Search Results (2,787)

Ulcerative colitis (UC) is a chronic inflammatory disease of the colon that is associated with dysbiosis in the gut microbiota. Eisenia bicyclis, a marine alga, is known for its anti-inflammatory, antioxidant, and gut microbiota-modulating properties. This study explored the mechanisms by which a 70% ethanol extract of E. bicyclis may alleviate UC, through both in vitro and in vivo experiments. LC-MS/MS analysis revealed eckol, 7-phloroeckol, dieckol, phlorofucofuroeckol A, and fucofuroeckol as key phenolic compounds present in the extract. The administration of E. bicyclis significantly improved symptoms in a dextran sulfate sodium (DSS)-induced colitis mouse model by reducing intestinal shortening, splenomegaly, and histological scores. Both cell and animal studies demonstrated that E. bicyclis suppressed the release of inflammatory cytokines, downregulated the mRNA expression of genes related to the mTOR pathway, and reduced the p-mTOR/mTOR ratio. Microbiota analysis revealed that, while the Firmicutes/Bacteroidetes ratio was elevated in UC mice, E. bicyclis administration normalized this imbalance, with a notable increase in the abundance of beneficial probiotics such as Bifidobacterium bifidum. In conclusion, a phenolic-rich extract of E. bicyclis demonstrates significant potential as a dietary supplement to prevent and mitigate UC by modulating both the mTOR signaling pathway and gut microbiota composition. Full article

This study investigates the strength development of cement-stabilized marine clay, which is influenced by a complex interplay of microstructural factors. To optimize its performance for coastal and offshore engineering, we explored the relationship between microstructure and unconfined compressive strength (UCS). Using Scanning Electron Microscopy (SEM) and the Pore/Crack Analysis System (PCAS), we analyzed samples with varying cement contents (10%, 15%, and 20%) and curing times (3, 7, 14, and 28 days). Key microstructural parameters, including porosity, particle shape, size, and arrangement, were quantified and correlated with UCS results. A novel comprehensive micro-parameter was introduced to encapsulate the combined effects of these factors, revealing an exponential relationship with strength development. The findings provide a quantitative framework for predicting the performance of cement-stabilized marine clay, contributing to more efficient solutions in geotechnical engineering. Full article

This study investigates the potential of graphene-based additives to improve the mechanical properties of compacted soil mixtures in rammed-earth construction, contributing to the development of environmentally friendly building materials. Two distinct soils were selected, combined with sand at optimized ratios, and treated with varying concentrations of a graphene liquid solution and a graphene-based paste (0.001, 0.005, 0.01, 0.05, and 0.1 wt.% relative to the soil-sand proportion). The effects of these additives were analyzed using the modified Proctor compaction and unconfined compressive strength (UCS) tests, focusing on parameters such as optimum water content (OWC), maximum dry density (MDD), maximum strength (q_u), and stiffness modulus (E). The results demonstrated that graphene’s influence on compaction behavior and mechanical performance depends strongly on the soil composition, with minimal variation between additive types. In finer soil mixtures, graphene disrupted particle packing, increased water demand, and reduced strength. In silt–sandy mixtures, graphene’s hydrophobicity and limited interaction with fines decreased water absorption and preserved density but likewise led to diminished strength. Conclusions from the experiments suggest a possible interaction between graphene, soil’s finer fraction, and potentially the swelling and non-swelling clay minerals, providing insights into the complex interplay between soil properties. Full article

Background/Objectives: Therapeutic management of inflammatory bowel diseases (IBD) is rapidly evolving in the era of novel biological therapies. However, real-world data relating to the usage trends and treatment persistence remain inconsistent. This study aimed to investigate trends in biological use, dose intensification, and treatment persistence in IBD patients, who received treatment in a large tertiary center in Greece. Methods: Patients with IBD who underwent at least one biological treatment between 2018 and 2022 were included in this retrospective study. Data on patients’ demographics, type of disease, use of biologicals, dose intensification, and treatment persistence were analyzed for time trends. Results: Data from 409 patients with IBD (mean age 39 (range 17–87), female 51%, 56.9% CD, mean duration of disease: 9.3 years) were included in the study. The number of patients on biologics was raised from 133 in 2018 to 368 in 2022 (a 28.1% yearly increase), while the percentage of patients who were treated with anti-TNF biosimilars increased to >60% of the total anti-TNF population in 2022. We observed a gradual increase in non-anti-TNF therapies in bio-naïve patients, in particular vedolizumab (46% of all biologicals in UC; 16% in CD) and ustekinumab (16.3% of all biologicals in UC, 31% in CD). The 3-year persistence rate of IFX was 64% in CD and 56% in UC, whereas it was 61% for ADA in CD. Dose intensification of anti-TNF was efficient in >50% of CD patients and >30% of UC patients; however, the majority of patients who required dose escalation within the first year eventually became unresponsive. The 3-year persistence of vedolizumab as a first-line treatment was 82% for CD and 69% for UC, respectively. The 3-year persistence of ustekinumab as first-line treatment for CD was 65%. No significant differences regarding the efficacy of anti-TNF, ustekinumab, or vedolizumab were detected when they were used as first-line treatments for Crohn’s disease; similarly, no significant differences were detected between infliximab and vedolizumab as first-line treatments for UC. Conclusions: There was a gradual increase in the use of biologicals, including biosimilars, between the years 2018–2022, reflecting adherence to current guidance with adoption of an early escalation strategy. Newer, post-anti-TNF biologics such as vedolizumab and ustekinumab have been rapidly incorporated into therapeutic approaches for both CD and UC. Full article

