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Search Results (1,582)

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19 pages, 4401 KiB  
Article
Spatio-Temporal Variability in CO2 Fluxes in the Atlantic Sector of the Southern Ocean
by Gabrielle Tavares de Carvalho, Luciano Ponzi Pezzi, Nathalie Lefèvre, Celina Cândida Ferreira Rodrigues, Marcelo Freitas Santini and Carlos Mejia
Atmosphere 2025, 16(3), 319; https://doi.org/10.3390/atmos16030319 (registering DOI) - 10 Mar 2025
Viewed by 139
Abstract
The Southern Ocean (SO) plays a fundamental role in the planet’s climate system, due to its ability to absorb and redistribute heat and CO2 (an important greenhouse gas). In addition, the SO connects three large oceanic basins the Pacific, the Atlantic, and [...] Read more.
The Southern Ocean (SO) plays a fundamental role in the planet’s climate system, due to its ability to absorb and redistribute heat and CO2 (an important greenhouse gas). In addition, the SO connects three large oceanic basins the Pacific, the Atlantic, and the Indian Oceans, and it has an important role in the nutrient distribution in these oceans. However, the SO is poorly sampled, with most measurements made in austral spring and summer. The variability in the air–sea CO2 flux is estimated, as well as the role of atmospheric and oceanic variables in this variability. The CO2 fluxes are calculated using the bulk parameterization method, in the Atlantic sector of the Southern Ocean, from 2003 to 2022, using in situ measurements, satellites, and a reanalysis data set. A neural network model is built to produce maps of the partial pressure of CO2 in seawater (pCO2sea). The CO2 flux varies from −0.05 to 0.05 gC m−2 month−1. The Atlantic sector of the SO is a sink of CO2 in summer and spring and becomes a source in austral winter and autumn. The CO2 absorption intensifies from 2003 to 2022 by 7.6 mmol m−2 month−1, due to stronger westerly winds, related to the trend in the positive phase of the Antarctic Oscillation and the extreme El Niño Southern Ocean (ENSO) events (e.g., El Niño and La Niña). Full article
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<p>Southern Ocean regions. The study area is located in the Atlantic sector of the Southern Ocean. The isolines illustrate the circumpolar oceanic fronts from south to north, and they are the Southern Boundary (SB), the Southern Antarctic Circumpolar Current Front (SACCF), the Polar Front (PF), and the Subantarctic Front (SF). To the north of the SAF is the Subtropical Front (STF) [<a href="#B31-atmosphere-16-00319" class="html-bibr">31</a>].</p>
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<p>(<b>a</b>) Scheme of the produced Deep Artificial Neural Network. The input data are sea surface salinity (SSS), sea surface temperature (SST) (°C), and chlorophyll-a concentration (CHL) (mg·m<sup>−3</sup>) (μatm). The ANN includes 3 hidden layers with 10, 8, and 5 nodes. The output layer gives the seawater partial pressure of CO<sub>2</sub> (pCO<sub>2sea</sub>) (μatm). (<b>b</b>) Pearson correlation between pCO<sub>2sea</sub> estimates using SSS, SST, and Chl as ANN input data. Scatterplots and regression lines were calculated from Test data (with 15% of the data set).</p>
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<p>CO<sub>2</sub> fluxes in gC m<sup>−2</sup> month<sup>−1</sup> distribution at Drake Passage with SOCAT data for February 2016 and 2019, and with ATMOS data for February 2022.</p>
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<p>Taylor diagram for comparison between the FCO<sub>2</sub> calculated with in situ data (Reference) and from the ANN pCO<sub>2sea</sub> reconstruction (ANN). The blue lines are the root mean square (RMS) error.</p>
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<p>Monthly anomalies in the CO<sub>2</sub> flux (in gC m<sup>−2</sup> month<sup>−1</sup>) calculated from 2003 to 2022.</p>
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<p>Monthly sea surface temperature (°C) anomalies produced after reanalysis, from 2003 to 2022.</p>
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<p>Time series of atmospheric and oceanographic variables in the Drake Passage, from 2003 to 2022. CO<sub>2</sub> flux (FCO<sub>2</sub>) (<b>a</b>), sea surface temperature (SST) and air temperature (Tair) (<b>b</b>), chlorophyll-a concentration (CHL) (<b>c</b>), difference in CO<sub>2</sub> partial pressure between the ocean and the atmosphere (ΔpCO<sub>2</sub>) (<b>d</b>), atmospheric pressure at sea level (SLP) (<b>e</b>), salinity surface water (SSS) (<b>f</b>), wind speed (u) (<b>g</b>), seawater partial pressure of CO<sub>2</sub> (pCO<sub>2sea</sub>) and atmospheric partial pressure of CO<sub>2</sub> (pCO<sub>2air</sub>) (<b>h</b>).</p>
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18 pages, 12151 KiB  
Article
LGR-Net: A Lightweight Defect Detection Network Aimed at Elevator Guide Rail Pressure Plates
by Ruizhen Gao, Meng Chen, Yue Pan, Jiaxin Zhang, Haipeng Zhang and Ziyue Zhao
Sensors 2025, 25(6), 1702; https://doi.org/10.3390/s25061702 - 10 Mar 2025
Viewed by 181
Abstract
In elevator systems, pressure plates secure guide rails and limit displacement, but defects compromise their performance under stress. Current detection algorithms face challenges in achieving high localization accuracy and computational efficiency when detecting small defects in guide rail pressure plates. To overcome these [...] Read more.
In elevator systems, pressure plates secure guide rails and limit displacement, but defects compromise their performance under stress. Current detection algorithms face challenges in achieving high localization accuracy and computational efficiency when detecting small defects in guide rail pressure plates. To overcome these limitations, this paper proposes a lightweight defect detection network (LGR-Net) for guide rail pressure plates based on the YOLOv8n algorithm. To solve the problem of excessive model parameters in the original algorithm, we enhance the baseline model’s backbone network by incorporating the lightweight MobileNetV3 and optimize the neck network using the Ghost convolution module (GhostConv). To improve the localization accuracy for small defects, we add a high-resolution small object detection layer (P2 layer) and integrate the Convolutional Block Attention Module (CBAM) to construct a four-scale feature fusion network. This study employs various data augmentation methods to construct a custom dataset for guide rail pressure plate defect detection. The experimental results show that LGR-Net outperforms other YOLO-series models in terms of overall performance, achieving optimal results in terms of precision (p = 98.7%), recall (R = 98.9%), mAP (99.4%), and parameter count (2,412,118). LGR-Net achieves low computational complexity and high detection accuracy, providing an efficient and effective solution for defect detection in elevator guide rail pressure plates. Full article
(This article belongs to the Section Sensing and Imaging)
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<p>Schematic diagram of the guide rail clamp.</p>
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<p>YOLOv8 network architecture diagram.</p>
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<p>LGR-Net network structure.</p>
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<p>CBAM structure. Where ⊗ denotes element-wise multiplication.</p>
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<p>CAM structure. <span class="html-fig-inline" id="sensors-25-01702-i001"><img alt="Sensors 25 01702 i001" src="/sensors/sensors-25-01702/article_deploy/html/images/sensors-25-01702-i001.png"/></span> represents element-wise addition and the application of the activation function sigmoid, respectively.</p>
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<p>SAM structure. <span class="html-fig-inline" id="sensors-25-01702-i002"><img alt="Sensors 25 01702 i002" src="/sensors/sensors-25-01702/article_deploy/html/images/sensors-25-01702-i002.png"/></span> represents the activation function Sigmoid.</p>
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<p>MobileNetV3 structure.</p>
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<p>GhostConv structure.</p>
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<p>Defect types.</p>
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<p>Images after data augmentation.</p>
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<p>LGR-Net training results.</p>
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<p>Visualization of ablation experiment data. ((A)—YOLOv8n, (B)—YOLOv8n + i, (C)—YOLOv8n + ii, (D)—YOLOv8n + i + ii, (E)—YOLOv8n + i +ii + iii, (F)—LGR-Net).</p>
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<p>Visualization of detection results from ablation experiments.</p>
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<p>Detection results for small hole defects.</p>
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<p>Detection results for scratch defects.</p>
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<p>Detection results for crack defects.</p>
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<p>Detection results for wear defects.</p>
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<p>LGR-Net deployment demonstration.</p>
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26 pages, 13401 KiB  
Article
Analysis of Mesostructure Characteristics and Clogging Mechanism of Pervious Concrete Based on CT Scanning and Image Processing Techniques
by Lan Liu, Taidong Guo, Zhi Cheng, Zhongzhen Wang, Xiaozhi Cheng, Zhijun Cheng and Zhe Ma
Materials 2025, 18(6), 1189; https://doi.org/10.3390/ma18061189 - 7 Mar 2025
Viewed by 215
Abstract
This study utilized CT scanning and image processing techniques to extract and analyze the internal mesostructure and cement paste distribution of porous concrete. The effects of the mesostructure and cement paste distribution on the compressive strength and permeability were studied. Additionally, the research [...] Read more.
