From Hell is a 2001 American thriller film mystery film directed by the Hughes brothers and loosely based on the graphic novel From Hell by Alan Moore and Eddie Campbell about the Jack the Ripper murders.

Plot

In 1888, Mary Kelly (Heather Graham) and her small group of London prostitutes trudge through unrelenting daily misery. When their friend Ann Crook (Joanna Page) is kidnapped, they are drawn into a conspiracy with links higher up than they could possibly imagine. The kidnapping is soon followed by the gruesome murder of another woman, Martha Tabram (Samantha Spiro); and it becomes apparent that they are being hunted down, one by one as various prostitutes are murdered and mutilated post-mortem.

The murder of Martha and her companions grabs the attention of Whitechapel Police Inspector Frederick Abberline (Johnny Depp), a brilliant, yet troubled, man whose police work is often aided by his psychic "visions." His colleague, Sergeant Peter Godley, tries to grasp his friend's wild theories. Abberline's investigations reveal that the murders, while gruesome, imply that an educated person is responsible due to the precise and almost surgical method used. Ann is found a few days later in a workhouse having been lobotomized after officials and doctors supposedly found her to be insane.