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18 pages, 3346 KiB  
Review
The Catastrophic Water Loss of Ancient Lake Prespa: A Chronicle of a Death Foretold
by Dejan Trajkovski and Nadezda Apostolova
Hydrology 2024, 11(12), 199; https://doi.org/10.3390/hydrology11120199 - 25 Nov 2024
Viewed by 165
Abstract
The Prespa–Ohrid lake system in the southwest Balkan region is the oldest permanent lake system in Europe and a global hotspot of biodiversity and endemism. Its smaller component, Lake Macro Prespa (or simply called Prespa), shared by North Macedonia, Albania and Greece has [...] Read more.
The Prespa–Ohrid lake system in the southwest Balkan region is the oldest permanent lake system in Europe and a global hotspot of biodiversity and endemism. Its smaller component, Lake Macro Prespa (or simply called Prespa), shared by North Macedonia, Albania and Greece has suffered a dramatic water-level fall (nearly 10 m since the 1950s). It was greater in the periods 1987–1993 and 1998–2004 and has further accelerated in the last 5 years. Analysis of satellite images (remote sensing) revealed that over the period 1984–2020 Prespa Lake lost 18.87 km2 of its surface (6.9% of its size, dropping from 273.38 km2 to 254.51 km2), with a decline in the volume of water estimated as about 54%, even reaching 56.8% in 2022. The environmental status of the lake has also been compromised and the process of its eutrophication is enhanced. The aim of this study is to summarize the current understanding of the diminishing trend in the water level and the factors that have contributed to it. The lake is highly sensitive to external impacts, including climate change, mainly restricted precipitation and increased water abstraction for irrigation. Importantly, nearly half of its outflow is through karst aquifers that feed Ohrid Lake. Of note, the hydrology and especially hydrogeology of the catchment has not been studied in sufficient detail and accurate data for the present state are missing, largely due to a lack of coordinated investigations by the three neighboring countries. However, recent estimation of the water balance of Prespa Lake, elaborated with the consideration of only the natural sources of inflow (precipitation and river runoff) and outflow (evaporation and loss of water through the karst channels) suggested a negative balance of 53 × 106 m3 annually. Our study also offers an estimated projection for the water level in the future in different climate scenarios based on linear regression models that predict its complete loss before the end of the present century. Full article
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<p>Map showing the location of the Lake Prespa basin in the northeastern Mediterranean region and the most significant locations in the area. Mountains and mountain peaks (with Δ), political boundaries (red dotted lines) and Prespa Lakes catchment (green line) are shown. The coastal area around the sinkhole Zaver (its location is indicated) is believed to be the main point from where water sinks into the karst aquifer under Mount Mali Thate/Galicica and flows into Ohrid Lake, which is located at a lower altitude. The major portion of this water emerges as part of the springs at St. Naum and Tushemisht (marked with arrows). Malik Lake’s location is only roughly depicted.</p>
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<p>Striking decrease in the water levels in Prespa Lake. (<b>a</b>) The former waterfront line was more than 1 km from the current line in Stenje—a water level gauge can be seen that was in use a few decades ago, now sadly showing where the water once was. (Photo credit: Maja Janevska-Ilieva, journal <span class="html-italic">Nova Makedonija</span>, picture taken in January 2020). (<b>b</b>) The shore in Pretor in January 2023 (Photo credit: Centar.mk, online news site). (<b>c</b>) Severe degradation of the water quality in the coastal area on the eastern coast, September 2024 (Photo credit: Metodija Jonovski). (<b>d</b>) Extremely shallow waters along the coast near Asamati, summer 2024 (Photo credit: Cveta Panovska). (<b>e</b>) Karst swallow hole at Zaver in January 2020 (Photo credit: Maja Janevska-Ilieva, journal <span class="html-italic">Nova Makedonija</span>). (<b>f</b>) Zaver in summer of 2024 is completely dry. A red arrow marks a stone wall that was probably built by the villagers from Goricë e Vogël to “isolate” the sinkhole from the lake and reduce the sinking of the water. The location of the Zaver sinkhole is marked with a blue arrow, which is now a dry pit, where vegetation grows.</p>
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<p>Historical record and current state of the water level of Prespa Lake. (<b>a</b>) The water levels of Prespa Lake measured in Stenje since 1951, showing the annual fluctuations related to the summer (dry)/winter (wet) period and the mean altitude. The historical maximum is shown (in 1963, +415 cm). (<b>b</b>) The drop in the water level recorded over the past 5 years.</p>
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<p>Projected estimates for the future decline in Prespa Lake’s water level according to a model of linear regression. Four different scenarios are shown depending on the climate changes in the area, expressed as precipitation (%)/evaporation (%) change. The blue line depicts the scenario of 0%/0%, i.e., the assumption that there will be no decrease in the precipitation rate and no increase in the evaporation of water from the lake by the end of the century, i.e., the annual volume of [Total inflow-Total outflow] was considered constant. The yellow line depicts a scenario of 30%/6% or a 30% reduction in annual precipitation and a 6% increase in annual evaporation by the end of the century.</p>
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<p>Bathymetric map of the present state of Prespa Lake. Measurements of the deepest points in the territory of N. Macedonia (location 1: 28.4 m and location 2: 20.2 m) were taken in September 2022 when the lake water level was at an altitude of 842.16 m a.s.l. The deeper areas are marked with circles—these are the only areas that may remain as ponds once the rest of the lake completely dries up in 50–60 years.</p>
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22 pages, 401 KiB  
Article
Women in Transition: The Dynamic Effects of Inward FDI on Female Employment in the Economy and Across Sectors
by Pascal L. Ghazalian
Economies 2024, 12(12), 318; https://doi.org/10.3390/economies12120318 - 25 Nov 2024
Viewed by 216
Abstract
This paper examines the effects of inward Foreign Direct Investment (FDI) on the female employment rate in the economy and the share of female employment across sectors. The empirical analysis is implemented through the Generalized Method of Moments (GMM) System estimator for dynamic [...] Read more.
This paper examines the effects of inward Foreign Direct Investment (FDI) on the female employment rate in the economy and the share of female employment across sectors. The empirical analysis is implemented through the Generalized Method of Moments (GMM) System estimator for dynamic panel models using different empirical specifications and FDI openness indicators. The main results show that the overall effects of inward FDI on the national female employment rate are not statistically significant. However, they reveal that inward FDI has promoted the share of female employment in the service sector and has led to decreases in the share of female employment in agriculture. The FDI effects on the share of female employment in the industrial sector are found to be statistically insignificant. These results are generally supported when running the empirical analysis through alternative FDI openness indicators. Also, supplementary analysis reveals some variations in the magnitude of these effects over different national income categories. The findings in this paper emphasize FDI’s gendered influences in the labour market. They are consistent with the prevalence of macroeconomic channels through which inward FDI impacts female employment across sectors, and they encompass the underlying implications of various counteracting microeconomic factors. Full article
20 pages, 7765 KiB  
Article
Rapid High-Precision Ranging Technique for Multi-Frequency BDS Signals
by Jie Sun, Jiaolong Wei, Zuping Tang and Yuze Duan
Remote Sens. 2024, 16(23), 4352; https://doi.org/10.3390/rs16234352 - 21 Nov 2024
Viewed by 284
Abstract
The rapid expansion of BeiDou satellite navigation applications has led to a growing demand for real-time high-precision positioning services. Currently, high-precision positioning services face challenges such as a long initialization time and heavy reliance on reference station networks, thereby failing to fulfill the [...] Read more.
The rapid expansion of BeiDou satellite navigation applications has led to a growing demand for real-time high-precision positioning services. Currently, high-precision positioning services face challenges such as a long initialization time and heavy reliance on reference station networks, thereby failing to fulfill the requirements for real-time, wide-area, and centimeter-level positioning. In this study, we consider the multi-frequency signals that are broadcast by a satellite to share a common reference clock and possess identical RF channels and propagation paths with strict temporal, spectral, and spatial coupling between signal components, resulting in strongly coherent propagation delays. Firstly, we accurately establish a multi-frequency signal model that fully exploits those coherent characteristics among the multi-frequency BDS signals. Subsequently, we propose a rapid high-precision ranging technique using the code and carrier phases of multi-frequency signals. The proposed method unitizes multi-frequency signals via a coherent joint processing unit consisting of a joint tracking state estimator and a coherent signal generator. The joint tracking state estimator simultaneously estimates the biased pseudorange and its change rate, ionospheric delay and its change rate, and ambiguities. The coherent signal generator updates the numerically controlled oscillator (NCO) to adjust the local reference signal’s code and carrier replicas of different frequencies, changing them according to the state estimated by the joint tracking state estimator. Finally, the simulation results indicate that the proposed method efficiently diminishes the estimated biased pseudorange and ionospheric delay errors to below 0.1 m. Furthermore, this method reduces the carrier phase errors by more than 60% compared with conventional single-frequency-independent tracking methods. Consequently, the proposed method can achieve rapid centimeter-level results ranging for up to 1 min without using precise atmosphere corrections and provide enhanced tracking sensitivity and robustness. Full article
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<p>Block diagram of the rapid high-precision ranging technique.</p>
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<p>The workflow of the rapid high-precision ranging technique.</p>
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<p>Auto-correlation functions of the BPSK(2), BPSK(10), and QMBOC(6,1,4/33) signals.</p>
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<p>Sky map of the visible BDS satellites at 16:51 on 30 July 2024.</p>
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<p>Estimation errors of the biased pseudorange and ionospheric delay on multi-frequency integrated signals: (<b>a</b>) six-frequency integrated; (<b>b</b>) five-frequency integrated; (<b>c</b>) quad-frequency integrated; (<b>d</b>) triple-frequency integrated.</p>
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<p>Code and carrier phase errors on multi-frequency integrated signals. (<b>a</b>) Code phase error using integrated six-frequency signals; (<b>b</b>) carrier phase error using integrated six-frequency signals; (<b>c</b>) code phase error using integrated five-frequency signals; (<b>d</b>) carrier phase error using integrated five-frequency signals; (<b>e</b>) code phase error using integrated quad-frequency signals; (<b>f</b>) carrier phase error using integrated quad-frequency signals; (<b>g</b>) code phase error using integrated triple-frequency signals; (<b>h</b>) carrier phase error using integrated triple-frequency signals.</p>
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<p>Code and carrier phase errors on multi-frequency integrated signals. (<b>a</b>) Code phase error using integrated six-frequency signals; (<b>b</b>) carrier phase error using integrated six-frequency signals; (<b>c</b>) code phase error using integrated five-frequency signals; (<b>d</b>) carrier phase error using integrated five-frequency signals; (<b>e</b>) code phase error using integrated quad-frequency signals; (<b>f</b>) carrier phase error using integrated quad-frequency signals; (<b>g</b>) code phase error using integrated triple-frequency signals; (<b>h</b>) carrier phase error using integrated triple-frequency signals.</p>
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<p>Estimation errors of the biased pseudorange and ionospheric delay on five-frequency integrated signals in a weak signal environment.</p>
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<p>Code and carrier phases error of the five-frequency integrated signals in a weak signal environment. (<b>a</b>) Code phase errors of B1I, B3I, B1C, B2a, and B2b; (<b>b</b>) carrier phase errors of B1I, B3I, B1C, B2a, and B2b.</p>
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<p>Estimation errors of the biased pseudorange and ionospheric delay on five-frequency integrated signals with selective frequency signal attenuation.</p>
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<p>Code and carrier phase errors on five-frequency signals with selective frequency signal attenuation. (<b>a</b>) Code phase error of B1I, B3I, B1C, B2a, and B2b; (<b>b</b>) carrier phase error of B1I, B3I, B1C, B2a, and B2b.</p>
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31 pages, 1833 KiB  
Article
Evaluation of the Effects of Body Forces and Diffusion Mechanisms on Droplet Separation in a Two-Phase Annular–Mist Flow
by Oktawia Dolna
Appl. Sci. 2024, 14(23), 10793; https://doi.org/10.3390/app142310793 - 21 Nov 2024
Viewed by 296
Abstract
For decades, studies have been conducted on the efficiency of gas purification processes with wet scrubbers, including the Venturi scrubbers, and this is the most commonly addressed issue in the field literature. The Venturi scrubber consists of a Venturi nozzle and a cyclone. [...] Read more.
For decades, studies have been conducted on the efficiency of gas purification processes with wet scrubbers, including the Venturi scrubbers, and this is the most commonly addressed issue in the field literature. The Venturi scrubber consists of a Venturi nozzle and a cyclone. The article addresses the empirical and analytical studies on the annular–mist flow regime that exists in the throat of the Venturi nozzle with a square cross-section. The uniform distribution of droplets over the cross-section area of the Venturi’s throat strongly correlates with the efficiency of the gas cleaning process using Venturi scrubbers. Due to the above, studies on the physics of the phenomena that affect the quantity of small droplets present in the core of the flow are highly justified. The influence of body forces and diffusive mechanisms impacting the number of droplets in the core flow were investigated to tackle the problem in question. Consequently, the fractions of droplets susceptible to turbulent or inertial–turbulent diffusion mechanisms can now be predicted using the outcomes of the research carried out. The droplets were divided into three fractions that differed by their sizes as follows: airborne droplets I confirm thar italic can be removed in all cases. (dd 10 µm), medium-sized droplets (dd 20 µm), and largest droplets (dd = (50 − 150) µm). The estimation of diffusion coefficients εd,M,εd,ref and stopping distances sM,sref of all fractions of droplets was carried out with the inclusion εd,M,sM and exclusion εd,ref,sref of the Magnus lift force M in equations of both the droplet’s stopping distance and its diffusion coefficient. The outcomes revealed that the inclusion of the M force translates significantly to the growth in values of εd,M,sM compared to εd,ref,sref. Hence, it was concluded that the M force impacts the increase in the speed of the diffusion of the droplets with dd 16.45 µm, which is favorable. Hence, the inertial–turbulent diffusion of larger droplets and the turbulent diffusion of medium ones seem to be supported by the M force. The local velocity gradient, which varied within the region of the flow’s hydraulic stabilization also impacted the mass content of droplets with diameter dd 10 µm in the core of the flow. As the flow development progressed, the number of droplets measured at n = 5 Hz varied nonlinearly up to the point where the boundary layer thickness reached the channel radius. The quantity of small droplets in the main flow was significantly influenced by turbulence intensity (Tu). The desired high number of small droplets in the core of the flow (mist flow) was estimated empirically, and it was achieved when gas flows at high speed and has a mean value of Tu. The former benefits the efficiency of gas purification. Investigations on the effects of body forces of inertia of the continuous phase on the separation of droplets with diameters of a few microns and sub-microns from the flow were performed by employing two channel elbows, namely e4 and e1. The curved channels were subsequently mounted at the end of the straight channel (SCh2). The curvature angle (α) of the e4 and e1 equaled 90C and 30C, respectively. The number of droplets existing in the mist flow was higher in value, as desired, when the e4 was used, unlike e1. Two-dimensional flow fields of the mist have been obtained using the Particle Imaging Velocimetry (PIV) technique and analyzed further . Topas LAP 332 Aerosol Spectrometer was used for the determination of droplet (dd 40 µm) size distribution (DSD) and particle concentrations, while the Droplet Size Analyzer D Kamika Instruments (DSA) was exploited to ascertain DSD of droplets with diameter dd>40 µm . Full article
28 pages, 50073 KiB  
Article
Projecting Climate Change Impacts on Channel Depletion in the Sacramento–San Joaquin Delta of California in the 21st Century
by Sohrab Salehi, Seyed Ali Akbar Salehi Neyshabouri, Andrew Schwarz and Minxue He
Forecasting 2024, 6(4), 1098-1123; https://doi.org/10.3390/forecast6040055 (registering DOI) - 21 Nov 2024
Viewed by 210
Abstract
The Sacramento–San Joaquin Delta (Delta) is a critical hub of California’s statewide water distribution system. Located at the confluence of California’s two largest rivers, the Sacramento River and the San Joaquin River, the Delta features a complex network of braided channels and over [...] Read more.
