SAM Organic Chemistry Amines, Amides
SAM Organic Chemistry Amines, Amides
SAM Organic Chemistry Amines, Amides
Functional group
R-NH2
Uses
1) Morphin
2) Diazepam/Valium
3) Procaine
1
4) Lidocaine
2
Nomenclature:
1) Locate parent chain containing amino fg
2) Give amino the lowest no
Eg:
Diamines
3
Classification of amines
Primary
Secondary
Tertiary
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Physical properties
iv. Tertiary amines are more volatile because they can only form
DDI among themselves. Hydrogen bonding is not possible
between tertiary amines.
Diagram:
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b. Solubility in water
i. Lower amines- Very soluble in water
1) Amine has very polar amino group
2) can form strong hydrogen bonds with very polar water
molecules.
Diagram:
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Chemical properties
1) Weak base
CH3NH2 + H+ CH3NH3+
c. Neutralisation reactions
7
Application in drugs
1) Procaine and Lidocaine are anaesthetics
8
SUBTOPIC: AMIDES
Uses:
1) Caffeine
2) Urea
9
3) Paracetamol
Chemical properties
1) Formation of amide
a. Involves 2 stages
i. Acid-base reaction
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2) Hydrolysis
a. Acidic hydrolysis
b. Alkaline hydrolysis
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