Rheumatoid Arthritis Orencia

Adult Rheumatoid Arthritis (RA)
ORENCIA is used to reduce signs and

symptoms of moderate to severe
Rheumatoid Arthritis in adults 18 years and
older. Taking ORENCIA may prevent
further damage to your bones and joints, and
may help your ability to perform daily
activities. ORENCIA may help those who
are not getting the results they need with
other medicines for RA.
In adults, ORENCIA may be used alone or
with other RA treatments other than Janus
kinase (JAK) inhibitors or biologic disease-
modifying antirheumatic drugs
(bDMARDs), such as tumor necrosis factor
(TNF) antagonists.
Polyarticular Juvenile Idiopathic
Arthritis (pJIA)
symptoms of moderate to severe
polyarticular JIA in patients 2 years of age
and older. ORENCIA may be used alone or
with methotrexate (MTX).
Adult Psoriatic Arthritis (PsA)
symptoms of active Psoriatic Arthritis in
adults 18 years and older. In adults,
ORENCIA may be used alone or with other
PsA treatments.
Rheumatoid arthritis is a chronic

inflammatory disorder that can affect more
than just your joints. In some people, the
condition can damage a wide variety of body
systems, including the skin, eyes, lungs,
heart and blood vessels.
An autoimmune disorder, rheumatoid
arthritis occurs when your immune system
mistakenly attacks your own body's tissues.
Unlike the wear-and-tear damage of
osteoarthritis, rheumatoid arthritis affects the
lining of your joints, causing a painful
swelling that can eventually result in bone
erosion and joint deformity.
The inflammation associated with
rheumatoid arthritis is what can damage
other parts of the body as well. While new
types of medications have improved
treatment options dramatically, severe
rheumatoid arthritis can still cause physical
disabilities.
Products & Services
Symptoms
Signs and symptoms of rheumatoid arthritis
may include:
 Tender, warm, swollen joints
 Joint stiffness that is usually worse in the
mornings and after inactivity
 Fatigue, fever and loss of appetite
Early rheumatoid arthritis tends to affect
your smaller joints first — particularly the
joints that attach your fingers to your hands
and your toes to your feet.
As the disease progresses, symptoms often
spread to the wrists, knees, ankles, elbows,
hips and shoulders. In most cases, symptoms
occur in the same joints on both sides of
your body.
About 40 percent of the people who have
rheumatoid arthritis also experience signs
and symptoms that don't involve the joints.
Rheumatoid arthritis can affect many
nonjoint structures, including:
 Skin
 Eyes
 Lungs
 Heart
 Kidneys
 Salivary glands
 Nerve tissue
 Bone marrow
 Blood vessels
Rheumatoid arthritis signs and symptoms
may vary in severity and may even come
and go. Periods of increased disease activity,
called flares, alternate with periods of
relative remission — when the swelling and
pain fade or disappear. Over time,
rheumatoid arthritis can cause joints to
deform and shift out of place.
When to see a doctor
Make an appointment with your doctor if
you have persistent discomfort and swelling
in your joints.
Risk factors
Factors that may increase your risk of
rheumatoid arthritis include:
 Your sex. Women are more likely than
men to develop rheumatoid arthritis.
 Age. Rheumatoid arthritis can occur at
any age, but it most commonly begins in
middle age.
 Family history. If a member of your
family has rheumatoid arthritis, you may
have an increased risk of the disease.
 Smoking. Cigarette smoking increases
your risk of developing rheumatoid
arthritis, particularly if you have a genetic
predisposition for developing the disease.
Smoking also appears to be associated
with greater disease severity.
 Environmental exposures. Although
poorly understood, some exposures such
as asbestos or silica may increase the risk
of developing rheumatoid arthritis.
Emergency workers exposed to dust from
the collapse of the World Trade Center
are at higher risk of autoimmune diseases
such as rheumatoid arthritis.
 Obesity. People — especially women
age 55 and younger — who are
overweight or obese appear to be at a
somewhat higher risk of developing
rheumatoid arthritis.
Complications
Rheumatoid arthritis increases your risk of
developing:
 Osteoporosis. Rheumatoid arthritis
itself, along with some medications used
for treating rheumatoid arthritis, can
increase your risk of osteoporosis — a
condition that weakens your bones and
makes them more prone to fracture.
 Rheumatoid nodules. These firm bumps
of tissue most commonly form around
pressure points, such as the elbows.
However, these nodules can form
anywhere in the body, including the
lungs.
 Dry eyes and mouth. People who have
rheumatoid arthritis are much more likely
to experience Sjogren's syndrome, a
disorder that decreases the amount of
moisture in your eyes and mouth.
 Infections. The disease itself and many
of the medications used to combat
rheumatoid arthritis can impair the
immune system, leading to increased
infections.
 Abnormal body composition. The
proportion of fat to lean mass is often
higher in people who have rheumatoid
arthritis, even in people who have a
normal body mass index (BMI).
 Carpal tunnel syndrome. If rheumatoid
arthritis affects your wrists, the
inflammation can compress the nerve that
serves most of your hand and fingers.
 Heart problems. Rheumatoid arthritis
can increase your risk of hardened and
blocked arteries, as well as inflammation
of the sac that encloses your heart.
 Lung disease. People with rheumatoid
arthritis have an increased risk of
inflammation and scarring of the lung
tissues, which can lead to progressive
shortness of breath.
 Lymphoma. Rheumatoid arthritis
increases the risk of lymphoma, a group
of blood cancers that develop in the
lymph system.

Rheumatoid Arthritis Orencia

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Adult Rheumatoid Arthritis (RA)

ORENCIA is used to reduce signs and

Rheumatoid arthritis is a chronic

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