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2013, European Respiratory Journal
The Journal of allergy and clinical immunology, 2017
The use of inflammatory biomarkers to delineate the type of lung inflammation present in asthma is increasingly common. However, the impact of obesity on these markers is unknown. We aimed to determine the impact of obesity on conventional markers of inflammation in asthma. We performed secondary analysis of data from 652 patients previously enrolled in two ACRN trials. We performed linear correlations between biomarkers and logistic regression analysis to determine the predictive value of IgE, blood eosinophils and FeNO in relationship to sputum eosinophils (>2%), as well as to determine if cut points existed that would maximize the sensitivity and specificity for predicting sputum eosinophilia in the three weight groups. Overall, statistically significant but relatively weak correlations were observed among all four markers of inflammation. Within obese subjects, the only significant correlation found was between IgE and blood eosinophils (r=0.33, p<0.001); furthermore, all ...
American Journal of Respiratory and Critical Care Medicine, 2013
Clinical and Molecular Allergy, 2018
Biochemical Pharmacology, 2020
Journal of Allergy and Clinical Immunology, 2006
CHEST Journal, 2013
Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia
To evaluate the relationship between obesity and asthma. This was a preliminary cross-sectional analysis involving 925 subjects with mild-to-moderate or severe asthma evaluated between 2013 and 2015. Obesity was defined on the basis of body mass index (BMI) and abdominal circumference. We collected clinical, laboratory, and anthropometric parameters, as well as pulmonary function test results and data regarding comorbidities. The subjects also completed asthma control and quality of life questionnaires. Obese individuals had a significantly higher number of neutrophils in peripheral blood than did nonobese individuals (p = 0.01). Among the obese individuals, 163 (61%) had positive skin-prick test results, as did 69% and 71% of the individuals classified as being overweight or normal weight, respectively. Obese individuals showed lower spirometric values than did nonobese individuals, and 32% of the obese individuals had uncontrolled asthma, a significantly higher proportion than tha...
Sao Paulo medical journal = Revista paulista de medicina
The combined effect of obesity and asthma may lead to significant impairment of quality of life (QOL). The aim here was to evaluate the prevalence of asthma among obese individuals, characterize the severity of impairment of quality of life and measure its relationship with pulmonary function. Observational cross-sectional study in public university hospital. Morbidly obese individuals (body mass index > 40 kg/m2) seen in a bariatric surgery outpatient clinic and diagnosed with asthma, were included. Anthropometric data were collected, the Standardized Asthma Quality of Life Questionnaire (AQLQ(S)) was applied and spirometry was performed. The subjects were divided into two groups based on the median of the score in the questionnaire (worse < 4 and better > 4) and were compared regarding anthropometric data and pulmonary function. Among the 4791 individuals evaluated, 219 were asthmatic; the prevalence of asthma was 4.57%. Of these, 91 individuals were called to start multi...
Sprogforum. Tidsskrift for sprog- og kulturpædagogik, 2020
Early Childhood Research Quarterly, 2023
Near Eastern Archaeology vol. 81 issue 3, 2018
Journal of Empirical Research on Human Research Ethics, 2020
Revista de História Regional, 2024
Journal of Flood Risk Management, 2021
International braz j urol, 2008
Archives of Otolaryngology–Head & Neck Surgery, 2002
IEEE Computer Graphics and Applications, 2011
Journal of Bone and Joint Surgery, American Volume, 2014