Search Results (219)

Background/Objectives: Yacon syrup (Smallanthus sonchifolius) has gained attention due to its high concentration of fructooligosaccharides (FOSs) and associated health benefits. This systematic review aimed to evaluate the effects of yacon syrup on metabolic parameters and intestinal health in humans over the last decade. Methods: Following PRISMA guidelines, we conducted a systematic search in databases, including Medline (PubMed), Science Direct, Embase, Scopus, and SciELO, up to October 2024. Inclusion criteria focused on clinical trials examining the impact of yacon syrup on glycemic control, lipid profile, insulin sensitivity, appetite regulation, and gut microbiota in healthy, overweight, or obese individuals. Seven studies met the inclusion criteria, encompassing 161 participants from diverse populations. Results: Yacon syrup supplementation demonstrated significant reductions in fasting insulin, HOMA-IR, and LDL cholesterol, alongside improvements in satiety and intestinal transit time. Acute supplementation with yacon syrup had inconsistent results for postprandial glycemia and insulin levels, probably due to prior individual gut microbiota composition. Longer interventions with yacon syrup were associated with enhanced microbiota modulation and appetite regulation, particularly in women. Mild gastrointestinal discomfort was reported, but with the continued use of yacon syrup, the symptoms decreased. Yacon syrup presents promising health benefits, including improved insulin sensitivity, weight management, and gut health. However, further research is needed to establish optimal dosing and long-term safety. Conclusions: This review highlights the potential of yacon syrup as a functional supplement for metabolic and gastrointestinal health. Full article

Levansucrases are key enzymes responsible for the synthesis of β-2,6-linked fructans, found in plants and microbes, especially in bacteria. Levansucrases have been applied in the production of levan biopolymer and fructooligosaccharides (FOSs) using sucrose as a substrate as well as in reducing sugar levels in fruit juice. As a result, levansucrases that are active at low temperatures are required for industrial applications to maintain product stability. Therefore, this work firstly reports the novel cold-active levansucrase (SacBPk) isolated from a sucrolytic bacterial strain, P. koreensis HL12. The SacBPk was classified into glycoside hydrolase family 68 subfamily 1 (GH68_1) and comprised a single catalytic domain with the Asp104/Asp267/Glu362 catalytic triad. Interestingly, the recombinant SacBPk demonstrated cold-active levansucrase activity at low temperatures (on ice and 4–40 °C) with the highest specific activity (167.46 U/mg protein) observed at 35 and 40 °C in 50 mM sodium phosphate buffer pH 6.0. SacBPk mainly synthesized levan polymer as the major product (129 g/L, corresponding to 25.8% of total sugar) with a low number of short-chain FOSs (GF2–4) (12.8 g/L, equivalent to 2.5% of total sugar) from 500 g/L sucrose after incubating at 35 °C for 48 h. These results demonstrate the industrial application potential of SacBPk levansucrase for levan and FOSs production. Full article

To enable early identification of failure risks in ship systems and equipment, a dynamic cloud center of gravity model is developed for real-time system-level health assessment. First, the Functional Analysis System Technique (FAST) was applied to decompose the operational functions and dependencies of the intelligent machinery room system, enabling the structured establishment of a hierarchical evaluation index system. The comprehensive weight is derived through synergistic application of the fuzzy set (FS) theory and entropy weight. This process integrated expert-defined functional boundaries with measurable parameters critical to system performance. Then, an improved cloud center of gravity method based on the Gaussian cloud model and sliding time window method is used for the system’s adaptive health value calculation. The dynamic health model can achieve continuous online assessment and track the further evolution of the system. Finally, the proposed model is applied to the Fuel Oil Supply System (FOSS). The integration of system performance output and disassembly inspection results demonstrates that the method proposed in the article more accurately reflects the true health status changes in the system when mapping health values. Full article

