Nothing Special   »   [go: up one dir, main page]
Scribd Logo
Upload

Welcome to Scribd!

  • 478 views

    Questions Renal Physiology Find The Mode of Action of A Diuretic Drug

    Uploaded by

    Group A1G3
    The document contains a series of questions and answers about renal physiology and the mode of action of a diuretic drug called Drug X. It discusses topics like the location of nephrons, the functions of different parts of the nephron like the proximal convoluted tubule and distal convoluted tubule. It also discusses how Drug X affects glomerular filtration rate and the levels of antidiuretic hormones. Through a series of experiments, it is concluded that Drug X likely causes a diuretic effect by preventing sodium, potassium, and chloride reabsorption in the thick ascending limb of the loop of Henle, resulting in less fluid reabsorption and more urine production.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Questions Renal Physiology Find The Mode of Action of A Diuretic Drug

    Uploaded by

    Group A1G3
    478 views3 pages
    The document contains a series of questions and answers about renal physiology and the mode of action of a diuretic drug called Drug X. It discusses topics like the location of nephrons, the functions of different parts of the nephron like the proximal convoluted tubule and distal convoluted tubule. It also discusses how Drug X affects glomerular filtration rate and the levels of antidiuretic hormones. Through a series of experiments, it is concluded that Drug X likely causes a diuretic effect by preventing sodium, potassium, and chloride reabsorption in the thick ascending limb of the loop of Henle, resulting in less fluid reabsorption and more urine production.

    Original Description:

    respuestas del simulador virtual

    Original Title

    Questions Renal Physiology Find the Mode of Action of a Diuretic Drug

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    The document contains a series of questions and answers about renal physiology and the mode of action of a diuretic drug called Drug X. It discusses topics like the location of nephrons, the functions of different parts of the nephron like the proximal convoluted tubule and distal convoluted tubule. It also discusses how Drug X affects glomerular filtration rate and the levels of antidiuretic hormones. Through a series of experiments, it is concluded that Drug X likely causes a diuretic effect by preventing sodium, potassium, and chloride reabsorption in the thick ascending limb of the loop of Henle, resulting in less fluid reabsorption and more urine production.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    478 views3 pages

    Questions Renal Physiology Find The Mode of Action of A Diuretic Drug

    Uploaded by

    Group A1G3
    The document contains a series of questions and answers about renal physiology and the mode of action of a diuretic drug called Drug X. It discusses topics like the location of nephrons, the functions of different parts of the nephron like the proximal convoluted tubule and distal convoluted tubule. It also discusses how Drug X affects glomerular filtration rate and the levels of antidiuretic hormones. Through a series of experiments, it is concluded that Drug X likely causes a diuretic effect by preventing sodium, potassium, and chloride reabsorption in the thick ascending limb of the loop of Henle, resulting in less fluid reabsorption and more urine production.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 3

    Renal Physiology: Find the mode of action of a

    diuretic drug
    Question 1: Nice! Let's keep going! Where are nephrons located? Don't forget you can always
    check for the answer on the holo-table.
    ✓ In both the cortex and medulla
    – In the cortex
    – In the medulla
    – In the adrenal gland

    Question 2: Which structure reabsorbs glucose and amino-acids, and secretes creatine?
    ✓ The proximal convoluted tubule
    – The thick ascending loop
    – The thick descending loop
    – The collecting duct

    Question 3: Finally, what are the known functions of the distal convoluted tubule?
    ✓ It reabsorbs sodium and chloride ions and produces ammonium
    – It releases water and dilutes urine
    – It collects the filtrate for the bladder
    – It absorbs water and concentrates urine

    Question 4: If Drug Xex is a diuretic that impacts the glomerular filtration rate, what would you
    expect?
    ✓ An increased glomerular filtration rate when taking Drug X
    – A decreased total secretion of urine creatinine
    – A increased total secretion of plasma creatinine
    – A decreased glomerular filtration rate when taking Drug X

    Question 5: With the data in the table on the screen on the analytical workbench and the equations
    on the wall screen, calculate the glomerular filtration rate before taking Drug Xdrug ex. You can use
    the calculator in the top right corner of the LabPad, next to the sound settings.
    ✓ 100 ml/min
    – 10 ml/min
    – 0.01 ml/min
    – 0.001 ml/min

    Question 6: Now calculate the same glomerular filtration rate, but under the effect of taking Drug
    Xdrug ex.
    ✓ 100 ml/min
    – 0.1 ml/min
    – 1 ml/min
    – 0.04 ml/min

