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    Examination Practice Worksheet: (3 Marks)

    Uploaded by

    Garshel Kelly
    This document contains an examination practice worksheet covering various topics in pharmacology and drug metabolism. It includes definitions of drug affinity, pharmacophore, and drug potency. It asks about monoamine oxidase inhibitors (MAOIs) and whether several statements about drug mechanisms of action and analytical techniques are true or false. It also includes questions requiring descriptions of how gamma-aminobutyric acid (GABA) and the GABAA receptor work in the central nervous system, the mechanism of action of barbiturates, and the metabolism of tetrahydrocannabinol (THC).

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    Examination Practice Worksheet: (3 Marks)

    Uploaded by

    Garshel Kelly
    20 views3 pages
    This document contains an examination practice worksheet covering various topics in pharmacology and drug metabolism. It includes definitions of drug affinity, pharmacophore, and drug potency. It asks about monoamine oxidase inhibitors (MAOIs) and whether several statements about drug mechanisms of action and analytical techniques are true or false. It also includes questions requiring descriptions of how gamma-aminobutyric acid (GABA) and the GABAA receptor work in the central nervous system, the mechanism of action of barbiturates, and the metabolism of tetrahydrocannabinol (THC).

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    Medicinal Chemistry

    Original Title

    Examination_Practice_worksheet

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    This document contains an examination practice worksheet covering various topics in pharmacology and drug metabolism. It includes definitions of drug affinity, pharmacophore, and drug potency. It asks about monoamine oxidase inhibitors (MAOIs) and whether several statements about drug mechanisms of action and analytical techniques are true or false. It also includes questions requiring descriptions of how gamma-aminobutyric acid (GABA) and the GABAA receptor work in the central nervous system, the mechanism of action of barbiturates, and the metabolism of tetrahydrocannabinol (THC).

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    20 views3 pages

    Examination Practice Worksheet: (3 Marks)

    Uploaded by

    Garshel Kelly
    This document contains an examination practice worksheet covering various topics in pharmacology and drug metabolism. It includes definitions of drug affinity, pharmacophore, and drug potency. It asks about monoamine oxidase inhibitors (MAOIs) and whether several statements about drug mechanisms of action and analytical techniques are true or false. It also includes questions requiring descriptions of how gamma-aminobutyric acid (GABA) and the GABAA receptor work in the central nervous system, the mechanism of action of barbiturates, and the metabolism of tetrahydrocannabinol (THC).

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    You are on page 1of 3

    Examination Practice worksheet

    Define the following terms:

    (i) drug affinity


    (ii) pharmacophore
    (iii) drug potency
    [3 marks]

    What drugs are concidered MAOIs?


    [2 mraks]

    Is the following statement TRUE OR FALSE?


    “When GABA binds to GABA receptors, they change shape slightly to allow ions to
    pass through their central channel. This channel mainly allows negatively charged
    chloride neurons to enter the neuron, thus increasing its excitability.”
    A) TRUE
    B) FALSE

    Is the following statement TRUE OR FALSE?


    “β-Lactam antibiotics act by inhibiting the synthesis of the peptidoglycan layer of the
    bacterial cell wall.”
    A) TRUE
    B) FALSE

    Is the following statement TRUE OR FALSE?


    “In HPLC analysis, the mobile phase is allowed to pass through or over the stationary
    phase which is fixed. The interaction between the solute and the mobile phase only, is
    responsible for achieving separation.”
    A) TRUE
    B) FALSE

    Write the mechanism for the cytochrome P450 mediated oxidative deamination of the
    following compound:
    H3C
    H
    H3C N
    CH3

    CH3

    Describe how GABA and the GABAA receptor work to depress the central nervous system
    (CNS).
    (10marks)

    Describe the mechanism of action for CNS depressants, like the barbiturates work to produce
    depolarize neurons.
    (5 marks)

    Some CNS stimulants work by affecting the degradation or reuptake of three important
    neurotransmitters.

    i. Name these three neurotransmitters.

    ii. Briefly describe how neurotransmitters degradation occurs,


    which enzyme is involved and how it produces CNS stimulation.

    iii. Briefly describe how neurotransmitter reuptake produces


    CNS stimulation.
    (3+5+2 marks)

    Suggest, by means of chemical equations and/or notes, feasible initial steps for the
    metabolism of 4-aminoazobenzene.
    [4 marks]
    With reference to tetrahydrocannabinol (THC), shown below, explain the steps involved in
    its metabolism and how it is eventually removed from the body. Be sure to discuss:

    THC

    i. the enzyme involved;


    ii. the purpose of the enzyme reactions;
    iii. the nature of the metabolites produced;
    iv. any compounds which may be conjugated to the metabolites;
    v. the purpose of any conjugate formed.

    [5 x 3 marks]

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