QuarkXPress is a computer application for creating and editing complex page layouts in a WYSIWYG (What You See Is What You Get) environment. It runs on Mac OS X and Windows. It was first released by Quark, Inc. in 1987 and is still owned and published by them.

The most recent version, QuarkXPress 2015 (internal version number 11.0), allows publishing in English ("International and U.S.") and 36 other languages, including Arabic, Chinese, Japanese, Portuguese, German, Korean, Russian, French, and Spanish.

QuarkXPress is used by individual designers and large publishing houses to produce a variety of layouts, from single-page flyers to the multi-media projects required for magazines, newspapers, catalogs, and the like. QuarkXPress once dominated the market for page layout software, with over 95% market share among professional users. As of 2010, one publisher estimated that US market share has fallen to below 25% and Adobe InDesign has become the market leader, although QuarkXPress still had significant marketshare.