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    Project Report On I.V. Fluid Manufacturing Unit

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    EIRI Board of Consultants and Publishers
    Intravenous fluids, also known as intravenous solutions, are supplemental fluids used in intravenous therapy to restore or maintain normal fluid volume and electrolyte balance when the oral route is not possible.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Project Report On I.V. Fluid Manufacturing Unit

    Uploaded by

    EIRI Board of Consultants and Publishers
    813 views8 pages
    Intravenous fluids, also known as intravenous solutions, are supplemental fluids used in intravenous therapy to restore or maintain normal fluid volume and electrolyte balance when the oral route is not possible.

    Original Title

    PROJECT REPORT ON I.V. FLUID MANUFACTURING UNIT

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    © © All Rights Reserved

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    Intravenous fluids, also known as intravenous solutions, are supplemental fluids used in intravenous therapy to restore or maintain normal fluid volume and electrolyte balance when the oral route is not possible.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    813 views8 pages

    Project Report On I.V. Fluid Manufacturing Unit

    Uploaded by

    EIRI Board of Consultants and Publishers
    Intravenous fluids, also known as intravenous solutions, are supplemental fluids used in intravenous therapy to restore or maintain normal fluid volume and electrolyte balance when the oral route is not possible.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 8
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    The key takeaways are that intravenous (IV) fluids are used to restore or maintain fluid and electrolyte balance when oral intake is not possible. Standard IV fluids include saline solutions, glucose solutions, lactated Ringer's solution, and colloid solutions.

    Standard IV fluids and electrolytes include NaCl, glucose, sodium lactate solution, Ringer's lactate, water for injection, sterile water for irrigation, and potassium chloride solutions.

    The aims of IV fluid administration are to avoid dehydration, maintain effective circulating volume, and prevent inadequate tissue perfusion during periods when oral intake is not possible.

    I.V.

    FLUID MANUFACTURING UNIT


    [EIRI/EDPR/4079] J.C.: 2219XL

    INTRODUCTION

    Intravenous fluids, also known as intravenous solutions, are supplemental fluids used
    in intravenous therapy to restore or maintain normal fluid volume and electrolyte
    balance when the oral route is not possible.

    IV fluid therapy is an efficient and effective way of supplying fluids directly into the
    intravascular fluid compartment, in replacing electrolyte losses, and in administering
    medications and blood products.

    STANDARD IVF & ELECTROLITES

    - NaCl 0.18 – 2.7%


    - Glucose 2.5 - 50%
    - Sodium Lactate (Hartmanns’s) Solution
    - Ringer Lactate
    - Water For injection
    - Sterile Water for Irrigation
    - Sodium Chloride 0.9% for irrigation
    - Sodium Chloride 0.18 – 0.45% and Glucose 4 – 10 %
    - Potassium Chloride 0.15 – 0.3% in Sodium Chloride 0.9%
    - Potassium Chloride 0.15 – 0.3% in Glucose 5%

    www.eiriindia.org 1
    The aims of IV fluid administration should be to

     Avoid dehydration

     Maintain an effective circulating volume

     Prevent inadequate tissue perfusion during a period when the patient is unable
    to achieve these goals through normal oral fluid intake

    “Intravenous fluids have a range of physiologic effects and should be considered to be


    drugs with indications, dose ranges, cautions, and side effects.”

    The intravenous route is the fastest way to deliver medications and fluid replacement
    throughout the body, because they are introduced directly into the circulation.

    Intravenous therapy may be used for fluid volume replacement, to correct electrolyte
    imbalances, to deliver medications, and for blood transfusions.

