Worldviews about Healthy Sexuality: Southeast Asia.

Objectives: Formulation of triplet combined solid dosage film coated
tablet  containing  amlodipine  besylate  (equivalent  to  5  mg
amlodipine), hydrochlorothiazide (12.5 mg) and losartan potassium
(50 mg) for the treatment of severe hypertension. Development and
validated of a simple, fast, precise, selective and accurate HPLC
method  for  the  simultaneous  determination  of  amlodipine  besylate,
hydrochlorothiazide and losartan potassium in the tablets.
Methods:  The  formulation  of  the  tablets  was  carried  out  as  per
standard  protocols. The  various  steps  involve  in  formulation  were
dispensing  of  raw  materials,  sieving,  preparation  of  granulating
solvent,  mixing,  granulation,  drying  (In  FBD),  lubrication,
compression and coating. The separation of these three drugs was
achieved on a Sun Shell C8 column (150 mm x 4.6 mm, 2.6 μm) with
phosphate  buffer-acetonitrile  (70:30%  v/v)  as  mobile  phase  at  1.0
mL/min flow rate and 230 nm detection.
Results  and  Conclusion: The  physical  parameters  of  tablets  were
satisfactory  with  average  weight  deviation  from  3.23  to  3.29%,
friability 0.04%, disintegration time 8.3 minutes, average hardness
85.43N and thickness from 3.92 to 4.01 mm. The assay was found to
be 99.89%, 99.99% and 99.97% of amlodipine, hydrochlorothiazide
and losartan potassium, respectively. The dissolution was found to be
98.8 to 99.70%, 97.85 to 98.95% and 97.98 to 99.99% of amlodipine,
hydrochlorothiazide  and  losartan  potassium,  respectively.  The
uniformity of content was 99.85 to 99.99% and 99.60 to 99.99% of
amlodipine  and  hydrochlorothiazide,  respectively.  The  retention
times  observed  were  to  be  7.338,  2.097  and  10.675  minutes  for
amlodipine  besylate,  hydrochlorothiazide  and  losartan  potassium,
respectively.  The  method  was  statistically  validated  for  linearity,
recovery,  limit  of  detection,  limit  of  quantification,  accuracy, precision,  robustness,  stability  of  drugs  in  pure  form  and  in
presence of matrices and forced degradation study. The method
was successfully applied for analysis of combined dose tablet.

The objective of the study was to assess the determinant factors of
low birth weight among newborns delivered at Mekelle Hospital,
northern Ethiopia.  A  cross-sectional  study  was  employed  and  cards
of 180 mothers who  gave birth to low birth weight babies were
assessed. Data was collected using pre prepared structured checklist
and analyzed using SPSS version 16.00. The association between
dependent  and  independent  variables  was  assessed  and  presented
using  descriptive  statistics,  student  t-test,  and  ANOVA  test.  Out  of
the180 mothers, 45% of them fall into the age category of 15-19
years.  The  study  finding  showed  maternal  age,  fetal  sex,  parity,
number of antenatal care, gestational age, birth order, and history of
abortion had significant association with low birth weight (P-value <
0.05).  This  study  depicted  that  low  birth  weight  is a  public  health
problem  in  the  study  area.  Hence,  attention  should  be  given  to
increase  community  awareness of antenatal  care  service,  access  to
family planning and male involvement, prevention of abortion, and
community mobilization to prevent early pregnancy.