The Sacramento–San Joaquin Delta (Delta) is a critical hub of California’s statewide water distribution system. Located at the confluence of California’s two largest rivers, the Sacramento River and the San Joaquin River, the Delta features a complex network of braided channels and over a hundred islands, most of which are located below sea level. The Delta’s complex nature and low-lying topography make it a unique hydrological area pertinent to climate change studies. This paper aims to estimate and explore the potential effects of climate change on the hydrological features of the Delta, especially Net Channel Depletion (NCD), which is one of the main contributors to the Net Delta Outflow (NDO). Downscaled CMIP6 General Circulation Model outputs are used to generate plausible future climate data. The Delta Channel Depletion model (DCD) is used to simulate daily hydrological processes for 61 plausible future climate scenarios. Simulation models are applied to the historical period (1930–2014) and projected future periods (2016–2100). A thorough water balance is computed in the DCD simulation model, offering insights into various elements in the hydrological cycle. Key hydrological features such as crop evapotranspiration, seepage, drainage, and runoff are simulated. Potential changes in NCD, calculated as the sum of diversions and seepage minus drainage, are also examined. The study identified a wide range of increases in NCD across all scenarios in the future period relative to the average of the historical period. These increases are projected to vary from 0.3% up to 20%. Moreover, a spatial analysis conducted across diverse regions of the Delta highlights notable variations in depletion across these areas. The results of this research indicate an anticipated increased stress on water resources, necessitating the adoption of innovative strategies to manage extreme events effectively and ensure the sustainability and resilience of water resource management. Full article
(This article belongs to the Section Environmental Forecasting)
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<p>Delta dynamics: an integrated view of the Sacramento–San Joaquin’s islands, weather stations, and CalSim3 subregions: (<b>A</b>) geographic positioning of the Delta, San Francisco Bay, and California’s two primary rivers (Sacramento and San Joaquin); (<b>B</b>) 168 Delta subareas (islands); (<b>C</b>) aerial image of Delta region and seven subregions defined in the CalSim3 simulation model [<a href="#B48-forecasting-06-00055" class="html-bibr">48</a>].</p>
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<p>Water balance of a typical Delta island (adopted and revised from [<a href="#B34-forecasting-06-00055" class="html-bibr">34</a>]).</p>
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<p>Technical roadmap illustrating the methodology for analyzing climate change impacts on channel depletion in the Sacramento–San Joaquin Delta.</p>
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<p>Box-and-whisker diagrams illustrating the projected uncertainty ranges for (<b>A</b>) average annual precipitation, (<b>B</b>) maximum air temperature, and (<b>C</b>) minimum air temperature at the Lodi station under various climate models and scenarios. Red circles denote the historical period averages for each variable.</p>
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<p>Historical simulated annual channel depletion, seepage, drainage, and diversion using historical meteorological data and simulation setup from [<a href="#B62-forecasting-06-00055" class="html-bibr">62</a>].</p>
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<p>Box-and-whisker diagrams for annual hydrological variables resulted from 61 GCM-Scenario simulations.</p>
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<p>Monthly simulated (<b>A</b>) net channel depletion, (<b>B</b>) diversion, (<b>C</b>) drainage, and (<b>D</b>) seepage (historical average and climate change scenarios average).</p>
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<p>Box-normal diagrams for the net channel depletion resulted from different GCM-Scenarios (subfigures <b>A</b>–<b>C</b> are the same box-normal diagrams for different CMIP6 model and scenarios).</p>
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<p>Net channel depletion for projected climate trends (black line depicts the average value of all scenarios, and red and blue lines indicate the upper and lower 90% confidence intervals, respectively).</p>
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<p>Annual (<b>A</b>) net channel depletion, (<b>B</b>) drainage, (<b>C</b>) diversion, and (<b>D</b>) seepage spatial distribution resulting from the historical simulation.</p>
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<p>Box-and-whisker diagram for annual net channel depletion (NCD) resulting from 61 GCM-Scenario simulations.</p>
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<p>Net annual channel depletion projections.</p>
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<p>Net annual channel depletion projections.</p>
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<p>Net annual channel depletion projections.</p>
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<p>Net annual channel depletion projections.</p>
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32 pages, 13420 KiB  
Article
A Mixed-Elastohydrodynamic Lubrication Model of a Capped-T-Ring Seal with a Sectioned Multi-Material Film Thickness in Landing Gear Shock Absorber Applications
by Aaron Feria Alanis, Ahmed A. Sheikh Al-Shabab, Antonis F. Antoniadis, Panagiotis Tsoutsanis and Martin Skote
Fluids 2024, 9(12), 271; https://doi.org/10.3390/fluids9120271 - 21 Nov 2024
Viewed by 294
Abstract
Numerical investigations of capped T-ring (CTR) seals performance in reciprocating motion for landing gear shock absorber applications are presented. A lubrication model using the Elastohydrodynamic lubrication theory and deformation mechanics is developed in a multi-material contact zone, and a procedure for coupling fluid [...] Read more.
Numerical investigations of capped T-ring (CTR) seals performance in reciprocating motion for landing gear shock absorber applications are presented. A lubrication model using the Elastohydrodynamic lubrication theory and deformation mechanics is developed in a multi-material contact zone, and a procedure for coupling fluid and deformation mechanics is introduced. By conducting Finite Element Method (FEM) simulations, the static contact pressure is obtained, which subsequently is used within the model developed herein consisting of a modified Reynolds equation and an asperity contact model, to calculate the fluid film pressure, and the deformation of the fluid channel is determined using an elastic deformation model applied to a multi-component multi-mechanical property channel. These computational results are used for estimations of the seal leakage and friction under various conditions. In addition, the influence of asperity orientation is compared with other parameters, such as sealing pressure and piston velocity. A correlation between asperity orientation and leakage was found, and a general trend of reduced leakage with longitudinally oriented asperities was established. Full article
(This article belongs to the Section Mathematical and Computational Fluid Mechanics)
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Figure 1
<p>CTR seal and housing cross-sectional geometry, and schematic representation of the T-ring piston sealing system.</p>
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<p>CTR seal and housing cross-sectional schematics, and CTR ring internal diameter.</p>
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<p>FEM model boundary condition. Orange arrows illustrate displacement boundaries, the precompression in the Y direction and the instroke–outstroke in the X direction. Magenta arrows represent the pressure boundary condition applied to the left part of the sealing assembly. RP stands for reference point in the groove.</p>
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<p>Fluid film channel enclosed by yellow line, and boundary conditions for mixed-EHL solution. Characteristic length for non-dimensional dimension X.</p>
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<p>Top view of asperity contact orientations adapted from [<a href="#B27-fluids-09-00271" class="html-bibr">27</a>]. Side view of asperity contact between a rough and smooth surface.</p>
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<p>Fluid film channel discretized in 3 sections for different material parameters.</p>
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<p>Computational process.</p>
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<p>(<b>a</b>) Recreated O-ring model. (<b>b</b>) Maximum contact pressure at different pre-compressions. A comparison between Zhang et al. [<a href="#B10-fluids-09-00271" class="html-bibr">10</a>] and the present FEM model. (<b>c</b>) Maximum contact pressure at different compression ratios in comparison with Zhang et al. [<a href="#B7-fluids-09-00271" class="html-bibr">7</a>].</p>
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<p>Mesh sensitivity analysis. (<b>a</b>) View of the mesh in the contact between the piston, a backup ring and the cap, denoted by yellow line, (<b>b</b>) contact pressure between the piston, backup rings and cap at different mesh sizes.</p>
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<p>Static contact pressure distribution at sealed pressures of (<b>a</b>) 5 MPa, (<b>b</b>) 10 MP, (<b>c</b>) 15 MPa.</p>
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<p>At the initial steps of the precompression stage, (<b>a</b>) contact pressure, (<b>b</b>) Von Mises stress distribution.</p>
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<p>At full precompression, (<b>a</b>) contact pressure, (<b>b</b>) Von Mises stress distribution.</p>
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<p>Loss of contact pressure in the vicinity of X = 0 due to part deformation at 10 MPa of sealed pressure. (<b>a</b>) Von Mises stress of the part comprising the backup rings and cap, (<b>b</b>) static contact pressure.</p>
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<p>(<b>a</b>) Benchmark mesh and boundary conditions of verification case, recreated from [<a href="#B19-fluids-09-00271" class="html-bibr">19</a>]. Sealed pressure is 0.1 MPa, (<b>b</b>) pressure distributions in the outstroke direction with U = 0.05 m/s, (<b>c</b>) pressure distributions in the outstroke direction with U = 0.1 m/s, (<b>d</b>) pressure distributions in the outstroke direction with U = 0.15 m/s.</p>
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<p>Pressure distributions at different sealed pressures in the instroke and outstroke directions: (<b>a</b>,<b>b</b>) 5 MPa, (<b>c</b>,<b>d</b>) 10 MPa, (<b>e</b>,<b>f</b>) 15 MPa.</p>
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<p>Fluid film pressure and asperity contact pressure distributions at different piston speeds at 5 MPa of sealed pressure: (<b>a</b>) Outstroke, (<b>b</b>) Instroke.</p>
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<p>Fluid film thickness at different piston velocities in the instroke (<b>a</b>) and outstroke (<b>b</b>) directions. Sealed pressure: 5 MPa.</p>
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<p>Fluid film and asperity contact pressure distribution with different sealing pressure and flow factors: (<b>a</b>,<b>b</b>) 5 MPa, (<b>c</b>,<b>d</b>) 10 MPa, (<b>e</b>,<b>f</b>) 15 MPa. Piston velocity: 100 mm/s.</p>
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<p>Fluid film thickness distribution for different <math display="inline"><semantics> <mrow> <mi>γ</mi> </mrow> </semantics></math> values at 100 mm/s of piston velocity in the outstroke direction for: (<b>a</b>) 5 MPa sealed pressure, (<b>b</b>) 10 MPa sealed pressure, and (<b>c</b>) 15 MPa sealed pressure.</p>
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<p>Variation in friction force with sealed pressure and piston velocity in the outstroke direction with isotropic asperities (<math display="inline"><semantics> <mrow> <mi>γ</mi> <mo>=</mo> <mn>1</mn> </mrow> </semantics></math>).</p>
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<p>Variation in friction force with sealed pressure and piston velocity in the instroke direction with isotropic asperities (<math display="inline"><semantics> <mrow> <mi>γ</mi> <mo>=</mo> <mn>1</mn> </mrow> </semantics></math>).</p>
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<p>Friction force for different asperity orientations and sealed pressures. Piston velocity of 100 mm/s in the (<b>a</b>) outstroke and (<b>b</b>) instroke directions.</p>
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<p>Friction force components at 5 MPa of sealed pressure and different piston velocities. Isotropic asperities.</p>
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<p>Elastic deformation comparison: (<b>a</b>) 5 MPa of sealed pressure, (<b>b</b>) 10 MPa of sealed pressure, (<b>c</b>) 15 MPa of sealed pressure.</p>
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<p>Flow rate per unit circumferential length at different sealed pressures in the instroke and outstroke motion. Isotropic asperities and piston velocity of 100 mm/s.</p>
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<p>Flow rate per unit circumferential length at different piston velocities in the instroke and outstroke motion. Isotropic asperities and sealed pressure of 10 MPa.</p>
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<p>Flow rate per unit circumferential length at different asperity orientation in the instroke and outstroke motion. Piston velocity of 100 mm/s and sealed pressure of 10 MPa.</p>
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<p>Flow volume in the (<b>a</b>) outstroke and (<b>b</b>) instroke motion.</p>
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<p>Net flow volume.</p>
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18 pages, 2011 KiB  
Article
Demographic and Geographic Characteristics Associated with the Type of Prescription and Drug Expenditure: Real World Evidence for Greece During 2015–2021
by Georgios Mavridoglou and Nikolaos Polyzos
Healthcare 2024, 12(22), 2312; https://doi.org/10.3390/healthcare12222312 - 19 Nov 2024
Viewed by 577
Abstract
Aim: Electronic prescribing has allowed for the collection of prescription data in real time in Greece for the first time. Hence, the aim of the current study was to present the characteristics of prescriptions for the Greek population during the period from 2015 [...] Read more.
Aim: Electronic prescribing has allowed for the collection of prescription data in real time in Greece for the first time. Hence, the aim of the current study was to present the characteristics of prescriptions for the Greek population during the period from 2015 to 2021. Methods: This retrospective study was based on data extracted from the nationwide Greek electronic prescription database between January 2015 and December 2021. Descriptive statistics methods were used for the needs of the study. As the basic figures examined depend on the size of the population, in order for the results to be comparable, we estimated the corresponding measures per inhabitant, using population data from the Greek Statistical Authority. Appropriate indicators for the comparison of consumption and expenditure over time were estimated. A study of the trend was also carried out using time series and linear regression models. In order to facilitate the design and implementation of specialized policies, it is useful to identify the drug categories with the highest consumption and expenditure, as well as the geographical areas that present similar characteristics. For the first, ABC analysis was used, which helps to identify the most popular categories of drugs, while for the second, cluster analysis was carried out. Agglomerative clustering was used to divide the regions into similar groups. This hierarchical clustering algorithm classifies the population into several clusters, with areas in the same cluster being more similar, and areas in different clusters being dissimilar. The Ward linkage method with Euclidean distance was used. Results: The analysis of prescription drug consumption and expenditure from 2015 to 2021 revealed significant fluctuations and trends across various drug categories, age groups, and geographical areas. Notably, the quantity of prescriptions increased by 20% since 2015, while expenditure surged by over 30%, with significant spikes following the end of the MoU in 2019 and the onset of the pandemic in 2020. In terms of expenditure, antineoplastic and immunomodulation agents (category L) held the largest share, driven by the introduction of new, costly drugs. The expenditure per inhabitant revealed gender and age disparities, with older populations, particularly women, incurring higher costs. Geographically, drug expenditure, and consumption varied significantly, with distinct regional clusters identified. These clusters, while showing some overlap in consumption and expenditure patterns, also highlighted unique regional characteristics. Conclusions: The insights into prescription drug consumption and expenditure trends offer a valuable basis for developing targeted interventions aimed at optimizing healthcare resource allocation. Moreover, the findings underscore the importance of addressing regional and demographic disparities in pharmaceutical use, thereby contributing to more equitable and cost-effective healthcare strategies. More specifically, the age distribution of prescriptions shows the increase in younger ages, which, as a result, anticipates the overall increase in prescriptions. The knowledge of the most convex categories of medicine, as well as the percentages of the use of generic drugs, shows where interventions should be made, with financial incentives and information through new information channels. The geographic disparities recorded should lead to policies that help the residents of hard-to-reach areas to access prescriptions. In addition, the present study provides a strategic framework for policymakers and healthcare managers to guide future studies and inform decision-making processes. Full article
(This article belongs to the Special Issue Efficiency, Innovation, and Sustainability in Healthcare Systems)
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<p>Linear trend analysis, (<b>a</b>) volume; (<b>b</b>) expenditure.</p>
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<p>ABC analysis; (<b>a</b>) for quantity and (<b>b</b>) expenditure by ATC-1 categories, 2015–2021. (A: alimentary tract and metabolism; B: blood and blood-forming organs; C: cardiovascular system; D: dermatology; G: genito-urinary system and sexual hormones; H: systemic hormonal preparations; J: anti-infectives for systemic use; L: antineoplastic and immunomodulating; M: musculo-skeletal system; N: nervous system; P: antiparasitic products; R: respiratory system; S: sensory organs; V: various).</p>
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<p>Ratio (expenditure/quantity) per year and ATC-1 category (A: alimentary tract and metabolism; B: blood and blood-forming organs; C: cardiovascular system; D: dermatology; G: genito-urinary system and sexual hormones; H: systemic hormonal preparations; J: anti-infectives for systemic use; L: antineoplastic and immunomodulating; M: musculo-skeletal system; N: nervous system; P: antiparasitic products; R: respiratory system; S: sensory organs; V: various).</p>
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<p>Consumption and expenditure per capita by sex and age group, as a per cent of mean, 2015–2021.</p>
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<p>Cluster analysis. Dendrograms of regions by (<b>a</b>) quantities and (<b>b</b>) values.</p>
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17 pages, 4657 KiB  
Article
Low-Complexity Convolutional Neural Network for Channel Estimation
by Simona Sibio, Cristian Sestito, Souheil Ben Smida, Yuan Ding and George Goussetis
Electronics 2024, 13(22), 4537; https://doi.org/10.3390/electronics13224537 - 19 Nov 2024
Viewed by 296
Abstract
This paper presents a deep learning algorithm for channel estimation in 5G New Radio (NR). The classical approach that uses neural networks for channel estimation requires more than one stage to obtain the full channel matrix. First, the channel has to be constructed [...] Read more.
