Electron Microscopy Data Bank

EMBL was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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primary_citation_author:"Zemla AT"

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EMD-28198

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Cryo-EM map of SARS-CoV-2 Omicron BA.2 spike in complex with LLNL-199

Release date: Feb. 21, 2024
Resolution: 3.26 Å
EM Method: Single-particle

Desautels TA, Arrildt KT, Zemla AT, Lau EY, Zhu F, Ricci D, Cronin S, Zost SJ, Binshtein E, Scheaffer SM, Dadonaite B, Petersen BK, Engdahl TB, Chen E, Handal LS, Hall L, Goforth JW, Vashchenko D, Nguyen S, Weilhammer DR, Lo JK, Rubinfeld B, Saada EA, Weisenberger T, Lee TH, Whitener B, Case JB, Ladd A, Silva MS, Haluska RM, Grzesiak EA, Earnhart CG, Hopkins S, Bates TW, Thackray LB, Segelke BW, Lillo AM, Sundaram S, Bloom JD, Diamond MS, Crowe Jr JE, Carnahan RH, Faissol DM

Nature (2024) 629 pp. 878-885 [ Pubmed: 38720086 DOI: doi:10.1038/s41586-024-07385-1 ]

Sample:

EMD-28199

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Cryo-EM map of SARS-CoV-2 Omicron BA.2 spike in complex with 2130-1-0114-112

Release date: Feb. 21, 2024
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8ekd
Q-score: 0.433

Desautels TA, Arrildt KT, Zemla AT, Lau EY, Zhu F, Ricci D, Cronin S, Zost SJ, Binshtein E, Scheaffer SM, Dadonaite B, Petersen BK, Engdahl TB, Chen E, Handal LS, Hall L, Goforth JW, Vashchenko D, Nguyen S, Weilhammer DR, Lo JK, Rubinfeld B, Saada EA, Weisenberger T, Lee TH, Whitener B, Case JB, Ladd A, Silva MS, Haluska RM, Grzesiak EA, Earnhart CG, Hopkins S, Bates TW, Thackray LB, Segelke BW, Lillo AM, Sundaram S, Bloom JD, Diamond MS, Crowe Jr JE, Carnahan RH, Faissol DM

Nature (2024) 629 pp. 878-885 [ DOI: doi:10.1038/s41586-024-07385-1 Pubmed: 38720086 ]

Sample:

2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Fab llnl-199 hc (14 kDa, Protein from Homo sapiens)
Fab llnl-199 lc (12 kDa, Protein from Homo sapiens)
Sars cov2 omicron ba.2 rbd (Complex from Severe acute respiratory syndrome coronavirus)
Sars cov2 omicron ba.2 rbd complex with fab llnl-199 (Complex)
Fab llnl-199 (Complex from Homo sapiens)
Spike protein s2' (20 kDa, Protein from Severe acute respiratory syndrome coronavirus)

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