This study utilized CT scanning and image processing techniques to extract and analyze the internal mesostructure and cement paste distribution of porous concrete. The effects of the mesostructure and cement paste distribution on the compressive strength and permeability were studied. Additionally, the research explored the blockage mechanisms and morphology in porous concrete, with CT scanning used to map the distribution of blockages within the material. The results indicate that the impact of the aggregate particle size on the compressive strength is much less significant than the effect of porosity. The images clearly show that the pore size is positively correlated with both porosity and aggregate size. Additionally, the distributions of pore size and cement paste thickness can be described using a lognormal distribution function and a two-parameter Weibull function, respectively. Blockage analysis revealed that the blockages were primarily concentrated within the top 0–30 mm of the porous concrete surface. As the pore size increases, the blockage depth increases, and blockages in the 10–30 mm range are challenging to remove with high-pressure water jets. A degradation model for the permeability performance of aggregate porous concrete, considering blockage consolidation, was established using parameters such as the blockage accumulation per unit area, aggregate particle size, and concrete porosity. This model provides theoretical and data-based references for evaluating the service life of porous concrete. Full article
(This article belongs to the Collection Concrete and Building Materials)
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<p>Particle grading of contaminants.</p>
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<p>Water Permeability Testing Device.</p>
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<p>CT scanned specimens.</p>
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<p>Extraction of pore distribution.</p>
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<p>The color differentiation of pores with varying diameters.</p>
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<p>3D reconstruction of the pervious concrete.</p>
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<p>Extraction of the cement paste thickness distribution.</p>
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<p>Compressive strength: (<b>a</b>) different porosities and (<b>b</b>) different aggregate sizes.</p>
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<p>Permeability coefficient: (<b>a</b>) different porosities; (<b>b</b>) different aggregate sizes.</p>
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<p>Pore distribution of the specimens with different porosities.</p>
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<p>Pore distribution of specimens with different aggregate sizes.</p>
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<p>Probability density distribution of pore sizes: (<b>a</b>) different porosities and (<b>b</b>) different aggregate sizes.</p>
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<p>Probability density distribution of aggregate sizes: (<b>a</b>) different porosities and (<b>b</b>) different aggregate sizes.</p>
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<p>Bonding region proportion of cement paste: (<b>a</b>) different porosities and (<b>b</b>) different aggregate sizes.</p>
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<p>Degradation of water permeability under different porosities: (<b>a</b>) permeability coefficient; (<b>b</b>) permeability rate.</p>
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<p>Degradation of water permeability under different aggregate sizes: (<b>a</b>) permeability coefficient; (<b>b</b>) permeability rate.</p>
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<p>Degree of permeability recovery after cleaning: (<b>a</b>) different porosities and (<b>b</b>) different aggregate sizes.</p>
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<p>Specimen surface after clogging.</p>
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<p>Blockage distribution in specimens with different aggregate sizes: (<b>a</b>) 2D distribution; (<b>b</b>) 3D distribution.</p>
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<p>Blockage distribution in specimens with different porosities: (<b>a</b>) 2D distribution, (<b>b</b>) 3D distribution.</p>
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<p>Blockage distribution in specimens with different porosities: (<b>a</b>) 2D distribution, (<b>b</b>) 3D distribution.</p>
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<p>Variation in porosity along height (same aggregate size): (<b>a</b>) different porosities; (<b>b</b>) different clogging states.</p>
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<p>Variation in porosity along the height (specimens with different aggregate sizes): (<b>a</b>) different aggregate sizes and (<b>b</b>) different clogging states.</p>
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<p>Variation in pore size with different clogging states: (<b>a</b>) different porosities; (<b>b</b>) different aggregate sizes.</p>
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11 pages, 827 KiB  
Protocol
The Hypotension Prediction Index in Free Flap Transplant in Head and Neck Surgery: Protocol of a Prospective Randomized Controlled Trial
by Jakub Szrama, Agata Gradys, Amadeusz Woźniak, Zuzanna Nowak, Tomasz Bartkowiak, Ashish Lohani, Krzysztof Zwoliński, Tomasz Koszel and Krzysztof Kusza
Life 2025, 15(3), 400; https://doi.org/10.3390/life15030400 - 4 Mar 2025
Viewed by 130
Abstract
Introduction: Microvascular free flap surgery is a treatment method for patients with head and neck cancer requiring reconstruction surgery. Patients undergoing this complex, long-lasting surgery are prone to prolonged episodes of intraoperative hypotension, which is associated with increased incidence of postoperative mortality, morbidity, [...] Read more.
Introduction: Microvascular free flap surgery is a treatment method for patients with head and neck cancer requiring reconstruction surgery. Patients undergoing this complex, long-lasting surgery are prone to prolonged episodes of intraoperative hypotension, which is associated with increased incidence of postoperative mortality, morbidity, and free flap failure. A new technology recently approved, named the Hypotension Prediction Index (HPI), allows precise hemodynamic monitoring of patients under general anesthesia, with a significant reduction of intraoperative hypotension events. This study aims to assess the impact of the Hypotension Prediction Index (HPI) on the incidence and severity of intraoperative hypotension in patients undergoing free flap surgery. Methods and analysis: Eligible patients will be randomly assigned to one of two groups: Group A, receiving invasive blood pressure monitoring with standard medical therapy, or Group B, undergoing hemodynamic monitoring using the Hypotension Prediction Index (HPI) software. The primary outcome is the time-weighted average (TWA) of mean arterial pressure (MAP) < 65 mmHg. Secondary outcomes include free flap viability and perioperative complications. Ethics and dissemination: Ethics approval was obtained from the Poznan University of Medical Sciences Ethics Committee (KB-560/22; date 1 July 2022). Results will be submitted for publication in a peer-reviewed journal. Trial registration number: NCT 05738603. Full article
(This article belongs to the Collection Clinical Trials)
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<p>HPI hemodynamic algorithm reprinted with permission from ref. [<a href="#B25-life-15-00400" class="html-bibr">25</a>]. (COPYRIGHT © 2023 Lorente, Ripollés-Melchor, Jiménez, Becerra, Mojarro, Fernández-Valdes-Bango, Fuentes, Moreno, Agudelo, Villar-Pellit de la Vega, Ruiz-Escobar, Cortés, Venturoli, Quintero, Acedo, Abad-Motos, Gómez, AbadGurumeta and Monge García) (the algorithm adopted from the pReDictH trial [<a href="#B25-life-15-00400" class="html-bibr">25</a>]). Abbreviations: dP/dt, the rate of pressure change with time during isovolumic contraction of the cardiac ventricles; Ea<sub>dyn</sub>, dynamic arterial elastance; SVV, stroke volume variation.</p>
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<p>A Consolidated Standards of Reporting Trials (CONSORT) flowchart of the trial.</p>
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17 pages, 4357 KiB  
Article
Effect of SDS Surfactant on Two-Phase Flows in Horizontal Pipelines
by Shidong Zhou, Wenjing Wu, Zijia Gong, Shuli Wang, Yongchao Rao and Yan Yang
Processes 2025, 13(3), 737; https://doi.org/10.3390/pr13030737 - 3 Mar 2025
Viewed by 111
Abstract
Surfactants significantly influence the flow patterns of gas-liquid two-phase flows. Understanding the behavior of multiphase flows in the presence of surfactants is crucial for optimizing hydrate transport in pipelines. This study presents experimental investigations into the effects of surfactant-induced surface tension variations on [...] Read more.
