Knowledge, Attitude and Practice On Medication Disposal of Registered Pharmacists in An Academic Institution
Knowledge, Attitude and Practice On Medication Disposal of Registered Pharmacists in An Academic Institution
Knowledge, Attitude and Practice On Medication Disposal of Registered Pharmacists in An Academic Institution
Arielle E. Cruz, Jocee Mae L. Ebdani, John Carlo T. Marcelo, Nielsienne F. Reyeg,
Pauline Anne Joy I. Santos, Carol Kim S. Toyoken, Carol Geraldine C. Pablo
A
INTRODUCTION
ccording to the World Health Organization (WHO) (2014), more than half
of all medication is inaptly prescribed, dispensed and sold, thus causing
unnecessary storage, as well as creating an ecological threat. Unused and
expired medicines are neglected in a variety of ways. Storing lapsed medi-
cines at home or offering them to loved ones, specifically to friends and family, may in-
crease the danger of incidental or unseemly ingestion of the medications (Seehusen &
Edwards, 2006). Furthermore, the most common ways of disposing expired medication
disposal – washing the drug down a sink, flushing them down the toilet, and throwing
them in the garbage cans – are not environmentally responsible methods of disposal
(Patel, Shah, & Upadhyay, 2011).
Various medicines have been found in groundwater, surface waterways, as well as in
drinking water. The increasing presence of pharmaceuticals and their metabolites in
water through the years has been perceived as possibly hazardous (Boehringer, 2004).
In the Philippines, countless analgesics like diclofenac, antibiotics, anti-platelet agents,
hormones, psychiatric drugs, anti-histamines were detected in nature at levels
hazardous for the ecosystem (Francepresse, 2018).
Unfortunately, ebb and flow water treatment frameworks fail to expel a number of
pharmaceuticals from drinking water and the latest and highly sensitive investigative
strategies make it possible to identify natural pharmaceutical compounds in
groundwater and consumable water even after treatment and decontamination
(Abahussain, Ball, & Matowe, 2006).
Safe and responsible disposal of medications is an important public health initiative
because it directly concerns both the pharmaceutical industry. Improper disposal
of expired medications has potentially negative consequences in the environment
and the human body. The Clean Air Act (1999), prohibited the use of burning as
a technique in treating health care waste. The DOH-DENR Manual on Health
Care Waste Management (2013) sought to reduce the amount of pharmaceutical
waste in the environment by recording elective advancements for the correct transfer
of healthcare wastes. Despite the perceived hazards of improper medication disposal,
there has been no research regarding this issue in the Philippines, and
no data about the practitioners' knowledge and practice of medication disposal.
The dearth of literature is indicative that studies on medication disposal are
insufficient.
The study aims to assess the knowledge and awareness that registered pharmacists
currently possess when it comes to medication disposal. It also aims to
identify the prevalent attitude patterns of registered pharmacists towards different
aspects of medication disposal, to identify the current practices based from
their knowledge and attitude, and to assess if there is a significant improvement
on their knowledge regarding proper medication disposal after the intervention.
METHODS
Research Design
The study is a mixed method, using a pre-intervention survey that assesses the
respondents' knowledge, followed by an open-ended questionnaire that would
assess the attitude and practices on disposal of expired personal medicines. This
research design typically involves two phases: (1) an initial quantitative instrument
phase, followed by (2) a qualitative data collection phase, in which the qualitative
phase supports the results from the quantitative phase (Wisdom & Creswell, 2013).
The researchers showed a 5-minute video and provided handouts to the respondents
that served as an educational intervention to enhance the respondent’s
knowledge about proper medication disposal and leaflets were also given for
additional information. A post-intervention survey was also given.
Sampling Method
A purposive sampling method was used to carry out a descriptive survey. The method is
used to obtain comprehensions of a phenomenon, individuals, or incidents.
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Study Site
The study site is a pharmacy school in Manila. The respondents are licensed pharmacists
taking up second degree Clinical Pharmacy, Doctor of Pharmacy, graduate school students
and pharmacists in the academe. All of them are currently affiliated with the school.
