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Acid-Base Imbalances

Acidosis Normal Alkalosis


pH < 7.35 7.35-7.45 > 7.45
(Respiratory) PCO2 > 45 35-45 < 35
(Metabolic) HCO3 < 22 22-26 > 26

Uncompensated values:
Respiratory acidosis
pH Below 7.35
PCO2 Above 45
HCO3 Normal

Respiratory alkalosis
pH Above 7.45
PCO2 Below 35
HCO3 Normal

Metabolic acidosis
pH Below 7.35
PCO2 Normal
HCO3 Below 22

Metabolic alkalosis
pH Below 7.45
PCO2 Normal
HCO3 Above 26

Respiratory
 Respiratory problems result from changes in carbon dioxide exhalation due to lung or
breathing disorders
o This is why the PCO2 levels will be affected

Metabolic
 Metabolic problems result from imbalance in the production of acids or bases and their
excretion by the kidneys
o This is why the HCO3 will be affected

Acidosis
 Respiratory causes of acidosis:
o Buildup of carbon dioxide in the blood from poor lung function or depressed
breathing
 Respiratory S&S of acidosis:
o Headache, confusion
o Breathing shallow and/or slowly
 Bradypnea
 Hypoventilation
 Metabolic causes of acidosis:
o Overproduction of acid that builds up in the blood
o Excessive loss of bicarbonate from the blood
 Metabolic S&S of acidosis:
o N/v, fatigue
o Breathing faster and deeper than normal
 Kussmaul respirations (deep, labored breathing pattern)

Alkalosis
 Respiratory causes of alkalosis:
o Low level of CO2 in blood
 hyperventilation
 S&S of alkalosis:
o Irritability
o Muscle twitching, cramping
o Tingling in fingers, toes, and around lips
 Paresthesia
 Metabolic causes of alkalosis:
o Overabundance of bicarbonate in blood (HCO3)
o Loss of acid from blood

Compensation
 If the pH is abnormal, then the body’s ability to compensate is failing
o Urgent to treat underlying cause
 Respiratory compensation is usually done through metabolic mechanisms
o Respiratory acidosis compensation
 HCO3 may become elevated once the kidneys kick in and release
bicarbonate into blood in an effort to buffer the blood pH back down to
normal
 Kidneys excrete hydrogen ions from the body in order to decreased
acidity of blood
o Respiratory alkalosis compensation
 The kidneys excrete more bicarbonate into the urine so that the blood pH
can become more acidic
 Kidneys retain more H+ in order to make pH more acidic
 Metabolic compensation is usually done through respiratory mechanisms and metabolic
mechanisms
o Metabolic acidosis compensation:
 Lungs hyperventilate to eliminate CO2
 Ex: Kussmaul respirations in the case of severe metabolic acidosis
 Kidneys conserve HCO3
o Metabolic alkalosis compensation:
 Lungs hypoventilate to raise CO2
 Kidneys conserve H+ and excrete HCO3

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