Surfactants significantly influence the flow patterns of gas-liquid two-phase flows. Understanding the behavior of multiphase flows in the presence of surfactants is crucial for optimizing hydrate transport in pipelines. This study presents experimental investigations into the effects of surfactant-induced surface tension variations on gas-liquid two-phase spiral flows in horizontal pipelines. Four distinct flow patterns were identified: spiral linear flow, spiral wave-stratified flow, spiral axial flow, and spiral dispersed flow. Notably, spiral bubbly flow and spiral slug flow were absent in gas-liquid two-phase spiral flows with a low concentration of the anionic surfactant sodium dodecyl sulfate (SDS). A flow pattern map was developed to describe gas-liquid two-phase spiral flows in horizontal pipelines with low SDS concentrations. The results indicate that increasing the liquid-phase velocity reduces the spiral diameter and attenuates the flow patterns while increasing the pitch of the spiral flows. Furthermore, at a constant gas-phase void fraction, the pressure drop is highest in spiral wave-stratified flow and lowest in spiral dispersed flow. Full article
(This article belongs to the Section Chemical Processes and Systems)
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<p>Flow chart about gas-liquid two-phase spiral pipelines flow experimental device; 1-tank, 2-water pump, 3-ball valve, 4-liquid-phase flowmeter, 5-air compressor, 6-gas phase flowmeter, 7-gas-liqiud mixer, 8-spiral vanes, 9-hyaline cast, 10-fluorescent lamp, 11-differental pressure gauge.</p>
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<p>Nine kinds of spiral vanes.</p>
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<p>Spiral linear flow (spiral vane was 2#, the concentration of SDS was 10 mg/kg, the velocity of liquid phase was 0.5 m/s, the velocity of gas phase was very low).</p>
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<p>Spiral wave stratified flow. (<b>a</b>) (Spiral vane was 2#, the concentration of SDS solution was 10 mg/kg, the velocity of liquid phase was 0.5 m/s, the velocity of gas phase was 0.5 m/s). (<b>b</b>) (Spiral vane was 4#, the concentration of SDS solution was 30 mg/kg, the velocity of liquid phase was 0.5 m/s, the velocity of gas phase was 1.0 m/s).</p>
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<p>Spiral axial flow. (<b>a</b>) (Spiral vane was 5#, the concentration of SDS solution was 90 mg/kg, the velocity of liquid phase was 2.5 m/s, the velocity of gas phase was 0.5 m/s). (<b>b</b>) (Spiral vane was 8#, the concentration of SDS solution was 70 mg/kg, the velocity of liquid phase was 2.0 m/s, the velocity of gas phase was 0.5 m/s).</p>
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<p>Spiral dispersed flow. (<b>a</b>) (Spiral vane was 6#, the concentration of SDS solution was 50 mg/kg, the velocity of liquid phase was 2.0 m/s, the velocity of gas phase was 2.5 m/s). (<b>b</b>) (Spiral vane was 8#, the concentration of SDS solution was 50 mg/kg, the velocity of liquid phase was 1.0 m/s, the velocity of gas phase was 1.0 m/s).</p>
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<p>Flow pattern map of gas-liquid two-phase spiral pipeline flow with SDS solution.</p>
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<p>Mandhane flow pattern map of gas-liquid two-phase flow in horizontal pipeline [<a href="#B23-processes-13-00737" class="html-bibr">23</a>] (reprinted from Mandhane et al. [<a href="#B23-processes-13-00737" class="html-bibr">23</a>], with permission from Elsevier).</p>
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<p>The influence of vane size on pressure drop.</p>
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<p>The influence of spiral angle on pressure drop.</p>
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20 pages, 4816 KiB  
Article
Research Progress and Prospects of Refrigerant Replacement Under the Background of Greenhouse Gas Emission Reduction: A Visualization Analysis of the CiteSpace Map
by Shengzhong Huang, Hui Zhang and Conghui Li
Sustainability 2025, 17(5), 2199; https://doi.org/10.3390/su17052199 - 3 Mar 2025
Viewed by 256
Abstract
As global environmental consciousness continues to expand, the issue of refrigerant alternatives has increasingly become a focal point for scholarly attention. Using CiteSpace visualization technology, a comprehensive and innovative research framework for refrigerant alternatives has been developed. This framework systematically organizes and analyzes [...] Read more.
As global environmental consciousness continues to expand, the issue of refrigerant alternatives has increasingly become a focal point for scholarly attention. Using CiteSpace visualization technology, a comprehensive and innovative research framework for refrigerant alternatives has been developed. This framework systematically organizes and analyzes not only the volume of publications related to refrigerant alternatives but also the collaborative relationships among authors and research institutions. By employing keyword co-occurrence maps, clustering diagrams, and timeline charts, an in-depth analysis of the academic literature on refrigerant alternatives has been performed, elucidating the core research themes, evolutionary trajectories, and emerging trends in this field. Research indicates an exponential increase in the number of studies on refrigerant alternatives; however, there is insufficient collaboration and communication among researchers and institutions. Key research hotspots in this field encompass the organic Rankine cycle, vapor-liquid equilibria, pressure drop characteristics, vapor compression refrigeration systems, exergy analysis, alternative refrigerants, and performance evaluation of carbon dioxide systems. In future research, the performance of various low GWP refrigerants in refrigeration cycle systems will continue to be a focal point. To address diverse application requirements, developing blended refrigerants represents a pragmatic technical approach. From a sustainability standpoint, natural refrigerants are anticipated to emerge as the ultimate alternative, with the technical challenges associated with their application constituting a critical area for future investigation. Full article
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<p>Number of refrigerant substitution literature.</p>
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<p>Graph of the issuing institution.</p>
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<p>Author cooperation map.</p>
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<p>Keyword colorimetric map.</p>
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<p>Keyword cluster analysis diagram.</p>
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<p>Time zone diagram of refrigerant replacement keywords.</p>
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<p>Emergence analysis diagram of refrigerant substitute keywords.</p>
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21 pages, 6114 KiB  
Article
Analysis of Flame Evolution Generated from Methyl Laurate Droplet Using Deep Learning
by Fikrul Akbar Alamsyah and Chi-Cheng Cheng
Appl. Sci. 2025, 15(5), 2678; https://doi.org/10.3390/app15052678 - 2 Mar 2025
Viewed by 395
Abstract
This research investigates the dynamic behavior of flames generated from methyl laurate droplets using advanced deep learning techniques. By analyzing high-resolution image sequences, we aim to extract valuable insights into the flame’s evolution, including its ignition, growth, and extinction phases. YOLOv9, a state-of-the-art [...] Read more.
This research investigates the dynamic behavior of flames generated from methyl laurate droplets using advanced deep learning techniques. By analyzing high-resolution image sequences, we aim to extract valuable insights into the flame’s evolution, including its ignition, growth, and extinction phases. YOLOv9, a state-of-the-art object detection model, is employed to automatically segment and track key flame features such as flame shape, size, and intensity. Our results demonstrate a high accuracy of 0.97 and 0.92 mAP for automatic object segmentation of the flame and droplet. Through quantitative analysis of these features, we seek to gain a deeper understanding of the underlying physical processes governing droplet combustion. The results of this study can contribute to the development of more accurate and efficient combustion models, as well as improved fire safety strategies. This study investigates the combustion dynamics of methyl laurate droplets at atmospheric pressure, providing foundational insights into its behavior as a biodiesel fuel. Future research under high-pressure conditions is recommended to better understand its performance in practical engine applications. Full article
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<p>Illustration of experimental design.</p>
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<p>YOLOv9 structure.</p>
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<p>(<b>a</b>) Example image of flame, and (<b>b</b>) Image of droplet with backlight.</p>
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<p>Flame visualization of methyl laurate.</p>
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<p>Droplet visualization of methyl laurate.</p>
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<p>Curves of mAP (mean average precision) during the training of YOLOv9 with the dataset: (<b>a</b>) flame, (<b>b</b>) droplet.</p>
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<p>Example of automatic image segmentation of (<b>a</b>) droplet, (<b>b</b>) flame.</p>
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<p>Visualization of automatic image segmentation of methyl laurate flame.</p>
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<p>Droplet auto-segmentation visualization of methyl laurate.</p>
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<p>Droplet diameter and temperature during combustion of methyl laurate.</p>
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<p>The centerline of flame evolution (<b>a</b>) without process, (<b>b</b>) with Savitzky–Golay filter.</p>
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<p>Flame evolution and temperature during combustion of methyl laurate.</p>
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<p>Reconstruction of flame geometry: (<b>a</b>) original shape of flame, (<b>b</b>) reconstruction of flame in 3D space.</p>
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<p>Flame volume and surface evolution during combustion of methyl laurate.</p>
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26 pages, 13558 KiB  
Article
Evaluation of Ecologically Based Activities Within the Scope of Sustainable Tourism and Recreation Planning
by Ebru Gürbüz and Zeynep Pirselimoğlu Batman
Sustainability 2025, 17(5), 2136; https://doi.org/10.3390/su17052136 - 1 Mar 2025
Viewed by 281
Abstract
This study aims to determine the potential of the area for diversifying ecologically based tourism and recreation activities, with a focus on balancing conservation and use to reduce the pressures on natural and cultural landscape values. Data related to the area were examined [...] Read more.
