Entry |
|
Name |
ICOSLG/ICOS-PI3K signaling pathway
|
Definition |
ICOSLG -> ICOS -> PI3Kdelta -> PIP3 -> AKT |
Expanded |
23308 -> 29851 -> (5293+(5295,5296,8503)) -> C05981 -> (207,208,10000) |
Class |
|
Type |
Reference
|
Pathway |
hsa04660 | T cell receptor signaling pathway |
|
Gene |
23308 | ICOSLG; inducible T cell costimulator ligand |
29851 | ICOS; inducible T cell costimulator |
5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
5295 | PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 |
5296 | PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 |
8503 | PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 |
207 | AKT1; AKT serine/threonine kinase 1 |
208 | AKT2; AKT serine/threonine kinase 2 |
10000 | AKT3; AKT serine/threonine kinase 3 |
|
Metabolite |
C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
Reference |
|
Authors |
Chen L, Flies DB |
Title |
Molecular mechanisms of T cell co-stimulation and co-inhibition. |
Journal |
|
Reference |
|
Authors |
Buchanan CM, Lee KL, Shepherd PR |
Title |
For Better or Worse: The Potential for Dose Limiting the On-Target Toxicity of PI 3-Kinase Inhibitors. |
Journal |
|
Reference |
|
Authors |
Wikenheiser DJ, Stumhofer JS |
Title |
ICOS Co-Stimulation: Friend or Foe? |
Journal |
|
LinkDB |
|