Advances in Protein-Protein Interactions—2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 14831
Special Issue Editor
Interests: drug discovery; protein-protein interactions; structural bioinformatics; molecular modelling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
There are over 300,000 protein–protein interaction (PPI) pairs identified in the human genome. Thus, it is not surprising that modulators of PPIs—ideally small “drug-like” molecules—are urgently being sought and developed by the pharmaceutical industry to address the unmet medical needs. However, the physical characteristics of the PPI interface make this task non-trivial. Furthermore, unlike the traditional pharmaceutical approach of focusing on finding a ‘single switch that works’, it is clear that the phenotype of many diseases relies on complex networks of PPIs. Destabilising these networks for a successful therapeutic approach will require perturbing multiple key interactions.
This Special Issue focuses on recent studies aiming to investigate protien–protein interactions, with an additional aim of developing drugs to modulate these interactions. Specifically, this Special Issue will explore the latest computational and structural biology methods, and studies that further our understanding of protein– protein interfaces and how to better develop molecules to modulate these are welcomed.
Dr. Jessica Holien
Guest Editor
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Keywords
- protein–protein interactions
- structural biology
- bioinformatics
- network analysis
- drug design
- drug development
- computational drug design
- protein–ligand interactions
- target identification
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