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26 pages, 23292 KiB  
Article
The Concept and Measurements of an Adjustable Holder for Large Magnets Applicable for a THz Undulator Working in Superradiant Emission
by Paweł J. Romanowicz, Jarosław Wiechecki, Daniel Ziemiański, Robert Nietubyć and Paweł Krawczyk
Appl. Sci. 2024, 14(22), 10338; https://doi.org/10.3390/app142210338 - 10 Nov 2024
Viewed by 556
Abstract
The main aim of this study is the concept of the magnet holder for the THz undulator utilized in the PolFEL superradiant light source. To achieve maximum flux at high K values (radiation frequencies ranging from 0.5 THz to 5 THz, and K [...] Read more.
The main aim of this study is the concept of the magnet holder for the THz undulator utilized in the PolFEL superradiant light source. To achieve maximum flux at high K values (radiation frequencies ranging from 0.5 THz to 5 THz, and K values exceeding 3), it is necessary to use large permanent magnets with dimensions of 100 × 100 × 39.9 mm. For the above assumptions and parameters and specific requirements for magnet positioning, existing design solutions in the literature were found to be insufficient. The main challenges in the design of this holder included the following: (a) the unusually large size of the magnets, (b) requirements of wide-range calibration, and (c) large magnetic forces acting on each magnet, which can approach almost 4 kN. Taking into consideration these challenges, the prototype of the magnet holder was developed and manufactured. The paper presents the findings from both numerical and experimental studies aimed at validating the mechanical behavior and deformation of the proposed magnet holder. The measurements were conducted using two methods—traditional with the use of dial indicators and a novel approach based on the application of the Digital Image Correlation. The results from these numerical and experimental studies indicate that all specified requirements have been satisfactorily met. The study confirms the capability for accurate magnet positioning, demonstrating stable deformation of the holder under a magnetic load. Additionally, it was proved that the positioning of the magnets is both linear and repeatable, with calibration achievable within a range of at least ±0.25 mm. Full article
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<p>Sketches of design solutions of magnet holders: (<b>a</b>) with tuning (1) and locking (2) screws; (<b>b</b>) with adjusting screws (1) and nuts (2); (<b>c</b>) with wedge (1) and adjustment screw (2) and aluminum holder susceptible to deformation with thinned frame walls (3).</p>
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<p>General concept of THz PolFEL undulator. In the central part, jaws with magnetic arrays are visible.</p>
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<p>Exemplary part of magnetic array with two periods of magnets with the direction of magnetization.</p>
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<p>Geometry of investigated structure: (<b>a</b>) assembly drawing of magnet holder; (<b>b</b>) geometry of magnet block.</p>
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<p>Boundary conditions for FEMM simulations.</p>
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<p>Meshed region used for the FEMM calculations.</p>
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<p>FEM model of magnet holder: (<b>a</b>) 3-D model and boundary conditions; (<b>b</b>) FEM mesh.</p>
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<p>Pretensioning of bolts using “Bolt Pretension” function.</p>
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<p>Experimental test stand for measurement of magnet holder: (<b>a</b>) with simulation of the “push-in” conditions and (<b>b</b>) simulation of the “pull-out” conditions.</p>
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<p>Experimental test stand for measurement of magnet holder: (<b>a</b>) experimental test stand with dial indicators; (<b>b</b>) CAD drawing with location of measurement points.</p>
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<p>Field distribution in Halbach array calculated in FEMM for THZ undulator for a gap of 100 mm.</p>
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<p>Magnetic forces for individual magnets pairs, measured for different undulator’s gaps; magnets with remanence 1.28T.</p>
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<p>Deformations under loads on adjustment screws; magnet pressed: (<b>a</b>) <span class="html-italic">F<sub>r</sub></span> = 0.5 kN; (<b>b</b>) <span class="html-italic">F<sub>r</sub></span> = 1.5 kN.</p>
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<p>Deformations under loads on adjustment screws; magnet pulled: (<b>a</b>) <span class="html-italic">F<sub>r</sub></span> = 0.5 kN; (<b>b</b>) <span class="html-italic">F<sub>r</sub></span> = 1.5 kN.</p>
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<p>Deformation of inner U-shaped frame due to large tightening of clamp screws.</p>
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<p>Displacement of magnet for different clamp-tightening <span class="html-italic">M<sub>c</sub></span> and adjustment screw <span class="html-italic">M<sub>r</sub></span> torques.</p>
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<p>Displacement of magnet under external load <span class="html-italic">F</span>: (<b>a</b>) with “push-in” magnet; (<b>b</b>) with “pull-out” magnet.</p>
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<p>Displacement of magnet during positioning (realized by tensioning the screws with torque <span class="html-italic">M<sub>r</sub></span>).</p>
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<p>Speckle pattern on the surface of magnet holder.</p>
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<p>Influence of clamp-tightening torque <span class="html-italic">M<sub>c</sub></span> on magnet displacement.</p>
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<p>Horizontal deformation of magnet grip caused by tightening of clamps: (<b>a</b>) series 3—<span class="html-italic">M<sub>c</sub></span> = 2 Nm; (<b>b</b>) series 3—<span class="html-italic">M<sub>c</sub></span> = 4 Nm.</p>
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<p>Deformation of magnet holder and repeatability of measurements.</p>
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<p>Influence of adjustment bolt torque <span class="html-italic">M<sub>r</sub></span> on horizontal inner frame deformation.</p>
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<p>Influence of adjustment bolt torque <span class="html-italic">M<sub>r</sub></span> and clamp-bolt-tightening torque <span class="html-italic">M<sub>c</sub></span> on magnet displacement.</p>
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<p>Influence of adjustment bolt torque <span class="html-italic">M<sub>r</sub></span> on magnet displacement.</p>
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<p>Vertical deformation of magnet holder for different adjustment bolt torques <span class="html-italic">M<sub>r</sub></span>: (<b>a</b>) bolts on left hand-side <span class="html-italic">M<sub>r</sub></span> = 10 Nm, bolts on right hand-side <span class="html-italic">M<sub>r</sub></span> = 0 Nm; (<b>b</b>) <span class="html-italic">M<sub>r</sub></span> = 10 Nm on all adjusting bolts.</p>