Bone-derived proteins, including carboxylated osteocalcin (cOC), are thought to play a role in cardiovascular and metabolic health. cOC is recognized for its strong affinity for calcium hydroxyapatite and its possible involvement in vascular calcification and lipid metabolism. Although the undercarboxylated form of osteocalcin (ucOC) has been widely researched, the connections between cOC and cardiovascular risk markers, such as mean arterial pressure (MAP), pulse pressure (PP), and the atherogenic index, are still not well understood. This cross-sectional study comprised 81 adults from Western Mexico; selection was based on rigorous inclusion criteria. Participants underwent various measurements, including anthropometric, biochemical, and cardiovascular assessments, such as the body mass index (BMI), body fat percentage, serum glucose, insulin resistance (HOMA-IR), glycated hemoglobin (HbA1c), lipid profile, creatinine, blood pressure parameters, and the atherogenic index. Serum cOC levels were determined using an enzyme-linked immunosorbent assay (ELISA). The study examined the relationships between cOC and cardiovascular/metabolic markers using inferential statistics and correlation coefficients. Multivariate linear analysis was performed to identify factors independently associated with the serum levels of cOC. Multivariate analysis revealed that MAP (B coefficient: 0.138, 95% CI: 0.028–0.247, p = 0.015) and the atherogenic index (B coefficient: 0.599, 95% CI: −0.039–1.161, p = 0.037) are independent predictors of cOC levels. A positive correlation was observed between cOC, PP, the atherogenic index, and HbA1, as well as an inverse correlation between cOC and HDL-c among the participants. Additionally, PP was positively correlated with HOMA-IR. Participants with elevated cOC levels showed higher MAP and atherogenic index values, indicating a potential connection between cOC and cardiovascular risk. cOC is independently associated with MAP and the atherogenic index, suggesting it may play a role in vascular remodeling and lipid metabolism. These results emphasize the importance of the bone–vascular axis in cardiovascular health and indicate that cOC might be a useful biomarker for assessing cardiovascular risk. Additional research is necessary to confirm these findings in larger, long-term studies and to investigate the mechanisms that connect cOC with cardiovascular outcomes. Full article

Youth-led action research has significantly influenced local and statewide policies aimed at supporting students experiencing homelessness in California. This study employs a Youth Participatory Action Research (YPAR) methodology, summarizing five years of research conducted by high school student cohorts and UC Berkeley graduate students to examine effective strategies for preventing and addressing student homelessness. The research engaged over 240 high school students, nine graduate research fellows, 120 university student mentors, and eight civic and community organizations through data collection, policy analysis, and stakeholder collaboration. Findings indicate that youth-led research strengthens alignment mechanisms, enhances cross-sector collaboration, and improves policy coordination, leading to more effective services and positive educational experiences for students experiencing homelessness. These results underscore the transformative role of youth-driven inquiry in shaping inclusive, evidence-based policies, and demonstrate the need for sustained youth engagement in policymaking to create long-term, systemic change. Full article