Pasta is a staple food consumed worldwide and is made from wholegrain semolina, which is a food rich in dietary fibre, proteins, minerals, vitamins, and bioactive compounds. However, fermentable oligo-, di-, and monosaccharides and polyols (FODMAP), part of soluble dietary fibre in pasta, can trigger/worsen irritable bowel syndrome (IBS) symptoms and increase the prevalence of gastrointestinal disorders. These dietary fibres include lactose, excess fructose relative to glucose, polyols, fructans (mostly fructooligosaccharides), and galactooligosaccharides. Due to a lack of information on the FODMAP profile for pasta, this research conducted a detailed analysis using high-performance anion-exchange chromatography with pulsed amperometric detection to determine the FODMAP compound content in commercially available pasta, with a focus on wholegrain products. The results showed that fructooligosaccharides (FOSs) are the dominant group of FODMAPs, and kestose is the predominant oligosaccharide in all pasta samples both dry (67.1–95.0%) and cooked (27.1–93.9%). Almost all pasta samples are classified as high-FODMAP foods. The degree of reduction in FODMAP compound content during cooking varies between pasta types and is influenced by the wheat type, cooking time, amount of water used for cooking, pasta shapes, and pasta supplementation. In samples of dry pasta, there are statistically significant differences in the results between all samples, while after cooking, there is evident grouping of the results in four clusters. The reduction in FOS content of pasta after cooking was in the range from 30.9% to 84%. Further research should be focused on higher activity of FODMAP degrading enzymes during pasta production process. Full article

Background: Prebiotics are non-digestible dietary compounds, defined as substrates that are utilised by host microorganisms conferring a health benefit. Although fructo-oligosaccharides (FOSs) and galacto-oligosaccharides (GOSs) are among the most studied prebiotics and support intestinal normobiosis, comprehensive data on their content in foods remain limited. Objectives: The objective was to quantify the content of FOSs (kestose, nystose, and 1 F-β-fructofuranosylnystose) and GOSs (raffinose and stachyose) in 35 foods, including fruit and nuts, legumes, and cereals. We also estimated the intakes of prebiotics in an Italian population. Methods: We analysed the prebiotic content in foods using high-performance anion-exchange chromatography with pulsed amperometric detection (HPAEC-PAD). We estimated the prebiotic intake of 100 healthy controls from a case-control study on colorectal cancer conducted in Italy between 2017 and 2019. We used dietary information collected through a food frequency questionnaire and the prebiotic data quantified in this and a previous study. Results: FOSs were mostly detected in cereal products, with wheat bran and whole-meal rye flour containing the highest amount (around 0.7 g/100 g each). GOSs were most abundant in legumes, especially in dried soy products (around 4.0 g/100 g each). Mean daily intake was 0.236 g for total FOSs and 0.371 g for total GOSs. Wheat bran, raspberries, chestnuts, walnuts, raisins, soy milk, and soy yoghurt overall accounted for 3.9% of kestose, 1.2% of nystose, 0% of 1F-β-fructofuranosylnystose, 15.5% of raffinose, and 8.3% of stachyose total intakes. Conclusions: The present study enables the development of a comprehensive database on prebiotic content in foods through a consistent analytical method. This makes prebiotic intake assessments more accurate than previously available data and facilitates future epidemiological studies investigating their potential effects on health. Full article

The role of prebiotics and probiotics in promoting gut health is increasingly recognized in food development and nutrition research. This study explored the enhancement of probiotic viability in the food industry through microencapsulated synbiotics, focusing on Lactiplantibacillus plantarum NCIMB 11974 with fructooligosaccharides (FOSs) and inulin as prebiotics. The effect of encapsulation in a chitosan-coated alginate matrix on probiotic survival under simulated gastrointestinal conditions showed a significant effect of 2% FOS concentration on the growth of Lactiplantibacillus plantarum NCIMB 11974. The optimization of microencapsulation parameters by the Taguchi method revealed a 2% sodium alginate concentration, a nozzle size of 200 µm, and a concentration of 0.4% chitosan solution as ideal, producing microcapsules with an estimated average diameter of 212 µm. Viability assessments in simulated gastric juice and simulated intestinal juice showed that chitosan-coated alginate microcapsules notably enhanced probiotic survival, achieving log 8 CFU mL⁻¹ viability in both environments, a marked improvement over the uncoated variant. The study emphasizes the importance of microencapsulation, particularly by sodium alginate and chitosan, as a viable strategy to improve the survival and delivery of probiotics through the digestive system. By improving the stability and survivability of probiotics, microencapsulation promises to expand the use of synbiotics in various foods, contributing to the development of functional foods with health-promoting properties. Full article