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<p>Vertical deformation of magnet holder for the following: (<b>a</b>) <span class="html-italic">M<sub>c</sub></span> = 4 Nm, <span class="html-italic">M<sub>r</sub></span> = 0 Nm, <span class="html-italic">F</span> = 0 kN; (<b>b</b>) <span class="html-italic">M<sub>c</sub></span> = 4 Nm, <span class="html-italic">M<sub>r</sub></span> = 5 Nm, <span class="html-italic">F</span> = 0 kN.</p>
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<p>Displacement of “magnet” and deformation of outer frame for the following: (<b>a</b>) <span class="html-italic">M<sub>c</sub></span> = 4 Nm, <span class="html-italic">M<sub>r</sub></span> = 5 Nm, <span class="html-italic">F</span> = var; (<b>b</b>) <span class="html-italic">M<sub>c</sub></span> = 4 Nm, <span class="html-italic">M<sub>r</sub></span> = var, <span class="html-italic">F</span> = 2.5 kN.</p>
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<p>Vertical deformation of magnet holder for the following: (<b>a</b>) <span class="html-italic">M<sub>c</sub></span> = 4 Nm, <span class="html-italic">M<sub>r</sub></span> = 5 Nm, <span class="html-italic">F</span> = 1.25 kN; (<b>b</b>) <span class="html-italic">M<sub>c</sub></span> = 4 Nm, <span class="html-italic">M<sub>r</sub></span> = 5 Nm, <span class="html-italic">F</span> = 2.5 kN.</p>
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<p>Vertical deformation of magnet holder for <span class="html-italic">M<sub>c</sub></span> = 4 Nm, <span class="html-italic">M<sub>r</sub></span> = 10 Nm, and <span class="html-italic">F</span> = 2.5 kN.</p>
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<p>Vertical deformation of magnet holder for <span class="html-italic">M<sub>c</sub></span> = 4 Nm, <span class="html-italic">M<sub>r</sub></span> = 7 Nm, and <span class="html-italic">F</span> = 2.5 kN during the following: (<b>a</b>) stage 4—tightening of adjustment screws; (<b>b</b>) stage 5—loosening of adjustment screws.</p>
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24 pages, 9406 KiB  
Article
Lightweight Digit Recognition in Smart Metering System Using Narrowband Internet of Things and Federated Learning
by Vladimir Nikić, Dušan Bortnik, Milan Lukić, Dejan Vukobratović and Ivan Mezei
Future Internet 2024, 16(11), 402; https://doi.org/10.3390/fi16110402 - 31 Oct 2024
Viewed by 1873
Abstract
Replacing mechanical utility meters with digital ones is crucial due to the numerous benefits they offer, including increased time resolution in measuring consumption, remote monitoring capabilities for operational efficiency, real-time data for informed decision-making, support for time-of-use billing, and integration with smart grids, [...] Read more.
Replacing mechanical utility meters with digital ones is crucial due to the numerous benefits they offer, including increased time resolution in measuring consumption, remote monitoring capabilities for operational efficiency, real-time data for informed decision-making, support for time-of-use billing, and integration with smart grids, leading to enhanced customer service, reduced energy waste, and progress towards environmental sustainability goals. However, the cost associated with replacing mechanical meters with their digital counterparts is a key factor contributing to the relatively slow roll-out of such devices. In this paper, we present a low-cost and power-efficient solution for retrofitting the existing metering infrastructure, based on state-of-the-art communication and artificial intelligence technologies. The edge device we developed contains a camera for capturing images of a dial meter, a 32-bit microcontroller capable of running the digit recognition algorithm, and an NB-IoT module with (E)GPRS fallback, which enables nearly ubiquitous connectivity even in difficult radio conditions. Our digit recognition methodology, based on the on-device training and inference, augmented with federated learning, achieves a high level of accuracy (97.01%) while minimizing the energy consumption and associated communication overhead (87 μWh per day on average). Full article
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<p>Proposed SM architecture used for old TM retrofitting.</p>
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<p>The system architecture consists of a collection of deployed SMs that communicate via MNO with the cloud.</p>
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<p>Distribution of ML models on edge devices, which provides the basis for FL.</p>
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<p>Design and components of edge device is depicted on the left, whereas right images display fabricated devices.</p>
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<p>View of metering device through camera lens of the edge device used for creation of datasets.</p>
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<p>Conversion to B/W image format using a fixed threshold: TH = 128 (<b>left</b>), TH = 192 (<b>right</b>).</p>
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<p>Initial image taken using camera on edge device, intermediate image after B/W conversion and the final image without artifacts.</p>
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<p>Scheme used for detecting differences between two digit images.</p>
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<p>Proposed CNN architecture used for digit recognition.</p>
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<p>The first test case comprises two distinct scenarios representing different training methodologies, one incorporating federated learning (FL) and the other without its use. (<b>a</b>) Scenario 1, which does not use FL. (<b>b</b>) Scenario 2, which utilizes averaging methodology for FL.</p>
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<p>Second test case displaying training scheme where second batch of devices is trained based on results of training on first batch.</p>
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<p>Power consumption profile of image capture + preprocessing + inference.</p>
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<p>Power consumption profile of data packet transmission via NB-IoT.</p>
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28 pages, 5219 KiB  
Article
Analysis of Farmers’ Perceptions on Sealing Techniques for Runoff Harvesting Ponds: A Case Study from Burkina Faso
by Tégawindé Vanessa Rosette Kaboré, Amadou Keïta, Abdou Lawane Gana, Dial Niang and Bassirou Boubé
Resources 2024, 13(10), 144; https://doi.org/10.3390/resources13100144 - 21 Oct 2024
Viewed by 748
Abstract
Water conservation in arid and semi-arid regions faces significant challenges due to low and irregular rainfall, worsened by climate change, which negatively affects rain-fed crop productivity. Various techniques, including supplemental irrigation using runoff harvesting ponds, aim to address these issues but often suffer [...] Read more.