Ethical Consideration
This study follows the Ethics Review Board and ethical clearance was submitted to the
ERB of the pharmacy school (FOPREC1-181929). Informed consent was prepared to
properly inform the respondents.
Data Analysis
Variables to be used for the quantitative portion of the study are age, gender, Pharmacy
cluster and scores in the knowledge, attitude portion of the survey questionnaire, as well
as their pre and post-test results.
Scoring
Knowledge section: The participant gets 1 point for the correct answer to each question. If
they choose “Uncertain” this indicates that they do not know the correct answer, thus
earning them a score of 0 (Khan, Sarriff, Khan, & Mallhi, 2014).
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Attitude section: The participant provides their agreement with each agreement
on a 5-point Likert scale. The ordinal scale goes as follows: 1 for “Strongly Disagree”,
2 for “Disagree”, 3 for “Neither Agree nor Disagree”, 4 for “Agree”, and 5 for
“Strongly Agree”. Likewise, reverse coding was used for negative statements.
Practice section: The participants answered open-ended questions which will then be
processed by MAXQDA to generate the frequently-occurring themes from the responses.
MAXQDA 2018 software program was used for the coding of qualitative data and
SPSS was used to analyze the answers of the respondents in the quantitative part of the
survey.
RESULTS
A total of sixty-seven (67) registered pharmacists of a pharmacy school participated in the
study. Table 1 summarizes the demographic characteristics of the respondents. The
majority of the respondents are age 21 to 30 years old, female, and from the Pharmacy
Doctor program.
Characteristics Number (%)
Age
21 to 30 years old 49 (73.17%)
31 to 40 years old 16 (23.88%)
41 to 50 years old 2 (2.99%)
Gender
Female 46 (68.66%)
Male 21 (31.34%)
Pharmacy Cluster
Second Degree Clinical Pharmacy 17 (25.37%)
Pharmacy Doctor 25 (37.31%)
Graduate School 11 (16.42%)
Academe 14 (20.90%)
Knowledge
The majority (95.58%) of the respondents answered correctly on the description of
proper medication disposal. Respondents from Second Degree Clinical Pharmacy (n=17),
Academe (n=14), and Graduate School (n=11) all had correct answers. One (1) out of the
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twenty-five (25) respondents from the Doctor of Pharmacy field got the wrong answer. A
majority felt that the best way of disposing medicine is by returning it to the Pharmacy
(61.19%) followed by flushing in the toilet (42.28%) and through collection program
(41.79%). More than half (68.66%) of the respondents think that the best way to dispose
of packaging and labeling materials is by tearing and mixing it with dry waste, while
53.73% would scratch out the information. Among the respondents, only six (6)
correctly identified all the proper ways of disposing of packaging and labeling materials.
The respondents believed that improper medication disposal can lead to accidental
exposure of children, pets, and wildlife to the medicine (95.52%), increased level of
pharmaceutical in rivers and drinking water supplies (79.10%) and identity theft
(37.31%). Majority (83.58%) of the respondents believe that the best source of
information about proper medication disposal is from the advice of a pharmacist, 70.14%
from Pharmaceutical companies, while 40.30% say that the information should come from
the government, and 26.87% of the respondents believe that the best source is social
media. Only 14 participants correctly identified all best sources of information. As for the
reasons of the respondents for their disposal of medications, the data shows that the
most common reason has to do with the medicine’s expiration and the least common
is the unaesthetic appeal of the medicine. On the factors which the respondents think
has to do with the degradation of drugs, 97.01% consider temperature as a major
factor, 94.03% for moisture, 94.03% for light, 86.57% for removal from packaging and
83.58% for oxidation. Fifty-three (53) of the respondents (79.10%) correctly identified
all of the possible reasons for disposing of medications. The majority (91.04%) of the
respondent correctly identified that the best way to store medicines is in a locked cabinet
which is cool, dry and away from direct sunlight. 8.96% of the respondents answered
either a bathroom cabinet where moisture is vastly present or "I don't know". Another
answer that nobody chose is in a kitchen cabinet which is near a stove or a sink.