Aims: Ulcerative colitis (UC) significantly impacts individuals’ self-perception, body image, and overall quality of life, while also imposing considerable economic costs. These challenges highlight the necessity for complementary therapeutic strategies with reduced adverse effects to support conventional pharmacological treatments. Among natural interventions, Montmorency tart cherries, noted for their high anthocyanin content have emerged as a natural anti-inflammatory agent for UC. The current trial aimed to investigate the effects of Montmorency tart cherries compared to placebo in patients with mild to moderate UC. Materials and methods: Thirty-five patients with UC were randomly assigned to receive either placebo or Montmorency tart cherry juice, of which they drank 60 mL per day for 6 weeks. The primary outcomes and health-related quality of life, measured via the Inflammatory Bowel Disease Quality of Life Questionnaire (IBDQ), and the secondary measures, including other health-related questionnaires, blood biomarkers, and faecal samples, were measured before and after the intervention. Linear mixed-effects models were adopted to contrast the changes from baseline to 6 weeks between trial arms. Effect sizes were calculated using Cohen’s d. Results: There were significantly greater improvements in the IBDQ (22.61 (95% CI = 5.24 to 39.99) d = 0.90) and simple clinical colitis activity index (−3.98 (95% CI = −6.69 to –1.28) d = −1.01) in the tart cherry trial arm compared to placebo. In addition, reductions in faecal calprotectin levels were significantly greater in the tart cherry trial arm compared to placebo (−136.17 µg/g (95% CI = −258.06 to –4.28) d = −1.14). Loss to follow-up (N = 1) and adverse events (N = 1) were low and compliance was very high in the tart cherry (95.8%) trial arm. Conclusions: Given the profoundly negative effects of UC on health-related quality of life and its fiscal implications for global healthcare systems, this trial indicates that twice-daily tart cherry supplementation can improve IBD-related quality of life as well as the severity of symptoms and therefore may be important in the management of UC. Full article

Steel slag powder (SS), ground granulated blast-furnace slag (GGBS), and flue gas desulfurization gypsum (FDG) are environmentally friendly and cost-effective substitute materials for ordinary Portland cement (OPC). This study investigated the use of industrial solid wastes, including SS, GGBS, and FDG, as auxiliary materials in OPC to stabilize pretreated recycled concrete aggregate (pretreated RCA). The use of pretreated RCA, mixed cementitious materials, and water at the optimum content created a mixture designated recycled cement-stabilized macadam (RCSM). A series of mechanical tests were conducted to clarify the performance of the RCSM, and microscopic tests were performed to elucidate the microcharacteristics of the mixed cementitious materials. With a curing time from 3 days to 28 days, the unconfined compression strength (UCS) of the mixed cementitious materials (A4) composed of SS, GGBS, FDG, and OPC increased by 5.94–10.79% compared with that of the cementitious material of OPC (A0). The UCS of the mixture composed (C4) of SS, GGBS, FDG, OPC, and pretreated RCA was greater than that of the mixture composed (C0) of OPC and RCA from 7 days to 90 days, increasing by 4.26–8.35%. The total drying shrinkage coefficient of C4 was lower than that of C0, whereas the temperature shrinkage coefficient of C4 was higher than that of C0, indicating that the use of A4 can effectively reduce drying shrinkage cracking in C4. The hydration products of A4 primarily consisted of flocculent calcium silicate hydrate (C-S-H) gel, fibrous calcium aluminate hydrate gel, and needle-like ettringite crystals. The interlocked growth of C-S-H gel and ettringite crystals continued and promoted an increase in the UCS of the cementitious system. The test results provide a reference for the application of similar materials. Full article

Background/Objectives: Ulcerative colitis (UC) and Crohn’s disease (CD) are the usual clinical forms of inflammatory bowel disease (IBD). Changes in the oral microbiota, especially the presence of emerging fungi and herpesviruses, have been shown to worsen the clinical aspects of IBD. The aim of this study was to screen for emerging pathogens in the oral yeast microbiota and the presence of herpesvirus in IBD patients. Methods: Oral swabs of seven UC or CD patients were collected. The samples were plated on Sabouraud Dextrose Agar and subcultured on CHROMagar Candida and CHROMagar Candida Plus. Polyphasic taxonomy was applied and identified using molecular tools, such as MALDI-TOF MS and ITS partial sequencing. Multiplex qPCR was used to identify the herpesvirus. Results: The mean age was 38.67 ± 14.06 years, 57.14% were female, and two had diabetes. The CD patients presented with Rhodotorula mucilaginosa, Candida orthopsilosis and Kodamaea jinghongensis, while the UC patients presented with Cutaneotrichosporon dermatis, Candida glabrata, Candida lusitanea and Candida tropicalis. Two UC individuals had at least one herpesvirus. In the first individual, a co-detection of Herpes Simplex Virus 1 (HSV-1) and C. lusitaniae was observed. The second presented with co-infections of Epstein–Barr virus (EBV), Human Herpesvirus 7 (HHV-7) and C. tropicalis. Conclusions: We identified rarely described yeasts and co-infections in IBD patients, highlighting the need to identify emerging pathogens in the oral microbiota, as they may contribute to opportunistic infections. Full article

