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Diagnostics
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Diagnosis and Management of Gynecological Cancers: Third Edition
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Diagnosis and Management of Gynecological Cancers: Third Edition

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 2113

Special Issue Editor

Prof. Dr. Robert Jach

E-Mail Website
Guest Editor
Division of Gynecologic Endocrinology, Jagiellonian University Medical College, Kopernika 23, 31-501 Krakow, Poland
Interests: gynecologic oncology; cervical cancer; cervical cancer screening; hysterectomy; laparoscopic surgery; cancer prevention; ovary; oncology; cervical cancer prevention
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

I cordially invite you to share your discoveries and observations in the field of oncological gynecology with the scientific community and the medical world. This Special Issue will publish reviews and original papers concerning recent advances in diagnostic (based on AI, radiotracers, SLN mapping, biomarkers, DNA/mRNA agents, and molecular biology), imaging (expert ultrasonography and hysteroscopy), and treatment modalities (tips and tricks in surgery, minimally invasive techniques, tailored systemic therapy, immunotherapy, side-effect management, complication management, terminal phase of cancer management, oncofertility, and cancer treatment during pregnancy) for these types of cancer.

I invite you to contribute to this fascinating field of research.

Prof. Dr. Robert Jach
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diagnostic technologies
  • gynecological cancers
  • ovarian cancer
  • endometrial cancer
  • diagnostic pathology
  • diagnostic image
  • machine learning

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

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Review

18 pages, 1024 KiB  
Review
Sensitivity and Specificity of Selected Biomarkers and Their Combinations in the Diagnosis of Ovarian Cancer
by Aleksandra Englisz, Marta Smycz-Kubańska and Aleksandra Mielczarek-Palacz
Diagnostics 2024, 14(9), 949; https://doi.org/10.3390/diagnostics14090949 - 30 Apr 2024
Viewed by 1852
Abstract
One of the greatest challenges in modern gynecological oncology is ovarian cancer. Despite the numerous studies currently being conducted, it is still sometimes detected at late clinical stages, where the prognosis is unfavorable. One significant contributing factor is the absence of sensitive and [...] Read more.
One of the greatest challenges in modern gynecological oncology is ovarian cancer. Despite the numerous studies currently being conducted, it is still sometimes detected at late clinical stages, where the prognosis is unfavorable. One significant contributing factor is the absence of sensitive and specific parameters that could aid in early diagnosis. An ideal screening test, in view of the low incidence of ovarian cancer, should have a sensitivity of greater than 75% and a specificity of at least 99.6%. To enhance sensitivity and specificity, diagnostic panels are being created by combining individual markers. The drive to develop better screening tests for ovarian cancer focuses on modern diagnostic methods based on molecular testing, which in turn aims to find increasingly effective biomarkers. Currently, researchers’ efforts are focused on the search for a complementary parameter to those most commonly used that would satisfactorily enhance the sensitivity and specificity of assays. Several biomarkers, including microRNA molecules, autoantibodies, cDNA, adipocytokines, and galectins, are currently being investigated by researchers. This article reviews recent studies comparing the sensitivity and specificity of selected parameters used alone and in combination to increase detection of ovarian cancer at an early stage. Full article
(This article belongs to the Special Issue Diagnosis and Management of Gynecological Cancers: Third Edition)
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Figure 1

Figure 1
<p>Sensitivity and specificity of CA125 when changing the standard cut-off of 35 U/mL to the cutoff values adopted by the investigators [<a href="#B18-diagnostics-14-00949" class="html-bibr">18</a>]; SN—sensitivity, SP—specificity.</p> Full article ">Figure 2
<p>Sensitivity and specificity of CA125 when changing the standard cut-off of 35 U/mL to the cutoff values adopted by the investigators [<a href="#B19-diagnostics-14-00949" class="html-bibr">19</a>]; SN—sensitivity, SP—specificity.</p> Full article ">Figure 3
<p>Comparison of AUC values for the parameters CA125, HE4, and ROMA in pre- and postmenopausal women [<a href="#B19-diagnostics-14-00949" class="html-bibr">19</a>,<a href="#B27-diagnostics-14-00949" class="html-bibr">27</a>,<a href="#B30-diagnostics-14-00949" class="html-bibr">30</a>].</p> Full article ">Figure 4
<p>Comparison of AUCs for parameters CA125, HE4, and ROMA [<a href="#B19-diagnostics-14-00949" class="html-bibr">19</a>,<a href="#B28-diagnostics-14-00949" class="html-bibr">28</a>,<a href="#B29-diagnostics-14-00949" class="html-bibr">29</a>].</p> Full article ">
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