Attitude
Twenty-five (25) respondents strongly agreed that they are aware of the proper medica-
tion disposal, twenty-seven (27) agreed, twelve (12) are uncertain, and three (3) disa-
greed. Majority of the respondents (32 out of 67, 47.76%) believed that they practice
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proper medication disposal, seventeen (17) strongly agreed, twelve (12) are uncertain,
and seven (7) disagreed. In sharing of their knowledge regarding medication disposal, a
majority (32 out of 67), which comprises 47.76% of the total respondents agreed, seven-
teen (17) strongly agreed, eight (8) are uncertain, and eight (8) disagreed and one (1)
strongly disagree.
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in bodies of water.
Different practices before throwing in trashcans also emerged such as crushing the
dosage form, putting it in a plastic bag, removing from packaging material and labeling as
hazardous before throwing it away. These are good practices that could minimize the
risk of retrieving the disposed medication.
A good number of respondents said that they mix the medicine with coffee grounds, kitty
litter, unpalatable substances, or dirt to make the render the product unattractive to pets
and children. This method, according to FDA is the correct way of disposing expired,
unwanted and unused medicine.
Table 5 summarizes the different ways of disposal of liquid dosage forms by the
respondents. Flushing of liquid dosage forms is the most common practice among
registered pharmacists, followed by flushing in the sink. Some throw the medicine in a
trashcan while still in its bottles. Among the answers of the respondents, flushing of
liquid dosage forms in the toilet wherein they dilute it first water or is the most common
practice of registered pharmacists, followed by flushing in the sink. Although convenient,
flushing medication in the toilet will end up in water supplies affecting drinking supplies
and aquatic life. Some pour the medicine on soil, gives to the garbage collector, throws in
a labeled container, endorse to maintenance personnel and returns to the pharmacy.
Some answered national collection programs, which is an ideal practice but it is not yet a
practice here in the Philippines.
Other than solid and liquid dosage forms, respondents were asked about their way of
disposal of semisolid preparations, and the majority answered flushing down the toilet
and throwing it in the trashcan, followed by returning the medication to the pharmacy.
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Aside from the actual dosage form, the primary and secondary packaging materials
should be disposed properly. Some medications, especially loose tablets or capsules are
contained in carton boxes or paper envelopes which contain their personal information.
It is important to know how to properly dispose of certain packaging materials to
prevent identity theft. According to the respondents, the best way to dispose packaging
materials is by throwing it straight to the trash can. Tearing the material is also a
common practice prior to disposal as well as scratching out the information written on
labels. In this way, the risk of identity theft will be greatly diminished. Destroying
packaging materials by burning or wetting are also being practiced but it is not an
advisable as it may have an undesirable impact on the environment. There were few who
flush their packaging materials in the toilet which should be avoided since it can clog
pipelines.
Theme No. 2. Effects of improper medicine disposal
Improper medication disposal always leads to harm and it is crucial that every person be
properly educated about the consequences of it. See Table 6. Most of the pharmacists
indicated accidental exposure, possible reuse of the drug, and the possibility of the
medication to be a pollutant as effects of improper medication disposal. Associated with
accidental exposure are the environment, children, and animals, which may lead to
unfavorable consequences. Possible reuse of the drug is an alarming concern especially
for those who collect garbage which may try taking the drug to reduce expenditures and
children trying the medicine out of curiosity. Other answers that were also listed were
identity theft, misuse of the medication, reselling of the drug products, bacterial
resistance in terms of antimicrobial drugs, and harm.
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Other government agencies were also mentioned such as Philippine Drug Enforcement
Agency, Department of Health and Department of Environmental Resources. Most
registered pharmacists answered manufacturing companies as a good source of
information and heavily associated it with providing information about proper disposal
in package inserts.
According to the respondents, healthcare providers are the best source of information.
Pharmacists, especially those in the community setting are the front-liners in providing
information about the medication that patients use. Pharmaceutical manufacturers must
also include information about the disposal in package inserts or the packaging material
itself. This is especially important for medications being sold without the aid of
pharmacists, such as supermarkets. The FDA is responsible for safeguarding public
health through the enforcement of its standards. Having mandated regulations about
proper medication disposal would raise awareness and establish correct practices.
