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Three interconnected positions are advocated: (1) although serving as a useful model, the immune self does not exist as such; (2) instead of a self/nonself demarcation, the immune system 'sees' itself, i.e., it does not ignore the... more
This chapter argues that scientific and philosophical progress in our understanding of the living world requires that we abandon a metaphysics of things in favour of one centred on processes. We identify three main empirical motivations... more
This is one of the first books to study neural development using computational and mathematical modeling. Modeling provides precise and exact ways of expression, which allow us to go beyond the insights that intuitive or commonsense... more
Benchmarking graph-oriented database workloads and graph-oriented database systems are increasingly becoming relevant in analytical Big Data tasks, such as social network analysis. In graph data, structure is not mainly found inside the... more
Biology takes a special place among the other natural sciences because biological units, be they pieces of DNA, cells, or organisms, reproduce more or less faithfully. Like any other biological process, reproduction has a large random... more
The chapter provides a brief introductory overview of biosemiotics — the study of meaning-making mechanisms in the living world. Biosemiotics is a study of those types of sign processes that are not based on human language. We describe... more
BACKGROUND: In spite of its indusrial usefulness and varied daily uses, lead (Pb) pollution is a widespread ecological problem that faces the humans in the 21th century. Pb was found to produces a wide range of toxic effects including... more
Le theme de l’individuation et de la persistance des entites vivantes constitue l’une des problematiques centrales de la philosophie de la biologie. Dans les sciences du vivant, l’organisme represente traditionnellement l’exemple... more
The Concept of Organism: Historical, Philosophical, Scientific Perspectives special issue of History and Philosophy of the Life Sciences 32:2-3 (2010) Guest editors: Philippe Huneman (CNRS-IHPST) and Charles T. Wolfe (Unit for... more
A mechanism of evolution that ensures adaptive changes without the obligatory role of natural selection is described. According to this mechanism, the first event is a plastic adaptive change (change of phenotype), followed by stochastic... more
The definitions of the concept of life were analyzed. It turned out that the variety of definitions is not accidental and fundamentally cannot be reduced to one comprehensive definition. The variety of definitions can be considered in the... more
Ce recueil d’écrits de Francisco Varela couvre l’ensemble de son œuvre, de la biologie théorique à l’éthique, en passant par la théorie de la connaissance et la philosophie de la conscience. Il donne à voir pour la première fois... more