This study aims to determine the potential of the area for diversifying ecologically based tourism and recreation activities, with a focus on balancing conservation and use to reduce the pressures on natural and cultural landscape values. Data related to the area were examined according to sustainable tourism principles, resulting in the identification of five feasible ecologically based tourism and recreation activities. In the subsequent phase, to analyze the compatibility of these activities with the area’s natural and cultural landscape values, suitability class values were mapped using GIS, based on evaluation criteria and indicators. The analysis identified suitable and highly suitable areas for camping, hiking, trekking, landscape, and nature photography, which were marked on the maps. By overlaying the activities, optimal land use was determined to cover 16.25% of the total area. Finally, the activities were assessed within the optimal land use framework using one-way analysis of variance, and relationships between different groups were identified. As a result, the most suitable activities for the study area were landscape and nature photography, while caravan camping was identified as a suitable activity. Full article
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<p>Location of the study area and Gemlik neighborhoods, neighborhoods located within the borders of the study area. (<b>a</b>) Turkey location in Europe; (<b>b</b>) Bursa location in Turkey; (<b>c</b>) Gemlik location in Bursa; (<b>d</b>) study area location in Gemlik; (<b>e</b>) study area border and Narlı, Karacaali, Büyükkumla, Küçükkumla location in the study area.</p>
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<p>General view of the area. (<b>a</b>) Büyükkumla coastline view; (<b>b</b>) general view of activity areas in the study area; (<b>c</b>) Narlı viewpoint; (<b>d</b>) Karacaali coastline; (<b>e</b>) general view of activity areas in the study area; (<b>f</b>) Küçükkumla-Büyükkulma-Narlı-Karacali route.</p>
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<p>Flow chart of this study.</p>
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<p>Most suitable and suitable areas according to evaluation criteria for tent camping.</p>
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<p>Most suitable and suitable areas according to evaluation criteria for caravan camping.</p>
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<p>Most suitable and suitable areas according to evaluation criteria for hiking.</p>
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<p>Most suitable and suitable areas according to evaluation criteria for trekking.</p>
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<p>Most suitable and suitable areas according to evaluation criteria for Landscape Viewing and Nature Photography.</p>
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<p>Potential suitable space uses according to activities. (<b>a</b>) Suitable potential areas for tent camping activities; (<b>b</b>) suitable potential areas for caravan camping activities; (<b>c</b>) suitable potential areas for tent hiking activities; (<b>d</b>) suitable potential areas for tent trekking activities; (<b>e</b>) suitable potential areas for landscape viewing and nature photography activities; (<b>f</b>) optimal land use.</p>
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<p>Proportional distribution of optimal land use.</p>
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16 pages, 8053 KiB  
Article
A Novel Hydrogen Leak Detection Method for PEM Fuel Cells Using Active Thermography
by Martina Totaro, Dario Santonocito, Giacomo Risitano, Orazio Barbera and Giosuè Giacoppo
Energies 2025, 18(5), 1185; https://doi.org/10.3390/en18051185 - 28 Feb 2025
Viewed by 363
Abstract
Hydrogen leakage in Proton Exchange Membrane (PEM) fuel cells poses critical safety, efficiency, and operational reliability risks. This study introduces an innovative infrared (IR) thermography-based methodology for detecting and quantifying hydrogen leaks towards the outside of PEM fuel cells. The proposed method leverages [...] Read more.
Hydrogen leakage in Proton Exchange Membrane (PEM) fuel cells poses critical safety, efficiency, and operational reliability risks. This study introduces an innovative infrared (IR) thermography-based methodology for detecting and quantifying hydrogen leaks towards the outside of PEM fuel cells. The proposed method leverages the catalytic properties of a membrane electrode assembly (MEA) as an active thermal tracer, facilitating real-time visualisation and assessment of hydrogen leaks. Experimental tests were conducted on a single-cell PEM fuel cell equipped with intact and defective gaskets to evaluate the method’s effectiveness. Results indicate that the active tracer generates distinct thermal signatures proportional to the leakage rate, overcoming the limitations of hydrogen’s low IR emissivity. Comparative analysis with passive tracers and baseline configurations highlights the active tracer-based approach’s superior positional accuracy and sensitivity. Additionally, the method aligns detected thermal anomalies with defect locations, validated through pressure distribution maps. This novel, non-invasive technique offers precise, reliable, and scalable solutions for hydrogen leak detection, making it suitable for dynamic operational environments and industrial applications. The findings significantly advance hydrogen’s safety diagnostics, supporting the broader adoption of hydrogen-based energy systems. Full article
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<p>(<b>a</b>) PEM fuel cell (<b>b</b>) test station.</p>
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<p>The experimental setup: in the foreground, on the tripod, the thermal IR camera, and in the background, the testing station with the single cell mounted on the bench.</p>
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<p>Two pictures of the gasket: (<b>a</b>) intact, (<b>b</b>) with intentional defect.</p>
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<p>Pictures of the used fuel cell (in the centre) with defective gasket: (<b>a</b>) as it is, (<b>b</b>) with passive tracer, (<b>c</b>) with active tracer.</p>
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<p>IR image of the fuel cell with intact gasket: (<b>a</b>) without tracer and (<b>b</b>) with active tracer. Labels (“Environment”, ”Plate”, “Gas mixture”) indicate where the temperature was measured for the graph of <a href="#energies-18-01185-f006" class="html-fig">Figure 6</a>).</p>
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<p>Heating rates of the plate (green) and the environment (red) as the gas mixture temperature increases (blue). The vertical dashed line indicates the insertion of the active tracer in contact with the single cell.</p>
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<p>IR Image with the defective gasket in baseline conditions. No leaks are visible.</p>
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<p>IR image of the thermal gas plume escaping near the defect visible on the passive tracer surface. The label “Leakage” indicates the point where the temperature was measured: (<b>a</b>) with a lower nitrogen flow rate; and (<b>b</b>) with a high nitrogen flow rate.</p>
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<p>Temperature profile of the passive tracer by increasing the nitrogen’s flow rate escaping from the PEM cell. Frame A and Frame B are depicted in <a href="#energies-18-01185-f008" class="html-fig">Figure 8</a>.</p>
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<p>(<b>a</b>) The thermal plume of gas escaping near the defect, displayed on the active tracer, yellow colour corresponds to the highest temperatures, purple colour to the lowest; (<b>b</b>) temperature along the height; (<b>c</b>) temperature along the width of the tracer.</p>
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<p>Correlation between temperature and mass flow increasing, (<b>a</b>) without H<sub>2</sub>–N<sub>2</sub> mixture, (<b>b</b>) with 50 mL/min of H<sub>2</sub> in H<sub>2</sub>–N<sub>2</sub> mixture, (<b>c</b>) with 75 mL/min of H<sub>2</sub> in of H<sub>2</sub>–N<sub>2</sub> mixture.</p>
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<p>Contact pressure distribution of the cell with gasket (<b>a</b>) intact and (<b>b</b>) defective.</p>
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<p>Correlation between (<b>a</b>) the actual position of the leakage evaluated with the sensor arrays and (<b>b</b>) the leakage position revealed from the thermographic image.</p>
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14 pages, 1742 KiB  
Article
Characterization of Glycoprotein 5-Specific Response in Pigs Vaccinated with Modified Live Porcine Reproductive and Respiratory Syndrome Virus Vaccine Derived from Two Different Lineages
by Jing Huang, Venkatramana D. Krishna, Igor A. D. Paploski, Kimberly VanderWaal, Declan C. Schroeder and Maxim C.-J. Cheeran
Vaccines 2025, 13(3), 247; https://doi.org/10.3390/vaccines13030247 - 27 Feb 2025
Viewed by 303
Abstract
Background/Objectives: Porcine reproductive and respiratory syndrome virus (PRRSV) is classified into various lineages based on the phylogenetic variation of orf5, which encodes a major surface glycoprotein GP5 containing both neutralizing and non-neutralizing linear epitopes. Several positively selected sites have been identified on [...] Read more.
