Helium-4 (4
2He or 4He) is a non-radioactive isotope of the element helium. It is by far the most abundant of the two naturally occurring isotopes of helium, making up about 99.99986% of the helium on Earth. Its nucleus is identical to an alpha particle, and consists of two protons and two neutrons.

Alpha decay of heavy elements in the Earth's crust is the source of most naturally occurring helium-4 on Earth. While it is also produced by nuclear fusion in stars, most helium-4 in the Sun and in the universe is thought to have been produced by the Big Bang, and is referred to as "primordial helium". However, primordial helium-4 is largely absent from the Earth, having escaped during the high-temperature phase of Earth's formation. Radioactive decay from other elements is the source of most of the helium-4 found on Earth, produced after the planet cooled and solidified.

Helium-4 makes up about one quarter of the ordinary matter in the universe by mass, with almost all of the rest being hydrogen.