In every era, climate variability and frequent food shortages have made it necessary to store harvested grains for more than one season. Underground grain storage has been used since ancient times throughout the world. Italy (Cerignola) and Malta (Valletta and Floriana) have preserved rare examples of more recent (from the 16th century onward) large concentrations of grain pits, capable of accumulating substantial reserves to cope with famine or siege. No longer in operation, they represent an important part of the cultural heritage of the agricultural economy. The purpose of this narrative review was, after a geographical framing of grain pits in the Eurasian and African macro-areas, to take the Italian and Maltese grain pits as historical case studies to draw attention to the reevaluation of underground grain storage in the context of climate change and food insecurity. Today, as in the past, grain reserves play a significant role in food security in developing countries and, due to climate change and geopolitical events that can cause disruptions in grain supplies, are also increasingly important for developed countries. A comparison of traditional and modern underground storage systems reveals the great flexibility of this technology, ranging from basic pits of different sizes to large underground granaries equipped with a support structure. The advantages of underground storage, such as environmental sustainability due to thermal insulation of the soil and airtight conditions that make high energy inputs for grain cooling and pesticide use unnecessary, are still useful today, perhaps more so than in the past. Prospects for development include technical solutions involving the application of innovative information technology-based monitoring systems and the use of modern materials to ensure the performance of waterproofing, seepage control, and static safety, all tools for further evolution of this ancient storage system. Full article

This study addresses the challenges of integrating heterogeneous environmental geospatial data by proposing a framework based on ontology-based data access (OBDA). Geospatial data are important for decision-making in various domains, such as environmental monitoring, disaster management, and urban development. Data integration is a common challenge within these domains due to data heterogeneity and semantic discrepancies. The proposed framework uses semantic web technologies to enhance data interoperability, accessibility, and usability. Several practical examples were demonstrated to validate its effectiveness. These examples were based in Lake Mjøsa, Norway, addressing both spatial and non-spatial scenarios to test the framework’s potential. By extending the GeoSPARQL ontology, the framework supports SPARQL queries to retrieve information based on user requirements. A web-based SPARQL Query Interface (SQI) was developed to execute queries and display the retrieved data in tabular and visual format. Utilizing free and open-source software (FOSS), the framework is easily replicable for stakeholders and researchers. Despite some limitations, the study concludes that the framework is able to enhance cross-domain data integration and semantic querying in various informed decision-making scenarios. Full article

Background/Objectives: Microorganisms are the leading cause of infections in the root canal system, contributing to the failure of endodontic treatments. This in vitro study aimed to compare the antimicrobial effects of four different endodontic sealers: Endomethasone N (Septodont, Saint Maur-des-Fossés, France), Sealapex (Kerr Corporation, Orange, CA, USA), AH Plus Jet (Dentsply DeTrey GmbH, Konstanz, Germany), and MTA Fillapex (Angelus, Londrina, Brazil). Methods: The sealers were tested against common oral pathogens, including Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Candida albicans, and Streptococcus mutans, using the agar diffusion method. Inhibition zones were measured at 24, 48, and 72 h to assess antimicrobial efficacy. Results: The results showed that Endomethasone was the most effective sealer against all tested microorganisms, demonstrating consistent inhibition across all time intervals. MTA Fillapex also exhibited a significant antimicrobial effect, particularly against Streptococcus mutans, with its efficacy increasing over time. AH Plus Jet displayed limited effectiveness, showing significant results only against Staphylococcus aureus. Conclusions: Overall, this study confirms the superior antimicrobial performance of Endomethasone, while the other materials, particularly MTA Fillapex and Sealapex, also showed notable effects in experimental conditions. The antimicrobial activity of all materials, except AH Plus Jet, increased over the 72-h period. Full article

