Search Results (18,022)

While cities have always embodied difference, with their diverse inhabitants contributing to urban culture and economy, the underlying legitimation of belonging in the democratic nation-state continues to be based on an essentialized national identity. This study sheds light on the ways in which diverse cities, and specifically public spaces as spaces of encounter, are produced discursively on the level of the nation-state. The study employs Critical Frame Analysis (CFA) to examine the Austrian Security Police Act amendments between 2005 and 2018. This analysis focuses on how policy-making processes on the level of national legislation have discursively shaped public spaces in Vienna as zones of (in)security. The analysis reveals that national governments in Austria have increasingly framed urban public spaces as areas of insecurity. This framing aligns with broader nationalist agendas that seek to delineate who belongs within the nation, thereby exacerbating tensions between local multicultural practices and national discourses. The study highlights a significant gap between everyday multicultural encounters in urban spaces and national policies that reinforce exclusionary, homogeneous identities. These findings underscore the role of public space as a battleground for broader ideological conflicts over national identity and belonging. Full article

Background/Objectives: Right ventricular pacing is an effective and safe treatment option for patients experiencing symptomatic bradycardia. However, some individuals may develop left ventricular dysfunction as a consequence. Growth differentiation factor 15 (GDF-15), which is not present in a healthy adult heart, is upregulated in cardiomyocytes in response to various stress stimuli. This study aimed to explore the potential of GDF-15 as a biomarker for chronic right ventricular pacing. Methods: This single-center cross-sectional cohort study analyzed data from 265 consecutive patients (60.4% male) with either single- or dual-chamber pacemakers, all lacking pre-existing heart failure, who attended the outpatient department for routine follow-up. Chronic right ventricular (RV) pacing was defined as pacing exceeding 40% over the past year. Serum samples were collected, and GDF-15 levels were measured using a commercially available immunoassay (R&D Systems Inc., Minneapolis, MN, USA). Student’s t-test was utilized to assess group differences, and receiver operating characteristic (ROC) analysis was employed to evaluate diagnostic performance. Results: When stratifying patients by pacing burden, GDF-15 levels were significantly higher in those with pacing over 40% compared to those with 40% or less (789 ± 293 pg/mL vs. 1186 ± 592 pg/mL; p < 0.001). The ROC analysis indicated that GDF-15 serves as a marker for chronic RV pacing, yielding an area under the curve of 0.713 (95% confidence interval 0.650–0.776; p < 0.001). Conclusions: This study suggests that GDF-15 may be a valuable biomarker for chronic right ventricular pacing. Full article

In the current context of smart grids, microgrids have proven to be an effective solution to meet the energy needs of neighborhoods and collective buildings. This study investigates the voltage behavior and other critical parameters within a direct current (DC) microgrid to enhance system efficiency, stability, and reliability. The dynamic performance of a DC microgrid is analyzed under varying load and generation conditions, with particular emphasis on the voltage response and load-sharing mechanisms required to ensure stable operation. The findings indicate that specific control strategies, particularly droop methods, are effective in mitigating voltage fluctuations, enhancing power quality, and ensuring proper load distribution across multiple sources. This study also addresses significant challenges, including voltage regulation and fault resilience, to provide guidelines for designing robust and efficient DC microgrids. These insights are essential to inspire further advancements in control strategies and facilitate the practical deployment of DC microgrids as a sustainable solution for distributed energy systems, especially in scenarios prioritizing high DC load penetration and renewable energy integration. Full article

It is customary to classify approaches in statistical mechanics (SM) as belonging either to Boltzmanninan SM (BSM) or Gibbsian SM (GSM). It is, however, unclear how the Boltzmann equation (BE) fits into either of these approaches. To discuss the relation between BE and BSM, we first present a version of BSM that differs from standard presentation in that it uses local field variables to individuate macro-states, and we then show that BE is a special case of BSM thus understood. To discuss the relation between BE and GSM, we focus on the BBGKY hierarchy and note the version of the BE that follows from the hierarchy is “Gibbsian” only in the minimal sense that it operates with an invariant measure on the state space of the full system. Full article

Setting up a global SARS-CoV-2 surveillance system requires an understanding of how virus isolation and propagation practices, use of animal or human sera, and different neutralisation assay platforms influence assessment of SARS-CoV-2 antigenicity. In this study, with the contribution of 15 independent laboratories across all WHO regions, we carried out a controlled analysis of neutralisation assay platforms using the first WHO International Standard for antibodies to SARS-CoV-2 variants of concern (source: NIBSC). Live virus isolates (source: WHO BioHub or individual labs) or spike plasmids (individual labs) for pseudovirus production were used to perform neutralisation assays using the same serum panels. When comparing fold drops, excellent data consistency was observed across the labs using common reagents, including between pseudovirus and live virus neutralisation assays (RMSD of data from mean fold drop was 0.59). Utilising a Bayesian model, geometric mean titres and assay titre magnitudes (offsets) can describe the data efficiently. Titre magnitudes were seen to vary largely even for labs within the same assay group. We have observed that overall, live Microneutralisation assays tend to have the lowest titres, whereas Pseudovirus Neutralisation have the highest (with a mean difference of 3.2 log2 units between the two). These findings are relevant for laboratory networks, such as the WHO Coronavirus Laboratory Network (CoViNet), that seek to support a global surveillance system for evolution and antigenic characterisation of variants to support monitoring of population immunity and vaccine composition policy. Full article

One major disadvantage of fused filament fabricated components (FFF) is its well-known anisotropy, which results from the layer-wise adding of material, and that it is not always possible to avoid loading in the layer build-up direction. In particular, components that are exposed to multi-axial load conditions must manage with reduced tensile strength in the build-up direction. This work is therefore concerned with improving the tensile strength transverse to the layering by changing the layer structure without directly changing the material itself. Therefore, the print-defining G-Code was modified to change the arrangement between the layers. The effectiveness of this method was investigated by means of tensile tests using thermoplastic samples made of Acrylonitrile Styrene Acrylate (ASA), Poly Cyclohexylenedimethylene Terephthalate Glycol (PCTG), Poly Ethylene Terephthalate Glycol (PETG) and Poly Lactic Acid (PLA) for layer thicknesses of 0.16 mm and 0.28 mm. The results show that the G-Code modification generally resulted in an increase in tensile strength. For PETG, an improvement of 25% was achieved. Full article

Background/Objectives: The extracellular calcium-sensing receptor (CaSR) is a multifunctional receptor proposed as a possible drug target for inflammatory bowel disease. We showed previously that CaSR inhibition with NPS 2143, a negative allosteric modulator of the CaSR, somewhat ameliorated the symptoms of chemically induced severe colitis in mice. However, it was unclear whether the potential of CaSR inhibition to reduce colitis may have been overshadowed by the severity of the induced inflammation in our previous study. Therefore, we tested if CaSR inhibition could prevent medium-grade colitis. Methods: Female BALB/c mice were treated with NPS 2143 or a vehicle prior to the induction of colitis with 2.5% DSS. On the day of sacrifice, colons and plasma were collected. The histology score was determined based on hematoxylin-eosin-stained sections. Mucin content, proliferation (Ki67), and immune cell infiltration (CD3 and CD20) were quantified based on immunostainings. Gene expression was measured by RT-qPCR. Results: Treatment with NPS 2143 had no effect on the clinical symptom score of the mice. However, the colons of the mice in the treated group were significantly longer (p < 0.05), and NPS 2143 significantly reduced colon ulceration (p < 0.05). The treatment also significantly reduced the expression of COX2 in the proximal colon and IL-22 in the distal colon. The proliferation of cells in the lymph nodes was significantly lower after the treatment, but no difference was observed in the epithelial cells. Conclusions: In summary, while NPS 2143 had an anti-inflammatory effect on medium-grade colitis, this effect appeared to be milder than in severe colitis, as observed previously, indicating that the effectiveness of CaSR inhibition as an anti-inflammatory measure in the colon is proportional to disease severity. Full article

Coronavirus Disease 2019 causes significant morbidity, and different variants of concern (VOCs) can impact organ systems differently. We conducted a single-center retrospective cohort analysis comparing biomarkers and clinical outcomes in hospitalized patients infected with the wild-type or Alpha (wt/Alpha) VOC against patients infected with the Omicron VOC. We included 428 patients infected with the wt/Alpha VOC and 117 patients infected with the Omicron VOC. The Omicron cohort had higher maximal median high-sensitivity Troponin-T (hs-TnT) levels (wt/Alpha: 12.8 ng/L, IQR 6.6–29.5 vs. Omicron: 27.8 ng/L, IQR 13.7–54.0; p < 0.001) and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) (wt/Alpha: 256 ng/L, IQR 74.5–913.5 vs. Omicron: 825 ng/L, IQR 168–2759; p < 0.001) levels. This remained true for patients under 65 years of age and without pre-existing cardiovascular disease (hs-TnT (wt/Alpha: 6.1 ng/L, IQR 2.5–10.25 vs. Omicron: 8.6 ng/L, IQR 6.2–15.7; p = 0.007) and NT-proBNP (wt/Alpha: 63 ng/L, IQR 25–223.75 vs. Omicron: 158 ng/L, IQR 75.5–299.5; p = 0.006)). In-hospital mortality was similar between the two groups (wt/Alpha: 53 or 12.7% vs. Omicron: 9 or 7.7%; p = 0.132) and more patients infected with wt/Alpha VOC required intensive care admission (wt/Alpha: 93 or 22.2% vs. Omicron: 14 or 12%; p = 0.014). Increased cardiac biomarkers were correlated with a higher risk of mortality and ICU admission in both groups. Herein, we detected higher levels of cardiac biomarkers in hospitalized patients infected with the Omicron VOC when compared to wt/Alpha, being indicative of higher cardiac involvement. Although hs-TnT and NT-proBNP levels were higher in the Omicron cohort and both markers were linked to in hospital mortality in both groups, the mortality rates were similar. Full article

This paper discusses the properties of OMV Starfalt^® PmB 45/80 RC bituminous binder developed by the Austrian oil company OMV Downstream GmbH (OMV, Vienna, Austria), intended to be used for the recycling of reclaimed asphalt mixtures (RAP). The binder is characterized by various adjusted properties like higher needle penetration, higher softening point and higher elastic recovery (close to 95–100%), with the aim to compensate for the properties of the aged binder contained in the reclaimed asphalt. Three experimental sections were laid in the Czech Republic. Monitoring was performed on these sections (cores were taken after 0, 6, 12, 24, 44 and 93 months) with a consecutive analysis of the properties of the used binder—the binder was extracted from the cores and tested for penetration, softening point, critical temperature at bending beam rheometer (BBR), complex modulus and phase angle using a dynamic shear rheometer (DSR). The previously described binder was used during the construction of trial sections in the villages Domasov and Lednice and near the city Opava. In the first case, a surface course mixture of asphalt concrete type (AC surf 11+) contained 18% of RAP, whereas in the second and third case, a binder course mixture of asphalt concrete type (AC bin 22 S) comprised 23% and 39% of RAP, respectively. After approx. 8 years (Domasov and Lednice) and 3.5 years (Opava) in service, no failures or defects were recorded at any of the sections. This paper gives an update of the research work carried out in 2019 with the latest results from 2023. Full article

Background: Despite existing evidence of the high predictive value of natriuretic peptides (NPs) in patients with heart failure (HF), patients treated with guideline-directed therapy who have low or near-normal NP levels are unlikely to be correctly stratified for risk of clinical outcomes. The aim of this study is to detect plausible predictors for poor one-year clinical outcomes in patients with HFpEF and low NT-proBNP treated with in accordance with conventional guidelines. Methods: A total of 337 patients with HF with preserved ejection fraction (HFpEF) who had low levels of N-terminal natriuretic pro-peptide (NT-proBNP) at discharge due to optimal guideline-based therapy were enrolled in the study. The course of the observation was 3 years. Echocardiography and the assessment of conventional hematological and biochemical parameters, including NT-proBNP, tumor necrosis factor-alpha, high-sensitivity C-reactive protein (hs-CRP), adropin, irisin, visfatin, and fetuin-A, were performed at baseline and at the end of the study. Results: Three-year cumulative clinical endpoints (cardiovascular death, myocardial infarction or unstable angina or acute coronary syndrome, worsening HF, sudden cardiac death, or cardiac-related surgery or all-cause death) were detected in 104 patients, whereas 233 did not meet the endpoint. After adjusting for an age ≥ 64 years and a presence of atrial fibrillation, diabetes mellitus, chronic kidney disease (CKD) stages 1–3 and dilated cardiomyopathy, the multivariable Cox regression analysis showed that an irisin level of ≤7.2 ng/mL was an independent predictor of cumulative clinical endpoint. Moreover, patients with levels of irisin > 7.2 ng/mL had a better Kaplan–Meier survival rate than those with a lower serum irisin level (≤7.2 ng/mL). Conclusions: Multivariable analysis showed that an age ≥ 64 years; the presence of atrial fibrillation, diabetes mellitus, CKD stages 1–3 and dilated cardiomyopathy; an LAVI ≥ 39 mL/m²; and serum levels of hs-CRP ≥ 6.10 mg/L, irisin ≤ 7.2 ng/mL, and visfatin ≤ 1.1 ng/mL were predictors of poor clinical outcomes in HFpEF with low levels of NT-proBNP. A serum level of irisin ≤ 7.2 ng/mL could emerge as valuable biomarker for predicting long-term prognosis among HFpEF patients with low or near-normal levels of NT-proBNP. Full article

Background/Objectives: Cardiogenic shock (CS) remains a critical condition with high mortality rates despite advances in treatment. This study aimed to evaluate the prognostic significance of urinary output at various time intervals during CS and its effectiveness as a predictor of 30-day mortality, particularly in comparison to the Simplified Acute Physiology Score 3 (SAPS 3). Methods: We conducted a retrospective analysis of 96 patients diagnosed with CS, assessing urinary output at different intervals (0–6 h, 6–12 h, 12–24 h, and 0–24 h) as potential predictors of 30-day mortality. SAPS 3 was calculated for all patients, and its predictive value was compared to that of urinary output using both univariate and multivariate analyses. Additional analyses included ROC curve assessment and Kaplan–Meier survival analysis. Results: Urinary output at 6–12 h was significantly associated with 30-day mortality in univariate analysis. Area under the receiver operating characteristic curves (AUROCs) for urinary output at 0–6 h, 6–12 h, and 12–24 h was 0.61 (p = 0.07), 0.63 (p = 0.04), and 0.61 (p = 0.08), respectively. These AUROCs did not differ significantly between the three urinary output parameters. Regarding the cumulative urinary output of 0–24 h, the most pronounced impact was observed in patients producing less than 0.5 mL/kg/h. In multivariate analysis, when combined with SAPS 3, the predictive power of urinary output diminished. SAPS 3 alone demonstrated significant predictive value with an AUROC of 0.77 (p < 0.001). Conclusions: While early urinary output is a valuable predictor of 30-day mortality in patients with CS, its prognostic strength is limited when considered alongside comprehensive risk assessments like SAPS 3. These findings suggest that a multifaceted approach, incorporating both early and comprehensive indicators, is essential for accurately predicting outcomes in CS patients. Full article

As fully automated vehicles (FAVs) advance towards SAE Level 5 automation, the role of in-vehicle intelligent agents (IVIAs) in shaping passenger experience becomes critical. Even at SAE Level 5 automation, effective communication between the vehicle and the passenger will remain crucial to ensure a sense of safety, trust, and engagement. This study explores how different types and combinations of information provided by IVIAs influence user experience, acceptance, and trust. A sample of 25 participants was recruited for the study, which experienced a fully automated ride in a driving simulator, interacting with Iris, an IVIA designed for voice-only communication. The study utilized both qualitative and quantitative methods to assess participants’ perceptions. Findings indicate that critical and vehicle-status-related information had the highest positive impact on trust and acceptance, while personalized information, though valued, raised privacy concerns. Participants showed high engagement with non-driving-related activities, reflecting a high level of trust in the FAV’s performance. Interaction with the anthropomorphic IVIA was generally well received, but concerns about system transparency and information overload were noted. The study concludes that IVIAs play a crucial role in fostering passenger trust in FAVs, with implications for future design enhancements that emphasize emotional intelligence, personalization, and transparency. These findings contribute to the ongoing development of IVIAs and the broader adoption of automated driving technologies. Full article

The rising integration of AI-driven assessment in education holds promise, yet it is crucial to evaluate the correlation between trust in general AI tools, AI-based scoring systems, and future behavioral intention toward using these technologies. This study explores students’ perspectives on AI-assisted assessment in higher education. We constructed a comprehensive questionnaire supported by relevant studies. Several hypotheses grounded in the literature review were formulated. In an experimental setup, the students were tasked to read a designated chapter of a paper, answer an essay question about this chapter, and then have their answers evaluated by an AI-based essay grading tool. A comprehensive data analysis using Bayesian regression was carried out to test several hypotheses. The study finds that remote learners are more inclined to use AI-based educational tools. The students who believe that AI-based essay grading is less effective than teacher feedback have less trust in AI-based essay grading, whereas those who find it more effective perceive more benefit from it. In addition, students’ affinity for technology does not significantly impact trust or perceived benefits in AI-based essay grading. Full article

The performance of Static Nanomaterials Random-Access Memories (SRAMs) is often degraded in the sub-threshold region as it is susceptible to increased access energy and leakage power. However, the low-power operation of SRAM is very much essential for efficient device functioning. Accordingly, designing robust SRAM cells that maintain stability and minimize power consumption is a key challenge. In this regard, with this ongoing work, the authors present novel designs of SRAMs using memristor technology by mitigating the shortcomings discussed above. This paper proposes a novel SRAM architecture of four transistors and five memristors, by integrating memristor technology to achieve drastic improvement in performance at subthreshold regions. Further, it performs an analysis of the metrics of static noise margin and power consumption to comprehensively evaluate the proposed SRAM designs. Simulation using Cadence Virtuoso for 65 nm technology demonstrates that power consumption for a 4T5M cell is about two and a half times lower than for 4T4M and 1.2 times lower than for 4T3M, hence proving that it will be promising for extremely low-power applications. Full article

MR elastography is a non-invasive imaging technique that provides quantitative maps of tissue biomechanical properties, i.e., elasticity and viscosity. Currently, hepatic MR elastography is deployed in the clinic to assess liver fibrosis in MAFLD patients. In addition, research has demonstrated MR elastography’s ability to non-invasively assess chronic liver disease and to characterize breast cancer lesions and brain tumors. MR elastography requires efficient mechanical wave generation and penetration, motion-sensitized MRI sequences, and MR elastography inversion algorithms to retrieve the biomechanical properties of the tissue. MR elastography promises to enable non-invasive and versatile assessment of tissue, leading to better diagnosis and staging of several clinical conditions. Full article