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Recommended Dosages: 1st Trimester 2nd Trimester 3rd Trimester Postpartum

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MISOPROSTOL

Recommended Dosages
800µg Induced abortion1
800µg vaginal
12 hrly (max x3)

Missed abortion
800µg vaginal
3 hrly (max x2)
600µg OR
600µg sublingual
3 hrly (max x2) PPH treatment
& prophylaxis6
Incomplete 600µg oral or
abortion2,3 sublingual single dose
600µg oral
single dose
400µg Cervical ripening Induced abortion1,4:
pre-instrumentation interruption of
pregnancy
400µg vaginal 400µg vaginal
3 hrs before procedure 3 hrly (max x5)

200µg Intrauterine fetal death4


(13-17 wks)
200µg vaginal
6 hrly (max x4)

100µg Intrauterine fetal death4


(18-26 wks)
100µg vaginal
6 hrly (max x4)

50µg Intrauterine fetal death5


(27-43 wks)
25-50µg vaginal
4 hrly (max x6)

25µg
Induction of labour2,5
25µg vaginal
4 hrly (max x6)
OR
20µg oral solution
2 hrly (max x12)

Care with previous uterine scar


and caesarean section

1st Trimester 2nd Trimester 3rd Trimester Postpartum

Check for updates at www.figo.org and www.misoprostol.org


Notes: 1. Only use where legal 5. Do not use if previous caesarean section:
2. Included in the WHO Model list of essential Make sure you use the correct dosage - overdose can
medicines lead to complications
3. Leave to work for 1-2 weeks unless bleeding or 6. Oxytocin is first line as it is more effective than
infection misoprostol
4. Halve dose if previous caesarean section
Recommendations from the Bellagio Group (Weeks & Faúndes Int J Gynaecol Obstet 2007;99 (s2):S156)

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