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Extracellular Vesicles (EVs) in Cancer Progression and Metastasis: Molecular Insights...
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Extracellular Vesicles (EVs) in Cancer Progression and Metastasis: Molecular Insights and Clinical Outlook

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 15 March 2025 | Viewed by 584

Special Issue Editor

Dr. Alfredo Cappariello

E-Mail Website
Guest Editor
Department of Life, Health, and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
Interests: extracellular vesicles; malignant tumors; anti-inflammatory; anti-fibrosis

Special Issue Information

Dear Colleagues,

Extracellular vesicles (EVs) are cell-derived particles that integrate with physiological processes in all life forms, having been identified in prokaryotes, animals, and plants. They encompass molecules that exert crucial biological effects in cell-to-cell communication and cell homeostasis. Notably, EVs play a critical role in cancer progression and metastasis.

This Special Issue, entitled "Extracellular Vesicles (EVs) in Cancer Progression and Metastasis: Molecular Insights and Clinical Outlook", aims to cover a selection of recent research topics and current review articles in the field of EVs in cancer. Our focus will be on the pro/anti-oncogenic, pro/anti-angiogenic, and pro/anti-metastatic functions mediated by EVs, whether secreted by cancer cells or by the metastatic and primary tumor microenvironment. We warmly encourage article submissions on the effects of bacterial- and plant-derived EVs on tumor physiology, as well as on the topic of the theranostic potential of EVs as tools for precision medicine in cancer. Adherence to MISEV2023 guidelines will be considered a strong plus for original articles.

Dr. Alfredo Cappariello
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mammalian extracellular vesicles
  • plant-derived extracellular vesicles
  • bacterial-derived extracellular vesicles
  • cancer progression
  • cell migration and invasion
  • tumor microenvironment
  • epithelial-to-mesenchymal transition (EMT)
  • drug delivery
  • diagnostics
  • precision medicine

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Published Papers (1 paper)

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Review

30 pages, 2460 KiB  
Review
Recent Advances of Small Extracellular Vesicles for the Regulation and Function of Cancer-Associated Fibroblasts
by Chengdong Liang, Maoye Wang, Yongli Huang, Judy Wai Ping Yam, Xu Zhang and Xiaoxin Zhang
Int. J. Mol. Sci. 2024, 25(23), 12548; https://doi.org/10.3390/ijms252312548 - 22 Nov 2024
Viewed by 457
Abstract
Cancer-associated fibroblasts (CAFs) are a heterogeneous cell population in the tumor microenvironment (TME) that critically affect cancer progression. Small extracellular vesicles (sEVs) act as information messengers by transmitting a wide spectrum of biological molecules, including proteins, nucleic acids, and metabolites, from donor cells [...] Read more.
Cancer-associated fibroblasts (CAFs) are a heterogeneous cell population in the tumor microenvironment (TME) that critically affect cancer progression. Small extracellular vesicles (sEVs) act as information messengers by transmitting a wide spectrum of biological molecules, including proteins, nucleic acids, and metabolites, from donor cells to recipient cells. Previous studies have demonstrated that CAFs play important roles in tumor progression by regulating tumor cell proliferation, metastasis, therapeutic resistance, and metabolism via sEVs. In turn, tumor-derived sEVs can also regulate the activation and phenotype switch of CAFs. The dynamic crosstalk between CAFs and cancer cells via sEVs could ultimately determine cancer progression. In this review, we summarized the recent advance of the biological roles and underlying mechanisms of sEVs in mediating CAF-tumor cell interaction and its impact on cancer progression. We also reviewed the clinical applications of tumor- and CAF-derived sEVs, which could identify novel potential targets and biomarkers for cancer diagnosis, therapy, and prognosis. Full article
(This article belongs to the Special Issue Extracellular Vesicles (EVs) in Cancer Progression and Metastasis: Molecular Insights and Clinical Outlook)
►▼ Show Figures

Figure 1

Figure 1
<p>The origins of CAFs. CAFs are mainly derived from normal fibroblasts, MSCs, stellate cells, bone marrow stromal cells, epithelial cells, endothelial cells, pericytes, adipocytes, tumor stem cells, and smooth muscle cells.</p> Full article ">Figure 2
<p>The sEV-mediated communication axis between CAFs and tumor cells. Tumor cells can interact with CAFs via sEVs to regulate tumor progression and stromal microenvironment formation.</p> Full article ">Figure 3
<p>Role of sEVs between CAFs and tumor cells. Activated CAFs in the TME release sEVs to tumor cells and mediate both pro- and anti-tumor effects. The main effects include modulating tumor cell proliferation, metastasis, therapeutic resistance, and metabolic reprogramming. In addition, tumor cells also promote the activation of normal fibroblasts into CAFs and phenotypic switching of CAFs through sEVs.</p> Full article ">Figure 4
<p>Clinical application related to sEV biogenesis and function. Several approaches have been designed to specifically block the biogenesis of sEVs in tumor cells, mainly including the use of viruses carrying functional nucleic acids or small-molecule inhibitors. Moreover, engineering sEVs to carry drugs, siRNA, antibodies, or CRISPR/Cas9 can directly target the lesion and inhibit tumor cells. In addition, liquid biopsy analysis of sEVs is beneficial for diagnosis and prognosis.</p> Full article ">
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