Liver and Gallbladder Issues

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Fatty Liver & Gallbladder Issues

Causes, Mechanisms and Treatments
Dr Ben Lynch, ND
#SHEICON2016 (c) www.seekinghealth.com

Disclaimer & Disclosures
The information presented here is for informational and educational purposes only. Docere, Inc and
Benjamin Lynch will not be liable for any direct, indirect, consequential, special, exemplary, or other
damages arising from the use or misuse of any materials or information published.
President and CEO of:

• Seeking Health Educational Institute (www.seekinghealth.org)
• Seeking Health (www.seekinghealth.com)
• MTHFR.Net (www.mthfr.net)
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SeekingHealth (c) www.seekinghealth.com
Objectives
1. Why Important to Discuss
2. Mechanisms of Liver and Gallbladder Dysfunction
3. Fructose as a driver to Fatty Liver
4. Cholestasis as trigger for SIBO
5. Diagnosis
6. Prevention and Treatments
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Threat Grows From Liver Illness Tied to Obesity

Fatty Liver Prevalence
15% in non-obese patients

65% in obese patients (BMI > 30 – 39.9)
85% in extremely obese patients (BMI > 40)

Why
No medications available.
Options:
Gallbladder removal
Liver transplant
Lifestyle / Diet . . .
Threat Grows From Liver Illness Tied to Obesity

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Why
Many known mechanisms are determined.
. . .
Remarkably few health professionals applying.
Even fewer – identifying it early.
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(c) 2015: Benjamin Lynch, ND
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Liver & GB Function
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Functions of Gallbladder?
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Fatty Liver & GB Causes
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Fatty Liver Risk Factors Gallstone Risk Factors
1. Stress 1. Stress
2. Obesity 2. Obesity
3. Pregnancy (mother and child) 3. Pregnancy (mother)
4. Improper breathing 4. Improper breathing
5. Oxidative stress 5. Oxidative stress
6. Genetic polymorphisms 6. Genetic polymorphisms
7. Nutritional deficiencies 7. Nutritional deficiencies
8. Processed food 8. Processed food
9. Fructose 9. Fructose
10. Medications 10. Medications
11. Pathogens 11. Pathogens
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Associated Conditions
1. Diabetes type II
2. Dyslipidemia
3. Metabolic syndrome
4. Coronary heart disease
5. Atherosclerosis
6. Cancer
7. Sleep apnea
8. Bacterial overgrowth – recurrent (small intestine)
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SIBO
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Issues:
• 25 g fructose / serving
• Rest feed intestinal bugs
• à S/Sx
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tsp
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9.5
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Summary:
Fructose à Overeating à Metabolic Shift
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What’s the Cause?!
SIBO present? GB stagnation? Fatty liver? 33
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1:20,000 Prevalence
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Water and Organ Percentage
Plasma 92%
Liver 85%
Lungs 83%
Muscles 79%
Kidneys 79%
Brain 73%
Heart 73%
Skin 64%
Bones 31%
Fat 20%
http://water.usgs.gov/edu/propertyyou.html and Gabriel Cousens

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Oxygen Utilization by Organ
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(c) 2014: Benjamin Lynch, ND 40
How??
Shifting Aerobic Metabolism to Anaerobic
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Let’s Review . . .

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Why . . . ??

Glutathione needed
Aerobic metabolism Inhibited:

Pseudohypoxia!

ROS > Antioxidants à Metabolic Shift

Aerobic metabolism Inhibited:
Pseudohypoxia!

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Genetics
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(c) 2015: Benjamin Lynch, ND
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What important nutrient is deficient in 70% of pregnant women?
What important pathway occurs mostly in the liver?
What important pathway works extra hard during pregnancy?
What important cofactors are needed for PEMT?
What common problem occurs in the liver area of pregnant women?
WHY??
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What medical condition
commonly has
gallbladder issues?
Lab Testing
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Fatty Liver Lab Findings
1. FT3/FT4 ratio
2. n-6/n-3 PUFA ratio
3. BMI
4. Enlarged waist circumference
5. HOMA-IR
6. Uric acid
7. Triglycerides
8. Total cholesterol
9. Lactate
10. GGT
11. ALT
12. AST
13. Fasting insulin
14. Adenosine
15. MCV/MCH
16. Serum ferritin
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Who’s at risk?
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SeekingHealth http://www.medicalalgorithms.com/fatty-liver-index-fli-of-bedogni-et-al-for-predicting-he patic-stea tosis (c) www.seekinghealth.com
http://www.diazyme.com/ and http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Inte rpretive/200039
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Strategic Medicine
Identifying, Treating and Preventing the Triggers
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Psoriatic
15 yrs later –
Arthritis
Onset – Lactose intolerance Vomit/Diarrhea infxn -> SIBO
2nd Pregnancy gone after pregnancy 3rd Pregnancy -> gallstones antibiotics recurring
Lactose intolerant (-) for lactose Diarrhea w/ GB removal - SIBO