Background/Objectives: Porcine reproductive and respiratory syndrome virus (PRRSV) is classified into various lineages based on the phylogenetic variation of orf5, which encodes a major surface glycoprotein GP5 containing both neutralizing and non-neutralizing linear epitopes. Several positively selected sites have been identified on the GP5 ectodomain, indicating host immune pressure on these sites. This present study aimed to investigate the kinetics of antibody responses to GP5 and to map the epitope-specific response to the GP5 ectodomain from different PRRSV lineages after vaccination with commercially available modified live virus (MLV) vaccines. Methods: Post-weaning pigs were vaccinated with MLV vaccines derived from either lineage 1D (Prevacent PRRS®) or lineage 5 (Ingelvac PRRS®). Animals were challenged with a heterologous (lineage 1A) strain at 64 days post-vaccination (dpv). Blood samples were collected at various times post-vaccination and challenge. Kinetics of antibody response to different PRRSV antigens were monitored and virus neutralization against archetypal and contemporary strains belonging to lineage 5 and 1A were evaluated. In addition, antibody responses to peptides derived from the GP5 ectodomain of different viral lineages were assessed. Results: Our results showed that the GP5-specific antibody response observed between 18 and 35 dpv was delayed compared to responses to the viral nucleocapsid protein. The polyclonal antibody response in both vaccinated groups showed similar levels of binding to variant GP5 peptides from different sub-lineages. Notably, in both vaccinated groups, the antibody directed to a peptide representing the GP5 ectodomain of a lineage 1C strain (variant 1C.5) displayed a rise in titer at 64 dpv, which was further increased by the challenge with the lineage 1A strain. Less than 50% of animals developed heterologous neutralizing antibodies post-vaccination with both MLV vaccines. However, higher neutralization titers were observed in all vaccinated animal post-challenge. Conclusions: Together, these data provide insights into the antibody responses to the GP5 ectodomain in MLV-vaccinated swine herds. Full article
(This article belongs to the Special Issue Vaccines for Porcine Viruses)
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<p>Timeline and experimental design. Pigs were either vaccinated with the respective modified live virus (MLV) vaccines or left unvaccinated, followed by a virus challenge (IA/2014) at 64 days post-vaccination (dpv). Thick ticks represent sample collections for both peripheral blood mononuclear cells and serum while the thin ticks represent sample collections for serum only. This figure was created with <a href="http://BioRender.com" target="_blank">BioRender.com</a>.</p>
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<p>Relative levels of antibody responses in animals vaccinated with L1D or L5 vaccines, and controls, against PRRSV isolates from different lineages. Serum samples were collected at 64 days post-vaccination. (<b>A</b>) D11-052871 is a viral isolate belonging to lineage 5, (<b>B</b>) IA/2014 belongs to lineage 1A and (<b>C</b>) 46/2020 belongs to lineage 1C.5. Data were presented as mean ± SEM with individual values denoted by closed symbols. All optical density (OD450) values were normalized relative to a reference serum recognizing the corresponding antigen. ns = not significant; ** <span class="html-italic">p</span> &lt; 0.01, *** <span class="html-italic">p</span> &lt; 0.001, **** <span class="html-italic">p</span> &lt; 0.0001, one-way ANOVA.</p>
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<p>Kinetics of antibody responses to PRRSV antigens post-vaccination with L1D and L5 MLV. Serum samples were collected at 0, 6, 13, 18, 35, 53, and 64 days post-vaccination. (<b>A</b>) Kinetics of the L5 whole virus-specific antibody response post-vaccination. (<b>B</b>) Kinetics of the nucleocapsid (N)-specific antibody response post-vaccination. (<b>C</b>) Kinetics of recombinant GP5-specific antibody responses post-vaccination. Data are shown as means ± SEMs. Values were normalized as relative levels compared to a reference serum recognizing the corresponding antigen.</p>
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<p>Frequencies of PRRSV antigen-specific antibody-secreting cells (ASCs) post-vaccination. PBMCs were isolated from unvaccinated animals or animals vaccinated with L5-derived MLV vaccine at different time points post-vaccination and then cultured to determine IgG-ASCs for different antigens including PRRSV D11-052871 (lineage 5) (<b>A</b>), N (<b>B</b>), and GP5 (<b>C</b>) using the ELISPOT assay. Data are shown as means ± SEMs.</p>
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<p>Antibody responses to peptides (aa 32–aa 61) designed from the GP5 ectodomain of different lineages. Relative levels of antibody response to the GP5 ectodomain are shown using serum samples collected at (<b>A</b>) 64 dpv and (<b>B</b>) 14 days post-challenge (dpc) from vaccinated and challenged (L1D MLV and L5 MLV), unvaccinated and challenged (control), or unvaccinated (naïve) groups. Peptides corresponding to L5 (D11-052871), L1C (46/2020), L1A (IA/2014), L1C* (KP283416) and L1D (KY348849) were used to assess vaccination response. Two-way ANOVA. (<b>C</b>) Kinetics of antibody response to the GP5 ectodomain peptide derived from 46/2020 (lineage 1C.5). The arrow indicates challenge with an L1A isolate (IA/2014) at 64 dpv. Data are shown as means ± SEMs. Values are normalized as relative levels compared to a reference serum.</p>
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38 pages, 18640 KiB  
Review
Water Hammer Phenomenon in Coronary Arteries: Scientific Basis for Diagnostic and Predictive Modeling with Acoustic Action Mapping
by Khiem D. Ngo, Thach Nguyen, Huan Dat Pham, Hadrian Tran, Dat Q. Ha, Truong S. Dinh, Imran Mihas, Mihas Kodenchery, C. Michael Gibson, Hien Q. Nguyen, Thang Nguyen, Vu T. Loc, Chinh D. Nguyen, Hoang Anh Tien, Ernest Talarico, Marco Zuin, Gianluca Rigatelli, Aravinda Nanjundappa, Quynh T. N. Nguyen and The-Hung Nguyen
Diagnostics 2025, 15(5), 553; https://doi.org/10.3390/diagnostics15050553 - 25 Feb 2025
Viewed by 353
Abstract
Background: In the study of coronary artery disease, the mechanisms underlying atherosclerosis initiation and progression or regression remain incompletely understood. Our research conceptualized the cardiovascular system as an integrated network of pumps and pipes, advocating for a paradigm shift from static imaging of [...] Read more.
Background: In the study of coronary artery disease, the mechanisms underlying atherosclerosis initiation and progression or regression remain incompletely understood. Our research conceptualized the cardiovascular system as an integrated network of pumps and pipes, advocating for a paradigm shift from static imaging of coronary stenosis to dynamic assessments of coronary flow. Further review of fluid mechanics highlighted the water hammer phenomenon as a compelling analog for processes in coronary arteries. Methods: In this review, the analytical methodology employed a comprehensive, multifaceted approach that incorporated a review of fluid mechanics principles, in vitro acoustic experimentation, frame-by-frame visual angiographic assessments of in vivo coronary flow, and an artificial intelligence (AI) protocol designed to analyze the water hammer phenomenon within an acoustic framework. In the analysis of coronary flow, the angiograms were selected from patients with unstable angina if they had previously undergone one or more coronary angiograms, allowing for a longitudinal comparison of dynamic flow and phenomena. Results: The acoustic investigations pinpointed pockets of contrast concentrations, which might correspond to compression and rarefaction zones. Compression antinodes were correlated to severe stenosis, due to rapid shifts from low-pressure diastolic flow to high-pressure systolic surges, resulting in intimal injury. Rarefaction antinodes were correlated with milder lesions, due to de-escalating transitions from high systolic pressure to lower diastolic pressure. The areas of nodes remained without lesions. Based on the locations of antinodes and nodes, a coronary acoustic action map was constructed, enabling the identification of existing lesions, forecasting the progression of current lesions, and predicting the development of future lesions. Conclusions: The results suggested that intimal injury was likely induced by acoustic retrograde pressure waves from the water hammer phenomenon and developed new lesions at specifically exact locations. Full article
(This article belongs to the Special Issue New Advances in Cardiovascular Risk Prediction)
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<p>Flowchart of the analysis-combined-investigation review.</p>
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<p>The left anterior descending (LAD) artery exhibits severe narrowing in its proximal segment (indicated by an arrow), while the right coronary artery (RCA) demonstrates a subtotal lesion in its mid-segment. Current angiographic techniques capture these lesions but fail to provide critical insights into their formation mechanisms or potential progression over time. (<b>A</b>) The lesion in the proximal LAD has a characteristic “rat tail” appearance—featuring progressively severe narrowing in the distal direction. (<b>B</b>) The mid-RCA lesion has a “reversed rat tail” pattern, characterized by more severe narrowing proximally and a gradual reduction in severity distally. WHY?</p>
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<p>(<b>A</b>–<b>D</b>) <b>Laminar flow</b>. These four coronary images are of consecutive sequence. (<b>A</b>) This is the angiogram of the right coronary artery (RCA), which is filled with contrast in black. (<b>B</b>) The blood (in white) is seen well organized with sharp border and a pointed tip, typical for laminar flow, moving in (yellow arrow). (<b>C</b>,<b>D</b>) The blood is seen following the apex of the curves (yellow arrow). This is the laminar flow following the curves in a helical fashion.</p>
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<p>This is the angiogram of the right coronary artery. The lesions are at locations <b>1</b>, <b>2</b>, and <b>3</b>. Why is the lesion at 1 more severe than the ones at <b>2</b> and <b>3</b>? Why is the lesion at 2 less severe than <b>1</b> and <b>3</b>? Why is there no lesion in <b>4</b>? Could fluid mechanics and acoustics explain the mechanism of formation and growth of the lesions at these specific locations?</p>
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<p>(<b>A</b>) Artificial intelligence algorithm to segment the arteries and the catheter. (<b>B</b>) Window size = 10 pixels. (<b>C</b>) Window size = 15 pixels. (<b>D</b>) Window size = 20 pixels.</p>
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<p>(<b>A</b>) Artificial intelligence algorithm to segment the arteries and the catheter. (<b>B</b>) Window size = 10 pixels. (<b>C</b>) Window size = 15 pixels. (<b>D</b>) Window size = 20 pixels.</p>
