemical properties
9.1. Information on basic physical and chemical properties

Properties Value Method: Notes

Appearance and colour: White powder. -- --
Odour: Odourless -- --
Odour threshold: -- --
pH: 3.5 - 6.5 -- --
(0.5%
aqueous
solution)
Melting point / freezing N.A. -- --
point:
Initial boiling point and N.A. -- --
boiling range:
Flash point: N.A. -- --
Evaporation rate: N.A. -- --
Solid/gas flammability: N.A. -- --
Upper/lower flammability N.A. -- --
or explosive limits:
Vapour pressure: N.A. -- --
Vapour density: N.A. -- --
Relative density: 0.70 g/ml -- --
Solubility in water: Soluble -- --
Solubility in oil: -- --
Partition coefficient N.A. -- --
(n-octanol/water):
Auto-ignition temperature: N.A. -- --
Decomposition 230 °C -- --
temperature:
Viscosity: N.A. -- --
Explosive properties: Not explosive -- --
Oxidizing properties: Not oxidising -- --

9.2. Other information

Properties Value Method: Notes

Miscibility: N.A. -- --
Fat Solubility: N.A. -- --
Conductivity: N.A. -- --
Substance Groups -- --
relevant properties

SECTION 10: Stability and reactivity

10.1. Reactivity
Stable in normal condiction.
10.2. Chemical stability
Stable in normal conditions of use and storage.
10.3. Possibility of hazardous reactions
Under normal circumstances no hazardous reactions are foreseeable.
10.4. Conditions to avoid
None in particular. However follow the usual precautions against chemicals.
10.5. Incompatible materials
Strong Alkalis.

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10.6. Hazardous decomposition products
Carbon oxides ( COx).
Nitrogen oxides (NOx)
Ammonia.

SECTION 11: Toxicological information

11.1. Information on toxicological effects
Toxicological information of the substance:
ALLANTOIN USP - CAS: 97-59-6
Acute toxicity.:
Test: LD50 - Route: Oral - Species: Rat > 5000 mg/kg
Skin corrosion/irritation.:
Test: Skin Irritant Negative
Serious eye damage/irritation:
Test: Eye Irritant Negative
Sespiratory or skin sensitization.:
Test: Respiratory Sensitization - Route: Inhalation Negative

If not differently specified, the information required in Regulation (EU)2015/830 listed below must be
considered as N.A.:
Acute toxicity.;
Skin corrosion/irritation.;
Serious eye damage/irritation;
Sespiratory or skin sensitization.;
Germ cells mutagenicity.;
Carcinogenicity.;
Reproductive toxicity.;
STOT-single exposure;
STOT-repeated exposure.;
Aspiration hazard..

SECTION 12:Ecological information

12.1. Toxicity
Adopt good working practices, so that the product is not released into the environment.

ALLANTOIN USP - CAS: 97-59-6

Aquatic acute toxicity.:
Endpoint: LC50 - Species: Fish > 5000 mg/l
Endpoint: LC0 - Species: Pseudomonas sp. > 10 g/l
12.2. Persistence and degradability
ALLANTOIN USP - CAS: 97-59-6
Biodegradability: Biodegradable - Test: N.A. - Duration h: N.A. - %: N.A. - Notes: N.A.
BOD: 63.8 mg/g
COD: 240 mg/g
12.3. Bioaccumulative potential
ALLANTOIN USP - CAS: 97-59-6
Low potential of bioaccumulation. - Test: log Kow -3.14 - Duration h: N.A. - Notes: N.A.
12.4. Mobility in soil
N.A.
12.5. Results of PBT and vPvB assessment
vPvB Substances: None - PBT Substances: None
12.6. Other adverse effects
None

SECTION 13: Disposal considerations

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13.1. Waste treatment methods
Recover if possible. In so doing, comply with the local and national regulations currently in
force.

SECTION 14: Transport information

14.1. UN number
Not classified as dangerous in the meaning of transport regulations.
14.2. UN proper shipping name
N.A.
14.3. Transport hazard class(es)
N.A.
14.4. Packing group
N.A.
14.5. Environmental hazards
N.A.
14.6. Special precautions for user
N.A.
14.7. Transport in bulk according to Annex II of Marpol and the IBC Code
N.A.

SECTION 15: Regulatory information

15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture
Dir. 98/24/EC (Risks related to chemical agents at work)
Dir. 2000/39/EC (Occupational exposure limit values)
Regulation (EC) n. 1907/2006 (REACH)
Regulation (EC) n. 1272/2008 (CLP)
Regulation (EC) n. 790/2009 (ATP 1 CLP) and (EU) n. 758/2013
Regulation (EU) 2015/830
Regulation (EU) n. 286/2011 (ATP 2 CLP)
Regulation (EU) n. 618/2012 (ATP 3 CLP)
Regulation (EU) n. 487/2013 (ATP 4 CLP)
Regulation (EU) n. 944/2013 (ATP 5 CLP)
Regulation (EU) n. 605/2014 (ATP 6 CLP)
Restrictions related to the product or the substances contained according to Annex XVII Regulation
(EC) 1907/2006 (REACH) and subsequent modifications:
Restrictions related to the product:
No restriction.
Restrictions related to the substances contained:
No restriction.
Where applicable, refer to the following regulatory provisions :
Directive 2003/105/CE ('Activities linked to risks of serious accidents') and subsequent
amendments.
Regulation (EC) nr 648/2004 (detergents).
1999/13/EC (VOC directive)

Provisions related to directives 82/501/EC(Seveso), 96/82/EC(Seveso II):

N.A.
15.2. Chemical safety assessment
No

SECTION 16: Other information

This document was prepared by a competent person who has received appropriate training.
Main bibliographic sources:
ECDIN - Environmental Chemicals Data and Information Network - Joint Research Centre,
Commission of the European Communities

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Safety Data Sheet
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SAX's DANGEROUS PROPERTIES OF INDUSTRIAL MATERIALS - Eight Edition - Van
Nostrand Reinold
CCNL - Appendix 1
Insert further consulted bibliography
The information contained herein is based on our state of knowledge at the above-specified date. It
refers solely to the product indicated and constitutes no guarantee of particular quality.
It is the duty of the user to ensure that this information is appropriate and complete with respect to
the specific use intended.
This MSDS cancels and replaces any preceding release.

ADR: European Agreement concerning the International Carriage of

Dangerous Goods by Road.
CAS: Chemical Abstracts Service (division of the American Chemical
Society).
CLP: Classification, Labeling, Packaging.
DNEL: Derived No Effect Level.
EINECS: European Inventory of Existing Commercial Chemical Substances.
GefStoffVO: Ordinance on Hazardous Substances, Germany.
GHS: Globally Harmonized System of Classification and Labeling of
Chemicals.
IATA: International Air Transport Association.
IATA-DGR: Dangerous Goods Regulation by the "International Air Transport
Association" (IATA).
ICAO: International Civil Aviation Organization.
ICAO-TI: Technical Instructions by the "International Civil Aviation Organization"
(ICAO).
IMDG: International Maritime Code for Dangerous Goods.
INCI: International Nomenclature of Cosmetic Ingredients.
KSt: Explosion coefficient.
LC50: Lethal concentration, for 50 percent of test population.
LD50: Lethal dose, for 50 percent of test population.
LTE: Long-term exposure.
PNEC: Predicted No Effect Concentration.
RID: Regulation Concerning the International Transport of Dangerous Goods
by Rail.
STE: Short-term exposure.
STEL: Short Term Exposure limit.
STOT: Specific Target Organ Toxicity.
TLV: Threshold Limiting Value.
TWATLV: Threshold Limit Value for the Time Weighted Average 8 hour day.
(ACGIH Standard).
WGK: German Water Hazard Class.

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