Water conservation in arid and semi-arid regions faces significant challenges due to low and irregular rainfall, worsened by climate change, which negatively affects rain-fed crop productivity. Various techniques, including supplemental irrigation using runoff harvesting ponds, aim to address these issues but often suffer from water loss due to infiltration, influenced by the pond liner type. This study uses a factorial analysis to assess the farmers’ perceptions of four pond sealing techniques. Using the Waso-2 method, a survey conducted in 2022 among 41 rainwater harvesting pond owners across three regions of Burkina Faso revealed that farmers prioritized impermeability and ease of maintenance over cost and availability. Concrete, scoring 16/20, was the most preferred, chosen by over 75% of farmers for its durability and resistance to weathering, despite its high cost. Geomembrane, with a score of 12/20, was valued for its waterproofing properties but had durability concerns. Clay, although cheap and available, scored 8/20 due to poor waterproofing on unstable ground. Bitumen, the least favored with a score of 6/20, was hindered by scarcity and lack of familiarity. To enhance supplemental irrigation in Burkina Faso and similar regions, waterproof concrete or durable geomembrane liners are recommended. Further research into improving bitumen and clay liners is also suggested. These findings provide key insights into farmers’ preferences, offering guidance for developing effective water conservation strategies to boost agricultural productivity and address food security challenges in the context of climate change. Full article
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<p>Location of the study area in the Sudano-Sahelian zone of Burkina Faso.</p>
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<p>Presentation of the WASO-2 Survey Tool. (<b>a</b>) Overview of the creation steps and process for the WASO-2 survey tool. (<b>b</b>) Illustration of the WASO-2 survey tool in both closed and opened states, showing stick placements.</p>
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<p>Cause and effect diagram showing factors that increase water seepage in RWHP.</p>
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<p>Algorithm for sample size determination.</p>
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<p>This is the figure of the onsite process. (<b>a</b>) Briefing of all RWHP owners in the village of Kombougo on the principle of Waso-2 before the individual surveys. (<b>b</b>) Individual survey of a RWHP owner in the village of Gomtoaga using Waso-2.</p>
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<p>Box plot of Q1 variables.</p>
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<p>Box plot of Q2 variables.</p>
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<p>Principal component analysis between Q1 and Q2 variables.</p>
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<p>Box Plot of Q3 Variables.</p>
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<p>Box plot of Q4 variables.</p>
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<p>Principal component analysis of local solution combinations (Q3) proposed by farmers and the clay origin (Q4).</p>
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<p>Box plot of variables Q5 and Q6 for comparison between bitumen and geomembrane.</p>
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<p>Box plot of Q7 variables for comparison of clay, bitumen, geomembrane, and concrete.</p>
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<p>Box plot of Q8 variables for comparison of the liner’s prices.</p>
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<p>Principal component analysis of sealing solution (Q7) proposed to farmers and the price they suggested (Q8).</p>
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13 pages, 654 KiB  
Article
Depression and Functioning during the COVID-19 Pandemic among Adults across Tunisia
by Jessica E. Lambert, Fatma Charfi, Uta Ouali, Amina Aissa and Joop de Jong
Int. J. Environ. Res. Public Health 2024, 21(10), 1363; https://doi.org/10.3390/ijerph21101363 - 16 Oct 2024
Viewed by 887
Abstract
We aimed to understand how risk (trauma history, health problems, financial problems, family problems) and protective (friend support, family support) factors influenced daily functioning (e.g., self-care, mobility, social participation) among Tunisian adults during the COVID-19 pandemic, directly and through their impact on depression, [...] Read more.
We aimed to understand how risk (trauma history, health problems, financial problems, family problems) and protective (friend support, family support) factors influenced daily functioning (e.g., self-care, mobility, social participation) among Tunisian adults during the COVID-19 pandemic, directly and through their impact on depression, with a focus on gender differences. We recruited a representative sample of 2014 participants (1024 males, 990 females) using random digit dialing of mobile phone numbers across all 24 governorates in Tunisia. Females reported higher depression, greater impaired functioning, and a higher likelihood of having had COVID-19. Path analysis showed a good fit to the model when paths for males and females were allowed to vary, providing evidence for gender differences. Associations between trauma exposure and depression and depression and age with functioning were stronger among females. Social support from friends was a protective factor for males only. For males, all study variables were associated with functioning indirectly through their association with depression, except for support from friends. For females, family responsibilities and health problems had both direct and indirect effects, whereas other study variables were only linked with functioning through depression. Findings provide insights into factors that can be targeted in interventions aimed at reducing depression and improving daily functioning for males and females. Full article
(This article belongs to the Special Issue 2nd Edition: Public Health during and after the COVID-19 Pandemic)
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<p>Hypothesized mediation model.</p>
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12 pages, 6563 KiB  
Article
A Numerical Study of the Vibration Characteristics of a Haptic Actuator for a Dial Gear Shifter
by Joonsik Won, Kinyeong Ko, Heesoo Eom, Chulsook Kim, Jihyun Cho and Howuk Kim
Appl. Sci. 2024, 14(20), 9242; https://doi.org/10.3390/app14209242 - 11 Oct 2024
Viewed by 598
Abstract
Human–machine interaction (HMI) is becoming increasingly important, especially in the automotive industry, where advancements in automated driving and driver assistance systems are key to enhancing driver safety and convenience. Among the many HMI interfaces, tactile sensing has been widely used in automotive applications [...] Read more.
Human–machine interaction (HMI) is becoming increasingly important, especially in the automotive industry, where advancements in automated driving and driver assistance systems are key to enhancing driver safety and convenience. Among the many HMI interfaces, tactile sensing has been widely used in automotive applications as it enables instant and direct interactions with drivers. An area that remains underexplored among the tactile HMI interfaces is the application of haptic feedback to gear shifter modules. Therefore, this study investigates the design optimization of a dial gear shifter by analyzing the vibrations transmitted to the knob surface from an integrated haptic actuator. Specifically, we first tuned the mechanical properties of the haptic actuator (in terms of the resonance frequency and vibration level) in a simulation model by referring to experimental results. Next, a numerical model of a dial gear shifter was constructed, integrated with a haptic actuator, and tuned with the experimental results. The model was further optimized based on the design of the experiment and sensitivity analyses. The optimized design yielded a 24.5% improvement in the vibration level compared with the reference design, exceeding the minimum threshold (>~2.5 m/s2 at 200 Hz) required for tactile sensing. The vibration enhancement (>22.x%) was also confirmed under the simulated hand-grabbing condition. This study is technically significant as it demonstrates that the haptic vibration in a dial gear shifter can be efficiently optimized through numerical analyses. This research will be used for the actual prototyping of a dial gear shifter to provide a safe driving experience for drivers. Full article
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<p>Structure of the haptic actuator in (<b>a</b>) the exploded view and (<b>b</b>) the assembly view.</p>
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<p>Geometry of the simulation model for the haptic actuator in (<b>a</b>) top-down view and (<b>b</b>) side view.</p>
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<p>Test setup for characterizing the vibration response of the haptic actuator.</p>
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<p>Overall simulation process to obtain the optimal design of the dial gear shifter.</p>
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<p>(<b>a</b>) Three-dimensional model of the dial gear shifter integrating the haptic actuator (i.e., the red solid box) and (<b>b</b>) the construction of the FE model.</p>
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<p>Design parameters to enhance the vibration response at the dial gear-shifting knob: (<b>A</b>) radius of knob grip, (<b>B</b>) longitudinal length of knob grip, (<b>C</b>) with and without the side supports in the cavity, and (<b>D</b>) attaching method between the knob grip and the knob outer part.</p>
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<p>Simulated mode shapes of the haptic actuator.</p>
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<p>Comparison of frequency response functions in the FEA and the experiment.</p>
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<p>Vibration response at the knob grip of the baseline model, observed at the height and the angle of the knob grip.</p>
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<p>Sensitivity analysis of each design parameter for (<b>a</b>) the radius of the knob grip, (<b>b</b>) the longitudinal length of the knob grip, (<b>c</b>) the presence of the side supports, and (<b>d</b>) the method of attaching the knob grip.</p>
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<p>Optimized design of dial gear shifter to potentiate the level of haptic vibration.</p>
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<p>Vibration response at the knob grip of the design-optimized model, observed at the height and the angle of the knob grip.</p>
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13 pages, 632 KiB  
Article
Breath Analysis: Identification of Potential Volatile Biomarkers for Non-Invasive Diagnosis of Chronic Kidney Disease (CKD)
by Alessia Di Gilio, Jolanda Palmisani, Marirosa Nisi, Valentina Pizzillo, Marco Fiorentino, Stefania Rotella, Nicola Mastrofilippo, Loreto Gesualdo and Gianluigi de Gennaro
Molecules 2024, 29(19), 4686; https://doi.org/10.3390/molecules29194686 - 2 Oct 2024
Viewed by 866
Abstract
Recently, volatile organic compound (VOC) determination in exhaled breath has seen growing interest due to its promising potential in early diagnosis of several pathological conditions, including chronic kidney disease (CKD). Therefore, this study aimed to identify the breath VOC pattern providing an accurate, [...] Read more.
Recently, volatile organic compound (VOC) determination in exhaled breath has seen growing interest due to its promising potential in early diagnosis of several pathological conditions, including chronic kidney disease (CKD). Therefore, this study aimed to identify the breath VOC pattern providing an accurate, reproducible and fast CKD diagnosis at early stages of disease. A cross-sectional observational study was carried out, enrolling a total of 30 subjects matched for age and gender. More specifically, the breath samples were collected from (a) 10 patients with end-stage kidney disease (ESKD) before undergoing hemodialysis treatment (DIAL); (b) 10 patients with mild-moderate CKD (G) including 3 patients in stage G2 with mild albuminuria, and 7 patients in stage G3 and (c) 10 healthy controls (CTRL). For each volunteer, an end-tidal exhaled breath sample and an ambient air sample (AA) were collected at the same time on two sorbent tubes by an automated sampling system and analyzed by Thermal Desorption–Gas Chromatography–Mass Spectrometry. A total of 110 VOCs were detected in breath samples but only 42 showed significatively different levels with respect to AA. Nonparametric tests, such as Wilcoxon/Kruskal–Wallis tests, allowed us to identify the most weighting variables able to discriminate between AA, DIAL, G and CTRL breath samples. A promising multivariate data mining approach incorporating only selected variables (showing p-values lower than 0.05), such as nonanal, pentane, acetophenone, pentanone, undecane, butanedione, ethyl hexanol and benzene, was developed and cross-validated, providing a prediction accuracy equal to 87% and 100% in identifying patients with both mild–moderate CKD (G) and ESKD (DIAL), respectively. Full article
(This article belongs to the Section Analytical Chemistry)
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Graphical abstract
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<p>Boxplot and <span class="html-italic">p</span>-values obtained by Wilcoxon signed-rank test demonstrating the abundance values related to acetone (e.g., endogenous and non-diagnostic VOC)s and butanedione (e.g., endogenous and potentially diagnostic VOCs).</p>
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<p>PC1 vs. PC2 scoreplot. Healthy subjects (CTRL) in light blue; dialysis patients (DIAL) in yellow and patients with mild and moderate renal impairment (G) in red.</p>
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<p>LD1 vs. LD2 scoreplot. Healthy subjects (CTRL) in light blue; dialysis patients (DIAL) in yellow and patients with mild and moderate renal impairment (G) in red.</p>
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<p>ROC curves.</p>
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21 pages, 15462 KiB  
Article
An Empirical Investigation on the Visual Imagery of Augmented Reality User Interfaces for Smart Electric Vehicles Based on Kansei Engineering and FAHP-GRA
by Jin-Long Lin and Meng-Cong Zheng
Mathematics 2024, 12(17), 2712; https://doi.org/10.3390/math12172712 - 30 Aug 2024
Viewed by 745
Abstract
Smart electric vehicles (SEVs) hold significant potential in alleviating the energy crisis and environmental pollution. The augmented reality (AR) dashboard, a key feature of SEVs, is attracting considerable attention due to its ability to enhance driving safety and user experience through real-time, intuitive [...] Read more.
Smart electric vehicles (SEVs) hold significant potential in alleviating the energy crisis and environmental pollution. The augmented reality (AR) dashboard, a key feature of SEVs, is attracting considerable attention due to its ability to enhance driving safety and user experience through real-time, intuitive driving information. This study innovatively integrates Kansei engineering, factor analysis, fuzzy systems theory, analytic hierarchy process, grey relational analysis, and factorial experimentation to evaluate AR dashboards’ visual imagery and subjective preferences. The findings reveal that designs featuring blue planar and unconventional-shaped dials exhibit the best performance in terms of visual imagery. Subsequent factorial experiments confirmed these results, showing that drivers most favor blue-dominant designs. Furthermore, in unconventional-shaped dial designs, the visual effect of vertical 3D is more popular with drivers than horizontal 3D, while the opposite is true in round dials. This study provides a scientific evaluation method for assessing the emotional experience of AR dashboard interfaces. Additionally, these findings will help reduce the subjectivity in interface design and enhance the overall competitiveness of SEV vehicles. Full article
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<p>Assessment architecture diagram of this study.</p>
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<p>Design proposal for 18 AR dashboards.</p>
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<p>Schematic diagram of design proposal switching.</p>
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<p>Linguistic variables describing weights of the FAHP.</p>
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<p>The scree plot of eigenvalues and the number of factors.</p>
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<p>The results of the simple effects analysis of the main color within the interaction between the main color and visual effects. Error bars represent +1 SEM. (Notes: * <span class="html-italic">p</span> ≤ 0.05, ** <span class="html-italic">p</span> ≤ 0.01, *** <span class="html-italic">p</span> ≤ 0.001).</p>
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<p>The results of the simple effects analysis of dial styling within the interaction between visual effects and dial styling. Error bars represent +1 SEM. (Notes: * <span class="html-italic">p</span> ≤ 0.05, ** <span class="html-italic">p</span> ≤ 0.01, *** <span class="html-italic">p</span> ≤ 0.001).</p>
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13 pages, 1858 KiB  
Article
Challenges in Lipidomics Biomarker Identification: Avoiding the Pitfalls and Improving Reproducibility
by Johanna von Gerichten, Kyle Saunders, Melanie J. Bailey, Lee A. Gethings, Anthony Onoja, Nophar Geifman and Matt Spick
Metabolites 2024, 14(8), 461; https://doi.org/10.3390/metabo14080461 - 19 Aug 2024
Viewed by 1229
Abstract
Identification of features with high levels of confidence in liquid chromatography–mass spectrometry (LC–MS) lipidomics research is an essential part of biomarker discovery, but existing software platforms can give inconsistent results, even from identical spectral data. This poses a clear challenge for reproducibility in [...] Read more.
Identification of features with high levels of confidence in liquid chromatography–mass spectrometry (LC–MS) lipidomics research is an essential part of biomarker discovery, but existing software platforms can give inconsistent results, even from identical spectral data. This poses a clear challenge for reproducibility in biomarker identification. In this work, we illustrate the reproducibility gap for two open-access lipidomics platforms, MS DIAL and Lipostar, finding just 14.0% identification agreement when analyzing identical LC–MS spectra using default settings. Whilst the software platforms performed more consistently using fragmentation data, agreement was still only 36.1% for MS2 spectra. This highlights the critical importance of validation across positive and negative LC–MS modes, as well as the manual curation of spectra and lipidomics software outputs, in order to reduce identification errors caused by closely related lipids and co-elution issues. This curation process can be supplemented by data-driven outlier detection in assessing spectral outputs, which is demonstrated here using a novel machine learning approach based on support vector machine regression combined with leave-one-out cross-validation. These steps are essential to reduce the frequency of false positive identifications and close the reproducibility gap, including between software platforms, which, for downstream users such as bioinformaticians and clinicians, can be an underappreciated source of biomarker identification errors. Full article
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<p>Distinct and overlapping identifications between Lipostar and MS DIAL. (<b>A</b>) MS<sup>1</sup> data only and (<b>B</b>) MS<sup>2</sup> data only.</p>
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<p>Breakdown of lipid classes identified: (<b>A</b>) common MS<sup>2</sup> identifications and (<b>B</b>) unique MS<sup>2</sup> identifications.</p>
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<p>Violin plots for annotation confidence scores of matching and non-matching lipid identifications for Lipostar and MS DIAL. Individual scores range from 0 to 100. MS<sup>2</sup> identifications are only shown here.</p>
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<p>(<b>A</b>,<b>B</b>) Actual and predicted <span class="html-italic">t</span><sub>R</sub> plotted as boxplots by lipid class: 8 most abundant lipid classes shown. The upper and lower bounds of boxes show the interquartile range. (<b>C</b>) predicted <span class="html-italic">t</span><sub>R</sub> plotted against carbon atom count, with lipid class shown by color, for 8 most abundant lipid classes. (<b>D</b>) SHAP value beeswarm plots for feature importance, atom count, and 8 most abundant lipid classes shown—<span class="html-italic">x</span>-axis represents the impact on model output (predicted <span class="html-italic">t</span><sub>R</sub>), each dot represents a sample. The color scale indicates the impact of feature value, where red is an above-average value for a feature such as carbon count, and blue is a below-average value for a feature. TG—triglycerides, SM—sphingomyelins, SL—sphingolipids, PC—phosphatidylcholines, Cer—ceramides including alpha-hydroxy ceramides (Cer_AP), non-hydroxy ceramides containing dihydrosphingosine (Cer_NDS), and hydroxy ceramides containing dihydrosphingosine (Cer_HDS).</p>
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18 pages, 6972 KiB  
Article
The Accurate Inversion of the Vertical Ozone Profile in High-Concentration Aerosols Based on a New DIAL-A Case Study
by Na Ma, Jie Wang, Chenglei Pei, Sipeng Yang, Tianshu Zhang, Yujun Zhang, Jianing Wan and Yiwei Xu
Remote Sens. 2024, 16(16), 2997; https://doi.org/10.3390/rs16162997 - 15 Aug 2024
Viewed by 687
Abstract
Recently, in China, during the period of transition between spring and summer, the combination of sandstorms and ozone (O3) pollution has posed a significant challenge to the strategy of coordinated control of fine particulate matters (PM2.5) and O3 [...] Read more.
Recently, in China, during the period of transition between spring and summer, the combination of sandstorms and ozone (O3) pollution has posed a significant challenge to the strategy of coordinated control of fine particulate matters (PM2.5) and O3. On the one hand, the dust invasion brings many primary aerosols and causes a large range of transboundary transport. On the other hand, the high concentration of aerosol causes a severe disturbance to the distribution of O3. Traditionally, high-resolution assessments of the spatial distribution of aerosols and O3 can be carried out using LiDAR technology. However, the negligence of the influence of aerosols in the process of O3 retrieval in traditional differential absorption lidar (DIAL) leads to an error in the accuracy of ozone concentration. Especially when dust transit occurs, the errors become bigger. In this study, a self-customized four-wavelength differential-absorption LiDAR system was used to synchronously obtain the accurate vertical distributions of ozone and high-concentration aerosol. The wavelength index of concentrated aerosol was inverted and applied to the differential equation framework for O3 calculation. This novel approach to retrieving the vertical profile of O3 was proposed and verified by applying it to a dust pollution event that occurred from April to May 2021 in Anyang City Henan Province, which is located in Northern China. It was found that the extinction coefficient of aerosol reached 2.5 km−1 during the dust period, and O3 was mainly distributed between 500 m and 1500 m. The O3 error exceeded over 10% arising from the high-concentration aerosol below 1.5 km during the dust storm event. By employing the inversion algorithm while considering the aerosol effects, the ozone concentration error was improved by over 10% compared with the error recorded without considering the aerosol influence especially in dust events. Through this study, it was found that the algorithm could effectively realize the synchronous and accurate inversion of high-concentration aerosols and O3 and can provide key technical support for air pollution control in China in the future. Full article
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<p>Schematic diagram of the four-wavelength ozone lidar system.</p>
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<p>Optical properties of atmospheric aerosols: (<b>a</b>) profile of the atmospheric aerosol backscatter coefficient; (<b>b</b>) profile of the atmospheric aerosol extinction coefficient.</p>
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<p>Ozone concentration profile.</p>
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<p>Errors analysis caused by high-concentration aerosol: (<b>a</b>) the error distribution of backscatter coefficients; (<b>b</b>) the error distribution of extinction coefficients.</p>
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<p>(<b>a</b>) Error caused by the extinction term; (<b>b</b>) aerosol extinction coefficient.</p>
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<p>Concentration of ozone optimized with (After) and without (Before) aerosol consideration. (<b>a</b>) At 14:00 on 14 April 2021; (<b>b</b>) 07:00 on 15 April 2021; (<b>c</b>) 13:00 on 17 April 2021.</p>
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<p>Concentration of ozone optimized with (After) and without (Before) aerosol consideration. (<b>a</b>) At 14:00 on 14 April 2021; (<b>b</b>) 07:00 on 15 April 2021; (<b>c</b>) 13:00 on 17 April 2021.</p>
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<p>Improvement rate of ozone concentration profiles before (black), during (red), and after (green) sand dust event.</p>
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<p>Time series of ozone concentration at 200 m retrieved with (red) and without (black) considering aerosol and ground level (blue).</p>
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<p>The correlation coefficients of between ground level and with (red) and without (black) considering aerosol.</p>
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<p>Vertical distribution of ozone observed using ozone lidar from 26 to 30 May.</p>
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<p>Comparison of the monitoring results between a ground -level automatic ozone analyzer and ozone lidar at different altitudes.</p>
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<p>Vertical profiles of ozone concentrations at different times on 28 May.</p>
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16 pages, 10348 KiB  
Article
Pointer Meter Reading Method Based on YOLOv8 and Improved LinkNet
by Xiaohu Lu, Shisong Zhu and Bibo Lu
Sensors 2024, 24(16), 5288; https://doi.org/10.3390/s24165288 - 15 Aug 2024
Viewed by 707
Abstract
In order to improve the reading efficiency of pointer meter, this paper proposes a reading method based on LinkNet. Firstly, the meter dial area is detected using YOLOv8. Subsequently, the detected images are fed into the improved LinkNet segmentation network. In this network, [...] Read more.
In order to improve the reading efficiency of pointer meter, this paper proposes a reading method based on LinkNet. Firstly, the meter dial area is detected using YOLOv8. Subsequently, the detected images are fed into the improved LinkNet segmentation network. In this network, we replace traditional convolution with partial convolution, which reduces the number of model parameters while ensuring accuracy is not affected. Remove one pair of encoding and decoding modules to further compress the model size. In the feature fusion part of the model, the CBAM (Convolutional Block Attention Module) attention module is added and the direct summing operation is replaced by the AFF (Attention Feature Fusion) module, which enhances the feature extraction capability of the model for the segmented target. In the subsequent rotation correction section, this paper effectively addresses the issue of inaccurate prediction by CNN networks for axisymmetric images within the 0–360° range, by dividing the rotation angle prediction into classification and regression steps. It ensures that the final reading part receives the correct angle of image input, thereby improving the accuracy of the overall reading algorithm. The final experimental results indicate that our proposed reading method has a mean absolute error of 0.20 and a frame rate of 15. Full article
(This article belongs to the Section Industrial Sensors)
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<p>The principle of the pointer meter reading recognition method.</p>
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<p>Improved LinkNet architecture.</p>
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<p>Contrast between conventional and partial convolution.</p>
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<p>Schematic diagram of the CBAM mechanism.</p>
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<p>MS-CAM structure diagram.</p>
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<p>AFF structure diagram.</p>
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<p>Rotation correction model structure diagram.</p>
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<p>Reading detail display.</p>
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<p>Partial dataset display diagram.</p>
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<p>Data Enhancement strategy schematic.</p>
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<p>Reading visualization process.</p>
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<p>Reading result.</p>
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14 pages, 3190 KiB  
Article
An Improved CH4 Profile Retrieving Method for Ground-Based Differential Absorption Lidar
by Lu Fan, Yong Wan and Yongshou Dai
Atmosphere 2024, 15(8), 937; https://doi.org/10.3390/atmos15080937 - 5 Aug 2024
Viewed by 613
Abstract
Range-resolved CH4 concentration measurement is important prior data for atmospheric physical and chemical models. Ground-based differential absorption lidar (DIAL) can measure the vertical distribution of CH4 concentration in the atmosphere. The traditional method uses lidar observational data and the lidar equation [...] Read more.
Range-resolved CH4 concentration measurement is important prior data for atmospheric physical and chemical models. Ground-based differential absorption lidar (DIAL) can measure the vertical distribution of CH4 concentration in the atmosphere. The traditional method uses lidar observational data and the lidar equation to calculate profiles, but the inversion accuracy is greatly affected by noise. Although some denoising methods can improve accuracy at low altitudes, the low signal-to-noise ratio caused by the effect of aerosol Mie scattering and lower aerosol concentrations at high altitudes cannot be solved. Here, an improved cubic smoothing spline fitting CH4 concentration profile inversion method is proposed to address this challenge. By adding a penalty term of the second derivative of the conventional cubic spline function to the objective function, this penalty term acts to smooth the fitting, allowing the fitting function to avoid necessarily passing through those noisy sampling points. This avoids the large fluctuations caused by noisy sampling points, effectively suppresses noise, captures signals with lower noise levels, and thereby enhances the inversion accuracy of the profiles. Simulations and case studies demonstrated the superiority of the proposed method. Compared with the traditional method, cubic smoothing spline fitting can reduce the mean error of the whole CH4 profile by 85.54%. The standard deviation of CH4 concentration retrieved is 3.59 ppb–90.29 ppb and 0.01 ppb–6.75 ppb smaller than the traditional method and Chebyshev fitting, respectively. Three real cases also indicate that the CH4 concentration retrieved by cubic smoothing spline fitting is more consistent with in-situ measurements. In addition, long-term DIAL observations have also revealed notable diurnal and seasonal trends in CH4 concentration at observation sites. Full article
(This article belongs to the Section Atmospheric Techniques, Instruments, and Modeling)
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<p>The location of the observation site (acquired from Google Earth).</p>
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<p>The SNR profile measured by CH<sub>4</sub>-DIAL system.</p>
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<p>Simulations of the three methods. (<b>a</b>) ME of CH<sub>4</sub> profile retrieved by three methods. (<b>b</b>) Relationship between altitude and MAE of CH<sub>4</sub> profile calculated by three methods. (<b>c</b>) Difference in STD of the traditional method and Chebyshev fitting relative to cubic smoothing spline fitting.</p>
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<p>Case verification of the traditional method and cubic smoothing spline fitting. (<b>a</b>,<b>c</b>,<b>e</b>) show the vertical distribution of CH<sub>4</sub> concentration obtained from in-situ measurements and two methods based on CH<sub>4</sub>-DIAL data in three different true cases. (<b>b</b>,<b>d</b>,<b>f</b>) demonstrate the scatter plots of CH<sub>4</sub> concentration retrieved from two instruments in these three cases. The asterisk indicates that the R passed the statistical significance test (<span class="html-italic">p</span> &lt; 0.05).</p>
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<p>Diurnal variation in CH<sub>4</sub> concentration profile.</p>
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<p>Diurnal variation of the average CH<sub>4</sub> concentration in different seasons and throughout the year.</p>
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<p>Monthly and seasonal variations of the average CH<sub>4</sub> concentration.</p>
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31 pages, 2714 KiB  
Review
Review and Classification of Objectives in Dynamic Dial-a-Ride Systems: A Triple Bottom Line Approach of Sustainability
by Sapan Tiwari, Neema Nassir and Patricia Sauri Lavieri
Sustainability 2024, 16(13), 5788; https://doi.org/10.3390/su16135788 - 7 Jul 2024
Cited by 1 | Viewed by 1084
Abstract
Dynamic dial-a-ride problems (DDARPs) involve designing routes and schedules for customers with specific origins and destinations. While the optimization of DDARPs has been extensively examined, these analyses often focus solely on economic decisions. The recent literature emphasizes the inclusion of social and environmental [...] Read more.