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<p>A water hammer event occurs when there is an abrupt change in velocity or flow direction in the pipe systems such as power failure, pump start-up, and shut-down operations as a pressure wave propagates backward in the pipe [<a href="#B2-diagnostics-15-00553" class="html-bibr">2</a>].</p>
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<p>(<b>A</b>–<b>D</b>) <b>Collision in the right coronary artery</b>. This is a series of eight consecutive images of an angiogram of the right coronary artery (RCA) separated by a 0.067 s gap. (<b>A</b>) The artery is filled with contrasts. There is a moderate lesion at the mid-segment. (<b>B</b>) The blood (white) is seen entering the ostium of the RCA (arrow). This is the beginning of diastole. (<b>C</b>) The blood (white) is seen at the outer border of the first curve of the RCA (yellow arrow). (<b>D</b>) The blood (white) moves to the mid-segment of the RCA (yellow arrow). (<b>E</b>–<b>H</b>)<b>ollision during the transition from diastole to systole.</b> (<b>E</b>,<b>F</b>) The blood is seen reaching the mid-segment of the RCA (yellow arrow) at the end of diastole and beginning of systole. Here, the blood (white) is mixed with the contrast (black), seen as a random, disorganized flow (mixed of black and white) This is the visual image of disorganized, turbulent flow (red arrow). (<b>G</b>) The contrast (black) concentrates at the mid-segment, at the collision line (red arrow). The antegrade flow still moves forward slowly (yellow arrow). (<b>H</b>) The blood is seen reaching the beginning of the distal segment (yellow arrow). The turbulent flow (mixing black contrast and white blood) is still seen prominently at the collision site (red arrow).</p>
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<p>(<b>A</b>–<b>D</b>) <b>Collision in the right coronary artery</b>. This is a series of eight consecutive images of an angiogram of the right coronary artery (RCA) separated by a 0.067 s gap. (<b>A</b>) The artery is filled with contrasts. There is a moderate lesion at the mid-segment. (<b>B</b>) The blood (white) is seen entering the ostium of the RCA (arrow). This is the beginning of diastole. (<b>C</b>) The blood (white) is seen at the outer border of the first curve of the RCA (yellow arrow). (<b>D</b>) The blood (white) moves to the mid-segment of the RCA (yellow arrow). (<b>E</b>–<b>H</b>)<b>ollision during the transition from diastole to systole.</b> (<b>E</b>,<b>F</b>) The blood is seen reaching the mid-segment of the RCA (yellow arrow) at the end of diastole and beginning of systole. Here, the blood (white) is mixed with the contrast (black), seen as a random, disorganized flow (mixed of black and white) This is the visual image of disorganized, turbulent flow (red arrow). (<b>G</b>) The contrast (black) concentrates at the mid-segment, at the collision line (red arrow). The antegrade flow still moves forward slowly (yellow arrow). (<b>H</b>) The blood is seen reaching the beginning of the distal segment (yellow arrow). The turbulent flow (mixing black contrast and white blood) is still seen prominently at the collision site (red arrow).</p>
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<p>As the coronary artery is modeled as a tubular structure, the ostium of the coronary artery is an open end. As result, the flow will reverse as a rarefaction pulse, which has less concentrated particles.</p>
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<p><b>Pressure wave reflections in short artery.</b> A water hammer event can occur in the coronary arteries when there is an abrupt change in velocity or flow direction due to sudden contraction of the left ventricle, creating a pressure shockwave reflecting at the speed of sound. The short length of a tube or an artery can result in a higher frequency of pressure oscillations, which is also called vibration.</p>
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<p>(<b>A</b>,<b>B</b>) <b>Calcification without flow limiting lesion.</b> (<b>A</b>) The proximal segment of the left anterior descending (LAD) artery was well calcified (arrows), while the mid and distal segment were spared. (<b>B</b>) In the same view, the angiogram of the proximal segment of the LAD shows no severe lesion. Prolonged mild to moderate turbulence without high cholesterol level causes only injuries to the intima, leading to heavy calcification without forming atherosclerotic plaques.</p>
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<p>(<b>A</b>–<b>H</b>) This is a series of six consecutive images of an angiogram of the right coronary artery (RCA) right after stenting of the mid-segment. The baseline images before stenting are in <a href="#diagnostics-15-00553-f007" class="html-fig">Figure 7</a>. (<b>A</b>) The artery is filled with contrasts. (<b>B</b>) The blood (white) is seen entering the ostium of the RCA (arrow). This is the beginning of diastole. (<b>C</b>–<b>H</b>) The blood (white) moves forward without encountering the retrograde pressure wave. Most likely the arterial wall is scaffolded by the stent which interrupts the propagation of retrograde pressure wave on the arterial wall.</p>
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<p>The particles of air are in equilibrium, evenly spaced in a random pattern (adapted from reference [<a href="#B26-diagnostics-15-00553" class="html-bibr">26</a>]).</p>
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<p>When a pressure wave passes by, the air particles are concentrated in zones of high density (compression), alternating with areas of moderate density (rarefaction). The zones of compression depict high pressure and turbulence. The zone of rarefaction has lower pressure fluctuation, and therefore, less turbulence.</p>
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<p>This is a conceptual schema of air particles when a pressure wave passes by, producing zones of high concentration of particles (compression) or moderate level of concentration (rarefaction). These zones of antinodes depict high pressure. The zone of nodes, which is located between the zone of compression and rarefaction, has no pressure fluctuation and a minimal concentration of particles [<a href="#B32-diagnostics-15-00553" class="html-bibr">32</a>,<a href="#B33-diagnostics-15-00553" class="html-bibr">33</a>,<a href="#B34-diagnostics-15-00553" class="html-bibr">34</a>].</p>
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<p>(<b>A</b>,<b>B</b>) This is the angiogram of the right coronary artery at the end of diastole with all the contrast almost flushed out. Pockets of high contrast concentration persist. These stagnation zones represent the high or moderate concentration of contrast particles and may correspond to zones of compression and rarefaction at the location of anti-nodes. The anti-node at <b>4</b> may define the distal end of the coronary artery as a tube based on the retrograde direction of the pressure wave. The anti-nodes at <b>1</b> and <b>3</b> may depict the zones of compression, while <b>2</b> and <b>4</b> may depict the zone of rarefaction. In between these antinodes, these coronary segments are the locations of nodes, which are clear of lesions because possibly there is no clash with the pressure wave.</p>
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<p>(<b>A</b>–<b>D</b>) These are four consecutive coronary images. (<b>A</b>) The blood in white begins to move in at the beginning of diastole (1D). (<b>B</b>) The blood in white is seen moving to the proximal segment of the right coronary artery (RCA) (2D). (<b>C</b>) The blood arrives at the center of the mid-segment of the RCA. (<b>D</b>) The blood in white is seen to advance a little more, reaching the lesion at the mid RCA. (<b>E</b>) This is the fifth image of the sequence from diastole to systole. From (<b>A</b>–<b>D</b>), the blood moves in rapidly in diastole. (<b>E</b>) The blood is stopped abruptly due to water hammer shock. The contrast concentration is more prominent at the location 1, where the retrograde pressure wave at the beginning of systole collides with the tip of the antegrade flow of diastole. The blue arrow shows a place where contrast is concentrated at the end of diastole. At the same time, the pressure wave reflects at the speed of sound, the anti-node 4 at the open end of the coronary artery could be seen early.</p>
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<p>(<b>A</b>–<b>D</b>) These are four consecutive coronary images. (<b>A</b>) The blood in white begins to move in at the beginning of diastole (1D). (<b>B</b>) The blood in white is seen moving to the proximal segment of the right coronary artery (RCA) (2D). (<b>C</b>) The blood arrives at the center of the mid-segment of the RCA. (<b>D</b>) The blood in white is seen to advance a little more, reaching the lesion at the mid RCA. (<b>E</b>) This is the fifth image of the sequence from diastole to systole. From (<b>A</b>–<b>D</b>), the blood moves in rapidly in diastole. (<b>E</b>) The blood is stopped abruptly due to water hammer shock. The contrast concentration is more prominent at the location 1, where the retrograde pressure wave at the beginning of systole collides with the tip of the antegrade flow of diastole. The blue arrow shows a place where contrast is concentrated at the end of diastole. At the same time, the pressure wave reflects at the speed of sound, the anti-node 4 at the open end of the coronary artery could be seen early.</p>
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<p>(<b>A</b>–<b>D</b>) This is the right coronary artery in mid-systole because the contrast in black is still seen at the distal segment. The concentration of dense contrast (antinode) persists at the mid segment (labeled as 1) and at the proximal segment (labeled as 4).</p>
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<p>(<b>A</b>–<b>D</b>) This is the right coronary artery in mid-systole because the contrast in black is still seen at the distal segment. The concentration of dense contrast (antinode) persists at the mid segment (labeled as 1) and at the proximal segment (labeled as 4).</p>
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<p>(<b>A</b>–<b>D</b>) This is the right coronary artery in mid-systole because the contrast in black is still seen at the distal segment. The concentration of dense contrast (antinode) persisted through segments. Between the locations of the antinodes (<b>1</b>, <b>2</b>, <b>3</b>, and <b>4</b>) the segments had no lesions or only minimal plaques. The reason is because at the locations of nodes, there was no high-pressure change, so no major damage of the intima was experienced.</p>
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<p>Coronary acoustic action map. In this right coronary artery (RCA), the antinodes with elevated turbulent pressure show strong correlation with lesion formation and progression. The most severe lesion happens at the compression antinodes (location 1 and 3), while less severe lesion happens at the rarefaction antinodes (2 and 4). Conversely, at the segments in between the antinodes (4-1, 1-2 and 2-3), regions with minimal pressure fluctuations show little to no lesion.</p>