Seminars and school were also frequently answered and are common co-occuring
themes. A few also said that online and social media are reliable sources of information,
given its easy accessibility. Printed materials such as journals can also be good sources of
information regarding medication disposal.
Intervention
As seen in Table 2 there is an increase of 1.76 (p<0.05, 95%CI) on the mean scores of
pharmacists after the brief intervention given by the researchers. All of the questions
have an increase in the weighted mean from pretest to post-test. It also shows the result
of the paired samples t-test, having a significance value of less than 0.05; thereby
rejecting the null hypothesis. This implies that the difference between the pretest and
posttest is statistically significant. The question which had the highest increase
(238.46%) was about the best definition of proper medication disposal while the
question which had the lowest increase (4.64%) is about the FDA has a list of drugs and
the specific ways on how to properly dispose them.
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The majority correctly identified the best source of information about medication
disposal. There is also a lack of knowledge when it comes to the possible reasons for
disposing medicines. Majority correctly identified that expiration and end of treatment
lead to disposal of medications, however, many are not aware that the unaesthetic appeal
of medicine can also be a reason for disposal, and only half of the respondents chose side
effects as a reason for disposal. The storage for medicines has been correctly identified
by the respondents as well as the factors that may accelerate the expiration of drugs.
The low scores on the knowledge in medication disposal can be attributed to the lack of
education and information dissemination regarding the topic. In the pharmacy
curriculum, medication disposal has not been given enough importance and has only
been briefly taught. With the increasing demand for drugs and the increasing threat
accompanied by improper disposal of medications, it's about time that this issue must be
addressed.
In this study, the respondents felt that they were aware of the importance of proper
medication disposal and on its danger in the environment and the health of the public;
however, there was diversity on the response on whether they share their knowledge on
proper medication disposal. Pharmacists, as drug experts, must be knowledgeable on
drug information and it is their responsibility to impart their knowledge to their patients,
especially in the community setting. There was a relatively low response on their
confidence on their knowledge regarding medication disposal which greatly
compliments the high scores on their belief that there is a lack of information on proper
medication disposal here in the Philippines. In connection, the respondents also strongly
believed that in order to improve awareness on medication disposal there is a need to
incorporate this topic on the pharmacy program and fully inform the public of its
dangers. With regards to the practice of medication disposal, the respondents have
varied responses. Some believed that they practice proper medication but some are
uncertain. There was also a diverse response to medication disposal practice. Some of the
respondents had been uncertain on whether they dispose their medications properly.
In the study, most of the respondents possessed around 10-15 unused, unwanted, or
expired drugs. Analgesics were the common leftover drugs and most of them are in tablet
and syrup dosage form. According to the respondents, manufacturing companies and
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healthcare professionals, particularly the pharmacists, are the best source of information
for proper medication disposal. Majority of them believe that they are aware of the
proper medication disposal but the result in practice says otherwise. Flushing their
medication in sinks or toilets and throwing it in the trash are the most common ways of
disposal for solid and liquid dosage forms. As for the packaging materials, throwing
medication in the trash can is common.
After the intervention, there is a significant improvement in the knowledge of the
registered pharmacist regarding proper medication disposal, indicating that the brief
intervention was helpful.
CONCLUSION
The study reveals that some medical practices among registered pharmacists need
correction, as they exhibit poor knowledge and awareness of proper medication disposal.
Hence, there is an increasing need to educate pharmacists as well as establish guidelines
by the government agencies here in the Philippines regarding medication disposal to
help lessen environmental contamination of pharmaceuticals. As seen in the significant
increase in the mean score after the intervention, it can be gathered that it is effective in
improving the pharmacists’ knowledge, attitude, and, consequentially, practice, towards
proper medication disposal.
To further enhance the study on safe medication disposal, future studies might also
include other health care professionals as respondents and medical devices in the
criteria. The researchers recommend imparting medication disposal to the pharmacy
curriculum, to create policies and advocacies in order to impart knowledge and
awareness to the public regarding medication disposal.
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