Academia.edu no longer supports Internet Explorer.
To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to upgrade your browser.
2008, ChemInform
ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
2008 •
Journal of Phycology
Both modular and single-domain Type I polyketide synthases are expressed in the brevetoxin-producing dinoflagellate, Karenia brevis (Dinophyceae)2017 •
Journal of Phycology
Novel Sterols of the Toxic Dinoflagellate Karenia Brevis (Dinophyceae): A Defensive Function for Unusual Marine STEROLS?12003 •
2005 •
Journal of Phycology
CHARACTERIZATION AND EXPRESSION OF NUCLEAR-ENCODED POLYKETIDE SYNTHASES IN THE BREVETOXIN-PRODUCING DINOFLAGELLATE KARENIA BREVIS1: PKS PROTEINS IN KARENIA BREVIS2010 •
The dinoflagellate Karenia brevis (C. C. Davis) Gert Hansen et Moestrup produces a suite of brevetoxins, potent neurotoxins that have adverse effects on marine animal and human health. Brevetoxins are polyketides proposed to be synthesized by polyketide synthases (PKSs), and genes for type I PKSs have been predicted by PCR and transcript analysis. However, the full-length transcripts in K. brevis predict an unusual protein structure for type I PKS in that individual transcripts encode for single catalytic domains. In this study, we developed peptide antibodies to in silico translated transcripts for two PKS proteins to characterize their expression and localization. Immunoreactive proteins identified by Western blotting at 40 kDa (KR domain) and 100 kDa (KS domain) are consistent with the sizes predicted by the full-length transcripts. Immunolocalization and Western blot analysis indicate that these PKSs are associated with the chloroplasts. In order to establish evidence for a role in brevetoxin biosynthesis, PKS transcript and protein levels were examined in a “nontoxic”K. brevis substrain and its parental toxic isolate, K. brevis Wilson. DNA microarray analysis of the global transcript profiles in the “nontoxic” isolate showed that ∼7% of transcripts were differentially expressed, including photosystem genes; however, no difference was observed in PKS transcript abundance. By contrast, KS domain proteins were 55%–70% less abundant in “nontoxic”K. brevis cultures compared to toxic cultures. This finding suggests that K. brevis PKS expression is regulated posttranscriptionally, like many other processes in dinoflagellates. Further, the decrease in PKS protein abundance in the “nontoxic” cultures provides correlative evidence for their involvement in brevetoxin biosynthesis.
2012 •
Tetrahedron Letters
Occurrence of 12-methylgymnodimine in a spirolide-producing dinoflagellate Alexandrium peruvianum and the biogenetic implications2011 •
in A. LA MARCA - S. MANCUSO (a cura di), Catalogo della Mostra Fotografica Scavi archeologici italiani a Kyme d’Eolide (Turchia), Rende 2012, p. 38
La ceramica da cucina di età romana e tardo antica2012 •
2024 •
2018 •
10th edition of the International Conference on Computational Methods for Coupled Problems in Science and Engineering
A mechanobiological bone remodelling model coupling bone physiology and systemic calcium and phosphorus homeostasis2014 •
2015 •
ACS Sustainable Chemistry & Engineering
Influence of Extraction Conditions on Chemical Composition and Thermal Properties of Chestnut Wood Extracts as Tannin Feedstock2019 •
Revista Colombiana de Cirugía
Amenazada la cirugía general en el siglo XXI2017 •
Bulletin of Mathematical Biology
Latent Coinfection and the Maintenance of Strain Diversity2008 •
Investigative Opthalmology & Visual Science
ANRIL: A Regulator of VEGF in Diabetic Retinopathy2017 •