KEGG T01001: 23308

Homo sapiens (human): 23308

Entry

23308             CDS       T01001

Symbol

ICOSLG, B7-H2, B7H2, B7RP-1, B7RP1, B7h, CD275, GL50, ICOS-L, ICOSL, IMD119, LICOS

Name

(RefSeq) inducible T cell costimulator ligand

K06710

inducible T-cell co-stimulator ligand

Organism

hsa Homo sapiens (human)

Pathway

hsa04514

Cell adhesion molecules

hsa04672

Intestinal immune network for IgA production

Network

nt06537 TCR/BCR signaling

Element

N01696

ICOSLG/ICOS-PI3K signaling pathway

Disease

H00093

Combined immunodeficiency

Drug target

Rozibafusp alfa:

D11907

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    23308 (ICOSLG)
09150 Organismal Systems
  09151 Immune system
   04672 Intestinal immune network for IgA production
    23308 (ICOSLG)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    23308 (ICOSLG)
CD molecules [BR:hsa04090]
Proteins
  23308 (ICOSLG)

SSDB

Motif

Pfam:

C2-set_3 V-set Ig_3 C2-set_2 ig

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Pharos:

O75144(Tbio)

UniProt:

O75144 A0N0L8

Structure

LinkDB

Position

21:complement(44216981..44240943)

AA seq 302 aa
MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESK
TVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSL
GFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLL
DQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERD
KITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPETELTG
HV

NT seq 909 nt +upstreamnt +downstreamnt
atgcggctgggcagtcctggactgctcttcctgctcttcagcagccttcgagctgatact
caggagaaggaagtcagagcgatggtaggcagcgacgtggagctcagctgcgcttgccct
gaaggaagccgttttgatttaaatgatgtttacgtatattggcaaaccagtgagtcgaaa
accgtggtgacctaccacatcccacagaacagctccttggaaaacgtggacagccgctac
cggaaccgagccctgatgtcaccggccggcatgctgcggggcgacttctccctgcgcttg
ttcaacgtcaccccccaggacgagcagaagtttcactgcctggtgttgagccaatccctg
ggattccaggaggttttgagcgttgaggttacactgcatgtggcagcaaacttcagcgtg
cccgtcgtcagcgccccccacagcccctcccaggatgagctcaccttcacgtgtacatcc
ataaacggctaccccaggcccaacgtgtactggatcaataagacggacaacagcctgctg
gaccaggctctgcagaatgacaccgtcttcttgaacatgcggggcttgtatgacgtggtc
agcgtgctgaggatcgcacggacccccagcgtgaacattggctgctgcatagagaacgtg
cttctgcagcagaacctgactgtcggcagccagacaggaaatgacatcggagagagagac
aagatcacagagaatccagtcagtaccggcgagaaaaacgcggccacgtggagcatcctg
gctgtcctgtgcctgcttgtggtcgtggcggtggccataggctgggtgtgcagggaccga
tgcctccaacacagctatgcaggtgcctgggctgtgagtccggagacagagctcactggc
cacgtttga

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