Next (LSE: NXT), styled as next, is a British multinational clothing, footwear and home products retailer headquartered in Enderby, Leicestershire. It has around 700 stores, of which 502 are in the United Kingdom and Ireland, and around 200 are in continental Europe, Asia and the Middle East. Next is the largest clothing retailer by sales in the United Kingdom, having overtaken Marks & Spencer in early 2012 and 2014. It is listed on the London Stock Exchange and is a constituent of the FTSE 100 Index.
History: Hepworth's
The company was founded by Joseph Hepworth in Leeds in 1864 as a tailor under the name of Joseph Hepworth & Son. Initially Hepworth was in partnership with James Rhodes, but the partnership was dissolved in 1872.
On his own, Hepworth expanded the company rapidly, becoming a pioneer for the development of chain stores in Britain. By 1884 the company had 100 outlets.
For much of its history Hepworth's was predominantly in the ready-to-wear suit market, and in 1963 the company brought in the celebrated Saville Row designer Hardy Amies to help revitalise its ready-to-wear suit collection.
Phospholipase C, gamma 1, also known as PLCG1, is a protein that in humans is encoded by the PLCG1 gene.
Function
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RASGRP1 to translocate to the Golgi apparatus, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. The receptor protein tyrosine phosphatase PTPmu (PTPRM) is capable of dephosphorylating PLCG1. Two transcript variants encoding different isoforms have been found for this gene.
Has been shown to interact with CISH which negatively regulates it by targeting it for degradation. The deletion of Cish in effector T cells has been shown to augment TCR signaling and subsequent effector cytokine release, proliferation and survival. The adoptive transfer of tumor-specific effector T cells knocked out or knocked down for CISH resulted in a significant increase in functional avidity and long-term tumor immunity. There are no changes in activity or phosphorylation of Cish's purported target, STAT5 in either the presence or absence of Cish.
Phosphoinositide phospholipase C (PLC) (EC 3.1.4.11, triphosphoinositide phosphodiesterase, phosphoinositidase C, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase, monophosphatidylinositol phosphodiesterase, phosphatidylinositol phospholipase C, PI-PLC, 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase) is a family of eukaryotic intracellular enzymes that play an important role in signal transduction processes. These enzymes belong to a larger superfamily of Phospholipase C. Other families of phospholipase C enzymes have been identified in bacteria and trypanosomes. Phospholipases C are phosphodiesterases.
Phospholipase Cs participate in phosphatidylinositol 4,5-bisphosphate (PIP2) metabolism and lipid signaling pathways in a calcium-dependent manner. At present, the family consists of six sub-families comprising a total of 13 separate isoforms that differ in their mode of activation, expression levels, catalytic regulation, cellular localization, membrane binding avidity and tissue distribution. All are capable of catalyzing the hydrolysis of PIP2 into two important second messenger molecules, which go on to alter cell responses such as proliferation, differentiation, apoptosis, cytoskeleton remodeling, vesicular trafficking, ion channel conductance, endocrine function and neurotransmission.
Next can refer to:
Film, TV and stage
Publications
Science and technology
"Next" is the second season premiere episode of the American comedy-drama series Desperate Housewives, and the 24th episode overall. It was originally broadcast in the United States on September 25, 2005, on ABC. It was written by Jenna Bans and Kevin Murphy and was directed by Larry Shaw.
In the episode, Susan (Teri Hatcher) recovers from having been held hostage while Gabrielle (Eva Longoria) attempts to salvage her marriage to her incarcerated husband, Carlos (Ricardo Antonio Chavira). Meanwhile, Bree (Marcia Cross) deals with her mother-in-law following her husband's death and Lynette (Felicity Huffman) goes back to work. The episode also introduces the mystery storyline revolving around Betty Applewhite (Alfre Woodard) and her family.
According to Nielsen ratings, "Next" was watched by 28.4 million viewers, making it the most watched season premiere on ABC in nine years. The episode also ranks as the second-most watched in series history, behind the first season finale in May 2005. The episode received general positive reviews, with Cross earning universal praise for her performance. Critics enjoyed Woodward's acting as well as her character's storyline.
Next is the second album by The Sensational Alex Harvey Band. The album was released in 1973. It was released separately on CD, though it is widely available on a 2 in 1 album, the other album being their debut album Framed.
"Swampsnake" was covered by American rock band Zilch on their 1998 debut album 3.2.1..
"The Faith Healer" was covered by Australian psychedelic rock band The Church on their 1999 covers album A Box of Birds.
Track listing
All songs written and composed by Alex Harvey and Hugh McKenna, except where noted.