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<p>(<b>A</b>–<b>F</b>) <b>Laminar flow in right coronary angiogram</b>. (<b>A</b>–<b>D</b>) The blood (in white color) was observed moving along the apices of the curves (black arrowheads). The contrast (in black) with high viscosity occupied the inner curve (white arrows). (<b>E</b>,<b>F</b>) The blood in white is seen moving along the apices of the curves (three black arrows). The contrast in black with high viscosity occupies the inner curve. The contrast moves from one inner curve (first white arrow) to another inner curve (second white arrow). Laminar flow protects the intima from injury, so no lesion develops.</p>
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<p><b>Collision in the iliac artery.</b> This is a sequence of six consecutive angiographic images of the iliac artery. (<b>A</b>) The iliac artery is filled contrast in black. (<b>B</b>) Sixty-seven milliseconds later, the blood in homogenously white is seen moving down with a sharp tip of laminar flow (white arrow) (<b>C</b>) Subsequently, the pointed tip of the blood flow is halted abruptly, with all layers recoiling like a collapsing stack of dominoes (white arrow). (<b>D</b>) The tip of the flow then twists and turns on itself, resembling a vortex. (<b>E</b>,<b>F</b>) This turbulent vortical motion dissipates and is replaced by a mass of black contrast (arrowhead) moving in a retrograde direction along the inner curve (black arrow).</p>
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<p>The left anterior descending (LAD) artery exhibits severe narrowing in its proximal segment (indicated by an arrow), while the right coronary artery (RCA) demonstrates a subtotal lesion in its mid-segment. In (<b>A</b>), the lesion in the proximal LAD appears to have resulted from damage inflicted by antegrade flow from uncontrolled diastolic hypertension, with the injury impacting the arterial wall and producing a characteristic “rat tail” appearance—featuring progressively severe narrowing in the distal direction. In (<b>B</b>), the mid-RCA lesion is attributed to damage from retrograde flow due to persistent uncontrolled systolic hypertension, which induced wall damage, leading to a “reversed rat tail” pattern, characterized by more severe narrowing proximally and a gradual reduction in severity distally.</p>
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<p>(A) The left anterior descending (LAD) artery exhibits mild to moderate narrowing in its proximal segment (indicated by an arrow). (<b>B</b>) This patient was interested in having optimal medical management with well-controlled blood pressure by betablockers and statins to decrease the low-density lipoprotein (LDL) cholesterol level &lt; 75 mg%. There was laminar flow across the lesion (three yellow arrows in (<b>B</b>)). The patient has been stable for the last one year, without conversion to acute coronary syndrome.</p>
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<p>(<b>A</b>,<b>B</b>) <b>Left coronary artery angiogram</b>. (<b>A</b>) This is the left coronary angiogram with a patent left main (LM) and left circumflex (LCX) artery in a patient. (<b>B</b>) Three months later, a severe lesion in the mid-segment was observed (arrow). Could the physician have predicted the appearance of the severe lesion by reviewing the coronary flow of the July coronary angiogram? (<b>C</b>,<b>D</b>) The blood is seen moving in a proximal-to-distal segment at fast speed of diastole in laminar fashion with a thin boundary layer. (<b>E</b>) The blood flowed further downstream, but only at a minimal distance because this was the beginning of systole.</p>
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<p>(<b>A</b>,<b>B</b>) <b>Left coronary artery angiogram</b>. (<b>A</b>) This is the left coronary angiogram with a patent left main (LM) and left circumflex (LCX) artery in a patient. (<b>B</b>) Three months later, a severe lesion in the mid-segment was observed (arrow). Could the physician have predicted the appearance of the severe lesion by reviewing the coronary flow of the July coronary angiogram? (<b>C</b>,<b>D</b>) The blood is seen moving in a proximal-to-distal segment at fast speed of diastole in laminar fashion with a thin boundary layer. (<b>E</b>) The blood flowed further downstream, but only at a minimal distance because this was the beginning of systole.</p>
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<p>(<b>A</b>) The blood flowed further downstream (white arrow); however, there was a marked area with high concentration of contrast at the location transitioning from diastole to systole. This was the location of future lesion 3 months later (white arrowhead). This is the second image of the systole. (<b>B</b>) The high concentration of contrast (white arrowhead) continued at the location while the blood flow continued to flow forward distally (white arrow). This is the 3rd image of the systole. (<b>C</b>) The distal flow moved forward (black arrow, while there is some attenuation of the contrast (white arrow)). The flow looks more disorganized with a large boundary layer. This is the 4th image of the systole.</p>
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<p>(<b>A</b>) The contrast seemed to fade away (white arrowhead) with a thin boundary layer (white arrow). This is the 5th image of the systole. (<b>B</b>) Black contrast is seen moving backward to the proximal left circumflex (white arrow). This was the angiographic evidence of reverse flow. (<b>C</b>) Black contrast is seen more prominently and moves backwards to the proximal left circumflex (white arrow). This is the angiographic evidence of reverse flow (white arrow). In the next 3 images (<b>D</b>–<b>F</b>), there is persistent stagnant contrast at the proximal segment of the LCX. This was the location of future lesion 3 months later (a little distal to the origin of the side-branch).</p>
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13 pages, 1473 KiB  
Article
Sensitivity of Lumbar Total Joint Replacement Contact Stresses Under Misalignment Conditions—Finite Element Analysis of a Spine Wear Simulator
by Steven M. Kurtz, Steven A. Rundell, Hannah Spece and Ronald V. Yarbrough
Bioengineering 2025, 12(3), 229; https://doi.org/10.3390/bioengineering12030229 - 24 Feb 2025
Viewed by 336
Abstract
A novel total joint replacement (TJR) that treats lumbar spine degeneration was previously assessed under Mode I and Mode IV conditions. In this study, we relied on these previous wear tests to establish a relationship between finite element model (FEM)-based bearing stresses and [...] Read more.
A novel total joint replacement (TJR) that treats lumbar spine degeneration was previously assessed under Mode I and Mode IV conditions. In this study, we relied on these previous wear tests to establish a relationship between finite element model (FEM)-based bearing stresses and in vitro wear penetration maps. Our modeling effort addressed the following question of interest: Under reasonably worst-case misaligned conditions, do the lumbar total joint replacement (L-TJR) polyethylene stresses and strains remain below values associated with Mode IV impingement wear tests? The FEM was first formally verified and validated using the risk-informed credibility assessment framework established by ASME V&V 40 and FDA guidance. Then, based on criteria for unreasonable misuse outlined in the surgical technique guide, a parametric analysis of reasonably worst-case misalignment using the validated L-TJR FEM was performed. Reasonable misalignment was created by altering device positioning from the baseline condition in three scenarios: Axial Plane Convergence (20–40°), Axial Plane A-P Offset (0–4 mm), and Coronal Plane Tilt (±20°). We found that, for the scenarios considered, the contact pressures, von Mises stresses, and effective strains of the L-TJR-bearing surfaces remained consistent with Mode I (clean) conditions. Specifically, the mechanical response values fell below those determined under Mode IV (worst-case) boundary conditions, which provided the upper-bound benchmarks for the study (peak contact pressure 83.3 MPa, peak von Mises stress 32.2 MPa, and peak effective strain 42%). The L-TJR was judged to be insensitive to axial and coronal misalignment under the in vitro boundary conditions imposed by the study. Full article
(This article belongs to the Section Biomedical Engineering and Biomaterials)
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<p>Image depicting the loading conditions of the validated FEM of the L-TJR and in vitro wear simulator. Uniform loading was applied across the superior surface (green surface).</p>
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<p>Definitions of convergence angle, axial A/P offset, and coronal tilt angle and images of 3D CAD models illustrating the component positioning of cases 1 through 8.</p>
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<p>Contour plots representing the superposition of all contact pressures over the Mode I duty cycle for the baseline (40°), 30°, and 20° convergence angle simulations. The contact stress plots are viewed on the L-TJR superior polyethylene components from the bottom looking up. The up direction in the figure corresponds to the anterior direction.</p>
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<p>Contour plots representing the superposition of all contact pressures over the Mode I duty cycle for the baseline (0 mm A-P offset), 2 mm A-P offset, and 4 mm A-P offset simulations. The contact stress plots are viewed on the L-TJR superior polyethylene components from the bottom looking up. The up direction in the figure corresponds to the anterior direction.</p>
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<p>Contour plots representing the superposition of all contact pressures over the Mode I duty cycle for the baseline, −20°, −10°, 10°, and 20° of coronal tilt simulations. The contact stress plots are viewed on the L-TJR superior polyethylene components from the bottom looking up. The up direction in the figure corresponds to the anterior direction.</p>
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16 pages, 6287 KiB  
Article
A Risk Assessment of Water Inrush in Deep Mining in Metal Mines Based on the Coupling Methods of the Analytic Hierarchy Process and Entropy Weight Method: A Case Study of the Huize Lead–Zinc Mine in Northeastern Yunnan, China
by Ronghui Xia, Hongliang Wang, Ticai Hu, Shichong Yuan, Baosheng Huang, Jianguo Wang and Zhouhong Ren
Water 2025, 17(5), 643; https://doi.org/10.3390/w17050643 - 22 Feb 2025
Viewed by 281
Abstract
Deep mining in metal mines faces more and more complex geological conditions, such as “three highs and one disturbance” (high ground stress, high permeability, high temperature, and mining-induced disturbance), which can easily trigger water inrush disasters and seriously affect the safety and efficiency [...] Read more.
