Search Results (446)

In this work, the TiAl4822/Ti6Al4V metal–intermetallic laminate (MIL) composite was fabricated using vacuum hot pressing (VHP). The interfacial morphologies and mechanical properties of the composites were investigated. No discernible defect was observed in the well-bonded interface region. This interface region comprised two distinct areas: the Ti₂Al (6 $\mathsf{\mu }\mathrm{m}$) region near the TiAl layer and the Ti₃Al (4 $\mathsf{\mu }\mathrm{m}$) region near the Ti6Al4V layer. Electron backscatter diffraction analysis revealed that dynamic recrystallization (DRX) took place at the interface during the hot pressing process. The ductile brittle nature of Ti6Al4V and TiAl4822 layers and the formation of fine grains within the interface are conducive to enhancing toughness and tensile strength. Room temperature tensile testing exhibited that the tensile strength of TiAl4822/Ti6Al4V MIL composite was 636.9 MPa, approximately 225 MPa higher than single TiAl4822 alloy. The Ti6Al4V layer, as well as the formation of fine grain interface, effectively inhibited further propagation of the main crack through crack passivation, crack deflection, and load transformation. The bending strength of the TiAl4822/Ti6Al4V MIL composite was 1114.1 MPa. The fracture toughness of the TiAl4822/Ti6Al4V MIL composite reached 33.15 MPam^1/2, which increased by 78.2% compared with single TiAl4822 alloy. Full article

Background/Objectives: Over the past 25 years, numerous biological molecules, like recombinant lysosomal enzymes, neurotrophins, receptors, and therapeutic antibodies, have been tested in clinical trials for neurological diseases. However, achieving significant success in clinical applications has remained elusive. A primary challenge has been the inability of these molecules to traverse the blood–brain barrier (BBB). Recognizing this hurdle, our study aimed to utilize niosomes as delivery vehicles, leveraging the “molecular Trojan horse” technology, to enhance the transport of molecules across the BBB. Methods: Previously synthesized memantine derivatives (MP1–4) were encapsulated into niosomes for improved BBB permeability, hypothesizing that this approach could minimize peripheral drug toxicity while ensuring targeted brain delivery. Using the human neuroblastoma (SH-SY5Y) cell line differentiated into neuron-like structures with retinoic acid and then exposed to amyloid beta 1–42 peptide, we established an in vitro Alzheimer’s disease (AD) model. In this model, the potential usability of MP1–4 was assessed through viability tests (MTT) and toxicological response analysis. The niosomes’ particle size and morphological structures were characterized using scanning electron microscopy (SEM), with their loading and release capacities determined via UV spectroscopy. Crucially, the ability of the niosomes to cross the BBB and their potential anti-Alzheimer efficacy were analyzed in an in vitro transwell system with endothelial cells. Results: The niosomal formulations demonstrated effective drug encapsulation (encapsulation efficiency: 85.3% ± 2.7%), controlled release (72 h release: 38.5% ± 1.2%), and stable morphology (PDI: 0.22 ± 0.03, zeta potential: −31.4 ± 1.5 mV). Among the derivatives, MP1, MP2, and MP4 exhibited significant neuroprotective effects, enhancing cell viability by approximately 40% (p < 0.05) in the presence of Aβ1-42 at a concentration of 47 µg/mL. The niosomal delivery system improved BBB permeability by 2.5-fold compared to free drug derivatives, as confirmed using an in vitro bEnd.3 cell model. Conclusions: Memantine-loaded niosomes provide a promising platform for overcoming BBB limitations and enhancing the therapeutic efficacy of Alzheimer’s disease treatments. This study highlights the potential of nanotechnology-based delivery systems in developing targeted therapies for neurodegenerative diseases. Further in vivo studies are warranted to validate these findings and explore clinical applications. Full article

Silicon-based Hall application-specific integrated circuit (ASIC) chips have become very successful, making them ideal for flexible electronic and sensor devices. In this study, we designed, simulated, and tested flexible hybrid integration angle sensors that can be made using complementary metal-oxide-semiconductor (CMOS) technology. These sensors are manufactured on a 100 µm-thick flexible polyimide (PI) membrane, which is suitable for large-scale production and has strong potential for industrial use. The Hall sensors have a sensitivity of 0.205 V/mT. Importantly, their sensitivity remains stable even after being bent to a minimum radius of 10 mm and after undergoing 100 bending cycles. The experiment shows that these flexible hybrid integration devices are promising as angle sensors. Full article