This paper presents a deep learning algorithm for channel estimation in 5G New Radio (NR). The classical approach that uses neural networks for channel estimation requires more than one stage to obtain the full channel matrix. First, the channel has to be constructed by the received reference signal, and then, the precision is improved. In contrast, to reduce the computational cost, the proposed neural network method generates the channel matrix from the information captured from a few subcarriers along the slot. This information is extrapolated by applying the Least Square technique only on the Demodulation Reference Signal (DMRS). The received DMRS placed in the grid can be seen as a 2D low-resolution image and it is processed to generate the full channel matrix. To reduce complexity in the hardware implementation, the convolutional neural network (CNN) structure is selected. This solution is analyzed comparing the Mean Square Error (MSE) and the computational cost with other deep learning-based channel estimation, as well as the traditional channel estimation methods. It is demonstrated that the proposed neural network delivers substantial complexity savings and favorable error performance. It reduces the computational cost by an order of magnitude, and it has a maximum error discrepancy of 0.018 at 5 dB compared to Minimum Mean Square Error (MMSE) channel estimation. Full article
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<p>Example of DM-RS location in the resource grid.</p>
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<p>The LSTM layer.</p>
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<p>Example of FCDNN with two hidden layers.</p>
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<p>Example of a convolutional layer having <span class="html-italic">M<sub>C</sub></span> = 3, <span class="html-italic">K<sub>H</sub></span> = <span class="html-italic">K<sub>W</sub></span> = 3, <span class="html-italic">N<sub>C</sub></span> = 6. The yellow volume refers to the input neurons, while the light green volume refers to the output neurons. Accordingly, the orange block is the input sliding window, while the green block indicates the output neurons interested by that window.</p>
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<p>Diagram of the proposed neural network. The real (<b>a</b>) and imaginary (<b>b</b>) parts are processed in parallel.</p>
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<p>Comparison of the implemented CNNs: (<b>a</b>) the model of CNN that enhances the estimation provided by a preliminary interpolation stage; (<b>b</b>) the model of the proposed neural network that completely estimates the channel.</p>
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<p>Computational cost analysis among several DL channel estimations varying the number of antennas at the receiver. The transmitter (user terminal, UT) uses two antennas. The calculation is obtained from the above table considering the implemented designs and those reported in the literature [<a href="#B3-electronics-13-04537" class="html-bibr">3</a>,<a href="#B8-electronics-13-04537" class="html-bibr">8</a>,<a href="#B25-electronics-13-04537" class="html-bibr">25</a>].</p>
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<p>Computational cost analysis among several implemented DL channel estimations varying the number of antennas at the receiver. The transmitting UT uses eight antennas. The calculation is obtained from the above table considering the implemented designs and those reported in the literature [<a href="#B3-electronics-13-04537" class="html-bibr">3</a>,<a href="#B8-electronics-13-04537" class="html-bibr">8</a>,<a href="#B25-electronics-13-04537" class="html-bibr">25</a>].</p>
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<p>Diagram of the simulated system comparing the channel estimation from the proposed structure with CNNs with pre-interpolation, LS with post-interpolation, and MMSE with post-interpolation.</p>
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<p>MSE analysis varying the SNR. The comparison is between the implemented designs and the FCDNN postinterpolated proposed in [<a href="#B3-electronics-13-04537" class="html-bibr">3</a>].</p>
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15 pages, 4870 KiB  
Article
Biodiversity and Abundance of Angiosperms and Environmental Resilience in the Tidal Range of Yuanjiang Dry–Hot Valley, Southwestern China
by Fengchun Yang, Qiong He, Huaping Huang, Yanmei Cui, Jianyong Gou, Chaya Sarathchandra, Kritana Prueksakorn, Kiyota Hashimoto and Li Liu
Diversity 2024, 16(11), 703; https://doi.org/10.3390/d16110703 - 18 Nov 2024
Viewed by 522
Abstract
Yuanjiang dry–hot valley is located in the southwest of mainland China. It is a sparsely vegetated area with a fragile arid ecosystem. Although the valley previously had forest cover, it has become a tropical montane savannah in recent decades. Mechanisms controlling plant species [...] Read more.
