Hybrid grapes are grape varieties that are the product of a crossing of two or more Vitis species. This is in contrast to crossings between grape varieties of the same species, typically Vitis vinifera, the European grapevine. Hybrid grapes are also referred to as inter-specific crossings or "Modern Varieties." Due to their often excellent tolerance to powdery mildew, other fungal diseases, nematodes, and phylloxera, hybrid varieties have, to some extent, become a renewed focus for European breeding programs. The recently developed varieties, Rondo, and Regent are examples of newer hybrid grape varieties for European viticulturalists. Several North American breeding programs, such as those at Cornell and the University of Minnesota, focus exclusively on hybrid grapes, with active and successful programs, having created hundreds if not thousands of new varieties.

Hybrid varieties exhibit a mix of traits from their European, Asiatic, and North American parentage. Those varieties which derive from Vitis labrusca parentage (such as those still used in the production of Austrian Uhudler) have a strong "candied" or "wild strawberry" aroma, while those that derive from Vitis riparia often have a herbaceous nose with flavours reminiscent of black currants. Most hybrid grape varieties struggle to produce adequate tannin for red wine production, and usually display a level of acidity that exceeds what consumers of wines produced from vitis vinifera are accustomed to. These attributes proved unpopular in Europe, and were among the factors that led to the prohibition of the commercial growth of hybrid vines in many countries in Europe.