International Parkinson and Movement Disorder Society - Non-Motor Rating Scale
International Parkinson and Movement Disorder Society - Non-Motor Rating Scale
International Parkinson and Movement Disorder Society - Non-Motor Rating Scale
Authored by:
Kallol Ray Chaudhuri
Pablo Martinez-Martin
Anette Schrag
Daniel Weintraub
Alexandra Rizos
Carmen Rodriguez-Blazquez
Copyright © 2019 International Parkinson and Movement Disorder Society. All rights reserved.
MDS Permissions
Copyright © 2019 International Parkinson and Movement Disorder Society. All rights reserved.
International Parkinson and Movement Disorder Society –
Non-Motor Rating Scale (MDS-NMS)
RATER-ADMINISTERED VERSION
Rate symptoms over past 4 weeks
Patient Name or Identifier: ______________________________________
Date: ______________________________________
If the answer to the question is “Never”, rate frequency/duration as “0”, rate severity also as “0” and move
on to the next question.
Copyright © 2019 International Parkinson and Movement Disorder Society. All rights reserved. | Version 1.0 1
International Parkinson and Movement Disorder Society –
Non-Motor Rating Scale (MDS-NMS)
RATER-ADMINISTERED VERSION
Rate symptoms over past 4 weeks
Frequency Severity Frequency
(0-4) (0-4) x severity
A. Depression:
1. Felt sad or depressed? ....................................................................
2. Had difficulty experiencing pleasure? ...............................................
3. Felt hopeless? .................................................................................
4. Had negative thoughts about yourself? ............................................
5. Felt that life is not worth living? ........................................................
Subscale A Total
B. Anxiety:
1. Felt worried? ....................................................................................
2. Felt nervous? ...................................................................................
3. Had panic or anxiety attacks? ..........................................................
4. Been worried about being in public or in social situations?...............
Subscale B Total
C. Apathy:
1. Had a reduced motivation to start day-to-day activities? ..................
2. Had a reduced interest in talking to people? ....................................
3. Had a reduction in experiencing emotions?......................................
Subscale C Total
D. Psychosis:
1. Sensed things or people in margins of your visual field?
(passage or presence phenomena) ..................................................
2. Visually misinterpreted an actual object? (illusions) .........................
3. Seen, heard, felt, tasted, or smelled things that other people did
not? (hallucinations) .........................................................................
4. Believed things to be true that others did not?
(e.g., delusions of persecution, jealousy, or misidentification) ..........
Subscale D Total
E. Impulse Control and Related Disorders:
1. Had an increase in gambling, sexual, buying, or eating behaviors?
2. Had an increase in other behaviors (e.g., internet use, hobbies,
artistic activities, writing, hoarding)? .................................................
3. Repeatedly handled objects without any purpose? (punding) ..........
4. Routinely taken more anti-parkinsonian medications than
prescribed? (dopamine dysregulation syndrome) .............................
Subscale E Total
Copyright © 2019 International Parkinson and Movement Disorder Society. All rights reserved. | Version 1.0 2
International Parkinson and Movement Disorder Society –
Non-Motor Rating Scale (MDS-NMS)
RATER-ADMINISTERED VERSION
Rate symptoms over past 4 weeks
G. Orthostatic Hypotension:
1. Felt lightheaded or fainted when changing position? ........................
2. Had dizziness or weakness upon standing?.....................................
Subscale G Total
H. Urinary:
1. Had an urgent need to empty bladder? (urinary urgency) ................
2. Had to empty bladder more than every 2 hours?
(urinary frequency) ...........................................................................
3. Had to empty bladder more than twice overnight? (nocturia) ...........
Subscale H Total
I. Sexual:
1. Had decreased sexual drive or interest in sex? ................................
2. Had difficulty with sexual arousal (e.g., erectile dysfunction or
vaginal dryness) or sexual performance not related to motor
problems (e.g., not related to Parkinson’s rigidity)? .........................
Subscale I Total
J. Gastrointestinal:
1. Had any drooling of saliva? ..............................................................
2. Had difficulty swallowing? ................................................................
3. Had nausea or felt sick in the stomach?...........................................
4. Had constipation? (defined as < 3 bowel movements/week) ............
Subscale J Total
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International Parkinson and Movement Disorder Society –
Non-Motor Rating Scale (MDS-NMS)
RATER-ADMINISTERED VERSION
Rate symptoms over past 4 weeks
L. Pain:
1. Had muscle, joint, or back pain? ......................................................
2. Had a deep or dull aching pain within the body? ..............................
3. Had pain due to abnormal twisting movements of arms or legs
or body, often present in the early morning period? (dystonia) .........
