Nothing Special   »   [go: up one dir, main page]
Scribd Logo
Upload

Welcome to Scribd!

  • 40 views

    Basic Genetics

    Uploaded by

    Marydith Ortillo
    Genetics is important to transfusion medicine because blood group antigens generally follow predictable inheritance patterns and accurate pathogen testing relies on understanding genetics. There are several key areas of genetics relevant to transfusion medicine: classic genetics defines phenotypes and genotypes; population genetics applies principles like Mendel's laws of inheritance and Hardy-Weinberg equilibrium; and molecular genetics examines processes like DNA replication, transcription, and translation that determine blood group antigens. Understanding inheritance patterns is also important for determining blood type.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Basic Genetics

    Uploaded by

    Marydith Ortillo
    40 views20 pages
    Genetics is important to transfusion medicine because blood group antigens generally follow predictable inheritance patterns and accurate pathogen testing relies on understanding genetics. There are several key areas of genetics relevant to transfusion medicine: classic genetics defines phenotypes and genotypes; population genetics applies principles like Mendel's laws of inheritance and Hardy-Weinberg equilibrium; and molecular genetics examines processes like DNA replication, transcription, and translation that determine blood group antigens. Understanding inheritance patterns is also important for determining blood type.

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Genetics is important to transfusion medicine because blood group antigens generally follow predictable inheritance patterns and accurate pathogen testing relies on understanding genetics. There are several key areas of genetics relevant to transfusion medicine: classic genetics defines phenotypes and genotypes; population genetics applies principles like Mendel's laws of inheritance and Hardy-Weinberg equilibrium; and molecular genetics examines processes like DNA replication, transcription, and translation that determine blood group antigens. Understanding inheritance patterns is also important for determining blood type.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    40 views20 pages

    Basic Genetics

    Uploaded by

    Marydith Ortillo
    Genetics is important to transfusion medicine because blood group antigens generally follow predictable inheritance patterns and accurate pathogen testing relies on understanding genetics. There are several key areas of genetics relevant to transfusion medicine: classic genetics defines phenotypes and genotypes; population genetics applies principles like Mendel's laws of inheritance and Hardy-Weinberg equilibrium; and molecular genetics examines processes like DNA replication, transcription, and translation that determine blood group antigens. Understanding inheritance patterns is also important for determining blood type.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 20

    Basic Genetics

    Prepared by:
    Winona Mei A. Reyes, RMT
    How is Genetics important to Transfusion
    Medicine?
    Many areas of transfusion medicine rely on an
    understanding of blood group genetics and on accurate
    and sensitive methods of pathogen testing to keep the
    blood supply safe. Most of the antigens in the various
    blood group systems generally follow straightforward
    inheritance patterns, usually of a codominant nature
    • Classic Genetics
    – Phenotype: antigens present Genetics
    on all blood cells are
    • Cellular Genetics
    expressed
    – Mitosis
    – Genotype: controls what
    antigens may be expressed on – Meiosis
    the cell – Cell Division
    • Population Genetics • Molecular Genetics
    – Mendel’s Law of Segregation – DNA
    – Mendel’s Law of Independent – Replication
    Assortment – Repair, mutation, isolation
    – Hardy-Weinberg Principle – RNA
    – Inheritance Pattern – Transcription & Translation
    • Population Genetics
    –Mendel’s Law of Segregation
    –Mendel’s Law of Independent Assortment
    –Hardy-Weinberg Principle
    –Inheritance Pattern
    History
    Hardy-Weinberg Principle
    p+q=1
    P2 + 2pq + q2 = 1

    p = gene frequency of the dominant allele


    q = frequency of the recessive allele

    Cornerstone of population genetics


    Inheritance Pattern
    • Autosomal: traits not carried on sex chromosomes
    • Recessive trait
    • Dominant trait
    • X – linked
    • Dominant X – linked trait
    • Recessive X – linked trait
    • Autosomal dominant trait: do not skip generations
    • Cellular Genetics
    – Mitosis
    – Meiosis
    – Cell Division
    • Molecular Genetics
    – DNA
    – Replication
    – Repair, mutation, isolation
    – RNA
    – Transcription & Translation
    DNA
    A T

    G C
    TRANSCRIPTION
    TRANSLATION

    You might also like