Liquid Dosage
Liquid Dosage
Liquid Dosage
COLLEGE OF PHARMACEUTICS- II
PHARMACY (PHT 312)
Young
Elderly
After oral surgery
Types of Liquid Dosage Forms ?
Clear , Homogeneous
preparations Liquid
containing one or more preparations with
active ingredients 2 or more
dissolved in a suitable phases
vehicle. Finely
divided
Solid drug particles
suspended suspended
in in
Liquid/ Liquid/
Vehicle Vehicle
Drugs Drugs
Dissolved Dissolved
in Liquid drug
in dispersed
aqueous
vehicle non-aqueous Liquid/
solvent. Vehicle
Advantages of liquid dosage forms
Easier to swallow therefore easier for: children, old age
and unconscious patients.
Flexibility in dosing.
May be designed for any route of administration like oral,
topical, parenteral etc.
If given orally, more quickly effective than tablets and
capsules as drug become available immediately for
absorption.
Homogenous therefore give uniform dose than
suspension or emulsion which need shaking.
Disadvantages of liquid dosage forms
Less stable than solid dosage forms.
Bulky therefore difficult to transport and store.
May require special storage conditions.
Difficulty in measuring the dose accurately.
Difficulty in administration.
Chances of dose variability is more.
major signs of instability:
Color or odour change
Precipitation of drugs
microbial growth
chemical gas formation
Features of pharmaceutical solutions
Solutions:
Homogenous One-phase Transparent system
consisting of two or more components.
• The components do not separate on standing
polarity to itself.
mL solvent.
• DISADVANTAGES
Support growth of microorganisms when contaminated
Favorable medium for many chemical reactions.
Some hydrolysable drugs such as glycosides and esters
form unstable solutions when dissolved in water.
Which water to be used in pharmaceuticals?
16
GOOD LUCK ..