Objective: Upper crossed syndrome (UCS) is an abnormal upper extremity movement pattern characterized by muscle tightness in the neck, shoulders, and upper back, coupled with weakness in opposing muscle groups. This study aimed to investigate the effectiveness of Pilates training combined with fascial massage as an intervention in office workers with UCS. Methods: 34 subjects were recruited and randomly divided into an experimental group (n = 17) and a control group (n = 17). The control group underwent 12 weeks of Pilates training, and the experimental group received 12 weeks of Pilates training combined with fascial massage. Body posture was assessed using the forward head angle (FHA) and forward shoulder angle (FSA), joint mobility was evaluated using cervical spine range of motion (ROM), muscle activity was assessed using surface electromyography (sEMG), and quality of life was evaluated using pain level (VAS) and cervical spine dysfunction index (NDI). Results: After 12 weeks of intervention, the FHA, FSA, VAS, and NDI of the experimental group were significantly lower than those of the pre-intervention group (p < 0.05) and significantly lower than those of the control group (p < 0.05); the extension and left–right rotation cervical spine ROM of the experimental group were significantly higher than those of the pre-intervention group (p < 0.05) and significantly higher than those of the control group (p < 0.05); and sEMG indexes (mean power frequency and median frequency) of the upper trapezius and the pectoralis major in the experimental group were significantly higher than those of the pre-intervention group (p < 0.05) and significantly higher than the control group (p < 0.05). Conclusion: Compared with Pilates training alone, Pilates training combined with fascial massage demonstrated a more significant effect in improving muscle activation, body posture, and pain and enhancing the quality of life for patients with UCS. Full article

Background/Objectives: Uterine carcinosarcoma (UCS) refers to a rare high-grade aggressive epithelial non-endometrioid endometrial carcinoma, with tumour cells demonstrating epithelial–mesenchymal metaplastic transition and composed of both carcinomatous epithelial and sarcomatous (homologous or heterologous) components. Methods: The aim of this study was to evaluate the epidemiology, management approach, outcomes and survival patterns of patients with UCS. Seventy-seven cases of UCS treated with primary surgery in a single tertiary centre underwent retrospective cohort analysis across a ten-year period. Observational data on clinicopathological variables and treatment pathways were reviewed and independent risk factors for relapse and mortality were analysed. Results: The 5-year disease-free and overall survival rates were 52.10% and 46.6%, respectively. Cervical stromal involvement was independently related to disease-free survival (HR = 6.26; 95%CI 1.82–21.59; p = 0.004) and overall survival (HR = 3.64; 95%CI 1.42–9.38; p = 0.007), whilst sarcomatous component type was independently related to recurrence only (HR = 3.62; 95%CI 1.38–9.51; p = 0.009) after adjusting for other pathological and treatment variables. No significant difference in recurrence or mortality was found when comparing the performance of pelvic lymph node dissection (p = 0.803 and p = 0.192 respectively) or the administration of adjuvant treatment (p = 0.546 and p = 0.627 respectively). Conclusions: Whilst our data suggests an encouraging similarity in overall survival rates compared with the literature, UCS continues to represent significant treatment challenges—with a paucity of guidelines available. Data regarding molecular analysis was not systemically available in our cohort, the more recent introduction of which (alongside the revision of endometrial cancer staging) will undoubtedly provide UCS patients with improved therapeutic options in the future. Full article

To investigate the diffusion law of ultrafine cement slurry (UCS) with different water–cement ratios in tunnel second lining cracks during grouting, the grouting of ultrafine cement slurry with different water–cement ratios was carried out by experimental and theoretical analysis methods in this study. Through the collection and data analysis grouting experiment of the diffusion time history, the diffusion morphological characteristics based on different slurry viscosities were obtained, which were divided into three grouting diffusion patterns: circular diffusion zone, excessive diffusion zone, and elliptical diffusion zone. Furthermore, the spatiotemporal variation rules of the diffusion radius of ultrafine cement slurry with different water–cement ratios in tunnel secondary lining cracks were obtained as well. By analyzing the diffusion radius values under different water–cement ratios in each direction of x+, x−, y+, and y−, the critical water–cement ratios ξ were found to be 0.8, which affected the diffusion radius value in the vertical upward y+ direction. Meanwhile, when the grouting was completed, the maximum diffusion radius of the ultrafine cement slurry was obtained using different water–cement ratios in each direction. Moreover, the grouting diffusion equation of tunnel secondary lining cracks based on ultrafine cement slurry with different water–cement ratios is established. The research results can accurately predict the grouting diffusion pattern and diffusion radius in tunnel second lining cracks with different water–cement ratios of ultrafine cement slurry. Full article

