Rev is a transactivating protein that is essential to the regulation of HIV-1 protein expression. A nuclear localization signal is encoded in the rev gene, which allows the Rev protein to be localized to the nucleus, where it is involved in the export of unspliced and incompletely spliced mRNAs. In the absence of Rev, mRNAs of the HIV-1 late (structural) genes are retained in the nucleus, preventing their translation.
History
A novel protein was found to be involved in the translation of gag and env mRNA. The unknown protein functioned by removing repression of regulatory sequences and was named Art (anti-repression transactivator). Later studies suggested that the protein was involved in regulation of the RNA splicing mechanism. Therefore, the name of the protein was modified from Art to Trs (transregulator of splicing). The most recent studies have shown that the protein has multiple functions in the regulation of HIV-1 proteins, and its name has been changed to Rev (regulator of expression of virion proteins), which more generally describes its function.
Rev or Rév may refer to:
People
Music
Other uses
Revò (Ladin: Rvòu, German: Nußdorf am Nonsberg) is a comune (municipality) in Trentino in the northern Italian region Trentino-Alto Adige/Südtirol, located about 35 kilometres (22 mi) north of Trento.
Geography
Revò is situated on a grassy plain in the Val di Non, overlooking Lake Santa Giustina, and had already been settled by the 3rd century BC. It is backed by Monte Ozol, in the Maddalene mountain range, which is topped by an iron-age hill fort. The parish church of Santo Stefano dates back to at least 1128 AD and has a fine spire. The church of St Mary dates from the 18th century and has an octagonal spire. Other notable buildings include the Villa Campia-Maffei and the Casa Thun. Nearby, the River Sass has carved a narrow but deep canyon through the rock and visitors can walk along the trails and walkways that traverse the vertical-sided gorge in the "Parco Fluviale Novella".
The municipality of Revò contains the frazione (subdivision) Tregiovo. Revò borders the following municipalities: Cagnò, Cles, Cloz, Romallo, Rumo, Sanzeno, and Laurein.
Rev is an album by Jane's Addiction vocalist Perry Farrell, released in 1999. It is a combination of solo work and a best-of for the singer's bands.
Background
To fulfill requirements on a contract with Warner Bros. Records, this album was produced with a combination of solo, Jane's Addiction, and Porno for Pyros recordings. Originally, the solo tracks were intended for a side project called "Golabee". The title track features Tom Morello and John Frusciante on guitars. Farrell signed with Virgin Records shortly after Rev's release.
Track listing
Promo
References
The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS). AIDS is a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Without treatment, average survival time after infection with HIV is estimated to be 9 to 11 years, depending on the HIV subtype. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells.
HIV infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells. HIV infection leads to low levels of CD4+ T cells through a number of mechanisms, including pyroptosis of abortively infected T cells,apoptosis of uninfected bystander cells, direct viral killing of infected cells, and killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections.
Hiv (Persian: هيو, also Romanized as Hīv) is a village in Hiv Rural District, in the Central District of Savojbolagh County, Alborz Province, Iran. At the 2006 census, its population was 8,061, in 2,247 families.