Dynamic dial-a-ride problems (DDARPs) involve designing routes and schedules for customers with specific origins and destinations. While the optimization of DDARPs has been extensively examined, these analyses often focus solely on economic decisions. The recent literature emphasizes the inclusion of social and environmental factors in addition to economic considerations for a sustainable transportation system. This paper provides a conceptual review that identifies and classifies the most common DDARP objectives in the three dimensions of the Triple-Bottom-Line (3BL) approach of sustainability: environmental, economic, and social. This study analyzes the interconnections among different objectives and provides insights into multi-objective approaches used in transportation problems. The findings demonstrate the interconnectedness of objectives from different dimensions and highlight the involvement of various stakeholders in decision-making. The results show that optimizing one objective may have implications for other objectives, suggesting a trade-off to be considered. The results reveal that social objectives boost the economic dimension by improving service quality; however, environmental objectives negatively impact the economic dimension. Additionally, a geographical analysis was conducted, which revealed continent-wise variations in research focus and contributions. Future studies should focus more on the social and environmental dimensions to promote a sustainable transportation system. Full article
(This article belongs to the Collection Advances in Transportation Planning and Management)
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<p>The search and screening mechanism used.</p>
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<p>Year-wise distribution of selected papers.</p>
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<p>Country-wise distribution of the selected papers.</p>
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<p>Continent-wise distribution of the selected papers.</p>
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<p>Dimensions of sustainability as per 3BL.</p>
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<p>The general framework of the objectives used in this study.</p>
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<p>Objective-wise distribution of the selected papers.</p>
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<p>No. of papers for different dimensions.</p>
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<p>Number of papers from each continent in (<b>a</b>) economic; (<b>b</b>) social; (<b>c</b>) environmental dimension.</p>
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17 pages, 7536 KiB  
Article
Accuracy Evaluation of Differential Absorption Lidar for Ozone Detection and Intercomparisons with Other Instruments
by Guangqiang Fan, Bowen Zhang, Tianshu Zhang, Yibin Fu, Chenglei Pei, Shengrong Lou, Xiaobing Li, Zhenyi Chen and Wenqing Liu
Remote Sens. 2024, 16(13), 2369; https://doi.org/10.3390/rs16132369 - 28 Jun 2024
Cited by 1 | Viewed by 1066
Abstract
Differential absorption lidar is an advanced tool for investigating tropospheric ozone transport and development. High-quality differential absorption lidar data are the basis for studying the temporal and spatial evolution of ozone pollution. We assessed the quality of the ozone data generated via differential [...] Read more.
Differential absorption lidar is an advanced tool for investigating tropospheric ozone transport and development. High-quality differential absorption lidar data are the basis for studying the temporal and spatial evolution of ozone pollution. We assessed the quality of the ozone data generated via differential absorption lidar. By correcting the ozone lidar profile in real-time with an atmospheric correction term and comparing the lidar data to ozone data collected using an unmanned aerial vehicle (UAV), we quantified the statistical error of the ozone lidar data in the vertical direction and determined that the data from the two instruments were generally in agreement. To verify the reliability of the ozone lidar system and the atmospheric correction algorithm, we conducted a long-term comparison experiment using data from the Canton Tower. Over the two months, the UAV and lidar data were consistent with one another, which confirmed the viability of the ozone lidar optomechanical structure and the atmospheric correction algorithm, both in real-time and over a given time duration. In addition, we also quantified the relationship between statistical error and signal-to-noise ratio. When the SNR is less than 10, the corresponding statistical error is about 40%. The statistical error was less than 15% when the signal-to-noise ratio was greater than 20, and the statistical error was mostly less than 8% when the signal-to-noise ratio was greater than 40. In general, the statistical error of the differential absorption lidar data was inversely proportional to the signal-to-noise ratio of each echo signal. Full article
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<p>The comparison between simulated PRR and that was measured by ozone lidar.</p>
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<p>Block diagram of the Ozone lidar setup.</p>
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<p>(<b>a</b>) Unmanned aerial vehicle (UAV). (<b>b</b>) Personal ozone monitor (POM).</p>
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<p>Location of the four layers of the air pollutants sampled on the Canton Tower.</p>
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<p>(<b>a</b>) Corrections of ozone lidar caused by air molecule extinction, aerosol extinction, and atmospheric backscattering during the comparison period. (<b>b</b>) The comparison between POM and the ozone lidar profiles.</p>
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<p>(<b>a</b>) The mean ozone concentration measured by ozone lidar at 18:42 LT on 24 July 2017. Error bars give uncertainties for ozone measurement. (<b>b</b>) The statistical error of ozone concentration was measured by ozone lidar at 18:42 LT on 24 July 2017.</p>
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<p>Spatial and temporal distribution of (<b>a</b>) WRF wind speed; (<b>b</b>) WRF wind direction; and (<b>c</b>) lidar ozone concentration data.</p>
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<p>(<b>a</b>) Spatial and temporal distribution of ozone measured by ozone lidar in Guangzhou. (<b>b</b>) The comparison with the ozone instrument mounted on the Canton tower and (<b>c</b>) correlation analysis.</p>
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<p>Spatial and temporal distribution of ozone in Guangzhou from 15 September to 20 September.</p>
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<p>Correction terms for air molecule extinction, aerosol extinction and atmospheric backscattering, and ozone concentration after atmospheric correction at a height of 495 m.</p>
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<p>(<b>a</b>) Comparison of the ozone lidar inversion results after atmospheric correction and the data collected from the ozone instrument mounted on Canton Tower and (<b>b</b>) the correlation analysis.</p>
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<p>(<b>a</b>) The SNR of the signals at 289 nm and 316 nm wavelength; (<b>b</b>) The statistical error of the ozone concentration; (<b>c</b>) The relationship between ozone statistical error and SNR of the signal at 289 nm wavelength.</p>
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16 pages, 5174 KiB  
Article
Electrochemical Synthesis of the In Human S-oxide Metabolites of Phenothiazine-Containing Antipsychotic Medications
by Ridho Asra, Aigul Erbosynovna Malmakova and Alan M. Jones
Molecules 2024, 29(13), 3038; https://doi.org/10.3390/molecules29133038 - 26 Jun 2024
Cited by 1 | Viewed by 1391
Abstract
The tractable preparation of Phase I drug metabolites is a critical step to understand the first-pass behaviour of novel chemical entities (NCEs) in drug discovery. In this study, we have developed a structure–electroactivity relationship (SeAR)-informed electrochemical reaction of the parent 2-chlorophenothiazine and the [...] Read more.