intolerance sulfur foods refused found & tx
Shigella
infection
www.washingtonpost.com/national/health-science/medical-mystery-what-was-causing-a-womans-chronic-digestive-
distress/2014/09/29/ae03f4e0-1ff0-11e4-ae54-0cfe1f974f8a_story.html
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Treatment
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Treatment for Fatty Liver and SIBO
Identify and Remove/Reduce: Optimize:
1. Stressors 1. Exercise
2. Infections 2. Hydration
3. Food addictions / cravings 3. Sleep cycle
4. Genetic polymorphisms 4. Breathing
5. Mental blockages 5. Mindset
6. Medications 6. Goals / Desires
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Neopterin
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Questions to ask
‘How many cups of each do you drink on average daily?
____ soda pop ___ fruit juice ___ water
____ coffee ___ beer ___ wine
____ liquor ___ black tea ___ green tea
‘Do you tend to feel full and satisfied after a meal?’

‘Do you find yourself snacking often throughout the day?'
‘When stressed, do you tend to eat more?’
‘What are your main stressors?
‘How often do they occur?’
‘Do you go to bed and wake up at a usual timeframe – within an hour or so?
“What do you think was the Triggering Event – for all of this?”
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Steps to Reduce Onset or Treat Fatty Liver
Immediate Treatment –
Stop Soda & Fruit Juice / Increase Energy / Reduce Stress / Optimize Diet / Reduce Cravings
1. Adaptogens
2. B Complex w/o B12 and MTHF
3. Electrolytes
4. Acetyl-L-carnitine
5. Chia seeds
6. Magnesium taurate
7. PQQ
8. 5-HTP
9. L-Tyrosine
10. Fish Oil (EPA/DHA)
Additional Treatment Recommendations –

1. Identify pathogens – don’t kill yet (CDSA, viral, bacterial, fungal, lyme, mold)
2. Breathing
3. Evaluate estrogens and balance
4. Screen for SNPs to evaluate susceptibility
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Keep me going!
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Steps to Reduce Onset or Treat Fatty Liver & SIBO
Open Up and Reduce Burden to the Pathways!!
Next Step Treatment –
Support Methylation / Biopterin / Glucose – Shift Metabolism
1. PC
2. Fish Oil
3. SAMe
4. Vitamin E
5. Acetyl-L-Carnitine / Alpha Lipoic Acid
6. Biotin
7. Milk thistle
8. Ox bile
Additional Treatment Recommendations –
1. Vitamin D
2. Liposomal C, GSH, Curcumin
3. Visceral manipulation of liver and gallbladder
4. Sauna / Coffee enema
SeekingHealth
5. Begin elimination of pathogens – slowly and rotate 95
(c) www.seekinghealth.com
Is SIBO a Metabolic Problem??

http://www.medhelp.org/posts/Gastroenterology/Bacterial-overgrowth/show/1984072
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Thank you
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Fatty Liver & Gallbladder Issues

#SHEICON2016 (c) www.seekinghealth.com

President and CEO of:

SeekingHealth (c) www.seekinghealth.com

Threat Grows From Liver Illness Tied to Obesity

SeekingHealth (c) www.seekinghealth.com

15% in non-obese patients

SeekingHealth (c) www.seekinghealth.com

Threat Grows From Liver Illness Tied to Obesity

SeekingHealth (c) www.seekinghealth.com

Many known mechanisms are determined.

SeekingHealth (c) www.seekinghealth.com

http://water.usgs.gov/edu/propertyyou.html and Gabriel Cousens

(c) 2015: Benjamin Lynch, ND 46

(c) 2015: Benjamin Lynch, ND 48

Aerobic metabolism Inhibited:

(c) 2015: Benjamin Lynch, ND 49

(c) 2015: Benjamin Lynch, ND 50

(c) 2015: Benjamin Lynch, ND 51

What important pathway occurs mostly in the liver?

What important pathway works extra hard during pregnancy?

What important cofactors are needed for PEMT?

What common problem occurs in the liver area of pregnant women?

Lactose intolerant (-) for lactose Diarrhea w/ GB removal - SIBO

SeekingHealth (c) www.seekinghealth.com

SeekingHealth (c) www.seekinghealth.com

SeekingHealth (c) www.seekinghealth.com

‘Do you tend to feel full and satisfied after a meal?’

Additional Treatment Recommendations –

(c) 2015: Benjamin Lynch, ND 96

SeekingHealth (c) www.seekinghealth.com

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