9 - Pustular Psoriasis-Vijayashankar M
9 - Pustular Psoriasis-Vijayashankar M
9 - Pustular Psoriasis-Vijayashankar M
DOI: 10.7241/ourd.20124.71
Source of Support: MVJ Medical College and Research Hospital, Bangalore, India
Nil
Competing Interests:
None declared Corresponding author: Dr. Nithya Raghunath nithyareddy85@gmail.com
Our Dermatol Online. 2012; 3(4): 326-328 Date of submission: 08.05.2012 / acceptance: 11.06.2012
Abstract
Probiotics exhibit widespread effects on homeostasis and immunomodulation of both mucosal and systemic immunity. Probiotics counter
weight aggressive commensals in the body and reinforce the barrier function of the epithelium while also contributing to the regulation of
innate and adaptive immune responses of the host under healthy or pathogenic conditions. Probiotics could be used for prevention or treatment
of chronic allergic and inflammatory diseases, such as inflammatory bowel disease (IBD) and atopic dermatitis. We describe a case of pustular
psoriasis where probiotics were used for the treatment successfully.
Figure 3 and 4. Post-treatment: Healed pustular lesions with few erythematous plaques over back and legs after 4
weeks of treatment
Discussion None have shown any adverse effects [6]. The rationale of
Administration of probiotic Lactobacillus strains (a mixture usage of such probiotics is furthered by its potential multi-
of Lactobacillus rhamnosus 19070-2 and Lactobacillus pronged action. Though unclear the proposed mechanisms
reuteri DSM 12246) to children with atopic dermatitis has of action include modulation of immune response in the gut
been shown to result in a moderate improvement in the which can directly affect the development of inflammatory
clinical severity [5]. disease mechanisms in systemic sites of disease, such as
It is being reported that most of the probiotics containing lactic- the skin [7]. However, the mechanisms by which intestinal
acid producing bacteria (LAB) strains are nonpathogenic immune responses translate to systemic anti-inflammatory
and nontoxigenic microorganisms. Over 70 clinical studies effects remain to be established. In our case Lactobacillus
have been conducted over food containing microbial Sporogenes was used as it was the only available lactobacilli
ingredients to investigate potential probiotic-side effects. in the market along with biotin.
Copyright by Metikurke Vijayashankar, et al. This is an open access article distributed under the terms of the Creative Commons Attribution
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