Chromosomes and Dna

Chromosome and DNA MCQs
1. Which is incorrect?
A. Chromosomes 1st observed by Walther Fleming
B. Chromosomal theory of inheritance 1st formulated by Walter Sutton
C. 1st evidence of hereditary nature of DNA provided by Friedrich Meischer
D. Sex chromosomes discovered by Thomas Hunt Morgan
2. A chromosome is made of
A. 2 chromatids +1 centromere +secondary constriction
B. 1 chromatids + 1 centromere + primary constriction
C. 2 chromatids + 1 centromere + primary constriction
D. 2 chromatids + 2 centromere + secondary constriction
3. Chromosomes are composed of

A. 40% protein and 60% DNA
B. 50% protein and 50% DNA
C. 70% protein and 30% DNA
D. 60% protein and 40% DNA
4. A typical human chromosome contains _________ nucleotides in its DNA

A. 240 million
B. 140 million
C. 150 million
D. 160 million
5. Histones have an abundance of amino acids

A. Valine and lysine
B. Arginine and lysine
C. Valine and arginine
D. Histidine and threonine
6. A torsion of chromatin that is condensed only during cell division is

A. Euchromatin
B. Heterochromatin
C. Biochromatin
D. Nucleochromatin
7. Transfer of genetic material from one cell to another that can alter the genetic
makeup of recipient cell is called
A. Mutation
B. Transduction
C. Replication
D. Variation
8. Who discovered DNA?

A. P.A.Levene
B. Frederick Griffith
C. Friedrich Miescher
D. Rosalind Franklin
9. DNA contains
A. Purines (A and G) pyrimidines (U and c)
B. Purines (T and c) pyrimidines (A and G)
C. Purines (A and c) pyrimidines (U and G)
D. Purines (A and G) pyrimidines (T and c)
10. In DNA
A. A forms two bonds with T
B. G forms three bonds with C
C. A forms three bonds with T
D. Both a and b
11. DNA has a helical shape with the diameter of

A. 3 nm
B. 4 nm
C. 2 nm
D. 5 nm
12. In semi-conservative replication

A. The sequence of the original duplex is conserved after one round of replication
B. Generate DNA copies of entirely new molecules
C. Parental DNA become completely dispersed
D. Each strand of daughter molecules will be a mixture of old and new
13. The true E.Coli replicating enzyme is

A. DNA polymerase I
B. DNA polymerase II
C. DNA polymerase III
D. All of these
14. The rate of DNA replication by DNA polymerase is

A. 2000 nucleotides / sec
B. 1000 nucleotides / sec
C. 150 nucleotides / sec
D. 1050 nucleotides / sec
15. Replication always proceeds in a direction

A. 3′ – 5′
B. 5′ – 3′
C. Both directions
D. None of these
View Answer
16. Which statement is correct?

A. Leading strand elongates away from the replication fork
B. Lagging strand elongates towards the replication fork
C. The lagging strand is constructed discontinuously.
D. Both a and b
17. The length of Okazaki fragments in eukaryotes is

A. 150–250 nucleotides long
B. 200-300 nucleotides
C. 1000-2000 nucleotides
D. 100-200 nucleotides
18. In alkaptonuria
A. Patient’s urine contains homogenetic acid
B. Urine becomes black
C. Both a and b
D. Urine contains phenylalanine
19. The sequence of nucleotides that determines the amino acid sequence of a
protein is
A. Chromosome
B. DNA
C. RNA
D. Gene
20. Central dogma is

A. Transfer of information from DNA to mRNA
B. The basic mechanism of reading and expressing genes
C. Transfer of information from RNA to proteins
D. Synthesis of all three types of RNA
21. In prokaryotes there are

A. Three types of DNA polymerases
B. One type of RNA polymerase
C. Three types of RNA polymerase
D. Both a and b
22. Human cell contains ______ different kinds of tRNA molecules

A. 25
B. 35
C. 45
D. 15
23. In eukaryotes newly synthesized mRNA

A. Travels a large distance from the nucleus to cytoplasm
B. Is directly released into the cytoplasm
C. Contains a cap and tail
D. Both a and c
24. Which 3 codons are nonsense codons?

