Subject: Pysiology Topic: Thyroid Gland and Pancreas Lecturer: Dr. Gigi Francisco Date: January 2011
Subject: Pysiology Topic: Thyroid Gland and Pancreas Lecturer: Dr. Gigi Francisco Date: January 2011
Subject: Pysiology Topic: Thyroid Gland and Pancreas Lecturer: Dr. Gigi Francisco Date: January 2011
5. Coupling reaction
Conjugation of iodinated tyrosines (MIT,
monoiodotyrosine, and DIT,
diiodotyrosine)
o Trioiodothyronine, T3 (MIT + DIT
= T3)
o Thyroxine, T4 (DIT + DIT = T4)
EFFECT OF COLD
Thermogenesis
o Uncoupling protein
Dissociates oxidative phosphorylation from
ATP generation
HYPOTHYROIDISM
Low serum T4/T3; elevated TSH
Causes
o Dietary iodine deficiency
o Iatrogenic
Surgical removal
Irradiation
o Sequelae of Hashimoto’s Thyroidits
Autoimmune thyroditis
Goiter
Symptoms
o Fatigue
o Somnolence
o Sluggishness
o Slowed Heart Rate
o Decreased cardiac output
o Failure of Trophic functions (hair, skin)
o Myxedema
Diagnosis
o Decreased thyroxine
o Increased TSH
Treatment
o Thyroxine oral supplementation
o Iodine in the diet