With over 20 options, what is the best multiple sclerosis treatment for me? Selecting an appropriate disease-modifying therapy (DMT) needs to consider your risk of worsening disability over time. Your age, sex and race can affect your prognosis and can influence the power of treatment chosen. Details about your early relapses and MRI activity are very important for treatment decisions. Treatment selection should also consider responsiveness to vaccines, family planning and other medical problems (another autoimmune disease or cancer). For each individual living with multiple sclerosis, balancing power of treatment against serious risks of treatment needs to be considered.  The future of personalizing care to better pick the right medication shared. Barry Singer MD, Director of The MS Center for Innovations in Care, interviews Celia Oreja-Guevara MD PhD, Vice Chair of Neurology & Head of the Multiple Sclerosis Center, University Hospital, San Carlos, Madrid, Spain & John Foley MD, Director, Rocky Mountain MS Clinic, Salt Lake City, Utah