Developing mRNA-vaccine Technologies: RNA Biology
Developing mRNA-vaccine Technologies: RNA Biology
Developing mRNA-vaccine Technologies: RNA Biology
To cite this article: Thomas Schlake, Andreas Thess, Mariola Fotin-Mleczek & Karl-Josef Kallen
(2012) Developing mRNA-vaccine technologies, RNA Biology, 9:11, 1319-1330, DOI: 10.4161/
rna.22269
Keywords: mRNA, adjuvant, vaccine, mRNA production, mRNA design, mRNA uptake, formulation, protein expression
Abbreviations: ARCA, anti-reverse cap analog; cDNA, complementary DNA; CTL, cytotoxic T cell; dsRNA, double-stranded
RNA; EMCV, encephalomyocarditis virus; GMP, good manufacturing practice; HPLC, high performance liquid chromatography;
IRES, internal ribosome entry site; mRNA, messenger RNA; MHC, major histocompatibility complex; miRNA, microRNA;
ORF, open reading frame; pAPC, professional antigen presenting cell; pDNA, plasmid DNA; PEG, polyethylenglycol; siRNA,