Physical Pharmacy
Physical Pharmacy
Physical Pharmacy
COURSE SPECIFICATIONS
Focus: This course focuses on the correlation of these physicochemical principles to dosage form design, preparation, stabilization, evaluation and delivery to
patients
Outcomes: At the end of the course, the students are expected to:
acquire basic knowledge and skills pertinent to dosage formulation
apply the physicochemical properties of drugs as they relate to manufacturing and therapeutic response
interpret theoretical principles in terms of concrete laboratory situations
analyze and solve accurately problems encountered in drug design
At the end of the program, the graduate should be able to At the end of the second year level, the student should be able to:
1. practice pharmacy in a professional and ethical manner; 1. demonstrate knowledge and skills in identifying different dosage forms, drugs
2. provide pharmaceutical care; of biological origin, and ensuring quality of medical and pharmaceutical
3. conduct relevant research and disseminate findings; products, and services,
4. apply managerial and entrepreneurial skills; 2. demonstrate knowledge of the pharmacy and chemistry of pharmaceutical
5. communicate and facilitate effectively. products,
3. recognize important elements of the patient’s health profile and health promotion,
including pharmacovigilance in the context of the healthcare system,
4. read and interpret prescription correctly,
5. document important information used in patient care and pharmacy operations,
6. relates ethical principles to leadership and management in pharmacy;
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7. demonstrate appreciation of art;
8. practice good housekeeping in the laboratory and other working areas
9. identify the different elements or components in a pharmacy operation while
practicing good management skills
Laboratory
1. Concentration Expressions
2. Density & Specific Gravity
Laboratory
1. Solubility Determination
2. Colligative Properties of
Solutions
3. pH Determination
4. Buffer Preparation
5. Partition Coefficient
Unit IV. COMPLEXATION
9 PLO 3 ILO 1, ILO 2 Interactive Lecturing Recitation /
4.1 Complexes and Chelates using Lecture Board work
Demonstrate 4.1.2. Classification of Explaining the Forum
understanding complexes factors which Exam/quiz
of 4.1.2 Pharmaceutical affects Assigned reading
complexation applications of complexes complexation Laboratory
and chelation and chelates Problem sets reports
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Laboratory
Laboratory experiments
1. Determination of
pharmaceutical products
containing complexes
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phenomena surface tension
5.4 Rheology
Demonstrate 5.4.1 Types of flow Comparing the
knowledge on 5.4.2 Determination of various flow
the concepts rheologic properties properties
and 5.4.3 Techniques for between
applications of rheological measurements Newtonian and
rheology in 5.4.4 Application to non-Newtonian
pharmacy pharmaceutical materials
preparations
Laboratory
1. Coarse Dispersions
2. Interfacial and surface tension
3. Viscosity determination
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7.1 Linear Equation and Linear using Lecture Board work
(18 – FINAL GRADING Demonstrate Regression Applying Forum
PERIOD) understanding calculations on Exam/quiz
of linear linear equation Assigned reading
equation and and linear Laboratory
linear regression to Problem sets reports
regression zero-order, first-
7.2 Orders of Reaction order kinetics, Laboratory
Demonstrate 7.2.1 Factors affecting and half-life. experiments
knowledge of reaction rates
orders of 7.2.2 Zero-order process
reaction, half- 7.2.3 First-order process
life, shelf-life 7.3 Half-Life
and stability 7.4 Shelf-Life and Expiration
studies Dating Discussing the
7.4.1 Decomposition and significance of
stabilization of medicinal expiration
agents dating
7.5 Stability Studies Understanding
7.5.1 Methods of the stability-
evaluating the stability of testing
pharmaceutical regulatory
preparations requirements
and protocols
Laboratory
1. Shelf-life determination
Learning Resources LCD projector, Powerpoint presentations, LED TV, audio-visual materials
Basic Readings Martin’s Physical Pharmacy and Pharmaceutical Sciences
Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems
Aulton’s Pharmaceutics: The Design and Manufacture of Medicines
Extended Readings Pharmacopeias (eg. USP, BP, PP)
ASEAN Guidelines (eg. Stability, Variation)
WHO and ICH Guidelines (eg. Interchangeability, Validation, Pharmaceutical Quality Systems)
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Course Assessment Recitation / Board work
Exam/quiz
Laboratory reports
Course Policies
Committee Members
Consultation Schedule
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