A. UAA, UAU, UUA
B. UGA, UAG, UAA
C. UGG, UGA, UAU
D. UGG,UAA,UAG
25. Methionine is specified by

A. Stop codon
B. AUG
C. Start codon
D. Both B and C
26. In mitochondria, UGA is/specifies as

A. Stop codon
B. Tryptophan
C. Initiation codon
D. Methionine
27. Three nucleotide sequence on tRNA that specifies an amino acid is

A. Codon
B. Anticodon
C. Nonsense codon
D. Genetic code
28. Initiation complex in translation is composed of

A. Ribosome and aminoacyl-tRNA
B. Ribosome and tRNA
C. tRNA and aminoacyl-tRNA
D. None of these
29. Examples of chromosomal aberrations are

A. Sickle cell anemia
B. Phenylketonuria
C. Down’s syndrome
D. Both a and b
30. Point mutations are represented as

A. Presence of an extra chromosome
B. Loss of chromosome
C. Alteration in the sequence of DNA nucleotide
D. Insertions and inversion of gene
31. The strand of DNA which is not transcribed is called

A. Antisense
B. Template
C. Coding
D. None of these
32. Phenylketonuria is due to deficiency of

A. Phenylalanine
B. Phenylalanine hydroxylase
C. Phenylene
D. All of these
33. Molecular basis of sickle cell anemia was found by

A. F. Sanger
B. Beadle and Tatum
C. Vernone Ingram
D. Mendal
34. Which is incorrect about nucleosome

A. 2 turns of DNA coiled around histones
B. 8 histones as acidic proteins
C. 200 nucleotides in one nucleosome
D. None of these
35. Sex chromosomes were 1″ discovered in

A. Man
B. Pea plant
C. Fruitfly
D. None of these
36. A sugarcane cell has _________ chromosomes.

A. 20
B. 32
C. 40
D. 80
37. Centromere represents

A. Primary constriction
B. Secondary constriction
C. Tertiary constriction
D. Quaternary constriction
38. Which of the following cal kill mice if injected separately?

A. Live R type pneumococcus
B. Heat-killed R type pneumococcus
C. Live S type pneumococcus
D. Heat-killed S type pneumococcus
39. X-Ray diffraction pattern of DNA was prepared by

A. Rosalind Franklin
B. Maurice Wilkins
C. Watson
D. Crick
40. In sickle cell Hb, which chain is affected?

A. Alpha chain
B. Beta Chain
C. Both of these
D. None of these

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Chromosome and DNA MCQs

3. Chromosomes are composed of

4. A typical human chromosome contains _________ nucleotides in its DNA

5. Histones have an abundance of amino acids

6. A torsion of chromatin that is condensed only during cell division is

8. Who discovered DNA?

11. DNA has a helical shape with the diameter of

12. In semi-conservative replication

13. The true E.Coli replicating enzyme is

14. The rate of DNA replication by DNA polymerase is

15. Replication always proceeds in a direction

16. Which statement is correct?

17. The length of Okazaki fragments in eukaryotes is

20. Central dogma is

21. In prokaryotes there are

22. Human cell contains ______ different kinds of tRNA molecules

23. In eukaryotes newly synthesized mRNA

24. Which 3 codons are nonsense codons?

25. Methionine is specified by

26. In mitochondria, UGA is/specifies as

27. Three nucleotide sequence on tRNA that specifies an amino acid is

28. Initiation complex in translation is composed of

29. Examples of chromosomal aberrations are

30. Point mutations are represented as

31. The strand of DNA which is not transcribed is called

32. Phenylketonuria is due to deficiency of

33. Molecular basis of sickle cell anemia was found by

34. Which is incorrect about nucleosome

35. Sex chromosomes were 1″ discovered in

36. A sugarcane cell has _________ chromosomes.

37. Centromere represents

38. Which of the following cal kill mice if injected separately?

39. X-Ray diffraction pattern of DNA was prepared by

40. In sickle cell Hb, which chain is affected?

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