A number of trigraphs are found in the Latin script, most of these used especially in Irish orthography.

A

⟨aai⟩ is used in Dutch to write the sound /aːi̯/.

⟨abh⟩ is used in Irish to write the sound /əu̯/, or in Donegal, /oː/, between broad consonants.

⟨adh⟩ is used in Irish to write the sound /əi̯/, or in Donegal, /eː/, between broad consonants, or an unstressed /ə/ at the end of a word.

⟨aei⟩ is used in Irish to write the sound /eː/ between a broad and a slender consonant.

⟨agh⟩ is used in Irish to write the sound /əi̯/, or in Donegal, /eː/, between broad consonants.

⟨aim⟩ is used in French to write the sound /ɛ̃/ (/ɛm/ before a vowel).

⟨ain⟩ is used in French to write the sound /ɛ̃/ (/ɛn/ before a vowel). It also represents /ɛ̃/ in Tibetan Pinyin, where it is alternatively written än.

⟨aío⟩ is used in Irish to write the sound /iː/ between broad consonants.

⟨amh⟩ is used in Irish to write the sound /əu̯/, or in Donegal, /oː/, between broad consonants.

Suppressor of cytokine signaling 3 (SOCS3 or SOCS-3) is a protein that in humans is encoded by the SOCS3 gene. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling.

Function

The expression of SOCS3 gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma.

For signaling of IL-6, Epo, GCSF and Leptin, binding of SOCS3 to the respective cytokine receptor has been found to be crucial for the inhibitory function of SOCS3.

SOCS3 contributes to both leptin resistance and insulin resistance as a result of increased ceramide synthesis.

Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.

The SOCS3 protein can bind to JAK2 kinase, and inhibits the activity of JAK2 kinase.

Interactions

SOCS3 has been shown to interact with:

Suppressor of cytokine signaling 1 is a protein that in humans is encoded by the SOCS1 gene.SOCS1 orthologs have been identified in several mammals for which complete genome data are available.

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), GM-CSF, and interferon-gamma (IFN-γ). The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-γ action, which is required for normal postnatal growth and survival.

See also

Interactions

Suppressor of cytokine signaling 1 has been shown to interact with: