Nothing Special   »   [go: up one dir, main page]
You seem to have javascript disabled. Please note that many of the page functionalities won't work as expected without javascript enabled.
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.3
3.4
Journals
Sensors
Special Issues
Modern Sensor Technology in Ophthalmology and Optometry for Diagnostics and...
sensors-logo
Submit to Special Issue Submit Abstract to Special Issue Review for Sensors Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Modern Sensor Technology in Ophthalmology and Optometry for Diagnostics and Surgery

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biomedical Sensors".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 4911

Special Issue Editors

Prof. Dr. Bojan Pajic

E-Mail Website1 Website2
Guest Editor
1. Eye Clinic Orasis, Swiss Eye Research Foundation, 5734 Reinach AG, Switzerland
2. Division of Ophthalmology, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland
Interests: femtosecond laser technology; excimer laser and ablative solid state laser technology; diagnostic diode laser; corneal biomechanics; corneal surgery procedure; mathematical models for corneal biomechanics; corneal presbyopia procedure; autologous corneal inlay; cataract surgery techniques; high frequency deep sclerotomy (HFDS) glaucoma procedure; clinical trial in cataract, cornea and glaucoma surgery
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Željka Cvejić

E-Mail Website
Guest Editor
Department of Physics, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 4, 21000 Novi Sad, Serbia
Interests: structure and microstructure; design and optimization of electrical, magnetic and optical properties of nanomaterials; biomedical structural analysis; X-ray diffraction; Raman spectroscopy and imaging; vibrational spectroscopy; scattering; structure modelling, optometry and vision science
Special Issues, Collections and Topics in MDPI journals
Dr. Dragan Indjin

E-Mail Website
Guest Editor
Optoelectronics and Nanoscale Electronics, Pollard Institute, School of Electronic and Electrical Engineering, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK
Interests: optical absorption; semiconductor lasers; mid-infrared and terahertz lasers and detectors; quantum-cascade lasers; infrared and terahertz sensing and imaging, medical sensing and imaging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The global improvement of health care is based on innovative scientific research with the development of new technologies. The Special Issue “Modern Sensor Technology in Ophthalmology and Optometry for Diagnostics and Surgery” aims to publish comprehensive and relevant research results from all scientific and technical disciplines, including ophthalmology, vision sciences, optometry and physics of the eye. An essential factor of importance in ophthalmology and optometry is the interdisciplinary development. This includes both basic research, which deals with physical, chemical and biological phenomena in the eye, and clinical research, which focuses on the development and optimisation of technical technologies and sensors in ophthalmology. The interaction and collaboration of physicists, engineers, ophthalmologists and optometrists is nowadays indispensable for the development of relevant cutting-edge technologies. The results potentially lead to the further development of state-of-the-art medicine. The main task is to enable patients to be diagnosed as quickly and accurately as possible and to help them in a minimally invasive manner, both conservatively and surgically. In the surgical disciplines in particular, the aim is to keep the patient’s rehabilitation time as short as possible while achieving maximum results. We would like to encourage research groups with relevant expertise to publish papers in this Special Issue that pursue precisely these goals and demonstrate and illustrate the importance of interdisciplinary approaches in the sensor technology for diagnostics and surgery in ophthalmology.

Prof. Dr. Bojan Pajic
Prof. Dr. Željka Cvejić
Dr. Dragan Indjin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sensors in ophthalmology
  • sensors in optometry
  • medical sensors
  • mathematical modelling
  • biomechanical modelling
  • optical aberrations
  • vision care
  • surgery in ophthalmology
  • lasers in ophthalmology for diagnostics and surgery

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

14 pages, 1768 KiB  
Article
Direct Measurement of the Ciliary Sulcus Diameter Using Optical Coherence Tomography—Inter-Rater Variability
by Timo Eppig, Manuel Seer, Antonio Martinez-Abad, Virgilio Galvis, Saskia Schütz, Alejandro Tello, Michiel C. Rombach and Jorge L. Alió
Sensors 2024, 24(21), 6950; https://doi.org/10.3390/s24216950 - 29 Oct 2024
Viewed by 525
Abstract
The determination of sulcus-to-sulcus measurements has been challenging due to the limitations of current approaches. Ultrasound methods are highly operator-dependent and require extensive training, while traditional optical devices cannot visualize structures posterior to the iris. However, modern optical anterior segment coherence tomography (AS-OCT) [...] Read more.
The determination of sulcus-to-sulcus measurements has been challenging due to the limitations of current approaches. Ultrasound methods are highly operator-dependent and require extensive training, while traditional optical devices cannot visualize structures posterior to the iris. However, modern optical anterior segment coherence tomography (AS-OCT) devices are changing this paradigm by identifying some anatomical landmarks posterior to the iris. This study evaluates the reproducibility of optical sulcus measurements in the context of sizing a novel accommodative intraocular lens (IOL). Preoperative OCT scans of patients scheduled for cataract surgery were analyzed regarding the dimensions of the ciliary sulcus using a custom scan method with a clinically available anterior segment optical coherence tomographer. Measurements were compared between two different readers, and various derived parameters were compared. The measurements by both readers were highly correlated (R2 > 0.96), and their agreement was excellent (mean difference 0.02 mm with 95% limits of agreement from −0.11 to 0.15 mm). In contrast, the sulcus diameter measurement did not agree well with automatically calculated values, such as the anterior chamber width or white-to-white. This leads to the conclusion that modern swept-source AS-OCT measurements of the ciliary sulcus dimensions are feasible, reproducible, and may be a clinically useful tool. Full article
(This article belongs to the Special Issue Modern Sensor Technology in Ophthalmology and Optometry for Diagnostics and Surgery)
►▼ Show Figures

Figure 1

Figure 1
<p>An ultrasound biomicroscopy (UBM) image showing a ciliary sulcus measurement. (Adopted from Hashemian et al. [<a href="#B17-sensors-24-06950" class="html-bibr">17</a>] under Creative Commons License).</p> Full article ">Figure 2
<p>Illustration of the situation after implantation of a Lumina IOL (dashed orange line) into the ciliary sulcus. Centripetal compression of the proprietary haptics induces a lateral shift of the two optic pieces of the lens perpendicular to the optical axis.</p> Full article ">Figure 3
<p>Exemplary anterior segment scan (CASIA2) of the horizontal meridian with standard white on black color space. The surfaces of the cornea and the lens are detected and highlighted by green lines. The ciliary sulcus is hardly visible, as expected, due to the absorption of light by the posterior pigment epithelium of the iris.</p> Full article ">Figure 4
<p>(<b>A</b>) Two -dimensional analysis screen of the CASIA2 software (Version 50.7x) showing the overview of the ocular scan and depicting the measurement method for sulcus to sulcus (STS) and sulcus plane depth (SPD) with the two green rulers. The STS measurement was performed manually from the visual interpretation of the ciliary mass. The automated values such as anterior chamber width (ACW) were also recorded, and angle-to-angle (ATA) measurements were additionally logged in the tabulated output format. (<b>B</b>,<b>C</b>) Magnified regions of the ciliary structure giving an impression of the pigmented structures and the ciliary sulcus (the scale bar is 3.0 mm). The orange arrows show the estimated location of the sulcus.</p> Full article ">Figure 5
<p>Correlation between for the posterior lens diameter of the Lumina IOL from manufacturing records and the postoperative measurement using OCT. The error bars depict the manufacturing tolerance (horizontal) and the estimated OCT measurement accuracy (vertical).</p> Full article ">Figure 6
<p>Inter-rater correlation and Bland-Altman levels of agreement for sulcus-to-sulcus (STS) measurement (<b>A</b>,<b>B</b>) and sulcus plane depth (SPD) (<b>C</b>,<b>D</b>), respectively.</p> Full article ">Figure 7
<p>Inter-rater correlation and Bland-Altman levels of agreement for anterior chamber width (ATA) (<b>A</b>,<b>B</b>) and angle-to-angle (ACW) measurement (<b>C</b>,<b>D</b>), respectively.</p> Full article ">Figure 8
<p>Correlation and Bland-Altman levels of agreement for sulcus-to-sulcus (STS) with white-to-white (WTW) measurements (<b>A</b>,<b>B</b>).</p> Full article ">Figure 9
<p>Correlation and Bland-Altman levels of agreement anterior chamber width (ACW) with WTW (<b>A</b>,<b>B</b>).</p> Full article ">Figure 10
<p>Correlation and Bland-Altman levels of agreement for angle-to-angle (ATA) measurements with WTW (<b>A</b>,<b>B</b>).</p> Full article ">
10 pages, 2359 KiB  
Communication
Two-Photon Excited Fluorescence Lifetime Imaging of Tetracycline-Labeled Retinal Calcification
by Kavita R. Hegde, Krishanu Ray, Henryk Szmacinski, Sharon Sorto, Adam C. Puche, Imre Lengyel and Richard B. Thompson
Sensors 2023, 23(14), 6626; https://doi.org/10.3390/s23146626 - 24 Jul 2023
Cited by 2 | Viewed by 1338
Abstract
Deposition of calcium-containing minerals such as hydroxyapatite and whitlockite in the subretinal pigment epithelial (sub-RPE) space of the retina is linked to the development of and progression to the end-stage of age-related macular degeneration (AMD). AMD is the most common eye disease causing [...] Read more.
Deposition of calcium-containing minerals such as hydroxyapatite and whitlockite in the subretinal pigment epithelial (sub-RPE) space of the retina is linked to the development of and progression to the end-stage of age-related macular degeneration (AMD). AMD is the most common eye disease causing blindness amongst the elderly in developed countries; early diagnosis is desirable, particularly to begin treatment where available. Calcification in the sub-RPE space is also directly linked to other diseases such as Pseudoxanthoma elasticum (PXE). We found that these mineral deposits could be imaged by fluorescence using tetracycline antibiotics as specific stains. Binding of tetracyclines to the minerals was accompanied by increases in fluorescence intensity and fluorescence lifetime. The lifetimes for tetracyclines differed substantially from the known background lifetime of the existing natural retinal fluorophores, suggesting that calcification could be visualized by lifetime imaging. However, the excitation wavelengths used to excite these lifetime changes were generally shorter than those approved for retinal imaging. Here, we show that tetracycline-stained drusen in post mortem human retinas may be imaged by fluorescence lifetime contrast using multiphoton (infrared) excitation. For this pilot study, ten eyes from six anonymous deceased donors (3 female, 3 male, mean age 83.7 years, range 79–97 years) were obtained with informed consent from the Maryland State Anatomy Board with ethical oversight and approval by the Institutional Review Board. Full article
(This article belongs to the Special Issue Modern Sensor Technology in Ophthalmology and Optometry for Diagnostics and Surgery)
►▼ Show Figures