In order to solve the problems of high production cost and complex control of the inverted arch of an unsupported prestressed concrete composite slab, a flange truss high-ductility concrete composite slab floor is proposed to change the structure and pouring material to meet the requirements of no support during construction. The crack distribution and bending performance of the flange truss high-ductile concrete composite slab floor (CRHDCS) under different structures are clarified through the test and numerical analysis of four different rib plate structure floors. According to the analysis results, the calculation formulas of the cracking moment and short-term stiffness before cracking are modified, and the equivalent short-term stiffness formula of a single web member of the “V” truss to this kind of bottom plate is established. The results show that, unlike the short-term stiffness-change law of typical concrete composite slabs after cracking, the short-term stiffness of the designed bottom plate in this paper includes a short-term increase stage. The numerical simulation results are the same as the experimental ones; the maximum error is 10%. The maximum errors between the modified cracking moment and the short-term stiffness calculation formula are 6% and 8%, respectively. The influence rates of removing flange plate, truss-inverted binding, and adding rib plate on the cracking bending moment of foundation structure are −81.5%, 11.0%, and 22.2% respectively, and the influence rates on short-term stiffness are −87.6%, −1.5%, and 37.5% respectively. Full article

The longevity of railway vehicles is an important factor in their mechanical and structural design. Fatigue is a major issue that affects the durability of railway components, and therefore, knowledge of the fatigue resistance characteristics of critical components, such as the leaf springs, must be extensively investigated. This research covers the fatigue resistance of chromium–vanadium alloy steel, usually designated as 51CrV4, from the high-cycle regime (HCF) (${10}^3$–${10}^4$) up to very high-cycle fatigue (VHCF) (${10}^9$) under the bending loading conditions typical of leaf springs and under uniaxial tension/compression loading, respectively, for a stress ratio, $R_{\sigma }$, of −1. Different test frequencies were considered (23, 150, and 20,000 Hz) despite the material not exhibiting a relatively significant frequency effect. In order to create a new fatigue prediction model, two prediction models, the Basquin SN linear regression model and the Castillo–Fernandez–Cantelli (CFC) model, were evaluated. According to the analysis carried out, the CFC model provided a better prediction of the fatigue failures than the SN model, especially when outlier failure data were considered. The investigation also examined the failure modes, observing multiple cracks for higher loads and single cracks that initiated on the surface or from internal inclusions at lower loading. The present investigation aims to provide a fatigue resistance prediction model encompassing the HCF and VHCF regions for the fatigue design of railway wagon leaf springs, or even for other components made of 51CrV4 with a tempered martensitic microstructure. Full article

In the V-bending of sheet metals using a pair of plastic punch and die manufactured by a 3D printer, the effects of two different dimensions designed with the same tool geometry on the deformation behaviors of the punch, die, and sheet were evaluated. The deformation behavior and strain distribution of the punch, die, and sheet were analyzed using a digital image correlation method. Sheets from pure aluminum to ultra-high-strength steel were bent using the two tools with different spans; one was designed on the assumption of tool steel material, and the other was designed on the assumption of plastic material. In both tools, the large compressive strain appeared around the center of the punch tip and on the corners of the die. The tools with a long span for the plastic material gave a lower bending force and small deformation of the plastic tools. The angle difference between a bent sheet at the bottom dead center and a tool was smaller for the tools with the long span, although the springback in the bent sheet appeared. It was found that the design method on the assumption of the plastic material is effective for the V-bending plastic tools. Full article

Chemiresistive ammonia gas sensors with a low limit of detection of 0.15 ppm and moisture-independent characteristics based on p-type copper iodide (CuI) semiconductor films have been developed. CuI films were deposited on glass and polyethylene terephthalate (PET) substrates using a Successive Ionic Layer Adsorption and Reaction method to fabricate CuI/glass and CuI/PET gas sensors, respectively. They have a nanoscale morphology, an excess iodine and sulfur impurity content, a zinc blende γ-CuI crystal structure with a grain size of ~34 nm and an optical band gap of about 2.95 eV. The high selective sensitivity of both sensors to NH₃ is explained by the formation of the [Cu(NH₃)₂]⁺ complex. At 5 °C, the responses to 3 ppm ammonia in air in terms of the relative resistance change were 24.5 for the CuI/glass gas sensor and 28 for the CuI/PET gas sensor, with short response times of 50 s to 210 s and recovery times of 10–70 s. The sensors have a fast response–recovery and their performance was well maintained after long-term stability testing for 45 days. After 1000 repeated bends of the flexible CuI/PET gas sensor in different directions, with bending angles up to 180° and curvature radii up to 0.25 cm, the response changes were only 3%. Full article