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    CONTENTS

    INTRODUCTION
    STANDARD IVF & ELECTROLITES
    THE AIMS OF IV FLUID ADMINISTRATION SHOULD BE TO
    BASIC IV SETUP
    LET'S TAKE A LOOK AT THE MOST BASIC POSSIBLE SETUP FOR AN IV:
    LOCATION- ERODE, TAMILNADU
    GEOGRAPHICAL POSITION
    CLIMATE
    TRANSPORTATION
    BY ROAD
    BY RAIL
    TOURISM
    TYPES OF IV FLUIDS
    IV SOLUTIONS CAN ALSO BE CLASSIFIED BASED ON THEIR PURPOSE:
    CRYSTALLOIDS
    GENERAL CHARACTERISTICS OF CRYSTALLOID
    ISOTONIC IV FLUIDS
    0.9% NACL (NORMAL SALINE SOLUTION, NSS)
    DEXTROSE 5% IN WATER (D5W)
    LACTATED RINGER’S 5% DEXTROSE IN WATER (D5LRS)
    RINGER’S SOLUTION
    HYPOTONIC IV FLUIDS
    0.45% SODIUM CHLORIDE (0.45% NACL)
    0.33% SODIUM CHLORIDE (0.33% NACL)
    0.225% SODIUM CHLORIDE (0.225% NACL)
    2.5% DEXTROSE IN WATER (D2.5W)
    HYPERTONIC IV FLUIDS
    HYPERTONIC DEXTROSE SOLUTIONS
    DEXTROSE 10% IN WATER (D10W)
    DEXTROSE 20% IN WATER (D20W)
    DEXTROSE 50% IN WATER (D50W)
    NURSING CONSIDERATIONS FOR HYPERTONIC SOLUTIONS
    DARROW’S SOLUTION
    COLLOIDS

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    HUMAN ALBUMIN
    DEXTRANS
    LOW-MOLECULAR-WEIGHT DEXTRANS (LMWD)
    HIGH-MOLECULAR-WEIGHT DEXTRANS (HMWD)
    IV FLUID/ELECTROLYTE THERAPY
    NORMAL SALINE
    VOLUME EFFECTS OF NS
    RINGER'S FLUIDS
    ADVANTAGE:
    DEXTROSE SOLUTIONS
    EFFECT OF DEXTROSE IN FLUID:
    VOLUME EFFECTS
    5% DEXTROSE COMPOSITION:
    DEXTROSE SALINE (DNS)
    DEXTROSE WITH HALF STRENGTH SALINE
    10% DEXTROSE & 25% DEXTROSE
    ISOLYTE G,M,P,E
    PARACETAMOL 10 MG/ML SOLUTION COMPOSITION
    QUALITATIVE AND QUANTITATIVE COMPOSITION
    METRONIDAZOLE IV SOLUTION
    ECONOMIC PROFILE
    MARKET POSITION
    APPLICATION INSIGHTS
    VOLUME INSIGHTS
    INDIA LARGE VOLUME PARENTERAL (LVP) MARKET SHARE INSIGHTS
    NORTH AMERICA AT THE FOREFRONT OF THE GLOBAL INTRAVENOUS
    (IV) SOLUTION MARKET
    BUSINESS JUSTIFICATION
    PRODUCTS
    WHY IV FLUID?
    GLOBAL INTRAVENOUS SOLUTION MARKET: KEY TRENDS
    GLOBAL INTRAVENOUS SOLUTION MARKET: SEGMENTATION
    GLOBAL INTRAVENOUS SOLUTION MARKET: REGIONAL ANALYSIS
    GLOBAL INTRAVENOUS SOLUTION MARKET: COMPETITIVE LANDSCAPE
    MAJOR FIVE IV FLUID MONITORING DEVICES COMPANIES:
    B. BRAUN MELSUNGEN AG
    BAXTER INTERNATIONAL INC.
    BECTON, DICKINSON AND CO.

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    FORTIVE CORP.
    ICU MEDICAL INC.
    SOURCE OF MACHINES TECHNOLOGY
    USES AND APPLICATION
    SOME GENERAL INTRAVENOUS FLUIDS
    SPECIFICATION OF INDIAN PHARMACOPEIA ON I.V FLUIDS DEXTRAN
    40 INJECTION
    DEXTROSE INJECTION WHEN DETERMINED BY THE FOLLOWING METHOD
    DEXTRAN 110 INJECTIONS
    SODIUM CHLORIDE AND DEXTROSE INJECTION
    IDENTIFICATION:-
    ASSAY:
    BASIC RAW MATERIALS
    REQUIREMENTS OF RAW MATERIALS AND SPECIFICATIONS
    WATER FOR INJECTION
    HDPE PHARMA GRADE LAMINATE/ PLASTIC ROLL
    LABELING
    IDENTIFICATION
    HEAVY METALS
    COMPOSITION OF IV FLUID
    COMPOSITION OF COMMON IV FLUID (MEQ/L)
    COMPOSITION OF IV FLUIDS
    COMPOSITION OF COMMERCIAL I.V. FLUID AVAILABLE
    FORM FILL SEAL TECHNOLOGY
    1. FORM-FILL-SEAL TECHNOLOGY:-
    1.5 FILTRATION (MEMBRANE):-
    LIST OF MACHINERY IV BAG PRODUCTION FORM FILL AND SEAL MACHINE
    IV BAG PRODUCTION (IV PRODUCTION AND PACKING)
    THE PRODUCTION OF I.V. SOLUTION PRODUCTION LINE CONSISTS
    OF 5 MAIN PHASES:
    1. WATER PURIFYING
    2. DISTILLATION
    3. SOLUTION FILLING
    4. STERILIZATION
    5. PACKING
    A TYPICAL FFS PROCESS WORKS AS FOLLOWS.
    BASIC OF BFS TECHNOLOGY
    BLOW FILL SEAL EQUIPMENT

