The Bright and Dark Sides of Apoptosis and Other Modes of Cell “Death” in Cancer Therapy
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 26462
Special Issue Editor
Interests: DNA damage response; p53 signaling; senescence; polyploidy; multinucleation; radioresistance; chemoresistance; Li-Fraumeni syndrome
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Stress-induced programmed cell death (e.g., through apoptosis) and “functional death” (e.g., dormancy through premature senescence) in cancer cells have long been regarded as favorable outcomes in cancer therapy. In the past decade, however, it has become evident that while these responses are essential for initial tumor control, they can also contribute to disease relapse, at least in solid tumors. Apoptotic cancer cells, for example, not only secrete tumor-promoting factors but can also undergo a reversal process (through anastasis), giving rise to tumor repopulating progeny. Reversal of a subset of apoptotic/dormant cancer cells contributes to intratumor heterogeneity, which poses a major challenge in treating cancer patients with metastatic disease. Unfortunately, intratumor heterogeneity is overlooked in most preclinical methods used in anticancer studies.
The purpose of this Special Issue is to provide a comprehensive update on molecular events that underlie intratumor heterogeneity in the context of cancer therapy. Reviews and original articles addressing the dark side of stress-induced apoptosis and senescence in solid tumors are particularly welcomed.
Prof. Dr. Razmik Mirzayans
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- intratumor heterogeneity
- single-cell analysis
- senescence
- senotherapeutics
- apoptosis and tumorigenicity
- anastasis
- cell fusion
- novel therapeutic strategies targeting dormant cancer cells
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.