4. Had other types of pain? (e.g., nocturnal pain, orofacial pain) ..........
Subscale L Total
M. Other:
1. Had an unintentional weight loss?
(rate frequency as either not present (0) or present (4);
for severity rate 0 (only if frequency = 0), 1 (minimal), 2 (mild),
3 (moderate), or 4 (severe)) ............................................................
2. Had a decrease in sense of smell? (impaired olfaction)
(rate frequency as either not present (0) or present (4);
for severity rate 0 (only if frequency = 0), 1 (minimal), 2 (mild),
3 (moderate), or 4 (severe)) ............................................................
3. Felt excessively physically tired? (physical fatigue) ..........................
4. Felt excessively mentally tired? (mental fatigue) ..............................
5. Had excessive sweating not related to temperature? .......................
Subscale M Total
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International Parkinson and Movement Disorder Society –
Non-Motor Rating Scale (MDS-NMS)
RATER-ADMINISTERED VERSION
Rate symptoms over past 4 weeks
MDS-NMS Non-Motor Fluctuations (NMF) Subscale
Do you / Does the patient experience changes in non-motor symptoms (as listed below) in relation to the
timing of anti-parkinsonian medications (i.e., symptoms occurring or worsening during “Off” period)?
□ Yes □ No
SCORING
Typical degree of change from “On” to “Off” period:
0: No change
1: Minimal
2: Small
3: Medium
4: Large
Subscore “Change” = Sum of all “Degree of change” items
MDS-NMS NMF Total Score = Subscore “Change” multiplied by Subscore “Time”
”off”
Degree of change
(0-4)
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Patient Name/Identifier: ______________________________ Date: __________________________
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Patient Name/Identifier: ______________________________ Date: __________________________
Typical degree of
NON-MOTOR FLUCTUATIONS change from “On” to
(optional) “Off” period
1. Depression
2. Anxiety
3. Thinking or cognitive abilities
4. Bladder symptoms
5. Restlessness
6. Pain
7. Fatigue
8. Excessive sweating
Subscore “Change”
Subscore “Time”
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International Parkinson and Movement Disorder Society –
Non-Motor Rating Scale (MDS-NMS)
Glossary of Terms
B. Anxiety: an affective disorder characterized by sustained excessive worrying which can be (1)
generalized and include symptoms such as restlessness, being easily fatigued, mind going blank or
trouble concentrating, irritability, and muscle tension; (2) specific anxiety or panic attacks; (3) fear of
being in public (agoraphobia); or (4) fear of being in social situations (social phobia)
Anxiety or panic attack: an abrupt surge of intense fear or intense discomfort, can include
shortness of breath, heart beating fast, upset stomach, sweating, dizziness or faintness, sensation
of chill or heat, or sense something bad is going to happen or even a sense of dying
C. Apathy: a disorder characterized by decreased motor activity (less initiation of motor activity not due
to parkinsonism), emotional expression (less emotional engagement separate from decreased facial
expression due to parkinsonism), or speech (less likely to initiate or engage in conversation)
E. Impulse control disorders: a failure to resist an impulse or drive that leads to repeated
engagement in activities that become harmful to self or others; compared with pre-PD behavior
Hoarding: the needless collection of objects and an inability to get rid of them
Punding: the needless or purposeless repetition of a simple motor activity
Dopamine dysregulation syndrome: taking an excess (beyond what is prescribed) of
Parkinson’s disease medications for their motor or psychological effects, often with significant
mood changes during “on” (irritability, hypomania) or “off” (dysphoria) states
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International Parkinson and Movement Disorder Society –
Non-Motor Rating Scale (MDS-NMS)
G. Orthostatic hypotension: a drop in blood pressure severe enough to cause symptoms when
changing from sitting to standing position or from lying to sitting position
H. Urinary
Nocturia: excessive urination at night, defined as more than 2 times overnight
I. Sexual
Erectile dysfunction: inability of a man to maintain an erection sufficient for satisfying sexual
activity
L. Pain
Dystonia: a state of abnormal muscle tone resulting in muscular spasm and abnormal posture
Nocturnal pain: pain overnight
Orofacial pain: pain which is felt in the mouth, jaws, or face
M. Other
Olfaction: the action or capacity of smelling
Fatigue (physical): state of excessive physical weariness or exhaustion (after physical exertion),
different from sleepiness
Fatigue (mental): state of excessive mental weariness or exhaustion, different from sleepiness
Copyright © 2019 International Parkinson and Movement Disorder Society. All rights reserved. | Version 1.0 10