This study investigates the impact of printing layer orientation on the mechanical properties of 3D-printed temporary prosthetic materials. Traditionally, temporary prostheses are fabricated using acrylic resin (polymethyl methacrylate), but advancements have introduced bis-acrylic resins, CAD/CAM-based acrylic resin (milled), and 3D printing technologies. In 3D printing, material is manufactured in overlapping layers, which can be oriented in different directions, directly affecting the material’s resistance. Specimens were designed as bars (2 mm × 2 mm × 25 mm) and grouped according to their printing orientation: BP0 (0 degrees), BP45 (45 degrees), and BP90 (90 degrees). The models were created using Fusion 360 software (version 2.0.12600) and printed on a 3D DLP printer with DLP Slicer software (Chitu DLP Slicer, CBD Tech, version v1.9.0). The bars were then subjected to 3-point bending tests using an Instron Universal Testing Machine to measure Flexural Strength (FS) and Flexural Modulus (FM). Results demonstrated that the BP90 group exhibited the highest Flexural Strength (114.71 ± 7.61 MPa), followed by BP45 (90.10 ± 8.45 MPa) and BP0 (80.90 ± 4.01 MPa). Flexural Modulus was also highest in the BP90 group (3.74 ± 3.64 GPa), followed by BP45 (2.85 ± 2.70 GPa) and BP0 (2.52 ± 2.44 GPa). Significant statistical differences (p < 0.05) were observed, indicating changes in the mechanical properties of the 3D-printed material. The study concludes that printing orientation significantly influences the mechanical properties of temporary prosthetic materials, making the selection of an optimal orientation essential to enhance material performance for its intended application. Full article

Dielectric elastomer actuators (DEAs) are difficult to apply to flexible grippers due to their small deformation range and low output force. Hence, a DEA with a large bending deformation range and output force was designed, and a corresponding flexible gripper was developed to realize the function of grasping objects of different shapes. The relationship between the pre-stretch ratio and DEA deformation degree was tested by experiments. Based on the performance test results of the dielectric elastomer (DE), the bending deformation process of DEAs with different shapes was simulated by Finite Element Method (FEM) simulation. DEAs with different shapes were prepared through laser cutting and the relationship between the voltage and the bending angle, and the output force of the DEAs was measured. The result shows that under uniaxial stretching, the deformation of the DEA in the stretching direction gradually increases and decreases in the unstretched direction with the increase in the pre-stretch ratio. Under biaxial stretching, DEA deformation increases with the increase in the pre-stretch ratio. The shape of the DEA has a certain influence on the bending deformation range under the same conditions, and the elliptical DEA has a larger bending deformation range and higher output force compared with the rectangular DEA and the trapezium DEA. The elliptical DEA can produce a bending deformation of 40° and an output force of 37.2 mN at a voltage of 24 kV. The three-finger flexible gripper composed of an elliptical DEA can realize the grasping of a paper cup. Full article

With the ever-growing demand for high-speed optical communications, microwave photonics, and quantum key distribution systems, compact electro-optic (EO) modulators with high extinction ratios, large bandwidth, and high tuning efficiency are urgently pursued. However, most integrated lithium–niobate (LN) modulators cannot achieve these high performances simultaneously. In this paper, we propose an improved theoretical model of a chip-scale electro-optic (EO) microring modulator (EO-MRM) based on X-cut lithium–niobate-on-insulator (LNOI) with a hybrid architecture consisting of a 180-degree Euler bend in the coupling region, double-layer metal electrode structure, and ground–signal–signal–ground (G-S-S-G) electrode configuration, which can realize highly comprehensive performance and a compact footprint. After parameter optimization, the designed EO-MRM exhibited an extinction ratio of 38 dB. Compared to the structure without Euler bends, the increase was 35 dB. It also had a modulation bandwidth of 29 GHz and a tunability of 8.24 pm/V when the straight waveguide length was 100 μm. At the same time, the proposed device footprint was 1.92 × 10⁴ μm². The proposed MRM model provides an efficient solution to high-speed optical communication systems and microwave photonics, which is helpful for the fabrication of high-performance and multifunctional photonic integrated devices. Full article

The Diamond lattice cylindrical shell (Diamond LCS) was proposed by a mapping approach based on the triply periodic minimal surfaces (TPMS). The finite element models were built and their accuracy was verified by experimental results. Parameter studies were carried out to investigate the effect of geometric and loading parameters on the bending properties of the Diamond LCSs by the finite element model. The results show that Diamond LCS has a stable “V” deformation pattern under a three-point bending load. In the range of relative density (RD) = 15–30%, the higher the RD, the better the lateral bending performance of the Diamond LCS structure. The larger the variation radial coefficient, the higher the lateral load-carrying capacity of the structure. The smaller the loading angle of the punch, the better the lateral bending performance of the Diamond LCS structure. However, if the loading angle is too small, the structure is prone to large torsional deformation, and the deformation tends to destabilize. The increase in punch diameter effectively improves the deformation pattern and bending energy absorption characteristics of the structure. The smaller the span of the cylindrical support, the better the bending energy absorption characteristics of the structure. Full article