Deep mining in metal mines faces more and more complex geological conditions, such as “three highs and one disturbance” (high ground stress, high permeability, high temperature, and mining-induced disturbance), which can easily trigger water inrush disasters and seriously affect the safety and efficiency of deep mining. This paper focuses on the deep hydrogeological structural characteristics of the Huize lead–zinc mine. Firstly, two main factors affecting the production safety of the mining area, namely the water source and water channel of the mine, were analyzed. Based on this analysis, nine factors were determined as indicators for the risk assessment of water inrush, including the water head difference, water-bearing capacity, permeability coefficient, aquifer thickness, water pressure, fault type, fault scale, fault water conductivity, and karst zoning characteristics. Then, a water inrush risk assessment model for the deep mine was constructed, and the weights of the individual factors were determined using the analytic hierarchy process (AHP) and entropy weight method (EWM). Combined with the multi-factor spatial fitting function of the GIS, a zoning map of the risk assessment of water inrush was developed. The results showed that the aquifer groups of the Permian Liangshan Formation and the Carboniferous Maping Formation (P1l + C3m) were relatively safe, whereas the karst fissure aquifer of the Qixia–Maokou Formation (P1q + m) posed a high risk of water inrush, necessitating advanced exploration and water drainage in the area. These findings provide guidance for water control measures in the Huize lead–zinc mine and offer valuable insights into the prediction and prevention of mine water hazards associated with ore body mining in karst aquifers. Full article
(This article belongs to the Section Hydrogeology)
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<p>(<b>a</b>) Location map of the study area. (<b>b</b>) Schematic geological map of study area.</p>
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<p>Schematic hydrogeological map of study area.</p>
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<p>Hierarchical structure of evaluation factors.</p>
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<p>Thematic maps of evaluation factors: (<b>a</b>) water head difference; (<b>b</b>) water-bearing capacity; (<b>c</b>) hydraulic conductivity; (<b>d</b>) aquifer thickness; (<b>e</b>) water pressure; (<b>f</b>) fault type; (<b>g</b>) fault scale; (<b>h</b>) fault water conductivity; (<b>i</b>) karst zoning.</p>
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<p>Distribution of weight of evaluation factors based on EWM.</p>
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<p>Zoning map of the risk assessment of water inrush in deep mining.</p>
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25 pages, 22330 KiB  
Article
Risk Assessment and Spatial Zoning of Rainstorm and Flood Hazards in Mountainous Cities Using the Random Forest Algorithm and the SCS Model
by Zixin Xie and Bo Shu
Land 2025, 14(3), 453; https://doi.org/10.3390/land14030453 - 22 Feb 2025
Viewed by 321
Abstract
China has a vast land area, with mountains accounting for 1/3 of the country’s land area. Flooding in these areas can cause significant damage to human life and property. Therefore, rainstorms and flood hazards in Huangshan City should be accurately assessed and effectively [...] Read more.
China has a vast land area, with mountains accounting for 1/3 of the country’s land area. Flooding in these areas can cause significant damage to human life and property. Therefore, rainstorms and flood hazards in Huangshan City should be accurately assessed and effectively managed to improve urban resilience, promote green and low-carbon development, and ensure socio-economic stability. Through the Random Forest (RF) algorithm and the Soil Conservation Service (SCS) model, this study aimed to assess and demarcate rainstorm and flood hazard risks in Huangshan City. Specifically, Driving forces-Pressure-State-Impact-Response (DPSIR)’s framework was applied to examine the main influencing factors. Subsequently, the RF algorithm was employed to select 11 major indicators and establish a comprehensive risk assessment model integrating four factors: hazard, exposure, vulnerability, and adaptive capacity. Additionally, a flood hazard risk zoning map of Huangshan City was generated by combining the SCS model with a Geographic Information System (GIS)-based spatial analysis. The assessment results reveal significant spatial heterogeneity in rainstorm and flood risks, with higher risks concentrated in low-lying areas and urban fringes. In addition, precipitation during the flood season and economic losses were identified as key contributors to flood risk. Furthermore, flood risks in certain areas have intensified with ongoing urbanization. The evaluation model was validated by the 7 July 2020 flood event, suggesting that Huangshan District, Huizhou District, and northern Shexian County suffered the most severe economic losses. This confirms the reliability of the model. Finally, targeted flood disaster prevention and mitigation strategies were proposed for Huangshan City, particularly in the context of carbon neutrality and green urbanization, providing decision-making support for disaster prevention and emergency management. These recommendations will contribute to enhancing the city’s disaster resilience and promoting sustainable urban development. Full article
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<p>The regional schematic diagram of Mount Huangshan City.</p>
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<p>Research framework and technical ideas.</p>
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<p>The conceptual framework of driving force, pressure, state, impact, and response (DPSIR).</p>
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<p>The importance of rainfall disaster index in Mount Huangshan City based on the Stochastic Forest Model.</p>
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<p>Risk division of disaster-causing factors in Huangshan City.</p>
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<p>Division of disaster environmental exposure in Huangshan City. ((<b>a</b>). water body proximity, (<b>b</b>). precipitation, (<b>c</b>). elevation, (<b>d</b>). vegetation coverage).</p>
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<p>Division of disaster environmental vulnerability in Huangshan City. ((<b>a</b>). Population density, (<b>b</b>). arable land ratio).</p>
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<p>Division of disaster environmental response capacity in Huangshan City. ((<b>a</b>). per capita GDP, (<b>b</b>). road network density distribution).</p>
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<p>Comprehensive division of rain and flood disasters in Huangshan City.</p>
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<p>Spatial distribution of flood disaster factors in Huangshan City in 2020.</p>
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<p>Disaster topic in each county.</p>
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23 pages, 8165 KiB  
Article
The Impact of Built-Up Area Dispersion on the Cultural Heritage of the Region of the South Aegean, Greece
by Efstratia Chatzi, Evangelia-Theodora Derdemezi and Georgios Tsilimigkas
ISPRS Int. J. Geo-Inf. 2025, 14(3), 97; https://doi.org/10.3390/ijgi14030097 - 20 Feb 2025
Viewed by 268
Abstract
Cultural heritage serves as a repository of a place’s history and identity, integral to its landscape and central to all three sustainability goals. However, managing and protecting cultural heritage through regulatory planning often proves inadequate. This particularly applies to islands where infrastructure development [...] Read more.
Cultural heritage serves as a repository of a place’s history and identity, integral to its landscape and central to all three sustainability goals. However, managing and protecting cultural heritage through regulatory planning often proves inadequate. This particularly applies to islands where infrastructure development pressures and urban sprawl lead to significant changes. This study quantifies the impact of uncontrolled built-up area dispersion on islands’ cultural heritage, focusing on the Southern Aegean region. By identifying and delineating the boundaries of archaeological areas and historic sites, we assess pressures through the mapping and quantitative analysis of built-up areas derived from the Global Monitoring for Environment and Security (GMES) program. The results reveal spatial relations and potential conflicts, underscoring the insufficient protection of cultural heritage due to inadequate management and ineffective planning tools. Specifically, on islands like Mykonos and Naxos, over 80% of their archaeological areas are impacted by urban sprawl. Additionally, this study finds that six islands (Antiparos, Irakleia, Kea, Mykonos, Paros and Patmos) have over 60% of their built-up areas in exurban regions, exacerbating pressures on heritage sites. These findings highlight the need for an integrated spatial planning system that incorporates landscape and cultural heritage assets into strategic planning regulations, ensuring the preservation of these essential resources amidst ongoing development pressures. Full article
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<p>Methodological steps for analyzing the impact of built-up area dispersion on cultural heritage sites in the Southern Aegean region. Source: own elaboration.</p>
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<p>Location of Southern Aegean islands in the Greek territory. Source: own elaboration.</p>
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<p>Traditional and non-traditional settlements on Cyclades and Dodecanese islands of the Southern Aegean region, Greece. Source: own elaboration.</p>
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<p>Built-up areas (%) falling inside and outside the settlement boundaries: Cyclades vs. Dodecanese. Source: own elaboration.</p>
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<p>Indicative examples of the spatial distribution of built-up areas inside and outside the settlement boundaries on Cyclades and Dodecanese islands and their proximity to cultural heritage assets. Source: own elaboration.</p>
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<p>Cultural heritage impact assessment: built-up areas on the islands of the Southern Aegean region. Source: own elaboration.</p>
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