Yuanjiang dry–hot valley is located in the southwest of mainland China. It is a sparsely vegetated area with a fragile arid ecosystem. Although the valley previously had forest cover, it has become a tropical montane savannah in recent decades. Mechanisms controlling plant species distribution in such dry–hot valleys are unclear. Clarifying this will be beneficial to sustainable ecosystem management in dry–hot valleys. This study explored the relationship between diversity patterns of plant species and their environments in the lowland of this dry–hot valley. To achieve this, transects and plots were arranged along the river channel. Alpha and beta diversity indices were calculated to quantify biodiversity changes between species and environments. Estimated species, rarity, and abundance indices were also utilized to examine the correlation among species, their population size, and their environment: Species_estimated (expected number of species in t pooled plots), Singletons (the number of species with only one individual in t pooled plots), Uniques (the number of species living in one plot in t pooled plots), ACE (species richness estimator with coverage-based abundance), ICE (species richness estimator with coverage-based incidence), and Chao2 (species richness estimator extrapolated from Singletons). Fifty years of meteorological records, including temperature and precipitation, were utilized as climate variables. The results indicated the following findings: (1) alpha diversity was higher closer to the river, whereas the beta diversity was higher towards the lower sections of the river (Bray–Curtis < 0.5), but this trend was reversed in the perpendicular transects; (2) total phosphorous (TP) and total potassium (TK) were higher on flatter ground, tending to be associated with raised nitrogen (TN) and organic matter (OM); (3) soil nutrients were higher towards the lower sections of the river, corresponding to an increased number of species; (4) water supply determined plant distribution, with soil condition determining water retention; (5) the estimated species and their rarity and abundance indices were associated with proximity to the river, indicating heterogeneity of habitats and soil condition; and (6) fern species could be used as indicators representing the xeric environment of Yuanjiang dry–hot valley. Plant cover was reduced at low altitudes, with high temperatures and a low water supply. These results draw attention to the need for specific policy formation to protect the microhabitats and manage the environment of the Yuanjiang valley. Full article
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<p>Vegetation and environment in the lower altitudinal range of Yuanjiang dry–hot valley, Southwestern China. (<b>A</b>,<b>a</b>) Upper; (<b>B</b>,<b>b</b>) middle; (<b>C</b>,<b>c</b>) lower; (<b>A</b>), (<b>B</b>) and (<b>C</b>) indicate rainy season, while a, b and c are in dry.</p>
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<p>Research sites A–F (<b>top</b>) and diagram (<b>bottom left</b>) of L-transect and P-transect (P-transect, transect perpendicular to river channel, a and b are in the upper river, c and d are middle, and e and f are lower; L-transect, transect parallel to river channel; transect w, at a distance of 5 m to river channel; transect x, at a distance of 25 m; transect y, at distance of 45 m; transect z, at a distance of 65 m). Site coordinates and elevation (<b>bottom right</b>).</p>
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<p>Shannon–Weiner index (H), maximum Shannon–Weiner value (Hmax), evenness index (J), and overall dominance index across P-transects and L-transects.</p>
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<p>Overall change in species number along L- and P-transects.</p>
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<p>The variance of estimated species, rarity, and richness in plots 1–6 of L_transect. Red = transect w at a distance of 5 m to river channel; blue = transect x at a distance of 25 m; black = transect y at a distance of 45 m; and green = transect z at a distance of 65 m.</p>
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<p>The variance of estimated species, rarity, and richness indices in plots 1–4 of P_transect. Red, blue, black, green, yellow, and gray lines indicate transects a–f, respectively.</p>
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<p>Tidal range in Yuanjiang dry–hot valley. (<b>A</b>) River channel in low flow; (<b>B</b>) <span class="html-italic">Solanum virginianum</span>.</p>
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<p>Nutrients in ground surface soil in the studied transects.</p>
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14 pages, 2302 KiB  
Article
Possible Missing Sources of Atmospheric Glyoxal Part II: Oxidation of Toluene Derived from the Primary Production of Marine Microorganisms
by Renee T. Williams, Annika Caspers-Brown, Jennifer Michaud, Natalie Stevens, Michael Meehan, Camille M. Sultana, Christopher Lee, Francesca Malfatti, Yanyan Zhou, Farooq Azam, Kimberly A. Prather, Pieter Dorrestein, Michael D. Burkart and Robert S. Pomeroy
Metabolites 2024, 14(11), 631; https://doi.org/10.3390/metabo14110631 - 16 Nov 2024
Viewed by 354
Abstract
Background: Glyoxal has been implicated as a significant contributor to the formation of secondary organic aerosols, which play a key role in our ability to estimate the impact of aerosols on climate. Elevated concentrations of glyoxal over open ocean waters suggest that there [...] Read more.
Background: Glyoxal has been implicated as a significant contributor to the formation of secondary organic aerosols, which play a key role in our ability to estimate the impact of aerosols on climate. Elevated concentrations of glyoxal over open ocean waters suggest that there exists an additional source, different from urban and forest environments, which has yet to be identified. Methods: Based on mass spectrometric analyses of nascent sea spray aerosols (SSAs) and gas-phase molecules generated during the course of a controlled algal bloom, the work herein suggests that marine microorganisms are capable of excreting toluene in response to environmental stimuli. Additional culture flask experiments demonstrated that pathogenic attack could also serve as a trigger for toluene formation. Using solid-phase microextraction methods, the comparison of samples collected up-channel and over the breaking wave suggests it was transferred across the air–water interface primarily through SSA formation. Results: The presence and then absence of phenylacetic acid in the SSA days prior to the appearance of toluene support previous reports that proposed toluene is produced as a metabolite of phenylalanine through the Shikimate pathway. As a result, once in the atmosphere, toluene is susceptible to oxidation and subsequent degradation into glyoxal. Conclusions: This work adds to a minimal collection of literature that addresses the primary production of aromatic hydrocarbons from marine microorganisms and provides a potential missing source of glyoxal that should be considered when accounting for its origins in remote ocean regions. Full article
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<p>Temporal plot of GC total ion chromatograms of the mass collected on o-PDA-doped SPME fibers from panel 2 (see Experimental Design) during IMPACTS (<b>a</b>). Annotated EI-MS spectrum of toluene (RT 2.1 min) observed on 07/17/2014 (<b>b</b>). All retention times were confirmed with authentic standards.</p>
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<p>Ammonium (NH<sub>4</sub><sup>+</sup>, bars, μmol/L), nitrate (NO<sub>3−</sub>, squares, μmol/L), and phosphate (PO<sub>4</sub><sup>3−</sup>, circles, μmol/L) (<b>a</b>) heterotrophic bacteria (HB, line, cells/mL) and chitinase activity (NAG, nM/h, bars) (<b>b</b>) plotted against chlorophyll a levels (area, μg/L) during the course of IMPACTS.</p>
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<p>GC/MS total ion chromatograms of the headspace from the Zobell media control (<b>a</b>), TW7 control (<b>b</b>), <span class="html-italic">D. teriolecta</span> control (<b>c</b>), and TW7 + <span class="html-italic">D. teriolecta</span> (<b>d</b>) culture flasks collected using an air-tight syringe.</p>
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<p>(<b>a</b>) Temporal plot of selected ion chromatograms (<span class="html-italic">m</span>/<span class="html-italic">z</span> 137.059) from sea spray aerosols collected via impinger. (<b>b</b>) Annotated positive-ion mode ESI-MS/MS spectrum of <span class="html-italic">m</span>/<span class="html-italic">z</span> 137.059 (RT 4.4 min), which corresponds to phenylacetic acid.</p>
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<p>Schematic of the ocean-mimicking wave-breaking channel used during IMPACTS as it relates to SPME sampling of SSA (panel 2, over breaking wave) and gas-phase molecules (panel 1, prior to wave. The arrow represents where the air enters to be scrubbed. Aerosols are generated at 15 m formed by breaking waves; and panel 2). The wave channel is located in the Ocean-Atmosphere Facility within the Hydraulics Laboratory at Scripps Institution of Oceanography (SIO) in La Jolla, CA, USA.</p>
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18 pages, 1854 KiB  
Article
Do Environmental Tax and Energy Matter for Environmental Degradation in the UK? Evidence from Novel Fourier-Based Estimators
by Kwaku Addai, Souha Hanna Al Geitany, Seyed Alireza Athari, Panteha Farmanesh, Dervis Kirikkaleli and Chafic Saliba
Energies 2024, 17(22), 5732; https://doi.org/10.3390/en17225732 - 15 Nov 2024
Viewed by 644
Abstract
Currently, the UK has ambitious plans to reach net zero by 2050, despite other countries such as Russia and India targeting 2060 and 2070, respectively. Assuming that the UK emissions unceasingly decline at a given rate annually towards achieving net zero by 2050, [...] Read more.
Currently, the UK has ambitious plans to reach net zero by 2050, despite other countries such as Russia and India targeting 2060 and 2070, respectively. Assuming that the UK emissions unceasingly decline at a given rate annually towards achieving net zero by 2050, its economy would need to ensure a reduction of 105 MtCO2 per year of its emissions from the current 2021 levels. Given that global greenhouse gas emissions have not peaked and continue to rise, the UK seeks to implement costly and aggressive emission reduction policies towards fulfilling commitments under the 2021 Glasgow Climate Pact. This paper investigates the effect of environmental taxes on environmental degradation in the UK between 2000Q1 and 2019Q4 using novel Fourier approaches. Using the novel Fourier ARDL estimator, the long-run equilibrium estimates indicate that gross domestic product and environmental tax cause a fall in carbon emissions. However, in trade and primary energy use, a unit change caused rising carbon emissions in the UK. Especially, the results indicate that environmental taxes have a negative effect on environmental degradation in the UK, and ecological tax policy could be considered as an effective channel to attain environmental sustainability. The outcome provides the following policy insights: (i) The government of the UK should support international environmental tax coordination mechanisms, especially on carbon pricing, to avoid relocation of carbon-intensive investments. (ii) The UK government must note that imposing more taxes to encourage emissions reductions could bring complexity to the tax system and unnecessarily bring costly ways to deal with climate change. Higher domestic electricity prices could disproportionately hit low-income households and create distributional cost concerns, which require benefit payouts or compensation schemes. (iii) Switching to electric vehicles simultaneously requires investments in charging infrastructure and battery technologies. To avoid this chicken-and-egg problem, the government of the UK could play a coordinating role, including deploying targeted subsidies, regulations, direct government involvement, or setting higher carbon prices in special cases. Full article
(This article belongs to the Special Issue Energy Economics, Finance and Policy Towards Sustainable Energy)
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<p>Social effects of environmental taxes under the Pigouvian framework (source: [<a href="#B4-energies-17-05732" class="html-bibr">4</a>]).</p>
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<p>Tax types in the UK (source: [<a href="#B16-energies-17-05732" class="html-bibr">16</a>]).</p>
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<p>Analysis flowchart.</p>
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<p>Model stability using the cumulative stability test (CUSUM and CUSUM of squares estimators).</p>
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<p>Summary of empirical findings with methods.</p>
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8 pages, 1762 KiB  
Communication
High Expression of GABAA Receptor β Subunit Genes Is Associated with Longer Overall Survival in Medulloblastoma
by Jander M. Monteiro, Matheus Dalmolin, Marcelo A. C. Fernandes, Jaqueline I. R. Ramos, Carmen A. P. M. Ribas, Fernando I. Tabushi, Rafael Roesler and Gustavo R. Isolan
Brain Sci. 2024, 14(11), 1146; https://doi.org/10.3390/brainsci14111146 - 15 Nov 2024
Viewed by 450
Abstract
Background/Objectives: Most of the rapid inhibitory neurotransmission in the brain is mediated through activation of the γ-aminobutyric acid (GABA) type A (GABAA) receptor, which is a ligand-gated ion channel. GABAA receptor activation via GABA binding allows for an intracellular influx [...] Read more.
Background/Objectives: Most of the rapid inhibitory neurotransmission in the brain is mediated through activation of the γ-aminobutyric acid (GABA) type A (GABAA) receptor, which is a ligand-gated ion channel. GABAA receptor activation via GABA binding allows for an intracellular influx of Cl ions, thus inducing cellular hyperpolarization. Each GABAA receptor consists of a combination of five subunits, and several subunits have been proposed as biomarkers and therapeutic targets in cancer. Here, we show the expression of genes encoding β subunits of the GABAA receptor, namely GABRB1, GABRB2, and GABRB3, across the four different molecular subgroups of medulloblastoma (MB), which is the most common malignant pediatric brain tumor. We also show the associations of GABAA receptor β subunits with MB patients’ overall survival (OS). Methods: The expression of genes encoding GABAA receptor β subunits was analyzed using a previously described dataset comprising 763 MB tumor samples. Patients were classified into high- and low-gene-expression groups, and the Kaplan–Meier estimate was used to examine the relationship between gene expression levels and patient OS. Results: High GABRB1 expression was associated with better OS within each of the four molecular subgroups. The GABRB2 gene showed higher transcript levels in Group 3 MB compared to all other subgroups, and high expression was associated with better prognosis in Group 3 tumors. GABRB3 expression was significantly higher in Group 3 and Group 4 MB, and high expression of GABRB3 genes was associated with longer OS in the sonic hedgehog (SHH) subgroup. The high expression of GABRB1, GABRB2, and GABRB3 is associated with longer patient OS in a subgroup-specific manner. Conclusions: These results indicate a role for GABAA receptors containing β subunits in influencing MB progression. Full article
(This article belongs to the Special Issue Molecular and Cellular Biology of Brain Tumors and Neuro-Oncology)
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<p>Gene expression of <span class="html-italic">GABRB1</span>, the gene encoding the β1 subunit of the GABA<sub>A</sub> receptor, in different molecular subgroups of human MB. Tumors from the dataset described by Cavalli et al. [<a href="#B17-brainsci-14-01146" class="html-bibr">17</a>]. Results are presented in boxplot format as log2-transformed signal intensity. Bars show data for Group 3 (<span class="html-italic">n</span> = 113), Group 4 (<span class="html-italic">n</span> = 264), SHH (<span class="html-italic">n</span> = 172), and WNT (<span class="html-italic">n</span> = 63) MB; <span class="html-italic">p</span> values are indicated in this figure.</p>
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<p>Gene expression of the <span class="html-italic">GABRB1</span> β GABA<sub>A</sub> receptor subunit is associated with better prognosis in patients with MB. (<b>A</b>) OS analysis of patients with Group 3 MB tumors (<span class="html-italic">n</span> = 113), comparing high (<span class="html-italic">n</span> = 40) and low (<span class="html-italic">n</span> = 73) <span class="html-italic">GABRB1</span> expression. (<b>B</b>) OS analysis of patients with Group 4 MB tumors (<span class="html-italic">n</span> = 264), comparing high (<span class="html-italic">n</span> = 182) and low (<span class="html-italic">n</span> = 82) expression of <span class="html-italic">GABRB1</span>. (<b>C</b>) OS analysis of patients with SHH MB tumors (<span class="html-italic">n</span> = 172), comparing high (<span class="html-italic">n</span> = 136) and low (<span class="html-italic">n</span> = 36) <span class="html-italic">GABRB1</span> expression. (<b>D</b>) OS analysis of patients with WNT MB tumors (<span class="html-italic">n</span> = 63), comparing high (<span class="html-italic">n</span> = 49) and low (<span class="html-italic">n</span> = 14) <span class="html-italic">GABRB1</span> expression. In all plots, red lines represent patients with high <span class="html-italic">GABRB1</span> expression, and blue lines represent patients with low expression. The number of patients at risk at each time point is shown below each plot. Data show analyses of MB tumors in the dataset described by Cavalli et al. [<a href="#B17-brainsci-14-01146" class="html-bibr">17</a>]; <span class="html-italic">p</span> values are indicated in this figure.</p>
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<p>Gene expression of the <span class="html-italic">GABRB2</span> and <span class="html-italic">GABRB3</span> β GABA<sub>A</sub> receptor subunits is associated with better prognosis in specific molecular subgroups of MB. (<b>A</b>) <span class="html-italic">GABRB2</span> expression in molecular subgroups of MB, including Group 3 (<span class="html-italic">n</span> = 113), Group 4 (<span class="html-italic">n</span> = 264), SHH (<span class="html-italic">n</span> = 172), and WNT (<span class="html-italic">n</span> = 63) tumors, shown as violin plots. (<b>B</b>) OS analysis of patients with Group 3 MB tumors, comparing high (<span class="html-italic">n</span> = 24) and low (<span class="html-italic">n</span> = 89) <span class="html-italic">GABRB2</span> expression. (<b>C</b>) <span class="html-italic">GABRB3</span> expression in molecular subgroups of MB, shown as violin plots. (<b>D</b>) OS analysis of patients with SHH MB tumors, comparing high (<span class="html-italic">n</span> = 138) and low (<span class="html-italic">n</span> = 34) <span class="html-italic">GABRB3</span> expression. In the Kaplan–Meier plots (<b>B</b>,<b>D</b>), red lines represent patients with high <span class="html-italic">GABRB</span> expression, and blue lines represent those with low expression. The number of patients at risk at each time point is shown below each plot; <span class="html-italic">p</span> values are indicated in this figure.</p>
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23 pages, 1075 KiB  
Article
Does Institutional Quality Enhance the Effect of Health Outcomes on Economic Growth? Insights from Sub-Saharan African Countries
by Hafte Gebreselassie Gebrihet, Yibrah Hagos Gebresilassie and Gabriel Temesgen Woldu
Economies 2024, 12(11), 308; https://doi.org/10.3390/economies12110308 - 14 Nov 2024
Viewed by 834
Abstract
Institutional quality (InQ) plays an important role in shaping economic growth (ECG), influencing how economies develop and perform. The literature addresses the nexus between InQ and ECG and the link between health and ECG; findings are often contradictory, creating knowledge gaps. Importantly, research [...] Read more.
Institutional quality (InQ) plays an important role in shaping economic growth (ECG), influencing how economies develop and perform. The literature addresses the nexus between InQ and ECG and the link between health and ECG; findings are often contradictory, creating knowledge gaps. Importantly, research on the interplay between InQ, health, and ECG in Sub-Saharan African (SSA) countries is particularly limited. This study aims to address this gap by evaluating how health impacts ECG, with an emphasis on the mediating role of InQ in the health–growth nexus in SSA. This study examines these interplays across 35 SSA countries from 2012 to 2022. The life expectancy at birth (LEX) and real gross domestic product per capita (GDP) are used as proxies for health outcomes and ECG, respectively. The system generalised method of moments estimator is employed to analyse data. Results show that the LEX has a strong positive effect on economic growth in SSA countries. Furthermore, the InQ indicators (such as control of corruption, government effectiveness, rule of law and political stability, and absence of violence) are positively correlated with ECG. When the LEX interacts with InQ indicators, InQ is identified as a key channel through which LEX influences ECG. The findings confirm that InQ plays a crucial role in the health–growth nexus, with the positive impact of LEX on ECG being more pronounced in countries with higher levels of InQ, while the effect is weaker in countries with lower levels of InQ. The findings of this study have crucial policy implications, highlighting the intricate link among institutional quality, health outcomes, and economic growth. This study’s findings provide essential insights for policymakers to design focused strategies that improve InQ and health outcomes to achieve sustained ECG in SSA. Full article
(This article belongs to the Special Issue Studies on Factors Affecting Economic Growth)
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<p>Health outcome measured as life expectancy (total), 2012–2022. Source: Authors’ computation from WDI data source (2012–2022).</p>
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<p>Conceptual framework of the study. Source: Adopted from <a href="#B11-economies-12-00308" class="html-bibr">Azimi and Rahman</a> (<a href="#B11-economies-12-00308" class="html-bibr">2024</a>) with slight modification.</p>
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<p>Steps used to select a regression model. Source: Authors’ compilation from reviewed empirical literature.</p>
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24 pages, 7272 KiB  
Article
Comprehensive Analysis of BDS/GNSS Differential Code Bias and Compatibility Performance
by Yafeng Wang, Dongjie Yue, Hu Wang, Hongyang Ma, Zhiqiang Liu and Caiya Yue
Remote Sens. 2024, 16(22), 4217; https://doi.org/10.3390/rs16224217 - 12 Nov 2024
Viewed by 606
Abstract
High-precision DCBs are essential for effective multi-frequency and multi-constellation GNSS integration, especially in processing compatible signal observations. This study utilizes data from MGEX, iGMAS, and CORS stations to estimate and analyze long time series of BDS/GNSS DCBs, focusing on stability and influencing factors. [...] Read more.
High-precision DCBs are essential for effective multi-frequency and multi-constellation GNSS integration, especially in processing compatible signal observations. This study utilizes data from MGEX, iGMAS, and CORS stations to estimate and analyze long time series of BDS/GNSS DCBs, focusing on stability and influencing factors. Results indicate that DCBs for the same signal, but different channels exhibit similar ranges and trends. Among BDS DCBs, those from satellites with rubidium atomic clocks are more stable than those with hydrogen atomic clocks. An upgrade and maintenance of BDS in late 2022, reported by NABU, likely contributed to DCB jumps. BDS-compatible signal DCBs show weaker stability compared to GPS and Galileo. Variations in GNSS signal processing and receiver algorithms also impact DCB stability. Converting DCBs to OSBs and performing RMS statistics revealed that smaller differences between signals increase the susceptibility of observation equations to observation quality. Full article
(This article belongs to the Topic GNSS Measurement Technique in Aerial Navigation)
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<p>Distribution of multi-frequency and multi-system measurement stations (GPS: red, GLONASS: green, Galileo: purple, BDS: yellow).</p>
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<p>BDS DCB time series between B1I signal and B2I, B3I, B1C, B2a, B2b, and B2 (a + b) signals from January 2021 to August 2023 for BDS.</p>
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<p>BDS DCB time series between B1I signal and B2I, B3I, B1C, B2a, B2b, and B2 (a + b) signals from January 2021 to August 2023 for BDS.</p>
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<p>The overall stability of BDS B1I signal and B2I, B3I, B1C, B2a, B2b, and B2 (a + b) signals.</p>
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<p>Time series of GPS/Galileo/BDS in January 2021 to August 2023, where (<b>a</b>) GPS DCB; (<b>b</b>) Galileo DCB; (<b>c</b>) BDS DCB.</p>
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<p>GPS/Galileo/BDS DCB mean STD in January 2021 to August 2023.</p>
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<p>BDS C1P–C5P receiver DCB time series.</p>
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<p>BDS C1X–C5X receiver DCB time series.</p>
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<p>GAL C1C–C5Q receiver DCB time series.</p>
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<p>GAL C1X–C5X receiver DCB time series.</p>
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<p>GPS C1C–C5Q receiver DCB time series.</p>
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<p>GPS C1W–C5X receiver DCB time series.</p>
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<p>Comparison results of BDS DCB mean bias and STD.</p>
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<p>Comparison results of GPS and Galileo DCB mean bias and STD.</p>
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<p>Mean RMS of BDS OSB.</p>
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18 pages, 3061 KiB  
Article
Event-Triggered Transmission of Sensor Measurements Using Twin Hybrid Filters for Renewable Energy Resource Management Systems
by Soonwoo Lee, Hui-Myoung Oh and Jung Min Pak
Energies 2024, 17(22), 5651; https://doi.org/10.3390/en17225651 - 12 Nov 2024
Viewed by 420
Abstract
Recently, solar and wind power generation have gained attention as pathways to achieving carbon neutrality, and Renewable Energy Resource Management System (RERMS) technology has been developed to monitor and control small-scale, distributed renewable energy resources. In this work, we present an Event-Triggered Transmission [...] Read more.
Recently, solar and wind power generation have gained attention as pathways to achieving carbon neutrality, and Renewable Energy Resource Management System (RERMS) technology has been developed to monitor and control small-scale, distributed renewable energy resources. In this work, we present an Event-Triggered Transmission (ETT) algorithm for RERMS, which transmits sensor measurements to the base station only when necessary. The ETT algorithm helps prevent congestion in the communication channel between RERMS and the base station, avoiding time delays or packet loss caused by the excessive transmission of sensor measurements. We design a hybrid state estimation algorithm that combines Kalman and Finite Impulse Response (FIR) filters to enhance the estimation performance, and we propose a new ETT algorithm based on this design. We evaluate the performance of the proposed algorithm through experiments that transmit actual sensor measurements from a photovoltaic power generation system to the base station, demonstrating that it outperforms existing algorithms. Full article
(This article belongs to the Special Issue Renewable Energy Management System and Power Electronic Converters)
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<p>Structure of the ETT mechanism using twin filters.</p>
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<p>Photovoltaic and monitoring system used for experiments: (<b>a</b>) dual-axis rotation photovoltaic panel; (<b>b</b>) data transmission device; and (<b>c</b>) display of monitoring software.</p>
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<p>True, measured, and estimated values of active power for a 24 h (1440 min) period.</p>
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<p>Transmission timing of ETT algorithms for active power measurements.</p>
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<p>RMSEs of ETT algorithms for active power measurements.</p>
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<p>True, measured, and estimated values of phase voltage for a 24 h (1440 min) period.</p>
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<p>Transmission timing of ETT algorithms for phase voltage measurements.</p>
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<p>RMSEs of the ETT algorithms for phase voltage measurements.</p>
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<p>Scores of ETT algorithms.</p>
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