This paper introduces a novel adaptive control method for suspension vehicle systems in response to road disturbances. The considered model is based on an active symmetry quarter car (SQC) fractional order suspension system (FOSS). The word symmetry in SQC refers to the symmetry of the suspension system in the front tires or the rear tires of the car. The active suspension controller is generally driven by an external force like a hydraulic or pneumatic actuator. The external force of the actuator is determined using fractional dynamic sliding mode control (FDSMC) to counteract road disturbances and eliminate the chattering caused by sliding mode control (SMC). In FDSMC, a fractional integral acts as a low-pass filter before the system actuator to remove high-frequency chattering, necessitating an additional state for FDSMC implementation assuming all FOSS state variables are available but the parameters are unknown and uncertain. Hence, an adaptive procedure is proposed to estimate these parameters. To enhance closed-loop system performance, an adaptive proportional-integral (PI) procedure is also employed, resulting in the FDSMC-PI approach. A comparison is made between two SQC suspension system models, the fractional order suspension system (FOSS) and the integer order suspension system (IOSS). The IOSS controller is based on dynamic sliding mode control (DSMC) and a PI procedure (DSMC-PI). The results show that FDSMC outperforms DSMC. Full article

Objective: Biotics are increasingly being used in the treatment of irritable bowel syndrome (IBS). This study aimed to assess the efficacy and safety of a mixture of microencapsulated sodium butyrate, probiotics (Lactocaseibacillus rhamnosus DSM 26357, Lactobacillus acidophilus DSM 32418, Bifidobacterium longum DSM 32946, Bifidobacterium bifidum DSM 32403, and Bifidobacterium lactis DSM 32269), and short-chain fructooligosaccharides (scFOSs) in IBS patients. Methods: This was a randomized, double-blind, placebo-controlled trial involving 120 adult participants with IBS. The primary outcome of the 12-week intervention was the improvement in IBS symptoms and quality of life (QOL), assessed with the use of IBS-Adequate Relief (IBS-AR), IBS-Global Improvement Scale (IBS-GIS), IBS-Symptom Severity Score (IBS-SSS), and IBS-QOL. Secondary outcomes were the number and type of stools (assessed via the Bristol Stool Form scale), patient-recorded symptoms, anthropometric parameters, and levels of selected inflammatory cytokines. Results: As early as at 4 weeks, there was a higher percentage of patients in the biotic group reporting adequate relief of symptoms (based on IBS-AR) than in the placebo group (64.7% vs. 42.0%, respectively, p = 0.023). At 12 weeks, fewer patients in the biotic group reported a ‘worsening of symptoms’ (based on IBS-GIS) than in the placebo group (5.9% vs. 16.0% respectively, p = 0.015). There were no significant differences between groups in IBS-QOL or IBS-SSS or any of the secondary outcome measures except the patient-recorded ‘urgency to defecate’ (p = 0.015) at week 12, which was significantly lower in the biotic group. The intervention was safe and well tolerated. Conclusions: A biotic mixture consisting of microencapsulated butyrate, probiotics, and small amounts of scFOSs is safe and effective in improving gastrointestinal symptoms in patients with IBS. Full article