Background/Objectives: The solute carrier family 26, member 2 (SLC26A2) gene, which belongs to the family of SLC26 transporters, can be detected in multiple tissues. However, the studies of SLC26A2 in colon-related diseases are still limited and incompletely understood, especially in ulcerative colitis (UC). Methods: In this study, we attempted to search and identify putative UC candidate genes within a large number of known genes by multiple bioinformatics analyses. The potential cellular characteristics and biological functions of SLC26A2 in the pathogenesis of UC were also elucidated. Results: Notably, SLC26A2 was representative and down-regulated in the intestinal mucosa of patients with active UC, compared to healthy controls. Decreased levels of SLC26A2 were proved to have a more value in diagnosis of UC patients, and closely correlated with some UC characteristics, including the Mayo score and Paediatric Ulcerative Colitis Activity Index (PUCAI). Mechanistically, subsequent results from published datasets and our validated clinical data all strongly implied that SLC26A2 was negatively correlated with the IL-17 signaling pathway, and positively associated with the tight junction, which led to abnormal immune cell infiltration and inflammatory injuries. After establishing the UC mice models in vivo by orally administration of DSS in portable water, SLC26A2 was significantly down-regulated at the mRNA or protein level, when compared to that in the control groups. Furthermore, the correlation analyses confirmed that SLC26A2 was positively associated with CLDN3, and negatively correlated with IL-17A expression in colon tissues. In addition, according to the SLC26A2 expression, UC patients were divided into different subgroups. The potential target drugs for UC treatment, such as progesterone, tetradioxin, and dexamethasone, were initially predicted and exerted anti-inflammatory effects via the common molecule-SLC26A2. Conclusions: SLC26A2 might be served as a protective candidate in the UC pathogenesis as well as a potential drug target for UC treatment. Full article

Background/Objectives: Dose escalation has been commonly used to achieve and maintain response. We aimed to compare the outcomes of adalimumab or infliximab dose escalation in inflammatory bowel disease (IBD) patients. Methods: Treatment persistence (TP) and predictive factors for remission-free treatment discontinuation (r-fTD) were evaluated in patients treated with adalimumab or infliximab dose escalation between 2019 and 2024. Results: Dose escalation was identified in 142 patients treated with adalimumab (UC: 23.9%; CD: 76.1%) and in 126 patients treated with infliximab (UC: 23.8%; CD: 76.2%). The TP rate was significantly lower in the adalimumab group (35.2%) than the infliximab group (53.2%) (p = 0.003). The survival analysis showed that drug persistence was lower in the adalimumab group compared with the infliximab group (mean time: 74.3 vs. 99.5 months, p < 0.001). TP rates showed no significant differences between UC and CD for both adalimumab (mean time UC: 64.7 months vs. CD: 76.2 months, p = 0.403) and infliximab (mean time UC: 80.3 months and CD: 102.6 months, p = 0.151). The r-fTD rates were significantly higher in the adalimumab group (62.7%) than the infliximab group (39.7%) (p < 0.001). Primary lack of response and secondary loss of response (sLOR) rates were both higher in the adalimumab group (7.7% and 51.4%) than the infliximab group (1.6% and 28.6%). However, serious adverse events were lower in the adalimumab group (2.1%) than the infliximab group (7.9%) (p = 0.027). Conclusions: Infliximab dose escalation was more effective than adalimumab in both UC and CD patients. Regarding the side effect profile, adalimumab dose escalation was found to be safer compared with infliximab. Full article

Upconversion (UC) luminescence in doped lanthanide nanocrystals is associated with the energy migration (EM) process within clusters of dopant ions. The process of the synthesis of core–shell nanocrystals occurs at elevated temperatures, promoting the diffusion of the dopants into the shell accompanied by the decay of dopant clusters. The details of this unwanted effect are poorly understood. In this paper, we theoretically study a model of the diffusion of dopant ions in a nanocrystal using Monte Carlo (MC) simulations. We characterize the diffusion, spatial neighboring relations and clustering of dopant ions regarding the function of reduced temperature and MC time of the heating process. The dopants undergo a weak subdiffusion caused by trapping effects. The main results of this study are as follows: (i) the phase diagram of the variables reduced the temperature and MC time, which separates the enhanced and limited cluster-driven EM regimes, and (ii) a dependence of the average nearest distance between Yb ions as a function of reduced temperature, the concentration of Yb ions and MC time was found. In both cases, the requirements for an effective EM are formulated. Full article