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    BFS MOLDS AND TOOLING
    BFS TRIALS
    PROCESS
    1. BLOW MOLDING
    2. FILLING
    3. SEALING
    BLOW FILL SEAL MACHINES
    ASEPTIC PACKAGING
    BLOW FILL SEAL (BFS) AND FORM FILL SEAL (FFS) TECHNOLOGY
    MANUFACTURING PROCESS OF I.V. FLUID
    PROCESS IN DETAILS
    1. DISTILLED WATER PREPARATION:-
    2. SOLUTION PREPARATION:-
    3. INJECTION BLOW MOULDING
    4. MOULDING PROCESS
    5. FILLING PROCESS
    6. SEALING PROCESS
    7. MOULD OPENING PROCESS
    FILTRATION AND FILLING:-
    STERILIZATION:-
    QUALITY CONTROL:-
    THE WHOLE PROCESS CONSISTS OF THE FOLLOWING STEPS:-
    PROCESS FLOW DIAGRAM
    FLOW DIAGRAM OF MANUFACTURING OF I.V. FLUIDS
    SUPPLIERS OF RAW MATERIALS
    POTASSIUM PERMANGANATE
    SODIUM CHLORIDE (I.P. GRADE)
    DEXTROSE
    SUPPLIERS OF PLANT AND MACHINERY
    STERILIZING EQUIPMENTS
    PM METER
    LABELING MACHINES
    TANKS
    BOILER
    FILTER PRESS
    LABORATORY EQUIPMENTS
    MIXER
    MACHINERY PHOTOGRAPHS

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    MULTIPLE EFFECT WATER DISTILLATION PLANT
    MIXER
    STORAGE VESSEL
    BLOW FILL SEAL MACHINE
    AUTOMATIC BOTTLE LABELLING MACHINES
    RAW MATERIAL SUPPLIER
    SODIUM LACTATE
    NACL
    KCL
    CACL2
    PRODUCT PHOTOGRAPHS
    QUERY FROM CUSTOMERS
    FISCAL INCENTIVES

    APPENDIX – A:

    01. PLANT ECONOMICS


    02. LAND & BUILDING
    03. PLANT AND MACHINERY
    04. OTHER FIXED ASSESTS
    05. FIXED CAPITAL
    06. RAW MATERIAL
    07. SALARY AND WAGES
    08. UTILITIES AND OVERHEADS
    09. TOTAL WORKING CAPITAL
    10. TOTAL CAPITAL INVESTMENT
    11. COST OF PRODUCTION
    12. TURN OVER/ANNUM
    13. BREAK EVEN POINT
    14. RESOURCES FOR FINANCE
    15. INSTALMENT PAYABLE IN 5 YEARS
    16. DEPRECIATION CHART FOR 5 YEARS
    17. PROFIT ANALYSIS FOR 5 YEARS
    18. PROJECTED BALANCE SHEET FOR (5 YEARS)

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    COST ESTIMATION

    Plant Capacity 48,000 Nos/Day


    Land & Building (3000 sq.mt.) Rs. 3.02 Cr
    Plant & Machinery Rs. 6.23 Cr
    Working Capital for 1 Month Rs. 1.22 Cr
    Total Capital Investment Rs. 10.75 Cr
    Rate of Return 28%
    Break Even Point 56%

    www.eiriindia.org 8

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