Carob syrup, a traditional Mediterranean functional beverage obtained from Ceratonia siliqua (L.) pods, has been historically valued for its nutritional properties but is currently underutilized. This study compared the prebiotic potential of three handmade carob syrups produced by Tunisian women with commercial benchmarks from Italy, Greece and Cyprus. The prebiotic activity was evaluated by prebiotic scores, bifidogenic activity and volatilome characterization (SPME GC/MS) together with physicochemical and nutritional parameters. The results showed that Tunisian handmade products exhibited lower growth of pathogenic Escherichia coli compared to commercial samples. The prebiotic activity, tested against probiotic lactobacilli and bifidobacteria mixtures, showed a hierarchy of efficacy: fructo-oligosaccharides (FOSs) > Tunisian handmade products > Greek and Cypriot benchmarks > Italian benchmark. Volatilome analysis revealed about 40 compounds, mainly organic acids and aldehydes, with higher concentrations in handmade products. Positive correlations were found between prebiotic activity and short-chain fatty acids and n-hexadecanoic acid, while furfural showed negative correlations. The Tunisian artisanal products showed a higher prebiotic potential compared to the commercial counterparts, due to their higher content and diversity of organic acids. However, the presence of furfural in Tunisian products needs to be monitored due to potential toxicity concerns. Full article

Software testing is an important step in the software development life cycle to ensure the quality and security of software. Fuzzing is a security testing technique that finds vulnerabilities automatically without accessing the source code. We built a fuzzer, called JIMA-Fuzzing, which is an effective fuzzing tool that utilizes grammar detected from sample input. Based on the detected grammar, JIMA-Fuzzing selects a portion of the valid user input and fuzzes that portion. For example, the tool may greatly increase the size of the input, truncate the input, replace numeric values with new values, replace words with numbers, etc. This paper discusses how JIMA-Fuzzing works and shows the evaluation results after testing against the DARPA Cyber Grand Challenge (CGC) dataset. JIMA-Fuzzing is capable of extracting grammar from sample input files, meaning that it does not require access to the source code to generate effective fuzzing files. This feature allows it to work with proprietary or non-open-source programs and significantly reduces the effort needed from human testers. In addition, compared to fuzzing tools guided with symbolic execution or taint analysis, JIMA-Fuzzing takes much less computing power and time to analyze sample input and generate fuzzing files. However, the limitation is that JIMA-Fuzzing relies on good sample inputs and works primarily on programs that require user interaction/input. Full article

This paper investigates the leader-following $H_{\infty }$ consensus of fractional-order multi-agent systems (FOMASs) under input saturation via the output feedback. Based on the bounded real lemma for FOSs, the sufficient conditions of $H_{\infty }$ consensus for FOMASs are provided in $\alpha \in \left(0,1\right)$ and $\left[1,2\right)$, respectively. Furthermore, the iterative linear matrix inequalities (ILMIs) approaches are applied for solving quadratic matrix inequalities (QMIs). The ILMI algorithms show a method to derive initial values and transform QMIs into LMIs. Mathematical tools are employed to transform the input saturation issue into optimal solutions of LMIs for estimating stable regions. The ILMI algorithms avoid the conditional constraints on matrix variables during the LMIs’ construction and reduce conservatism. The approach does not disassemble the entire MASs by transformations to the Laplacian matrix, instead adopting a holistic analytical perspective to obtain gain matrices. Finally, numerical examples are conducted to validate the efficiency of the approach. Full article

A significant issue facing communicators in the current multicommunicative environment is securing the attention of potential audience members who are likely to be engrossed in their digital devices. The theory of attentional social presence suggests that communicators secure their attention using one of four types of social presence—budgeted, competitive, entitled, and invitational. In this essay, the theory of attentional social presence is extended by identifying strategies interactants use to resolve misalignments in expected or preferred types of social presence. The research design involved interviews with 32 individuals about their experiences with misalignment in attentional social presence. Transcripts of the interviews were coded following the qualitative approach of grounded theory. Three primary strategies emerged from the analysis—prescribing to eliminate misalignment, rationalizing to overlook misalignment, and co-creating to resolve misalignment. Understanding various methods for negotiating mismatches among chosen types of social presence will allow communicators to create more satisfying and productive interactions. Full article