This study investigated the low contact resistivity and Schottky barrier characteristics in p-GaN by modifying the thickness and doping levels of a p-InGaN cap layer. A comparative analysis with highly doped p-InGaN revealed the key mechanisms contributing to low-resistance contacts. Atomic force microscopy inspections showed that the surface roughness depends on the doping levels and cap layer thickness, with higher doping improving the surface quality. Notably, increasing the doping concentration in the p⁺⁺-InGaN cap layer significantly reduced the specific contact resistivity to 6.4 ± 0.8 × 10⁻⁶ Ω·cm², primarily through enhanced tunneling. Current–voltage (I–V) characteristics indicated that the cap layer’s surface properties and strain-induced polarization effects influenced the Schottky barrier height and reverse current. The reduction in barrier height by approximately 0.42 eV in the p⁺⁺-InGaN layer enhanced hole tunneling, further lowering the contact resistivity. Additionally, polarization-induced free charges at the metal–semiconductor interface reduced band bending, thereby enhancing carrier transport. A transition in current conduction mechanisms was also observed, shifting from recombination tunneling to space-charge-limited conduction across different voltage ranges. This research underscores the importance of doping, cap layer thickness, and polarization effects in achieving ultra-low contact resistivity, offering valuable insights for improving the performance of p-GaN-based power devices. Full article

The increasing demand for advanced transparent and flexible display technologies has led to significant research in thin-film transistors (TFTs) with high mobility, transparency, and mechanical robustness. In this study, we fabricated all-transparent TFTs (AT-TFTs) utilizing amorphous indium-zinc-tin-oxide (a-IZTO) as a dual-functional material for both the channel layer and transparent conductive electrodes (TCEs). The a-IZTO was deposited using radio-frequency magnetron sputtering, with its composition adjusted for both channel and electrode functionality. XRD analysis confirmed the amorphous nature of the a-IZTO layers, ensuring structural stability post-thermal annealing. The a-IZTO TCEs demonstrated high optical transparency (89.57% in the visible range) and excellent flexibility, maintaining a low sheet resistance with minimal degradation even after 100,000 bending cycles. The fabricated AT-TFTs exhibit superior field-effect mobility (30.12 cm²/V·s), an on/off current ratio exceeding 10⁸, and a subthreshold swing of 0.36 V/dec. The AT-TFT device demonstrated a minimum transmittance of 75.46% in the visible light range, confirming its suitability for next-generation flexible and transparent displays. Full article

To investigate the impact of airfoil angle of attack on the output performance of a valveless piezoelectric pump with airfoil baffles, this study conducted comprehensive performance tests and full-flow field simulations of piezoelectric pumps across a range of angles. At a driving voltage of 100 V and with a Clark Y airfoil set at an angle of 0°, the piezoelectric pump reached a peak output flow rate of 200.7 mL/min. An increase in the angle of attack corresponded to a decline in both the maximum output flow rate and the maximum back pressure of the pump. Flow field simulation results demonstrated that an increased airfoil angle of attack led to a gradual increase in entropy production within the piezoelectric pump. Turbulent dissipation and wall entropy production were found to be more pronounced compared to viscous entropy production. High turbulent dissipation was primarily observed at the pump chamber inlet, the trailing edges of the airfoils in both the inlet and outlet pipes, and the outlet bend. As the angle of attack increased, the complexity of the vortex core structures within the flow field escalated as well. Regions with significant wall entropy production were notably concentrated at the outlet bend. Full article

In this research, as-built Ti–6Al–4V anatomical plates were successfully fabricated using laser powder bed fusion (LPBF). This study thoroughly examines the microstructural evolution and its role in enhancing the mechanical properties of clavicle bone plates under sub-β-transus heat treatment for medical application. Scanning electron microscope (SEM) images of the as-built specimens reveal a dense formation of a hard α’ hcp martensite structure, which decomposes during annealing at 650 °C and ultimately transforms into an α + β lamellar structure at 950 °C. Additionally, coarse grains resulting from recrystallization and reduced dislocation density were observed through electron backscatter diffraction (EBSD) following heat treatment. Due to these microstructural evolutions, the desired mechanical properties of as-built Ti64 parts for surgical applications were achieved. Heat treatment of the anatomical plates at 950 °C demonstrated an excellent strength–ductility synergy under tensile deformation and the highest energy absorption capability under bending deformation, indicating sufficient durability for medical implantation applications. Full article