The tractable preparation of Phase I drug metabolites is a critical step to understand the first-pass behaviour of novel chemical entities (NCEs) in drug discovery. In this study, we have developed a structure–electroactivity relationship (SeAR)-informed electrochemical reaction of the parent 2-chlorophenothiazine and the antipsychotic medication, chlorpromazine. With the ability to dial-in under current controlled conditions, the formation of S-oxide and novel S,S-dioxide metabolites has been achieved for the first time on a multi-milligram scale using a direct batch electrode platform. A potential rationale for the electrochemical formation of these metabolites in situ is proposed using molecular docking to a cytochrome P450 enzyme. Full article
(This article belongs to the Special Issue Novel Studies of Organic Electrosynthesis)
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<p>Cyclic voltammetry behaviour of 2CPTZ and CPZ, GCE (WE), Pt (CE), and Ag/AgCl (<span class="html-italic">pseudo</span> RE), referenced to Fc/Fc<sup>+</sup>. Electrolyte: TBAPF<sub>6</sub>; solvent: MeCN. (<b>a</b>) CV studies of 2CPTZ with multiple sweeps up to 2.0 V and 3.0 V, with a scan rate of 0.20 Vs<sup>−1</sup>. (<b>b</b>) Multiple-scan analysis of 2CPTZ (5 mM) sweeping up to 2.0 V. (<b>c</b>) Multiple-scan analysis of 2CPTZ (5 mM) sweeping up to 3.0 V. (<b>d</b>) CV studies of CPZ with multiple sweeps up to 2.0 V and 3.0 V, with a scan rate of 0.20 Vs<sup>−1</sup>. (<b>e</b>) Multiple-scan analysis of CPZ (4 mM) sweeping up to 2.0 V. (<b>f</b>) Multiple-scan analysis of CPZ (5 mM) sweeping up to 3.0 V.</p>
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<p>HPLC analysis of 2CPTZ metabolites’ electrosynthesis under different constant current conditions using an ElectraSyn 2.0 at 25 °C for 24 h. (<b>a</b>) HPLC of the 2CPTZ and 2CPTZ-SO/SO<sub>2</sub>, (<b>b</b>) constant current of 0.5 mA, (<b>c</b>) constant current of 1.0 mA, (<b>d</b>) constant current of 1.5 mA, and (<b>e</b>) constant current of 2.0 mA.</p>
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<p>HPLC analysis of the CPZ metabolites’ electrosynthesis under different constant current conditions using ElectraSyn 2.0 at 25 °C for 24 h. (<b>a</b>) HPLC of the CPZ and CPZ-SO/SO<sub>2</sub> with solvent gradient indicated in pink (acetonitrile and 0.05% TFA in water), (<b>b</b>) constant current of 1.0 mA, (<b>c</b>) constant current of 1.5 mA, (<b>d</b>) constant current of 2.0 mA, (<b>e</b>) constant current of 2.5 mA, and (<b>f</b>) constant current of 3.0 mA.</p>
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<p>The stacked <sup>1</sup>H-NMR spectra (400 MHz, DMSO-d<sub>6</sub>) of the PTZs studied and their respective metabolites synthesised via electrochemical oxidation.</p>
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<p>Summary of PTZ site interaction with heme-Fe species inferred from docking studies. Numbers relate to non-IUPAC atomic positions in the docking model.</p>
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<p>Thioether–heme-Fe interaction of CPZ with CYP3A4. Colour coding: protein in grey scale with nitrogen (blue) and oxygen (red) highlighted; and CPZ in blue carbon chain, with sulfur (yellow), chlorine (green) highlighted.</p>
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<p>Previous approaches (a–d) [<a href="#B7-molecules-29-03038" class="html-bibr">7</a>,<a href="#B14-molecules-29-03038" class="html-bibr">14</a>,<a href="#B15-molecules-29-03038" class="html-bibr">15</a>,<a href="#B16-molecules-29-03038" class="html-bibr">16</a>,<a href="#B17-molecules-29-03038" class="html-bibr">17</a>] towards synthesising PTZs sulfoxide using chemical oxidants and microfluidic electrosynthesis and <span class="html-italic">this work</span>: a green electrosynthesis approach.</p>
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<p>General synthesis of novel PTZ-containing structures to explore linker length and amine effect. Summary of initial oxidation potentials observed in PTZ analogues derived from cyclic voltammetry measurements.</p>
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<p>A potential mechanism for sulfoxide and sulfone formation from PTZs under electrochemical conditions in non-anhydrous acetonitrile solvent.</p>
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<p><span class="html-italic">N</span>-dealkylation mechanism of CPZ to 2CPTZ.</p>
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25 pages, 821 KiB  
Article
Enhancing Service Quality of On-Demand Transportation Systems Using a Hybrid Approach with Customized Heuristics
by Sonia Nasri, Hend Bouziri and Wassila Aggoune Mtalaa
Smart Cities 2024, 7(4), 1551-1575; https://doi.org/10.3390/smartcities7040063 - 26 Jun 2024
Viewed by 1254
Abstract
As customers’ expectations continue to rise, advanced on-demand transport services face the challenge of meeting new requirements. This study addresses a specific transportation issue belonging to dial-a-ride problems, including constraints aimed at fulfilling customer needs. In order to provide more efficient on-demand transportation [...] Read more.
As customers’ expectations continue to rise, advanced on-demand transport services face the challenge of meeting new requirements. This study addresses a specific transportation issue belonging to dial-a-ride problems, including constraints aimed at fulfilling customer needs. In order to provide more efficient on-demand transportation solutions, we propose a new hybrid evolutionary computation method. This method combines customized heuristics including two exchanged mutation operators, a crossover, and a tabu search. These optimization techniques have been empirically proven to support advanced designs and reduce operational costs, while significantly enhancing service quality. A comparative analysis with an evolutionary local search method from the literature has demonstrated the effectiveness of our approach across small-to-large-scale problems. The main results show that service providers can optimize their scheduling operations, reduce travel costs, and ensure a high level of service quality from the customer’s perspective. Full article
(This article belongs to the Section Smart Transportation)
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<p>An on-demand transport network with two requests having time windows, maximal ride times, and loads.</p>
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<p>The vehicle tour schedule before the time windows calculation.</p>
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<p>The vehicle tour schedule after the time windows calculation.</p>
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<p>Flow chart of the ETS algorithm.</p>
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<p>Construction of a new solution with the interruption operator.</p>
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<p>Construction of a new solution with the swap operator.</p>
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<p>An illustrative example of the SXO.</p>
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<p>An illustrative example of the neighborhood strategy of the TS.</p>
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<p>The solution of the <math display="inline"><semantics> <mrow> <mi>d</mi> <mn>75</mn> </mrow> </semantics></math> instance obtained with the ELS.</p>
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<p>The schedule time for request 9 in the vehicle (<math display="inline"><semantics> <mrow> <mi>v</mi> <mo>=</mo> <mn>1</mn> </mrow> </semantics></math>) obtained with the ELS.</p>
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<p>The solution of the <math display="inline"><semantics> <mrow> <mi>d</mi> <mn>75</mn> </mrow> </semantics></math> instance obtained with the ETS.</p>
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<p>The details related to requests 7 and 9 in <math display="inline"><semantics> <mrow> <mo>(</mo> <mi>v</mi> <mo>=</mo> <mn>1</mn> <mo>)</mo> </mrow> </semantics></math> in the solution obtained with the ETS.</p>
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<p>Number of solutions obtained with the ETS that are better or worse than the solutions of the ELS.</p>
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