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VARISES

DIAGNOSA, PENATALAKSANAAN
KONVENSIONAL SAMPAI TERKINI
dr. Londung Brisman Sitorus SpB KV
Bedah Vaskular dan Endovaskular
RS EMC TANGERANG
Incidence/Prevelance

• It is estimated that more than 80 million Americans suffer from some form of venous disorder.
• Up to 13 million people in the U.S. suffer from CVI
• Peak incidence occurs in women aged 40-9 and men aged 70-79 years
• Statistics show one in three Americans over the age of 45 is affected by vein disease, and of those, only 4% are
being treated.
• Annual health care cost in the US to treat CVI is about $3billion; about 2 million workdays are lost per year due to venous
ulcers

Varicose Veins
• More than 24 million Americans have varicose veins
• Up to 50% of women have varicose veins while 24% of men aged 30-40 and 43% of men over 70 have varicose veins

DVT / PTS
• There are over 200,000 new cases of DVT each year in the U.S.
• The incidence of pulmonary embolism in patients with DVT ranges from 5 – 20% and can be fatal
• After an episode of DVT, 20 – 50% of patients develop Post Thrombotic Syndrome within the first 2 years

Venous Stasis Ulcers


• Affect 2.5 million people in the U.S.
• An estimated 500,000 persons are newly diagnosed each year
Function
 Transport blood back to the heart

 Prevent intravascular volume overload


Anatomy
Valves
Lower Extremity
Venous Hypertension

 Hydrostatic pressure vs Mechanical/muscular pressure


 A. K. Tassiopoulos et al.
 1153 cases of ulcerated legs and venous disease
 Reflux in superficial, deep, and perforating veins
 Incompetent valves
Risk Factors

 Genetic
 More in females
 Hormones
 Progesterone, estrogen
 Pregnancy
 Age: >50
 Greater height
 Prolonged standing
 Obesity
Signs and Symptoms

 Telangiectasias  Aching
 Reticular veins  Heaviness
 Varicosity  Early fatigue
 Thrombophlebitis  Edema
 Hyperpigmentation  Itching
 Bleeding from  Restless legs
clusters  Cramps
 Ulceration
Clinical Examination

Feel for saphena varix


(1cm medial to the
femoral a.) & a
transmitted cough Dilated short saph v. Indurated tender veins
impulse suggestive of saph-pop suggestive of
incompetence thrombophlebitis
Test for incompetence

Brodie –Trendelenburg test

Empty the
veins &
apply a mid
thigh
tourniquet

Let the patient stand

If the veins remain empty, but fill after If the veins fill before removal of
removal of tourniquet, the tourniquet, the incompetence must
incompetence must be above the be below the tourniquet
tourniquet
Perthes’ walking test

Place a tourniquet around the


thigh while the patient is
standing (note that the vv are
full)
Let the patient walk in place

If the veins empty with


walking, then the tourniquet is
preventing superficial reflux
from an incompetent valve
above, while deep veins are
patent with intact valves.
Classification: CEAP
*Eklof et al. J of Vasc Surg 2004

Clinical classification
 C0: no visible or palpable signs of venous disease
 C1: telangiectasies or reticular veins
 C2: varicose veins
 C3: edema
 C4a: pigmentation or eczema
 C4b: lipodermatosclerosis or atrophie blanche
 C5: healed venous ulcer
 C6: active venous ulcer
 S: symptomatic, including ache, pain, tightness, skin
 irritation, heaviness, and muscle cramps, and other
 complaints attributable to venous dysfunction
 A: asymptomatic
C1
C2
C3
CEAP Etiologic classification
 Ec: congenital
 Ep: primary
 Es: secondary (post-thrombotic)
 En: no venous cause identified

Anatomic classification
 As: superficial veins
 Ap: perforator veins
 Ad: deep veins
 An: no venous location identified

Pathophysiologic classification

 Basic CEAP
 Pr: reflux
 Po: obstruction
 Pr,o: reflux and obstruction
 Pn: no venous pathophysiology identifiable
Treatment

 Compression Therapy
 Stocking

 Drug Therapy

 Surgery
Compression Stockings

 Worn during the day  Operator dependent


 Elastic stockings with  Difficult to put on
adjustments in  Physical
pressure impediments/Co-
morbidities
 Lower pressure
stockings (20-30mm
Hg) for edema and DVT  50% of patients were
prophylaxis unable to them on
 Higher pressure (30- alone
40+mm Hg) for ulcers
and significant venous
disease  30-65% noncompliance
noted in clinical trials
in venous centers
Compression Therapy:
Indications
Efficacy of Compression Therapy

1. 22 trials comparing healing of venous ulcers using


compression stockings
 Compressive therapy more effective than non-compression
 Higher pressure were more effective than lower
 Multilayer compression was better than single layer bandaging
2. 466 patients with a healed ulcer
 Continued use of compression stocking reduced reoccurrence
within 3-5 year
3. ESCHAR study: 500 limb trial that compares surgery and
compression vs. compression alone for ulcer treatment
 Combination therapy had lower rates of reoccurrence of ulcer
at year 4 (24% vs. 52%)
More invasive

 Sclerotherapy
 0.2% sodium tetradecyl injected directly into spider angiomas and smaller
superficial varicosities
 Complications (<5%): allergic reaction, hypo/hyper-pigmentation, local skin necrosis

 Surgical excision of veins ( Stripping)


 Endovenous laser ablation of saphenous vein (EVLT), Radio Frequency
ablation ( RFA)
Sclerotherapy
Efficacy

 Meta-analysis of 64 studies (12,320 legs)


 Anaylzed ablation via Duplex US
 Follow upto 5 years
 Success rate of EVLT highest after 5 years
 Complications: DVT (<3%), local bruising and pain, paresthesias, foam emboli,
stroke
THANK YOU

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