    Question 7: Comparing your results between the two experiments, does Drug Xdrug ex affect the
    glomerular filtration rate? Do not forget you can slide down your Labpad to see the table on the
    screen.
    ✓ No, the glomerular filtration rate is similar when taking Drug X
    – We cannot be certain yet
    – Yes, the glomerular filtration rate has decreased when taking Drug X
    – Yes, the glomerular filtration rate has increased when taking Drug X

    Page 1
    Question 8: Knowing that ADH and aldosterone are both antidiuretic hormones, which clinical
    results would be consistent with the hypothesis that Drug Xdrug ex acts to increase urine output by
    affecting ADH or aldosterone signaling?
    ✓ Patients receiving Drug X would show lower than normal levels of ADH and/or aldosterone
    – Patients receiving Drug X would show a strong reduction in urine output in response to
    aldosterone injection
    – Patients receiving Drug X would show a strong reduction in urinary output in response to
    ADH injection
    – Patients receiving Drug X would have a higher than normal level of ADH and aldosterone

    Question 9: The collected fluid that exited the tubule had 2,000 counts per minute (cpm) of
    methoxy-inulin. Using the formulae on the screen and the calculator, what was the flow rate of the
    perfusate into the tubule and the amount of fluid reabsorbed?
    ✓ Vin = 2 and R = 1
    – Vin = 4 and R = 2
    – Vin = 1 and R = 0
    – Vin = 0.5 and R = -0.5

    Question 10: If the reabsorption process is indeed passive and due to higher osmotic pressure in
    the external saline, what would be your prediction for the volume reabsorbed in the absence of
    oxygen to make ATP?
    ✓ Without oxygen, the absorbed volume should be similar to what was measured in presence
    of oxygen (Vout lower than Vin and Cout higher than Cin)
    – Without oxygen, even more volume should be reabsorbed (Vout much lower than Vin and Cout
    much higher than Cin)
    – Without oxygen, there should not be any reabsorbed volume (Vout = Vin and Cout = Cin)
    – Without oxygen, more volume should enter the tubule (Vout higher than Vin and Cout lower
    than Cin

    Question 11: What findings can you draw from these data?
    ✓ Without oxygen, the absorbed volume should be similar to what was measured in presence
    of oxygen (Vout < Vin and Cout > Cin)
    – Without oxygen, even more volume should be reabsorbed (Vout << Vin and Cout >> Cin)
    – Without oxygen, there should not be any reabsorbed volume (Vout = Vin and Cout = Cin)
    – Without oxygen, more volume should enter the tubule (Vout > Vin and Cout < Cin

    Question 12: What experimental result would be consistent with Drug Xdrug ex acting by blocking
    the paracellular (in-between cells) Na+sodium route? You can use the poster on the wall for clues.
    ✓ Removal of Na+ will disable the action of Drug X on the nephron, but removal of K+ or Cl- will
    not.
    – Removal of Cl- from the perfusate will block the ability of Drug X to act on the nephron
    – Drug X will act on the nephron regardless of the removal of Na+, K+ or Cl-
    – Drug X will be unable to act on the nephron if either Na+, K+ or Cl- are removed from the
    perfusate

    Question 13: So finally, what do you conclude from these data? Have a look on the screen to check
    the ion transport model to help you.
    ✓ Drug X likely acts by blocking the NaK2Cl transporter
    – Drug X probably does not affect fluid reabsorption by the thick ascending limb of the nephron
    – Drug X likely acts by blocking the Na+/K+ ATPase
    – Drug X likely acts by blocking the paracellular Na+ uptake

    Question 14: So after all our experiments on the influence of Drug Xdrug ex on the glomerular
    filtration, on the levels of diuretic and antidiuretic hormones and on the epithelial transport of the
    thick ascending limb, how do you think Drug Xdrug ex causes a diuretic effect?

    Page 2
    ✓ By preventing Na+, K+ and Cl- reabsorption, causing less fluid to be reabsorbed, hence
    remaining in the tubule and in the urine
    – By blocking the ability of ADH to act on the nephron, preventing the antidiuretic effects and
    decreasing urine volume control
    – By increasing glomerular filtration, causing more volume to enter the tubule and ultimately
    increasing final urine volume
    – By preventing reabsorption of Na+ from the tubule through passive diffusion, causing less
    fluid to be reabsorbed, hence remaining in the tubule and in the urine

    Page 3

    You might also like