High-velocity clouds (HVCs) are large collections of gas found throughout the galactic halo of the Milky Way. Their bulk motions in the local standard of rest have velocities which are measured in excess of 70–90 km s⁻¹. These clouds of gas can be massive in size, some on the order of millions of times the mass of the Sun , and cover large portions of the sky. They have been observed in the Milky Way's halo and within other nearby galaxies.

HVCs are important to the understanding of galactic evolution because they account for a large amount of baryonic matter in the galactic halo. In addition, as these clouds fall into the disk of the galaxy, they add material that can form stars in addition to the dilute star forming material already present in the disk. This new material aids in maintaining the star formation rate (SFR) of the galaxy.

The origins of the HVCs are still in question. No one theory explains all of the HVCs in the galaxy. However, it is known that some HVCs are probably spawned by interactions between the Milky Way and satellite galaxies, such as the Large and Small Magellanic Clouds (LMC and SMC, respectively) which produce a well-known HVC called the Magellanic Stream. Because of the various possible mechanisms that could potentially produce an HVC, there are still many questions surrounding HVCs for researchers to study.