Figure 1

Figure 1
<p>Two-photon-excited fluorescence intensity micrograph (<b>left panel</b>) with color-coded intensities (arbitrary units) on the right side of the panel, and fluorescence lifetime micrograph of the same field (<b>right panel</b>) fit to a single component with time indicated by false colors with scale in nanoseconds on the right. Experiments were carried out on an infusion-stained, flat-mounted retina, following the removal of the RPE and neurosensory retina (97-year-old female donor; cause of death: cardiovascular disease). Sample was labelled with Cl-Tet. Approximate size of the field: 250 × 250 μm<sup>2</sup>; further details can be found in the Methods.</p> Full article ">Figure 2
<p>Fluorescence intensity micrograph (<b>left panel</b>) of doxycycline-stained drusen in the retina of a 79-year-old white male donor (cause of death: chronic myelocytic anemia); the intensities are false colored according to the scale (arbitrary units) on the right of the image. The (<b>right panel</b>) shows the time-resolved fluorescence decay of the aggregated pixels in the indicated region of interest (pink); The purple dots indicate the individual time-resolved fluorescence intensity data points, the red line through the dots indicates the best fit to the data, the orange curve before two nanoseconds indicates the instrument response function, and the vertical lines at 1.3 and 10 nanoseconds indicate the beginning and end, respectively, of the data included in the fit. The solid purple line in the lower part of the right panel depicts the “residuals”: the differences between the actual measured data points and the values calculated for that time point by the best fit parameters.</p> Full article ">Figure 3
<p>Close-ups of the druse in <a href="#sensors-23-06626-f002" class="html-fig">Figure 2</a> at higher (60×) magnification ((<b>upper left panel</b>): fluorescence intensity in false color with scale on right side in arbitrary units; (<b>lower left panel</b>): single component fluorescence lifetime in false color with scale on the right in nanoseconds) and best two component fits to the pink region of interest at X = −33 μm, Y = −17 μm in the upper left panel, with both lifetimes floating (<b>upper right panel</b>), and with one lifetime fixed to 3.7 ns (<b>lower right panel</b>). The upper and lower right panels depict the decays using the same conventions as described in the <a href="#sensors-23-06626-f002" class="html-fig">Figure 2</a> legend.</p> Full article ">
8 pages, 751 KiB  
Article
Development and Testing of a Compact Autorefractor Based on Double-Pass Imaging
by Linus Emmerich, Arne Ohlendorf, Alexander Leube, Nikolai Suchkov and Siegfried Wahl
Sensors 2023, 23(1), 362; https://doi.org/10.3390/s23010362 - 29 Dec 2022
Cited by 1 | Viewed by 2299
Abstract
Autorefraction is an objective way to determine the refractive error of the eye, without the need for feedback by the patient or a well-educated practitioner. To make refractive measurements more accessible in the background of the growing prevalence of myopia, a compact autorefractor [...] Read more.
Autorefraction is an objective way to determine the refractive error of the eye, without the need for feedback by the patient or a well-educated practitioner. To make refractive measurements more accessible in the background of the growing prevalence of myopia, a compact autorefractor was built, containing only few optical components and relying on double-pass imaging and the physical properties of the point-spread function and digital image processing instead. A method was developed to analyze spherical defocus as well as the defocus and angle of astigmatism. The device was tested using calibrator eye models in a range of ± 15 D spherical defocus and −3 D astigmatic defocus. Reliable results could be achieved across the whole measurement range, with only a small increase in deviation toward high values of refractive errors, showing the feasibility of a PSF-based approach for a compact and low-cost solution for objective measurements of refractive error. Full article
(This article belongs to the Special Issue Modern Sensor Technology in Ophthalmology and Optometry for Diagnostics and Surgery)
►▼ Show Figures

Figure 1

Figure 1
<p>Setup schematic.</p> Full article ">Figure 2
<p>Example for the intensity matrix of an astigmatic lens.</p> Full article ">Figure 3
<p>Results of all spherical defocus measurements.</p> Full article ">
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop